Published in Oncogene on July 28, 2005
The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58
DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res (2007) 2.09
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55
Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans. Genome Biol (2007) 1.41
Cellular and molecular biology of aging endothelial cells. J Mol Cell Cardiol (2015) 1.07
Mechanistic and biological aspects of helicase action on damaged DNA. Cell Cycle (2010) 0.86
Reorganization of chromosome architecture in replicative cellular senescence. Sci Adv (2016) 0.81
The associations between immunity-related genes and breast cancer prognosis in Korean women. PLoS One (2014) 0.81
Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging. J Clin Exp Pathol (2012) 0.80
Werner syndrome resembles normal aging. Cell Cycle (2009) 0.79
p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia. Oncogene (2013) 0.78
Aging on a different scale--chronological versus pathology-related aging. Aging (Albany NY) (2013) 0.77
Fibroblasts from Werner syndrome patients: cancer cells derived by experimental introduction of oncogenes maintain malignant properties despite entering crisis. Oncol Rep (2010) 0.75
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
The genetic association database. Nat Genet (2004) 11.29
Analysis of microarray data using Z score transformation. J Mol Diagn (2003) 6.82
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87
Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc Natl Acad Sci U S A (2002) 3.71
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
White spot syndromes of the retina: a hypothesis based on the common genetic hypothesis of autoimmune/inflammatory disease. Am J Ophthalmol (2003) 2.97
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol Cell (2004) 2.60
MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS One (2008) 2.60
Application of z-score transformation to Affymetrix data. Appl Bioinformatics (2003) 2.56
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem (2002) 2.53
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) (2009) 2.50
The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst) (2006) 2.43
Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42
No association between telomere length and survival among the elderly and oldest old. Epidemiology (2006) 2.33
Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics (2005) 2.18
Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity (2009) 2.11
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A (2009) 1.91
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell (2010) 1.84
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study. Schizophr Res (2002) 1.76
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A (2006) 1.70
Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest (2008) 1.68
Genetic and environmental pathways to complex diseases. BMC Syst Biol (2009) 1.67
Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem (2005) 1.64
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem (2005) 1.64
Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci U S A (2003) 1.64
Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem (2003) 1.62
Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology (2007) 1.59
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res (2005) 1.59
Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information. BMC Med Genomics (2010) 1.57
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56
DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55
Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging (2005) 1.52
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J (2009) 1.52
Rule-based human gene normalization in biomedical text with confidence estimation. Comput Syst Bioinformatics Conf (2007) 1.51
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis. Hum Genet (2008) 1.48
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48
Stability regulation of mRNA and the control of gene expression. Ann N Y Acad Sci (2005) 1.46
Cockayne syndrome group B cellular and biochemical functions. Am J Hum Genet (2003) 1.46
Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. Stem Cells (2008) 1.43
Mitochondrial DNA repair of oxidative damage in mammalian cells. Gene (2002) 1.42
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med (2012) 1.42
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci (2006) 1.42
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem (2003) 1.39
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. J Biol Chem (2007) 1.38
Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress. FASEB J (2003) 1.38
Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes. Glia (2013) 1.37
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage. Mol Cell Biol (2003) 1.37
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis (2003) 1.37
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J Biol Chem (2004) 1.36
The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging. Mech Ageing Dev (2008) 1.36
VENNTURE--a novel Venn diagram investigational tool for multiple pharmacological dataset analysis. PLoS One (2012) 1.36
Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender. Genome Biol (2007) 1.35
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem (2011) 1.35
Age-related changes in microRNA levels in serum. Aging (Albany NY) (2013) 1.35
Junction of RecQ helicase biochemistry and human disease. J Biol Chem (2004) 1.34
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging. Biogerontology (2008) 1.34
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res (2006) 1.34
p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene (2004) 1.33
The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life. Mech Ageing Dev (2003) 1.33
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation. J Exp Med (2010) 1.33
Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair (Amst) (2008) 1.31
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress. Mol Cell Biol (2005) 1.31
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells. Oncogene (2003) 1.30
Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. J Neurochem (2008) 1.30
Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging. Immunol Rev (2005) 1.28
Base excision repair capacity in mitochondria and nuclei: tissue-specific variations. FASEB J (2002) 1.27
WRN interacts physically and functionally with the recombination mediator protein RAD52. J Biol Chem (2003) 1.27
Mitochondrial DNA, base excision repair and neurodegeneration. DNA Repair (Amst) (2008) 1.27
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res (2006) 1.26
Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. FASEB J (2010) 1.25
Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B. Oncogene (2002) 1.24
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol Cell Biol (2003) 1.23