Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis.

PubWeight™: 2.13‹?› | Rank: Top 2%

🔗 View Article (PMC 1924790)

Published in Proc Natl Acad Sci U S A on July 18, 2007

Authors

Joanne L Attema1, Peter Papathanasiou, E Camilla Forsberg, Jian Xu, Stephen T Smale, Irving L Weissman

Author Affiliations

1: Institute of Stem Cell Biology and Regenerative Medicine, Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. joattema@stanford.edu

Articles citing this

Insights from genomic profiling of transcription factors. Nat Rev Genet (2009) 5.57

Genome-wide views of chromatin structure. Annu Rev Biochem (2009) 3.89

Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment. Mol Cell (2011) 2.77

Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors. Nat Methods (2010) 2.71

Genome-scale ChIP-chip analysis using 10,000 human cells. Biotechniques (2007) 2.28

Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program. Blood (2009) 1.94

Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells. Proc Natl Acad Sci U S A (2007) 1.81

Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood (2013) 1.80

Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq. Nat Protoc (2011) 1.74

MicroChIP--a rapid micro chromatin immunoprecipitation assay for small cell samples and biopsies. Nucleic Acids Res (2008) 1.70

Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells. Mol Biol Cell (2009) 1.58

Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells. PLoS One (2010) 1.46

G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment. Genes Dev (2012) 1.40

A histone demethylase is necessary for regeneration in zebrafish. Proc Natl Acad Sci U S A (2009) 1.31

CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors. Leukemia (2011) 1.25

Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab Chip (2009) 1.17

GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry. Blood (2012) 1.14

Limitations and possibilities of low cell number ChIP-seq. BMC Genomics (2012) 1.09

Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150. Stem Cells (2009) 1.06

The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis. Cell Rep (2014) 1.04

Dietary manipulation of histone structure and function. Annu Rev Nutr (2008) 1.02

Transcriptional regulation of lymphocyte development. Curr Opin Genet Dev (2008) 1.01

Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros. Stem Cells (2009) 0.98

Labeling human embryonic stem cell-derived cardiomyocytes with indocyanine green for noninvasive tracking with optical imaging: an FDA-compatible alternative to firefly luciferase. Cell Transplant (2010) 0.95

A streamlined method for rapid and sensitive chromatin immunoprecipitation. J Immunol Methods (2009) 0.94

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. Cell Stem Cell (2015) 0.94

Epigenetic modifications induced by RGC-32 in colon cancer. Exp Mol Pathol (2009) 0.94

Role of chromatin states in transcriptional memory. Biochim Biophys Acta (2009) 0.94

Promiscuous expression of H2B-GFP transgene in hematopoietic stem cells. PLoS One (2008) 0.93

RIP140 in thyroid hormone-repression and chromatin remodeling of Crabp1 gene during adipocyte differentiation. Nucleic Acids Res (2009) 0.92

Expansion of human hematopoietic stem cells for transplantation: trends and perspectives. Cytotechnology (2008) 0.89

PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells. EMBO J (2013) 0.89

Transcriptional repression of Gata3 is essential for early B cell commitment. Immunity (2013) 0.89

High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation. Lab Chip (2012) 0.88

A meta-analysis of microarray gene expression in mouse stem cells: redefining stemness. PLoS One (2008) 0.88

Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors. Theor Biol Med Model (2013) 0.86

Piwi genes are dispensable for normal hematopoiesis in mice. PLoS One (2013) 0.84

Epigenetic upregulation of urokinase plasminogen activator promotes the tropism of mesenchymal stem cells for tumor cells. Mol Cancer Res (2010) 0.84

Spleen as a site for hematopoiesis of a distinct antigen presenting cell type. Stem Cells Int (2011) 0.83

Cross talk between histone deacetylase 4 and STAT6 in the transcriptional regulation of arginase 1 during mouse dendritic cell differentiation. Mol Cell Biol (2014) 0.83

Epigenetic regulation of hematopoietic stem cell aging. Exp Cell Res (2014) 0.81

A Method to Study the Epigenetic Chromatin States of Rare Hematopoietic Stem and Progenitor Cells; MiniChIP-Chip. Biol Proced Online (2010) 0.80

