Published in PLoS One on March 17, 2009
Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLoS Pathog (2010) 2.09
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood (2011) 1.82
Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of γδ T cells. J Virol (2012) 1.21
Postinfluenza bacterial pneumonia: host defenses gone awry. J Interferon Cytokine Res (2010) 1.09
Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. PLoS One (2011) 1.03
Influenza and pneumonia mortality in 66 large cities in the United States in years surrounding the 1918 pandemic. PLoS One (2011) 0.86
[Severe forms of influenza A (H1N1) 2009 in pregnant women: experience of the University Hospital of Fez, Morocco and literature review]. Pan Afr Med J (2012) 0.78
Hierarchical effects of pro-inflammatory cytokines on the post-influenza susceptibility to pneumococcal coinfection. Sci Rep (2016) 0.77
Analysis of potential changes in seriousness of influenza A and B viruses in Hong Kong from 2001 to 2011. Epidemiol Infect (2015) 0.77
Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation. Infect Immun (2016) 0.76
Immunomodulators Targeting MARCO Expression Improve Resistance to Post-influenza Bacterial Pneumonia. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science (2001) 21.99
Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science (2005) 17.19
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26
A study of the genetic material determining an enzyme in Pneumococcus. Biochim Biophys Acta (1960) 16.02
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science (2006) 16.00
Characterization of the 1918 influenza virus polymerase genes. Nature (2005) 15.73
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80
1918 Influenza: the mother of all pandemics. Emerg Infect Dis (2006) 12.11
Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis (2008) 11.01
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature (2006) 6.46
Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature (2004) 6.11
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nat Rev Microbiol (2008) 5.98
Insights into the interaction between influenza virus and pneumococcus. Clin Microbiol Rev (2006) 5.92
Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe (2007) 5.46
Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. J Immunol (1991) 5.02
Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor. J Infect Dis (2002) 4.21
Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody. J Exp Med (1994) 4.16
Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans. J Virol (2000) 3.88
Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med (2008) 3.67
A role for Streptococcus pneumoniae in virus-associated pneumonia. Nat Med (2004) 3.49
Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines. Thorax (2001) 3.38
Influenza and the challenge for immunology. Nat Immunol (2006) 3.24
Scientific barriers to developing vaccines against avian influenza viruses. Nat Rev Immunol (2007) 3.00
Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. J Exp Med (2008) 2.77
Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia. J Immunol (2001) 2.00
Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proc Natl Acad Sci U S A (2006) 1.92
Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains. Infect Immun (2001) 1.86
Effect of antiviral treatment on the outcome of secondary bacterial pneumonia after influenza. J Infect Dis (2004) 1.83
Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood (2006) 1.83
The innate immune response to pneumococcal lung infection: the untold story. Trends Immunol (2004) 1.80
CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. Infect Immun (2004) 1.70
Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection. Infect Immun (2006) 1.67
Interleukin-12 promotes gamma interferon-dependent neutrophil recruitment in the lung and improves protection against respiratory Streptococcus pneumoniae infection. Infect Immun (2007) 1.64
Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans. J Infect Dis (2005) 1.51
Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice. Infect Immun (2007) 1.36
Lessons learned from reconstructing the 1918 influenza pandemic. J Infect Dis (2006) 1.17
Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion. Blood (2005) 1.10
Filamentous influenza A virus infection predisposes mice to fatal septicemia following superinfection with Streptococcus pneumoniae serotype 3. Infect Immun (2007) 1.03
Innate immunity and the pneumococcus. Microbiology (2006) 1.01
Differential contribution of bacterial N-formyl-methionyl-leucyl- phenylalanine and host-derived CXC chemokines to neutrophil infiltration into pulmonary alveoli during murine pneumococcal pneumonia. Infect Immun (2007) 0.93
Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumonia. Eur Respir J (2004) 0.92
A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice. Mamm Genome (2003) 0.91
Early predictors of mortality in pneumococcal bacteraemia. J Infect (2000) 0.86
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature (2011) 6.14
An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps. Curr Biol (2006) 3.69
Neuropilin-1: a surface marker of regulatory T cells. Eur J Immunol (2004) 2.82
Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol (2009) 2.80
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A (2014) 2.63
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell (2012) 2.60
Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones. Blood (2009) 2.58
Bacterial adhesins in host-microbe interactions. Cell Host Microbe (2009) 2.43
Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity (2011) 2.39
Host genetic background strongly influences the response to influenza a virus infections. PLoS One (2009) 2.28
Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse. Blood (2007) 2.21
Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro. Mol Cell Biol (2003) 2.17
Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells. Am J Respir Crit Care Med (2008) 2.15
Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies. J Exp Med (2007) 2.11
Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLoS Pathog (2010) 2.09
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis. Proc Natl Acad Sci U S A (2006) 2.01
Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps. Cell Microbiol (2007) 1.99
Tuning immune responses: diversity and adaptation of the immunological synapse. Nat Rev Immunol (2005) 1.98
Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Brain (2011) 1.95
CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 1.94
Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS One (2007) 1.86
Clinical utility of PCR for common viruses in acute respiratory illness. Pediatrics (2014) 1.86
Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children. J Infect Dis (2013) 1.84
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood (2011) 1.82
Microglia provide neuroprotection after ischemia. FASEB J (2006) 1.82
Epidemiology of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol (2008) 1.81
Neutrophil extracellular traps: casting the NET over pathogenesis. Curr Opin Microbiol (2007) 1.80
Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation. Blood (2013) 1.79
Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege. J Neurosci (2008) 1.73
Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo. J Immunol (2009) 1.69
Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol (2006) 1.62
Emergence of hypervirulent mutants resistant to early clearance during systemic serotype 1 pneumococcal infection in mice and humans. J Infect Dis (2014) 1.62
Autoimmune-mediated intestinal inflammation-impact and regulation of antigen-specific CD8+ T cells. Gastroenterology (2006) 1.62
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation. Sci Signal (2013) 1.56
Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans. J Infect Dis (2005) 1.51
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle. FEBS Lett (2007) 1.50
Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis. Virulence (2012) 1.50
Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related. J Infect Dis (2008) 1.49
Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response. Mol Syst Biol (2012) 1.48
Deriving a germinal center lymphocyte migration model from two-photon data. J Exp Med (2008) 1.44
The power of single and multibeam two-photon microscopy for high-resolution and high-speed deep tissue and intravital imaging. Biophys J (2007) 1.44
ETosis: a novel cell death pathway. Sci Signal (2008) 1.41
Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS Pathog (2007) 1.39
Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene. Proc Natl Acad Sci U S A (2007) 1.33
Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. J Immunol (2009) 1.28
Lysogenic transfer of group A Streptococcus superantigen gene among Streptococci. J Infect Dis (2008) 1.24
LytA, major autolysin of Streptococcus pneumoniae, requires access to nascent peptidoglycan. J Biol Chem (2012) 1.23
Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis. J Bacteriol (2009) 1.23
Hepatic dendritic cell subsets in the mouse. Eur J Immunol (2004) 1.22
Sortase-mediated assembly and surface topology of adhesive pneumococcal pili. Mol Microbiol (2008) 1.22
Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel approach in molecular epidemiology. J Clin Microbiol (2007) 1.20
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. J Immunol (2010) 1.19
Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression. EMBO Mol Med (2009) 1.19
Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion. J Immunol (2009) 1.18
Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection. PLoS Genet (2013) 1.17
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nat Med (2010) 1.16
Type I IFN negatively regulates CD8+ T cell responses through IL-10-producing CD4+ T regulatory 1 cells. J Immunol (2005) 1.16
Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation. Immunity (2010) 1.15
Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy. Proc Natl Acad Sci U S A (2009) 1.14
Developmental switch of intestinal antimicrobial peptide expression. J Exp Med (2008) 1.11
Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major. FASEB J (2007) 1.11
Disulfide bond formation and cysteine exclusion in gram-positive bacteria. J Biol Chem (2009) 1.09
Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies. PLoS One (2008) 1.09
Molecular and functional analysis of Shiga toxin-induced response patterns in human vascular endothelial cells. Blood (2003) 1.08
G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. J Immunol (2006) 1.06
Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity. J Mol Biol (2009) 1.05
Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors. Blood (2012) 1.05
IRF-1 expression is essential for natural killer cells to suppress metastasis. Cancer Res (2011) 1.03
Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. PLoS One (2011) 1.03
Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity (2009) 1.03
CD4 T Lymphocyte-mediated lung disease: steady state between pathological and tolerogenic immune reactions. Am J Respir Crit Care Med (2004) 1.02
Human regulatory T cells in allogeneic stem cell transplantation. Blood (2011) 1.01
Studies on the antibacterial effects of statins--in vitro and in vivo. PLoS One (2011) 1.00
Therapeutic intervention in cancer and chronic viral infections: antibody mediated manipulation of PD-1/PD-L1 interaction. Rev Recent Clin Trials (2012) 0.99
Intestinal immunity of Escherichia coli NISSLE 1917: a safe carrier for therapeutic molecules. FEMS Immunol Med Microbiol (2005) 0.99
The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time? FEMS Microbiol Rev (2006) 0.99
Shaping the fungal adaptome--stress responses of Aspergillus fumigatus. Int J Med Microbiol (2011) 0.99
Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells. Sci Signal (2011) 0.98
Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus. PLoS One (2009) 0.98
The molecular makeup and function of regulatory and effector synapses. Immunol Rev (2007) 0.98
Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation. Respir Res (2007) 0.98
Direct observation of phagocytosis and NET-formation by neutrophils in infected lungs using 2-photon microscopy. J Vis Exp (2011) 0.97
Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA. J Immunol (2011) 0.97
Immune response modifiers--mode of action. Exp Dermatol (2006) 0.97
Activating immunity in the liver. II. IFN-beta attenuates NK cell-dependent liver injury triggered by liver NKT cell activation. J Immunol (2002) 0.97
Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. Infect Immun (2010) 0.96
Human monocytes promote Th1 and Th17 responses to Streptococcus pneumoniae. Infect Immun (2011) 0.96
APC, T cells, and the immune synapse. Curr Top Microbiol Immunol (2010) 0.95
Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells. BMC Microbiol (2009) 0.94
White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion. Eukaryot Cell (2012) 0.94
Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis. Proc Natl Acad Sci U S A (2013) 0.93
Identification of a family of effectors secreted by the type III secretion system that are conserved in pathogenic Chlamydiae. Infect Immun (2010) 0.93
Establishment of murine cell lines by constitutive and conditional immortalization. J Biotechnol (2005) 0.93
Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging. Cell Cycle (2007) 0.92