Published in Nat Cell Biol on February 20, 2005
Transcriptional amplification in tumor cells with elevated c-Myc. Cell (2012) 8.24
Myc's broad reach. Genes Dev (2008) 7.56
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 6.19
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol (2005) 4.99
Myc influences global chromatin structure. EMBO J (2006) 4.71
The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ (2008) 4.31
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell (2007) 4.10
MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer (2010) 3.64
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell (2012) 2.78
The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev (2007) 2.57
Nucleolus, ribosomes, and cancer. Am J Pathol (2008) 2.53
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell (2012) 2.29
Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J (2009) 1.94
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol (2008) 1.93
Nucleolus: the fascinating nuclear body. Histochem Cell Biol (2007) 1.87
Inhibition of c-Myc activity by ribosomal protein L11. EMBO J (2007) 1.78
Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer. J Cell Biochem (2008) 1.77
The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding. Mol Cell Biol (2007) 1.75
Transcription-independent functions of MYC: regulation of translation and DNA replication. Nat Rev Mol Cell Biol (2008) 1.72
The ups and downs of Myc biology. Curr Opin Genet Dev (2009) 1.70
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol (2015) 1.61
The Myc trilogy: lord of RNA polymerases. Nat Cell Biol (2005) 1.60
Dysregulation of ribosome biogenesis and translational capacity is associated with tumor progression of human breast cancer cells. PLoS One (2009) 1.60
The role of Myc-induced protein synthesis in cancer. Cancer Res (2009) 1.54
Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation. PLoS One (2011) 1.53
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics (2012) 1.49
NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling. Biochem Res Int (2010) 1.49
MYC: connecting selective transcriptional control to global RNA production. Nat Rev Cancer (2015) 1.47
The RNA polymerase I transcription machinery. Biochem Soc Symp (2006) 1.46
N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. Proc Natl Acad Sci U S A (2006) 1.45
Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription. J Cell Biol (2006) 1.42
c-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood (2006) 1.39
Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58). J Biomed Sci (2015) 1.39
TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci U S A (2007) 1.39
The nucleolus: a model for the organization of nuclear functions. Histochem Cell Biol (2006) 1.39
A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell (2014) 1.35
Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc. Neoplasia (2006) 1.34
Dysregulation of the basal RNA polymerase transcription apparatus in cancer. Nat Rev Cancer (2013) 1.26
Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest (2015) 1.21
Myc in model organisms: a view from the flyroom. Semin Cancer Biol (2006) 1.21
Phenotypic transcription factors epigenetically mediate cell growth control. Proc Natl Acad Sci U S A (2008) 1.21
KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs. J Clin Invest (2013) 1.21
Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One (2009) 1.20
Autoregulatory suppression of c-Myc by miR-185-3p. J Biol Chem (2011) 1.16
Dysregulation of RNA polymerase I transcription during disease. Biochim Biophys Acta (2012) 1.16
Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling. Sci Signal (2012) 1.15
Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol (2011) 1.13
Drosophila growth and development in the absence of dMyc and dMnt. Dev Biol (2007) 1.13
Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene. Am J Pathol (2011) 1.12
Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila. Genes Dev (2011) 1.08
Search for basonuclin target genes. Biochem Biophys Res Commun (2006) 1.07
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics (2011) 1.07
Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC. Mol Cell (2011) 1.03
Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster. Mol Cell Biol (2005) 1.03
LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. Mol Biol Cell (2011) 1.03
Feedback regulation of c-Myc by ribosomal protein L11. Cell Cycle (2007) 1.02
MYC protein inhibits transcription of the microRNA cluster MC-let-7a-1~let-7d via noncanonical E-box. J Biol Chem (2011) 1.02
c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation. Nucleic Acids Res (2010) 1.01
Myc transcription factors: key regulators behind establishment and maintenance of pluripotency. Regen Med (2010) 1.00
Scission of the p53-MDM2 Loop by Ribosomal Proteins. Genes Cancer (2012) 1.00
Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression. J Biol Chem (2010) 0.99
Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis. Mol Cell Biol (2010) 0.99
Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications. Med Res Rev (2014) 0.98
The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1. Mol Cell Biol (2006) 0.97
c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland. BMC Biol (2009) 0.96
Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate. BMC Genomics (2012) 0.96
