PubRank

Scott J Hultgren

Author PubWeight™ 198.08‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Intracellular bacterial biofilm-like pods in urinary tract infections. Science 2003 7.10
2 Role of Escherichia coli curli operons in directing amyloid fiber formation. Science 2002 5.58
3 Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach. Proc Natl Acad Sci U S A 2006 5.13
4 Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis. Proc Natl Acad Sci U S A 2004 4.12
5 The biology and future prospects of antivirulence therapies. Nat Rev Microbiol 2008 3.83
6 Detection of intracellular bacterial communities in human urinary tract infection. PLoS Med 2007 3.54
7 Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract. Proc Natl Acad Sci U S A 2006 3.36
8 Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. Mol Microbiol 2002 3.26
9 Fiber formation across the bacterial outer membrane by the chaperone/usher pathway. Cell 2008 2.69
10 Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation. Cell 2002 2.54
11 Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation. Nat Chem Biol 2009 2.52
12 Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili. Cell Microbiol 2007 2.48
13 Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli. J Biol Chem 2001 2.34
14 Morphological plasticity as a bacterial survival strategy. Nat Rev Microbiol 2008 2.28
15 Effect of trimethoprim-sulfamethoxazole on recurrent bacteriuria and bacterial persistence in mice infected with uropathogenic Escherichia coli. Infect Immun 2002 2.20
16 Structural biology of the chaperone-usher pathway of pilus biogenesis. Nat Rev Microbiol 2009 2.19
17 Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int 2004 2.17
18 Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Sci Transl Med 2011 2.16
19 Filamentation by Escherichia coli subverts innate defenses during urinary tract infection. Proc Natl Acad Sci U S A 2006 2.15
20 A murine model of urinary tract infection. Nat Protoc 2009 2.15
21 Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein. Mol Microbiol 2006 2.14
22 Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation. Infect Immun 2006 2.11
23 Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization. Infect Immun 2005 2.10
24 Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli. Proc Natl Acad Sci U S A 2003 2.02
25 Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli. Microbes Infect 2010 1.95
26 Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin. Mol Microbiol 2005 1.90
27 Fiber assembly by the chaperone-usher pathway. Biochim Biophys Acta 2004 1.89
28 Genomic diversity and fitness of E. coli strains recovered from the intestinal and urinary tracts of women with recurrent urinary tract infection. Sci Transl Med 2013 1.88
29 Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog 2010 1.88
30 Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proc Natl Acad Sci U S A 2006 1.87
31 Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli. PLoS Pathog 2009 1.83
32 Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein. J Urol 2004 1.82
33 Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism. Mol Cell 2006 1.81
34 A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131. J Infect Dis 2013 1.76
35 Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature 2011 1.67
36 Functional genomic studies of uropathogenic Escherichia coli and host urothelial cells when intracellular bacterial communities are assembled. J Biol Chem 2007 1.64
37 Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection. Infect Immun 2012 1.64
38 Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis. Trends Microbiol 2004 1.62
39 The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP. Proc Natl Acad Sci U S A 2005 1.58
40 Maturation of intracellular Escherichia coli communities requires SurA. Infect Immun 2006 1.56
41 Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding. Proc Natl Acad Sci U S A 2009 1.56
42 Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli. Infect Immun 2005 1.55
43 Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection. FEMS Microbiol Rev 2012 1.55
44 Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection. Cell Host Microbe 2009 1.51
45 Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli specific. J Infect Dis 2012 1.48
46 QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli. Mol Microbiol 2009 1.47
47 A tale of two pili: assembly and function of pili in bacteria. Trends Microbiol 2010 1.47
48 Localized and efficient curli nucleation requires the chaperone-like amyloid assembly protein CsgF. Proc Natl Acad Sci U S A 2009 1.43
49 Structure-based drug design and optimization of mannoside bacterial FimH antagonists. J Med Chem 2010 1.40
50 The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth. J Bacteriol 2004 1.39
51 Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. Cold Spring Harb Perspect Med 2013 1.38
52 CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli. Infect Immun 2003 1.38
53 LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis. Mol Microbiol 2007 1.37
54 Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression. Infect Immun 2008 1.36
55 Population dynamics and niche distribution of uropathogenic Escherichia coli during acute and chronic urinary tract infection. Infect Immun 2011 1.36
56 Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli. J Bacteriol 2005 1.35
57 CsgE is a curli secretion specificity factor that prevents amyloid fibre aggregation. Mol Microbiol 2011 1.34
58 Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli. Cell Microbiol 2002 1.34
59 Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice. Infect Immun 2005 1.26
60 A central metabolic circuit controlled by QseC in pathogenic Escherichia coli. Mol Microbiol 2011 1.26
61 Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis. J Bacteriol 2002 1.24
62 Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis. J Bacteriol 2009 1.23
63 Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development. Infect Immun 2009 1.23
64 Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity. J Med Chem 2010 1.22
65 G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity. Cell Microbiol 2008 1.22
66 A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase. PLoS Pathog 2005 1.20
67 Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis. Infect Immun 2010 1.19
68 Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections. Infect Immun 2010 1.19
69 Catalysis of protein folding by chaperones in pathogenic bacteria. Proc Natl Acad Sci U S A 2004 1.18
70 Escherichia coli biofilms have an organized and complex extracellular matrix structure. MBio 2013 1.17
71 Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin. J Bacteriol 2002 1.16
