Published in JAMA on July 06, 2005
Effects of Coenzyme Q10 (CoQ) in Parkinson Disease (QE3) | NCT00740714
Body-mass index and mortality among 1.46 million white adults. N Engl J Med (2010) 13.34
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2011) 11.02
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 8.32
Measures of obesity and cardiovascular risk among men and women. J Am Coll Cardiol (2008) 5.28
Physical activity and weight gain prevention. JAMA (2010) 5.27
Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 5.25
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 5.13
Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 4.40
Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women. Circulation (2009) 3.93
A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med (2007) 3.37
Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms. Circulation (2007) 3.20
Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events. Circulation (2008) 3.03
Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. JAMA Intern Med (2015) 2.91
Further insight into the cardiovascular risk calculator: the roles of statins, revascularizations, and underascertainment in the Women's Health Study. JAMA Intern Med (2014) 2.82
Migraine and risk of haemorrhagic stroke in women: prospective cohort study. BMJ (2010) 2.63
The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials (2011) 2.59
Long-term use of supplemental multivitamins, vitamin C, vitamin E, and folate does not reduce the risk of lung cancer. Am J Respir Crit Care Med (2007) 2.55
Multivitamin use and risk of cancer and cardiovascular disease in the Women's Health Initiative cohorts. Arch Intern Med (2009) 2.54
Leisure time physical activity of moderate to vigorous intensity and mortality: a large pooled cohort analysis. PLoS Med (2012) 2.45
Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian General Population Nutrition Intervention Trial. J Natl Cancer Inst (2009) 2.43
Plants antioxidants: From laboratory to clinic. J Nephropathol (2013) 2.39
Comparison of LDL cholesterol concentrations by Friedewald calculation and direct measurement in relation to cardiovascular events in 27,331 women. Clin Chem (2009) 2.31
Reactive oxygen species in cardiovascular disease. Free Radic Biol Med (2011) 2.29
Oxidative stress in prostate cancer. Cancer Lett (2009) 2.28
Influence of systolic and diastolic blood pressure on the risk of incident atrial fibrillation in women. Circulation (2009) 2.26
Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes. Am J Clin Nutr (2010) 2.25
Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies. Arthritis Rheum (2009) 2.19
Egg consumption and risk of type 2 diabetes in men and women. Diabetes Care (2008) 2.14
Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst (2008) 2.07
HbA1c measured in stored erythrocytes and mortality rate among middle-aged and older women. Diabetologia (2007) 2.03
Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med (2011) 1.93
Alcohol consumption, weight gain, and risk of becoming overweight in middle-aged and older women. Arch Intern Med (2010) 1.85
Physical activity and risk of stroke in women. Stroke (2010) 1.85
Mediterranean diet and cognitive function in older age. Epidemiology (2013) 1.85
Kidney function and risk of cardiovascular disease and mortality in women: a prospective cohort study. BMJ (2009) 1.84
Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study. Arch Ophthalmol (2008) 1.74
Instrumental variables I: instrumental variables exploit natural variation in nonexperimental data to estimate causal relationships. J Clin Epidemiol (2009) 1.73
Body mass index, migraine, migraine frequency and migraine features in women. Cephalalgia (2009) 1.69
Lipoprotein(a), hormone replacement therapy, and risk of future cardiovascular events. J Am Coll Cardiol (2008) 1.69
Correction of HDL dysfunction in individuals with diabetes and the haptoglobin 2-2 genotype. Diabetes (2008) 1.64
Using accelerometers to measure physical activity in large-scale epidemiological studies: issues and challenges. Br J Sports Med (2013) 1.61
Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis (2009) 1.59
Alcohol consumption and risk of incident atrial fibrillation in women. JAMA (2008) 1.55
Selectivity in genetic association with sub-classified migraine in women. PLoS Genet (2014) 1.54
Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women. Diabetes (2010) 1.52
Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy. Atherosclerosis (2008) 1.48
Colorectal cancer screening and prevention in women. Dig Dis Sci (2015) 1.46
Randomised aspirin assignment and risk of adult-onset asthma in the Women's Health Study. Thorax (2008) 1.45
Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ (2010) 1.43
Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. Pharmacogenomics (2010) 1.42
Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality. Am J Epidemiol (2009) 1.42
Prospective cohort study of breast implants and the risk of connective-tissue diseases. Int J Epidemiol (2010) 1.40
Risk of cardiovascular events among women with high normal blood pressure or blood pressure progression: prospective cohort study. BMJ (2007) 1.40
Effects of antioxidant supplementation on the aging process. Clin Interv Aging (2007) 1.35
Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma. Clin Cancer Res (2009) 1.33
Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein. Metabolism (2008) 1.32
Oxidative stress, obesity, and breast cancer risk: results from the Shanghai Women's Health Study. J Clin Oncol (2009) 1.31
A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice. Cancer Prev Res (Phila) (2009) 1.27
Lipid levels and the risk of ischemic stroke in women. Neurology (2007) 1.23
Association of high-density lipoprotein cholesterol with incident cardiovascular events in women, by low-density lipoprotein cholesterol and apolipoprotein B100 levels: a cohort study. Ann Intern Med (2011) 1.20
Alcohol consumption and risk of cardiovascular disease and death in women: potential mediating mechanisms. Circulation (2009) 1.18
The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos Univ Med J (2012) 1.17
Job strain, job insecurity, and incident cardiovascular disease in the Women's Health Study: results from a 10-year prospective study. PLoS One (2012) 1.17
Redox signaling in cardiovascular health and disease. Free Radic Biol Med (2013) 1.16
Genome-wide association study of relative telomere length. PLoS One (2011) 1.16
The role of oxidized low-density lipoproteins in atherosclerosis: the myths and the facts. Mediators Inflamm (2013) 1.15
Polymorphisms in the vitamin D receptor and risk of ovarian cancer in four studies. Cancer Res (2009) 1.15
Vitamin and mineral supplements: do we really need them? Int J Prev Med (2012) 1.14
Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study. Clin Chem Lab Med (2010) 1.14
Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. Am J Clin Nutr (2007) 1.14