Conserved regulators of nucleolar size revealed by global phenotypic analyses. Sci Signal (2013) 0.95
MYC and transcription elongation. Cold Spring Harb Perspect Med (2014) 0.95
Nucleolar DNA: the host and the guests. Histochem Cell Biol (2016) 0.95
Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size. EMBO J (2010) 0.94
Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes. Subcell Biochem (2013) 0.94
Control of vertebrate development by MYC. Cold Spring Harb Perspect Med (2013) 0.94
Structure and epigenetics of nucleoli in comparison with non-nucleolar compartments. J Histochem Cytochem (2009) 0.93
The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proc Natl Acad Sci U S A (2015) 0.93
Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway. Cell Cycle (2009) 0.92
New frontiers in translational control of the cancer genome. Nat Rev Cancer (2016) 0.92
The role of hypoxia-inducible factor-2 in digestive system cancers. Cell Death Dis (2015) 0.92
Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle. J Physiol (2015) 0.91
Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro. Am J Physiol Endocrinol Metab (2016) 0.91
Yeast transcription elongation factor Spt5 associates with RNA polymerase I and RNA polymerase II directly. J Biol Chem (2011) 0.91
MYC regulation of cell growth through control of transcription by RNA polymerases I and III. Cold Spring Harb Perspect Med (2014) 0.91
Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription. Oncogene (2012) 0.91
Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers. Oncotarget (2015) 0.90
A conserved pathway that controls c-Myc protein stability through opposing phosphorylation events occurs in yeast. J Biol Chem (2006) 0.90
The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes. PLoS One (2011) 0.89
A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation. J Cell Sci (2012) 0.88
Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription. J Biol Chem (2013) 0.88
MYC cofactors: molecular switches controlling diverse biological outcomes. Cold Spring Harb Perspect Med (2014) 0.88
Decrease expression of microRNA-744 promotes cell proliferation by targeting c-Myc in human hepatocellular carcinoma. Cancer Cell Int (2014) 0.87
Loss of MTG16a (CBFA2T3), a novel rDNA repressor, leads to increased ribogenesis and disruption of breast acinar morphogenesis. J Cell Mol Med (2009) 0.87
Acidosis decreases c-Myc oncogene expression in human lymphoma cells: a role for the proton-sensing G protein-coupled receptor TDAG8. Int J Mol Sci (2013) 0.87
The effects of age and resistance loading on skeletal muscle ribosome biogenesis. J Appl Physiol (1985) (2015) 0.86
rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis. Oncotarget (2015) 0.85
Trisomy 21 consistently activates the interferon response. Elife (2016) 0.85
miR-320b suppresses cell proliferation by targeting c-Myc in human colorectal cancer cells. BMC Cancer (2015) 0.85
HE4 (WFDC2) gene overexpression promotes ovarian tumor growth. Sci Rep (2014) 0.85
Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways. Histochem Cell Biol (2016) 0.85
Subcellular localization of CIAPIN1. J Histochem Cytochem (2006) 0.83
Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods (2006) 12.63
A kinetic framework for a mammalian RNA polymerase in vivo. Science (2002) 4.42
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell (2003) 3.87
The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet (2002) 3.58
The epigenetics of rRNA genes: from molecular to chromosome biology. Annu Rev Cell Dev Biol (2008) 3.42
Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay. Methods (2008) 3.16
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell (2008) 3.04
Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood (2002) 3.00
Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes. Genes Dev (2010) 2.96
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev (2004) 2.96
Intergenic transcripts regulate the epigenetic state of rRNA genes. Mol Cell (2006) 2.89
Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene (2003) 2.59
Nuclear actin and myosin I are required for RNA polymerase I transcription. Nat Cell Biol (2004) 2.49
The requirement for cyclin D function in tumor maintenance. Cancer Cell (2012) 2.49
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev (2006) 2.47
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell (2005) 2.46
The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu Rev Pharmacol Toxicol (2010) 2.45
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell (2011) 2.41
The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. EMBO J (2002) 2.36
In situ detection and genotyping of individual mRNA molecules. Nat Methods (2010) 2.29
The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev (2005) 2.13
In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method. Mol Cell Proteomics (2007) 2.10
Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat Cell Biol (2009) 1.99
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol Cell (2003) 1.98
TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. Mol Cell (2009) 1.97
Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia. Lancet (2002) 1.97
Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a. Mol Cell (2007) 1.96
A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood (2008) 1.93
CSB is a component of RNA pol I transcription. Mol Cell (2002) 1.93
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol (2010) 1.91