A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies. Haematologica (2012) 0.79

Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol (2012) 0.78

Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications. Stem Cells Int (2015) 0.77

Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events. Stem Cells (2011) 0.77

The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis. PLoS One (2014) 0.77

Local chromatin dynamics of transcription factors imply cell-lineage specific functions during cellular differentiation. Epigenetics (2012) 0.76

Going small is the new big. Nat Methods (2010) 0.75

A comparative study of ChIP-seq sequencing library preparation methods. BMC Genomics (2016) 0.75

Visualization of early prostatic adenocarcinoma as a stem cell disease. Oncotarget (2016) 0.75

Articles cited by this

Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27

A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80

Genomic maps and comparative analysis of histone modifications in human and mouse. Cell (2005) 18.96

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature (2000) 16.75

Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68

A stem cell molecular signature. Science (2002) 14.47

Chromatin signatures of pluripotent cell lines. Nat Cell Biol (2006) 12.88

Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell (1997) 12.60

Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol Cell (2002) 11.35

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol (2003) 8.82

Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol (2002) 7.78

Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A (2001) 7.58

Cellular memory and the histone code. Cell (2002) 7.30

Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes Dev (2005) 7.21

Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev (2006) 6.32

Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev (1997) 5.21

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol (1993) 4.44

Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell (2002) 4.37

Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations. Nat Genet (2006) 3.44

Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity (2007) 3.26

Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines. Nature (2000) 3.25

Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet (2005) 3.11

Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system. Annu Rev Med (2005) 2.92

Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain. Proc Natl Acad Sci U S A (2000) 2.83

Histone H3 variants and their potential role in indexing mammalian genomes: the "H3 barcode hypothesis". Proc Natl Acad Sci U S A (2006) 2.68

Reversing histone methylation. Nature (2005) 2.57

Assembling a gene regulatory network for specification of the B cell fate. Dev Cell (2004) 2.46

Determinants of lymphoid-myeloid lineage diversification. Annu Rev Immunol (2006) 2.37

New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors. Cell (2006) 2.34

Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay, unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells. Stem Cells (2007) 2.10

Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll. Proc Natl Acad Sci U S A (2006) 1.98

Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein. Mol Cell Biol (2004) 1.94

Activation of the beta-globin locus control region precedes commitment to the erythroid lineage. Proc Natl Acad Sci U S A (1992) 1.87

Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells. Proc Natl Acad Sci U S A (2007) 1.81

An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1. Nucleic Acids Res (1991) 1.76

Chromatin remodeling in neural development and plasticity. Curr Opin Cell Biol (2005) 1.70

Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage. Mol Cell Biol (2005) 1.62

Activation by locus control regions? Curr Opin Genet Dev (1999) 1.42

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells. Genes Dev (2002) 1.34

Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro. Blood (2003) 1.28

Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. EMBO J (2004) 1.28

Developmental stage-specific epigenetic control of human beta-globin gene expression is potentiated in hematopoietic progenitor cells prior to their transcriptional activation. Blood (2003) 1.27

The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes. J Exp Med (2001) 1.26

Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitro. J Biol Chem (2004) 1.21

Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells. Nucleic Acids Res (2005) 1.20

Lineage promiscuity and plasticity in hematopoietic development. Ann N Y Acad Sci (2005) 1.01

Global genetic regulatory networks controlling hematopoietic cell fates. Curr Opin Hematol (2006) 0.93

Modern genome-wide genetic approaches to reveal intrinsic properties of stem cells. Curr Opin Hematol (2006) 0.79

Articles by these authors

(truncated to the top 100)

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35

A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81

Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med (2004) 11.29

Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature (2005) 11.23

Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31

Little evidence for developmental plasticity of adult hematopoietic stem cells. Science (2002) 9.63

Glycan foraging in vivo by an intestine-adapted bacterial symbiont. Science (2005) 9.08