A randomized trial of low-dose aspirin in the prevention of clinical type 2 diabetes in women. Diabetes Care (2008) 1.13
Vitamin E and changes in serum alanine aminotransferase levels in patients with non-alcoholic steatohepatitis. Aliment Pharmacol Ther (2013) 1.12
Fruit and vegetable intake and the risk of hypertension in middle-aged and older women. Am J Hypertens (2011) 1.11
Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women. Am J Clin Nutr (2008) 1.10
Metabolic syndrome, inflammation, and risk of symptomatic peripheral artery disease in women: a prospective study. Circulation (2009) 1.08
The effect of vitamin E supplementation on cardiovascular risk in diabetic individuals with different haptoglobin phenotypes. Atherosclerosis (2010) 1.08
δ-tocopherol is more active than α - or γ -tocopherol in inhibiting lung tumorigenesis in vivo. Cancer Prev Res (Phila) (2011) 1.07
Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women's Health Initiative Observational Study. Am J Clin Nutr (2008) 1.06
Essential hypertension and oxidative stress: New insights. World J Cardiol (2014) 1.04
Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. J Hypertens (2009) 1.03
Inhibition of lung cancer growth in mice by dietary mixed tocopherols. Mol Nutr Food Res (2009) 1.03
The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women. Am Heart J (2010) 1.03
Plasma and dietary antioxidant status as cardiovascular disease risk factors: a review of human studies. Nutrients (2013) 1.02
Smoking, smoking cessation, [corrected] and risk for symptomatic peripheral artery disease in women: a cohort study. Ann Intern Med (2011) 1.02
Vitamin E and all-cause mortality: a meta-analysis. Curr Aging Sci (2011) 1.01
Does vitamin E prevent or promote cancer? Cancer Prev Res (Phila) (2012) 1.01
A prospective study of circulating C-reactive protein, interleukin-6, and tumor necrosis factor α receptor 2 levels and risk of ovarian cancer. Am J Epidemiol (2013) 1.01
Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women. Arch Ophthalmol (2011) 1.00
A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis. Arthritis Res Ther (2009) 1.00
Migraine and functional outcome from ischemic cerebral events in women. Circulation (2010) 0.99
Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection. J Lipid Res (2013) 0.99
Caffeine consumption and the risk of breast cancer in a large prospective cohort of women. Arch Intern Med (2008) 0.98
MDM2 SNP309 is associated with endometrial cancer risk. Cancer Epidemiol Biomarkers Prev (2008) 0.98
Natural antioxidants and hypertension: promise and challenges. Cardiovasc Ther (2010) 0.98
Chemopreventive activity of vitamin E in breast cancer: a focus on γ- and δ-tocopherol. Nutrients (2011) 0.96
Impact of accelerometer data processing decisions on the sample size, wear time and physical activity level of a large cohort study. BMC Public Health (2014) 0.96
Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials. PLoS One (2013) 0.96
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature (2008) 38.13
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Inflammation and atherosclerosis. Circulation (2002) 20.77
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med (2005) 17.32
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2013) 17.18
Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med (2002) 16.23
Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA (2007) 15.32
Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology (2010) 14.07
Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2008) 13.35
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2011) 11.02
Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA (2007) 9.68
Statins: new American guidelines for prevention of cardiovascular disease. Lancet (2013) 9.56
Progress and challenges in translating the biology of atherosclerosis. Nature (2011) 9.41
Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 9.03
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation (2003) 8.61
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 8.32
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Advances in measuring the effect of individual predictors of cardiovascular risk: the role of reclassification measures. Ann Intern Med (2009) 7.62
C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation (2008) 7.33
Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med (2002) 7.32
C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation (2003) 6.99
Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease. Epidemiology (2008) 6.87
Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet (2009) 6.79
Visualizing genomes: techniques and challenges. Nat Methods (2010) 6.66
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med (2010) 6.48
Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative. Arch Intern Med (2012) 6.46
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation (2007) 6.34
Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med (2007) 6.29
Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. Am J Epidemiol (2005) 6.20
Migraine and risk of cardiovascular disease in women. JAMA (2006) 6.16
Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16
Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol (2009) 6.11
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol (2004) 6.08
Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med (2009) 6.00
Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98
Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women. Am J Med (2007) 5.95
C-reactive protein and the risk of developing hypertension. JAMA (2003) 5.75
Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA (2005) 5.74
The effect of including C-reactive protein in cardiovascular risk prediction models for women. Ann Intern Med (2006) 5.69
Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses' health study. Obstet Gynecol (2009) 5.59
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Laboratory-based versus non-laboratory-based method for assessment of cardiovascular disease risk: the NHANES I Follow-up Study cohort. Lancet (2008) 5.49
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Measures of obesity and cardiovascular risk among men and women. J Am Coll Cardiol (2008) 5.28
Physical activity and weight gain prevention. JAMA (2010) 5.27
Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 5.25
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 5.13
Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ (2009) 4.98
Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78
Risk of death and cardiovascular events in initially healthy women with new-onset atrial fibrillation. JAMA (2011) 4.73
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet (2009) 4.71
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care (2006) 4.62
Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA (2004) 4.47