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci U S A (2011) 1.90
Prevalence and underdiagnosis of COPD by disease severity and the attributable fraction of smoking Report from the Obstructive Lung Disease in Northern Sweden Studies. Respir Med (2005) 1.89
Cellular stress and nucleolar function. Cell Cycle (2005) 1.88
Identification of novel functional TBP-binding sites and general factor repertoires. EMBO J (2007) 1.77
Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood (2004) 1.77
The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Curr Biol (2005) 1.75
Flow cytometric in situ proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor family. Cytometry A (2009) 1.73
Proximity ligation assays: a recent addition to the proteomics toolbox. Expert Rev Proteomics (2010) 1.70
Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation. Mol Cell Biol (2005) 1.66
The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus. EMBO Rep (2008) 1.64
Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription. Genes Dev (2008) 1.63
Ten-year cumulative incidence of COPD and risk factors for incident disease in a symptomatic cohort. Chest (2005) 1.61
Parallel visualization of multiple protein complexes in individual cells in tumor tissue. Mol Cell Proteomics (2013) 1.60
Co-morbidity in mild-to-moderate COPD: comparison to normal and restrictive lung function. COPD (2011) 1.59
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis. Proc Natl Acad Sci U S A (2008) 1.59
The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription. EMBO Rep (2006) 1.59
WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies. PLoS Biol (2010) 1.57
Prevalence of chronic obstructive pulmonary disease according to BTS, ERS, GOLD and ATS criteria in relation to doctor's diagnosis, symptoms, age, gender, and smoking habits. Respiration (2005) 1.55
The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres. EMBO Rep (2013) 1.55
Novel and highly recurrent chromosomal alterations in Sézary syndrome. Cancer Res (2008) 1.51
Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. EMBO Rep (2002) 1.48
Modulation of RNA polymerase assembly dynamics in transcriptional regulation. Mol Cell (2008) 1.47
TFIIH plays an essential role in RNA polymerase I transcription. Cell (2002) 1.43
Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells. Nucleic Acids Res (2007) 1.42
Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7. Mol Cell (2013) 1.41
The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J (2010) 1.40
AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci U S A (2009) 1.40
NoRC-dependent nucleosome positioning silences rRNA genes. EMBO J (2006) 1.39
A DNA microarray for fission yeast: minimal changes in global gene expression after temperature shift. Yeast (2004) 1.38
VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J (2010) 1.37
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation. Proc Natl Acad Sci U S A (2009) 1.36
NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells (2013) 1.35
The chromatin remodeling complex NoRC controls replication timing of rRNA genes. EMBO J (2004) 1.34
Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nat Cell Biol (2009) 1.30
Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation. Mol Endocrinol (2003) 1.28
Stress-specific role of fission yeast Gcn5 histone acetyltransferase in programming a subset of stress response genes. Eukaryot Cell (2006) 1.23
Seven-year cumulative incidence of COPD in an age-stratified general population sample. Chest (2006) 1.21
Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling. J Neurosci (2011) 1.20
Genome-scale design of PCR primers and long oligomers for DNA microarrays. Nucleic Acids Res (2003) 1.19
Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation. J Cell Mol Med (2012) 1.19
Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels. J Cell Sci (2003) 1.17
Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization. J Pathol (2012) 1.16
The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo. Nucleic Acids Res (2004) 1.16
Recruitment of the nucleolar remodeling complex NoRC establishes ribosomal DNA silencing in chromatin. Mol Cell Biol (2004) 1.15
The nucleolus—guardian of cellular homeostasis and genome integrity. Chromosoma (2013) 1.14
The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions. Proc Natl Acad Sci U S A (2012) 1.13
Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci (2008) 1.12
Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I. Mol Cell Biol (2008) 1.10
High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation. Mol Cell Proteomics (2009) 1.10
Visualising individual sequence-specific protein-DNA interactions in situ. N Biotechnol (2011) 1.10
Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles. BMC Genomics (2010) 1.09
Mechanism of transcription factor recruitment by acidic activators. J Biol Chem (2005) 1.09
Increasing the dynamic range of in situ PLA. Nat Methods (2011) 1.08
Proximity ligation assays for sensitive and specific protein analyses. Anal Biochem (2005) 1.07
Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage. PLoS One (2010) 1.07
Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans. EMBO Rep (2009) 1.05
Molecular tools for a molecular medicine: analyzing genes, transcripts and proteins using padlock and proximity probes. J Mol Recognit (2004) 1.05