72 Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation. J Am Chem Soc 2012 1.15
73 Interaction of uropathogenic Escherichia coli with host uroepithelium. Curr Opin Microbiol 2005 1.13
74 Crystal structure of the P pilus rod subunit PapA. PLoS Pathog 2007 1.11
75 Structural and energetic basis of folded-protein transport by the FimD usher. Nature 2013 1.11
76 Host subversion by formation of intracellular bacterial communities in the urinary tract. Microbes Infect 2004 1.11
77 Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract. Infect Immun 2008 1.07
78 The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection. MBio 2012 1.07
79 Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides. J Med Chem 2012 1.05
80 Chaperone-subunit-usher interactions required for donor strand exchange during bacterial pilus assembly. J Bacteriol 2003 1.04
81 Targeting virulence for antimicrobial chemotherapy. Curr Opin Pharmacol 2003 1.03
82 Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor. Proc Natl Acad Sci U S A 2013 1.03
83 P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli. J Bacteriol 2004 1.02
84 Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice. Antimicrob Agents Chemother 2012 1.02
85 Streptozocin-induced diabetic mouse model of urinary tract infection. Infect Immun 2008 1.02
86 Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors. J Bacteriol 2012 1.02
87 Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation. Proc Natl Acad Sci U S A 2013 1.02
88 Sticky fibers and uropathogenesis: bacterial adhesins in the urinary tract. Future Microbiol 2006 0.99
89 Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection. Infect Immun 2011 0.99
90 Virulence plasmid harbored by uropathogenic Escherichia coli functions in acute stages of pathogenesis. Infect Immun 2010 0.99
91 Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections. Infect Immun 2012 0.98
92 Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic Escherichia coli. Infect Immun 2012 0.97
93 Recent advances into the pathogenesis of recurrent urinary tract infections: the bladder as a reservoir for uropathogenic Escherichia coli. Int J Antimicrob Agents 2002 0.97
94 Adaptor function of PapF depends on donor strand exchange in P-pilus biogenesis of Escherichia coli. J Bacteriol 2007 0.97
95 Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones-targeting virulence of uropathogenic E. coli. Bioorg Med Chem 2006 0.96
96 Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. Infect Immun 2010 0.96
97 The differential affinity of the usher for chaperone-subunit complexes is required for assembly of complete pili. Mol Microbiol 2010 0.95
98 The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism. Proc Natl Acad Sci U S A 2012 0.94
99 Real-time and equilibrium (19)F-NMR studies reveal the role of domain-domain interactions in the folding of the chaperone PapD. Proc Natl Acad Sci U S A 2002 0.94
100 Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study. Bioorg Med Chem 2012 0.94
101 Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod. Mol Biosyst 2007 0.93
102 Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis. Proc Natl Acad Sci U S A 2013 0.93
103 Update on biofilm infections in the urinary tract. World J Urol 2011 0.93
104 Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria. J Comb Chem 2002 0.93
105 Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes. Infect Immun 2013 0.92
106 Down-regulation of the kps region 1 capsular assembly operon following attachment of Escherichia coli type 1 fimbriae to D-mannose receptors. Infect Immun 2005 0.92
107 Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine. Proc Natl Acad Sci U S A 2012 0.90
108 Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. J Bacteriol 2013 0.90
109 Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms. Chemistry 2012 0.89
110 Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization. J Am Chem Soc 2012 0.89
111 Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin. Structure 2011 0.88
112 Bacterial adhesion--a source of alternate antibiotic targets. IDrugs 2009 0.88
113 Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli. Bioorg Med Chem Lett 2008 0.87
114 Molecular basis of usher pore gating in Escherichia coli pilus biogenesis. Proc Natl Acad Sci U S A 2013 0.86
115 AhrC and Eep are biofilm infection-associated virulence factors in Enterococcus faecalis. Infect Immun 2013 0.85
116 Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection. Curr Opin Infect Dis 2015 0.84
117 Dissection of pilus tip assembly by the FimD usher monomer. J Mol Biol 2013 0.84
118 NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly. Org Biomol Chem 2005 0.84
119 Structural biology: anthrax hijacks host receptor. Nature 2004 0.84
120 From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections. Curr Urol Rep 2013 0.84
121 Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli. J Med Chem 2005 0.84
122 Impairment of the biomechanical compliance of P pili: a novel means of inhibiting uropathogenic bacterial infections? Eur Biophys J 2012 0.83
123 Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides. Bioorg Med Chem 2003 0.83
124 What does it take to stick around? Molecular insights into biofilm formation by uropathogenic Escherichia coli. Virulence 2012 0.82
125 Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity. Eur J Med Chem 2011 0.81
126 Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins. Org Biomol Chem 2005 0.81
127 Blueprinting the regulatory response of Escherichia coli to the urinary tract. Trends Microbiol 2005 0.81
128 Molecular blueprint of uropathogenic Escherichia coli virulence provides clues toward the development of anti-virulence therapeutics. Virulence 2012 0.80
129 The complex interactions of bacterial pathogens and host defenses. Curr Opin Microbiol 2013 0.79
130 Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity. Org Biomol Chem 2014 0.78
131 Recent advances in the molecular basis of pathogen recognition and host responses in the urinary tract. Int Rev Immunol 2002 0.77
132 Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections. Microbiol Spectr 2016 0.77
133 Innate defense evicts bacterial squatters. Nat Immunol 2002 0.76
134 LRP6 holds the key to the entry of anthrax toxin. Cell 2006 0.76
135 Estrogen and recurrent UTI: what are the facts? Sci Transl Med 2013 0.76
136 Antitoxins: therapy for stressed bacteria. Nat Chem Biol 2011 0.76
137 Innovative Solutions to Sticky Situations: Antiadhesive Strategies for Treating Bacterial Infections. Microbiol Spectr 2016 0.75
138 Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria. Org Biomol Chem 2003 0.75