Published in JAMA on December 10, 2003
Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull (2011) 4.27
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
C-reactive protein in patients with COPD, control smokers and non-smokers. Thorax (2005) 2.72
Inflammation, hypertension, and the metabolic syndrome. JAMA (2003) 2.57
Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection. Hypertension (2008) 2.14
Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts. Int J Epidemiol (2008) 2.14
Prevalence, awareness and risk factors of hypertension in a large cohort of Iranian adult population. J Hypertens (2013) 1.86
The relationship between inflammation, obesity and risk for hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA). J Hum Hypertens (2010) 1.86
Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. PLoS One (2009) 1.80
Low birth weight and markers of inflammation and endothelial activation in adulthood: the ARIC study. Int J Cardiol (2008) 1.73
Inflammation and hypertension: the interplay of interleukin-6, dietary sodium, and the renin-angiotensin system in humans. Am J Hypertens (2011) 1.72
C-reactive protein, inflammatory conditions, and cardiovascular disease risk. Am J Med (2007) 1.64
Risk factors for incident atrial fibrillation with and without left atrial enlargement in women. Int J Cardiol (2013) 1.57
Rosuvastatin attenuates the elevation in blood pressure induced by overexpression of human C-reactive protein. Hypertens Res (2011) 1.50
Peripheral augmentation index and vascular inflammation in autosomal dominant polycystic kidney disease. Nephrol Dial Transplant (2011) 1.47
Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. Cell Metab (2015) 1.47
Diabetes and hypertension: is there a common metabolic pathway? Curr Atheroscler Rep (2012) 1.45
Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST). J Hypertens (2010) 1.28
Uric acid and insulin sensitivity and risk of incident hypertension. Arch Intern Med (2009) 1.21
Multimarker approach for the prediction of heart failure incidence in the community. Circulation (2010) 1.15
A low-glycemic load diet reduces serum C-reactive protein and modestly increases adiponectin in overweight and obese adults. J Nutr (2011) 1.15
Is oxidative stress, a link between nephrolithiasis and obesity, hypertension, diabetes, chronic kidney disease, metabolic syndrome? Urol Res (2012) 1.14
Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation. Biol Psychiatry (2015) 1.13
Systemic inflammation, heart rate variability and air pollution in a cohort of senior adults. Occup Environ Med (2010) 1.11
Mendelian randomization in nutritional epidemiology. Nutr Rev (2009) 1.10
The underlying mechanisms for development of hypertension in the metabolic syndrome. Nutr J (2008) 1.10
Relations of biomarkers representing distinct biological pathways to left ventricular geometry. Circulation (2008) 1.09
Adeno-associated virus-mediated human C-reactive protein gene delivery causes endothelial dysfunction and hypertension in rats. Clin Chem (2008) 1.09
Vascular function, inflammation, and variations in cardiac autonomic responses to particulate matter among welders. Am J Epidemiol (2009) 1.08
Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial. Sleep (2014) 1.07
Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective. Drug Des Devel Ther (2010) 1.06
Seventeen year risk of all-cause and cause-specific mortality associated with C-reactive protein, fibrinogen and leukocyte count in men and women: the EPIC-Norfolk study. Eur J Epidemiol (2013) 1.06
Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. J Hypertens (2009) 1.03
Vascular inflammation and endothelial dysfunction in experimental hypertension. Int J Hypertens (2011) 1.03
Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. Biomed Res Int (2014) 1.01
High risk blood pressure and obesity increase the risk for left ventricular hypertrophy in African-American adolescents. J Pediatr (2012) 1.01
Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. Hypertension (2008) 1.00
Cognitive Behavioral Therapy and Tai Chi Reverse Cellular and Genomic Markers of Inflammation in Late-Life Insomnia: A Randomized Controlled Trial. Biol Psychiatry (2015) 0.99
Racial differences in tumor necrosis factor-α-induced endothelial microparticles and interleukin-6 production. Vasc Health Risk Manag (2011) 0.98
Enhanced blood pressure variability in a high cardiovascular risk group of African Americans: FIT4Life Study. J Am Soc Hypertens (2010) 0.96
C-reactive protein and hypertension. J Hum Hypertens (2013) 0.94
Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome: NHANES 2009-2010. J Am Heart Assoc (2014) 0.94
Prediction of incident hypertension risk in women with currently normal blood pressure. Am J Med (2009) 0.93
Dyslipidaemia as a predictor of hypertension in middle-aged men. Eur Heart J (2008) 0.93
Visceral fat and prevalence of hypertension among African Americans and Hispanic Americans: findings from the IRAS family study. Am J Hypertens (2008) 0.93
Lipoprotein subclass abnormalities and incident hypertension in initially healthy women. Clin Chem (2011) 0.92
The cooperative roles of inflammation and oxidative stress in the pathogenesis of hypertension. Antioxid Redox Signal (2013) 0.92
Areca nut chewing and systemic inflammation: evidence of a common pathway for systemic diseases. J Inflamm (Lond) (2012) 0.92
Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water. CMAJ (2005) 0.92
C-reactive protein and uric Acid levels in patients with psoriasis. Indian J Clin Biochem (2011) 0.91
The combination of abdominal obesity and high-sensitivity C-reactive protein predicts new-onset hypertension in the general Japanese population: the Tanno-Sobetsu study. Hypertens Res (2015) 0.91
Periodontal disease and risk of myocardial infarction: the role of gender and smoking. Eur J Epidemiol (2007) 0.90
The impact of hypertension on patients with acute coronary syndromes. Int J Hypertens (2011) 0.90
Adipose tissue and metabolic syndrome: too much, too little or neither. Eur J Clin Invest (2015) 0.89
hs-CRP: A potential marker for hypertension in Kashmiri population. Indian J Clin Biochem (2010) 0.89
C-reactive protein is associated with aortic stiffness in a cohort of African American and white women transitioning through menopause. Menopause (2011) 0.89
Elevated C-reactive protein in children from risky neighborhoods: evidence for a stress pathway linking neighborhoods and inflammation in children. PLoS One (2012) 0.89
Microalbuminuria in rheumatoid arthritis in the post penicillamine/gold era: association with hypertension, but not therapy or inflammation. Clin Rheumatol (2010) 0.89
Do productive activities reduce inflammation in later life? Multiple roles, frequency of activities, and C-reactive protein. Gerontologist (2013) 0.88
Association of exome sequences with plasma C-reactive protein levels in >9000 participants. Hum Mol Genet (2014) 0.88
Novel risk factors in long-term hypertension incidence in type 1 diabetes mellitus. Am Heart J (2010) 0.87
Association of kidney function and albuminuria with prevalent and incident hypertension: the Atherosclerosis Risk in Communities (ARIC) study. Am J Kidney Dis (2014) 0.87
Hypertension is an independent risk factor for type 2 diabetes: the Korean genome and epidemiology study. Hypertens Res (2015) 0.86
Neighborhood walkable urban form and C-reactive protein. Prev Med (2013) 0.86
Socioeconomic indices as independent correlates of C-reactive protein in the National Longitudinal Study of Adolescent Health. Psychosom Med (2013) 0.86
Association between leukocyte and metabolic syndrome in urban Han Chinese: a longitudinal cohort study. PLoS One (2012) 0.86
The role of CRP and inflammation in the pathogenesis of age-related macular degeneration. Biochem Med (Zagreb) (2012) 0.85
Periodontal disease and incidence of hypertension in the health professionals follow-up study. Am J Hypertens (2012) 0.85
Association between mobility mode and C-reactive protein levels in men with chronic spinal cord injury. Arch Phys Med Rehabil (2008) 0.84
Relationships among serum C-reactive protein, receptor for advanced glycation products, metabolic dysfunction, and cognitive impairments. BMC Neurol (2013) 0.84
Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus - Mechanisms, Management, and Clinical Considerations. Circulation (2016) 0.84
Use of statins and blood pressure. Am J Hypertens (2007) 0.83
Association between serum levels of C-reactive protein and personality traits in women. Behav Brain Funct (2008) 0.83
Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles. Hypertension (2016) 0.83
Fetal sex and the circulating renin-angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension. J Hum Hypertens (2013) 0.82
Treating chronic periodontitis: current status, challenges, and future directions. Clin Cosmet Investig Dent (2010) 0.82
High-normal blood pressure and long-term risk of type 2 diabetes: 35-year prospective population based cohort study of men. BMC Cardiovasc Disord (2012) 0.82
Reduction of C-reactive protein and the use of anti-hypertensives. Vasc Health Risk Manag (2007) 0.82
Association Between High-Sensitivity C-Reactive Protein and Total Stroke by Hypertensive Status Among Men. J Am Heart Assoc (2015) 0.82
Personality and inflammation: the protective effect of openness to experience. Ethn Dis (2010) 0.82
Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life. J Hypertens (2013) 0.82
Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an American Indian population. PLoS One (2013) 0.82
Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypertensive rats after macrophage depletion. Microcirculation (2013) 0.82
Relations of plasma high-sensitivity C-reactive protein to various cardiovascular risk factors. J Korean Med Sci (2005) 0.82
Circulating inflammatory and endothelial markers and risk of hypertension in white and black postmenopausal women. Clin Chem (2011) 0.82
Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats. BMC Cardiovasc Disord (2012) 0.81
Hypertension as an autoimmune and inflammatory disease. Hypertens Res (2016) 0.81
24-Hour ambulatory blood pressure associates inversely with prostaglandin F(2α), interleukin-6 and F(2)-isoprostane formation in a Swedish population of older men. Int J Clin Exp Med (2012) 0.81
Functional neural-bone marrow pathways: implications in hypertension and cardiovascular disease. Hypertension (2014) 0.81
The kallikrein-kinin system as a regulator of cardiovascular and renal function. Compr Physiol (2011) 0.81
Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk. J Clin Invest (2017) 0.81
Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein. PLoS One (2015) 0.80