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature (2004) 8.36

The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots. Nature (2005) 8.20

Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol (2002) 7.78

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature (2007) 7.72

Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol (2002) 7.03

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (2008) 6.66

Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A (2005) 6.32

A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell (2009) 6.26

Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06

Stems cells and the pathways to aging and cancer. Cell (2008) 5.99

A role for Dicer in immune regulation. J Exp Med (2006) 5.81

Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med (2005) 5.68

Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity (2013) 5.47

Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res (2003) 5.30

CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell (2009) 5.30

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell (2007) 5.28

T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med (2005) 5.26

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell (2009) 5.22

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc Natl Acad Sci U S A (2006) 5.21

Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell (2004) 5.20

Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach. Proc Natl Acad Sci U S A (2006) 5.13

Plasticity of adult stem cells. Cell (2004) 5.13

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature (2010) 5.05

Polar PIN localization directs auxin flow in plants. Science (2006) 4.81

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev (2003) 4.71

Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev (2006) 4.61

Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res (2007) 4.53

Auxin transport is sufficient to generate a maximum and gradient guiding root growth. Nature (2007) 4.50

In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation (2006) 4.48

Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A (2003) 4.41

Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell (2002) 4.37

Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol (2006) 4.32

JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell (2004) 4.28

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20

Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell (2012) 4.10

Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A (2003) 4.09

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med (2012) 4.05

Coronary arteries form by developmental reprogramming of venous cells. Nature (2010) 3.95

Cancer stem cells in solid tumors. Curr Opin Biotechnol (2007) 3.91

Endochondral ossification is required for haematopoietic stem-cell niche formation. Nature (2008) 3.87

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A (2009) 3.87

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med (2009) 3.82

Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nat Biotechnol (2011) 3.81

Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med (2003) 3.74

Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell (2007) 3.59

Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci U S A (2002) 3.50

Developmental and species-divergent globin switching are driven by BCL11A. Nature (2009) 3.49

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci U S A (2010) 3.41

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci U S A (2014) 3.39

Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell (2010) 3.37

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A (2008) 3.27

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 3.25

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med (2004) 3.17

Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet (2005) 3.11

The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression. Proc Natl Acad Sci U S A (2006) 3.07

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol (2011) 3.05

Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip. Nature (2011) 3.03

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol (2002) 2.97

Isolation and characterization of a protochordate histocompatibility locus. Nature (2005) 2.96

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci U S A (2011) 2.96

Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med (2002) 2.96

The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A (2006) 2.94

Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system. Annu Rev Med (2005) 2.92

Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85

The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res (2006) 2.85

Arabidopsis sterol endocytosis involves actin-mediated trafficking via ARA6-positive early endosomes. Curr Biol (2003) 2.84

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A (2006) 2.83

Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med (2010) 2.79

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76

Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nat Immunol (2012) 2.72

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (2013) 2.71

Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes Dev (2009) 2.70

Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science (2007) 2.69

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Blood (2011) 2.69

microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. J Exp Med (2010) 2.68

Dynamic assembly of silent chromatin during thymocyte maturation. Nat Genet (2004) 2.68

Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell (2008) 2.67

Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity (2007) 2.65

Ethics. The ISSCR guidelines for human embryonic stem cell research. Science (2007) 2.62

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature (2016) 2.53

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood (2008) 2.52

Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev (2009) 2.46

Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands. Dev Cell (2006) 2.45

Retracted Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions. Nature (2008) 2.42

JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell (2009) 2.41

Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol (2008) 2.40

Hematopoietic stem cell: self-renewal versus differentiation. Wiley Interdiscip Rev Syst Biol Med (2010) 2.38

Two pathways of synaptic vesicle retrieval revealed by single-vesicle imaging. Neuron (2009) 2.38

Root-specific CLE19 overexpression and the sol1/2 suppressors implicate a CLV-like pathway in the control of Arabidopsis root meristem maintenance. Curr Biol (2003) 2.38

The 14-amino acid CLV3, CLE19, and CLE40 peptides trigger consumption of the root meristem in Arabidopsis through a CLAVATA2-dependent pathway. Plant Cell (2005) 2.36

AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res (2010) 2.35