PubRank

William I Weis

Author PubWeight™ 209.16‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 2007 20.32
2 Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature 2007 14.06
3 Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature 2011 13.92
4 GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science 2007 11.74
5 Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature 2011 9.61
6 Deconstructing the cadherin-catenin-actin complex. Cell 2005 8.39
7 Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell 2005 7.62
8 Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature 2012 6.18
9 Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature 2011 5.35
10 Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature 2012 3.83
11 Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature 2012 3.83
12 Structure of the δ-opioid receptor bound to naltrindole. Nature 2012 3.69
13 Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol 2005 3.41
14 Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature 2010 3.19
15 Structure and mechanism of cadherins and catenins in cell-cell contacts. Annu Rev Cell Dev Biol 2007 2.86
16 Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol 2004 2.83
17 E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A 2012 2.82
18 An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity. Bioessays 2012 2.81
19 Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure 2005 2.53
20 Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 2013 2.49
21 High-resolution crystal structure of human protease-activated receptor 1. Nature 2012 2.44
22 Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol 2002 2.38
23 Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol 2009 2.37
24 Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure 2008 2.36
25 Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J 2008 2.33
26 Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem 2002 2.31
27 Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell 2006 2.28
28 The β-catenin destruction complex. Cold Spring Harb Perspect Biol 2013 2.22
29 Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature 2013 2.14
30 Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell 2004 2.13
31 Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem 2005 2.04
32 Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure. Nat Struct Biol 2002 1.97
33 ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell 2002 1.88
34 Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One 2008 1.86
35 AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. J Cell Biol 2010 1.81
36 X-ray structure determination at low resolution. Acta Crystallogr D Biol Crystallogr 2009 1.60
37 A monoclonal antibody for G protein-coupled receptor crystallography. Nat Methods 2007 1.60
38 Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell 2011 1.57
39 Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature 2016 1.55
40 Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR. J Biol Chem 2004 1.53
41 In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. Proc Natl Acad Sci U S A 2010 1.37
42 Crystal structure of the S.cerevisiae exocyst component Exo70p. J Mol Biol 2005 1.37
43 Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism. Nature 2007 1.36
44 A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. Science 2011 1.32
45 Biochemical and structural analysis of alpha-catenin in cell-cell contacts. Biochem Soc Trans 2008 1.32
46 αE-catenin is an autoinhibited molecule that coactivates vinculin. Proc Natl Acad Sci U S A 2012 1.25
47 Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. J Biol Chem 2010 1.18
48 N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor. PLoS One 2012 1.17
49 Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins. J Biol Chem 2006 1.17
50 Mechanism for recognition of an unusual mycobacterial glycolipid by the macrophage receptor mincle. J Biol Chem 2013 1.15
51 The cytoplasmic face of cell contact sites. Curr Opin Struct Biol 2002 1.14
52 Structure of the armadillo repeat domain of plakophilin 1. J Mol Biol 2004 1.10
53 Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog. Proc Natl Acad Sci U S A 2002 1.10
54 Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism. J Biol Chem 2007 1.08
55 Roles of cadherins and catenins in cell-cell adhesion and epithelial cell polarity. Prog Mol Biol Transl Sci 2013 1.05
56 Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes. J Biol Chem 2009 1.03
57 αE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors. Mol Biol Cell 2013 1.03
58 Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2. EMBO J 2003 1.02
59 Trimeric structure of langerin. J Biol Chem 2010 1.02
60 Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J 2014 1.02
61 Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J Biol Chem 2002 1.02
62 structural Studies of Wnts and identification of an LRP6 binding site. Structure 2013 0.99
63 Danio rerio αE-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αE-catenin. J Biol Chem 2013 0.96
64 Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site. J Mol Biol 2010 0.95
65 Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain. J Mol Biol 2011 0.94
66 Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease. J Biol Chem 2009 0.94
67 Catenins: playing both sides of the synapse. Curr Opin Cell Biol 2007 0.94
68 In vitro methods for investigating desmoplakin-intermediate filament interactions and their role in adhesive strength. Methods Cell Biol 2004 0.92
69 α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium. Dev Cell 2012 0.90
70 The first propeller domain of LRP6 regulates sensitivity to DKK1. Mol Biol Cell 2009 0.90
71 Segmented helical structure of the neck region of the glycan-binding receptor DC-SIGNR. J Mol Biol 2009 0.90
72 Structural and thermodynamic characterization of cadherin·β-catenin·α-catenin complex formation. J Biol Chem 2014 0.89
73 Biochemical and structural characterization of β-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1. J Mol Biol 2010 0.88
74 Cell biology: how to build a cell junction. Nature 2004 0.87
75 Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife 2014 0.85
76 Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation. Proc Natl Acad Sci U S A 2013 0.84
77 The evolutionary origin of epithelial cell-cell adhesion mechanisms. Curr Top Membr 2013 0.84
78 Common polymorphisms in human langerin change specificity for glycan ligands. J Biol Chem 2013 0.83
79 The beta-catenin binding protein ICAT modulates androgen receptor activity. Mol Endocrinol 2011 0.81
80 Protein evolution in cell and tissue development: going beyond sequence and transcriptional analysis. Dev Cell 2011 0.81
81 Applications of molecular replacement to G protein-coupled receptors. Acta Crystallogr D Biol Crystallogr 2013 0.77
82 Studying epithelial morphogenesis in Dictyostelium. Methods Mol Biol 2015 0.75