Published in Science on January 25, 2008
T cell activation. Annu Rev Immunol (2009) 7.40
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
Calcium signaling in immune cells. Nat Immunol (2009) 1.97
Scaffold proteins and immune-cell signalling. Nat Rev Immunol (2009) 1.84
Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. Nat Genet (2010) 1.49
Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nat Neurosci (2012) 1.49
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A (2011) 1.47
Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci (2012) 1.12
The closing and opening of TRPC channels by Homer1 and STIM1. Acta Physiol (Oxf) (2011) 0.99
Homer and the ryanodine receptor. Eur Biophys J (2009) 0.91
Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression. Immunology (2010) 0.91
Structural basis for complement evasion by Lyme disease pathogen Borrelia burgdorferi. J Biol Chem (2013) 0.86
Evolutionary insights into premetazoan functions of the neuronal protein homer. Mol Biol Evol (2014) 0.84
Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.81
Homer2 protein regulates plasma membrane Ca²⁺-ATPase-mediated Ca²⁺ signaling in mouse parotid gland acinar cells. J Biol Chem (2014) 0.79
HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice. PLoS Genet (2015) 0.79
Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3. J Immunol (2010) 0.79
Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model. Cell Rep (2015) 0.78
The gene expression response of chronic lymphocytic leukemia cells to IL-4 is specific, depends on ZAP-70 status and is differentially affected by an NFκB inhibitor. PLoS One (2014) 0.77
Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants. Oncotarget (2016) 0.75
Homer1 (VesL-1) in the rat esophagus: focus on myenteric plexus and neuromuscular junction. Histochem Cell Biol (2017) 0.75
Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation. Sci Rep (2017) 0.75
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
NFAT signaling: choreographing the social lives of cells. Cell (2002) 8.17
NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol (2005) 6.25
Egr-2 and Egr-3 are negative regulators of T cell activation. Nat Immunol (2005) 3.74
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature (2006) 3.61
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci U S A (2002) 3.28
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature (1999) 3.21
Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. J Biol Chem (1996) 2.99
Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J (1995) 2.92
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat Immunol (2001) 2.55
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell (2003) 2.54
Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron (2000) 1.68
Homer as both a scaffold and transduction molecule. Sci STKE (2002) 1.44
CD4+ T cells pass through an effector phase during the process of in vivo tolerance induction. J Immunol (2003) 1.19
Effects of Vesl/Homer proteins on intracellular signaling. Exp Biol Med (Maywood) (2005) 1.09
Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science (2006) 10.25
Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell (2005) 7.87
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med (2009) 7.45
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity (2009) 6.86
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell (2002) 5.84
STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol (2006) 5.68
Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron (2006) 5.48
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol (2011) 5.22
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron (2006) 4.98
SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell (2010) 4.72
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature (2007) 4.68
A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med (2007) 4.40
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron (2008) 3.97
Egr-2 and Egr-3 are negative regulators of T cell activation. Nat Immunol (2005) 3.74
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol (2007) 3.47
Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell (2003) 3.11
Serial assessment of human tumor burdens in mice by the analysis of circulating DNA. Cancer Res (2007) 3.05
Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome. J Clin Invest (2004) 3.01
Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons. J Neurosci (2005) 2.96
Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med (2004) 2.94
Summary recommendations for standardization and reporting of metabolic analyses. Nat Biotechnol (2005) 2.90
Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission. Neuron (2006) 2.79
The immediate early gene arc/arg3.1: regulation, mechanisms, and function. J Neurosci (2008) 2.73
Circulating transforming growth factor-beta in Marfan syndrome. Circulation (2009) 2.69
Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation. J Neurosci (2005) 2.69
Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature (2003) 2.31
STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell (2008) 2.30
Integration of new neurons into functional neural networks. J Neurosci (2006) 2.18
Homer2 is necessary for EtOH-induced neuroplasticity. J Neurosci (2005) 2.17
Mapping behaviorally relevant neural circuits with immediate-early gene expression. Curr Opin Neurobiol (2005) 2.16
Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ. Cell (2012) 2.14
Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci U S A (2008) 2.13
Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem (2004) 2.08
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci (2003) 2.06
Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice. Infect Immun (2009) 2.05
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol (2002) 2.03
A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol (2004) 1.97
An optimized system for expression and purification of secreted bacterial proteins. Protein Expr Purif (2005) 1.96
Susceptibility of human metabolic phenotypes to dietary modulation. J Proteome Res (2006) 1.96
Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity. J Allergy Clin Immunol (2008) 1.93
Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development (2005) 1.93
Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. J Comp Neurol (2006) 1.90
Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer. Oncogene (2005) 1.90
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature (2008) 1.88
Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. J Neurosci (2002) 1.88
Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma. Nature (2013) 1.86
Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. J Exp Med (2003) 1.85
Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons. Proc Natl Acad Sci U S A (2006) 1.85
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev (2004) 1.84
Homer proteins regulate sensitivity to cocaine. Neuron (2004) 1.83
Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. J Immunol (2003) 1.82
Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a. J Neurosci (2003) 1.77
PD-1 on dendritic cells impedes innate immunity against bacterial infection. Blood (2009) 1.74
Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology (2005) 1.73
A critical role for SOCS3 in innate resistance to Toxoplasma gondii. Cell Host Microbe (2011) 1.70
Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. Sci Transl Med (2013) 1.70
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. Proc Natl Acad Sci U S A (2010) 1.70
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int J Cancer (2007) 1.67
The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia. Cancer Res (2004) 1.67
Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression. J Neurosci (2005) 1.64
RelB forms transcriptionally inactive complexes with RelA/p65. J Biol Chem (2003) 1.63
Bacteriolytic therapy can generate a potent immune response against experimental tumors. Proc Natl Acad Sci U S A (2004) 1.63
Retracted Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism. Cell (2011) 1.62
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol (2010) 1.61
Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron (2010) 1.59
Inactivation of the Cdkn2a locus cooperates with HMGA1 to drive T-cell leukemogenesis. Leuk Lymphoma (2013) 1.58
A single in vivo exposure to cocaine abolishes endocannabinoid-mediated long-term depression in the nucleus accumbens. J Neurosci (2004) 1.57
Arc-dependent synapse-specific homeostatic plasticity. Proc Natl Acad Sci U S A (2010) 1.56
Comparison of uptake of multiple clinical radiotracers into brown adipose tissue under cold-stimulated and nonstimulated conditions. J Nucl Med (2007) 1.56
A nanoparticle formulation that selectively transfects metastatic tumors in mice. Proc Natl Acad Sci U S A (2013) 1.55
XTRPC1-dependent chemotropic guidance of neuronal growth cones. Nat Neurosci (2005) 1.55
Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nat Neurosci (2010) 1.54
Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. Proc Natl Acad Sci U S A (2006) 1.54
Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene (2002) 1.54
Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell (2011) 1.52
Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem (2006) 1.50
Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron (2011) 1.49
Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nat Neurosci (2012) 1.49
High-dose cyclophosphamide and rituximab without stem cell transplant: a feasibility study for low grade B-cell, transformed and mantle cell lymphomas. Leuk Lymphoma (2011) 1.49
Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Res (2006) 1.48
Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. J Neurosci (2009) 1.47
Advances in targeting cell surface signalling molecules for immune modulation. Nat Rev Drug Discov (2013) 1.46
Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Cell (2002) 1.46
Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Neuron (2007) 1.45
Homer as both a scaffold and transduction molecule. Sci STKE (2002) 1.44
TRPC channels as STIM1-regulated SOCs. Channels (Austin) (2009) 1.43
Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet (2007) 1.43
The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol Res (2008) 1.43
Roles of FHIT and WWOX fragile genes in cancer. Cancer Lett (2005) 1.42
The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. Cancer Res (2007) 1.42
Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation. Blood (2007) 1.42
Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. J Neurosci (2002) 1.40
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc Natl Acad Sci U S A (2011) 1.40
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39
Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels. Proc Natl Acad Sci U S A (2009) 1.38
Homer proteins: implications for neuropsychiatric disorders. Curr Opin Neurobiol (2006) 1.38
Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). J Neurosci (2009) 1.36