Microarray analysis of differential gene expression profile in peripheral blood cells of patients with human essential hypertension. Int J Med Sci (2011) 0.80
Combined oral contraception and obesity are strong predictors of low-grade inflammation in healthy individuals: results from the Danish Blood Donor Study (DBDS). PLoS One (2014) 0.80
Aldosterone Receptor Antagonism Reduces Urinary C-Reactive Protein Excretion in Angiotensin II-Infused, Hypertensive Rats. J Am Soc Hypertens (2010) 0.79
High sensitivity C-reactive protein associated with different health predictors in middle-aged and oldest old Chinese. Biomed Environ Sci (2012) 0.79
C-reactive protein is elevated in the offspring of parents with essential hypertension. Arch Dis Child (2006) 0.79
Role of the immune system in hypertension: modulation by dietary antioxidants. Int J Angiol (2011) 0.79
The Malaria-High Blood Pressure Hypothesis. Circ Res (2016) 0.79
Plasma NT pro-BNP, hs-CRP and big-ET levels at admission as prognostic markers of survival in hospitalized patients with dilated cardiomyopathy: a single-center cohort study. BMC Cardiovasc Disord (2014) 0.78
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Inflammation and atherosclerosis. Circulation (2002) 20.77
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med (2005) 17.32
Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med (2002) 16.23
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA (2007) 15.32
Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2008) 13.35
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 12.09
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2011) 11.02
Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA (2007) 9.68
C-reactive protein levels and outcomes after statin therapy. N Engl J Med (2005) 9.47
Progress and challenges in translating the biology of atherosclerosis. Nature (2011) 9.41
Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 9.03
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation (2003) 8.61
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 8.32
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Advances in measuring the effect of individual predictors of cardiovascular risk: the role of reclassification measures. Ann Intern Med (2009) 7.62
Plasma adiponectin levels and risk of myocardial infarction in men. JAMA (2004) 7.46
C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation (2008) 7.33
Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med (2002) 7.32
C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation (2003) 6.99
Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet (2009) 6.79
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med (2010) 6.48
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation (2007) 6.34
Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med (2007) 6.29
Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. Am J Epidemiol (2005) 6.20
Migraine and risk of cardiovascular disease in women. JAMA (2006) 6.16
Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16
Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol (2009) 6.11
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol (2004) 6.08
Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med (2009) 6.00
Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98
Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women. Am J Med (2007) 5.95
Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med (2004) 5.86
Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA (2005) 5.74
The effect of including C-reactive protein in cardiovascular risk prediction models for women. Ann Intern Med (2006) 5.69
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Laboratory-based versus non-laboratory-based method for assessment of cardiovascular disease risk: the NHANES I Follow-up Study cohort. Lancet (2008) 5.49
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Measures of obesity and cardiovascular risk among men and women. J Am Coll Cardiol (2008) 5.28
Physical activity and weight gain prevention. JAMA (2010) 5.27
Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 5.25
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 5.13
Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ (2009) 4.98
C-reactive protein and the risk of incident colorectal cancer. JAMA (2004) 4.94
Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94
Serum aldosterone and the incidence of hypertension in nonhypertensive persons. N Engl J Med (2004) 4.92
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78
Risk of death and cardiovascular events in initially healthy women with new-onset atrial fibrillation. JAMA (2011) 4.73
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet (2009) 4.71
Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes (2004) 4.67
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation (2004) 4.58
Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA (2004) 4.47
Association between a literature-based genetic risk score and cardiovascular events in women. JAMA (2010) 4.46
A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med (2009) 4.46
Prevalence of dry eye syndrome among US women. Am J Ophthalmol (2003) 4.46
Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy american women. Clin Chem (2007) 4.45
Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 4.40