Histone arginine methylation and its dynamic regulation.

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature (2007) 3.32

The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci U S A (2007) 2.53

Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res (2009) 2.31

An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environ Health Perspect (2010) 2.16

Environmental chemical exposures and human epigenetics. Int J Epidemiol (2011) 1.97

Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell (2013) 1.87

Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta (2008) 1.69

Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A (2006) 1.69

Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii. PLoS Pathog (2007) 1.69

Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains. EMBO J (2007) 1.50

The epigenetics of autoimmunity. Cell Mol Immunol (2011) 1.47

Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3. Nat Commun (2015) 1.46

Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc Natl Acad Sci U S A (2007) 1.40

SKB1-mediated symmetric dimethylation of histone H4R3 controls flowering time in Arabidopsis. EMBO J (2007) 1.37

Quantitative proteomic analysis of histone modifications. Chem Rev (2015) 1.32

Neuroscience of alcoholism: molecular and cellular mechanisms. Cell Mol Life Sci (2009) 1.32

Analysis of histones in Xenopus laevis. I. A distinct index of enriched variants and modifications exists in each cell type and is remodeled during developmental transitions. J Biol Chem (2008) 1.26

Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol (2009) 1.26

The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24

Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression. BMC Bioinformatics (2010) 1.22

Histone arginine methylation is required for vernalization-induced epigenetic silencing of FLC in winter-annual Arabidopsis thaliana. Proc Natl Acad Sci U S A (2008) 1.22

Epigenetic regulation in African trypanosomes: a new kid on the block. Nat Rev Microbiol (2009) 1.20

Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation. Mol Cell Biol (2010) 1.18

Structural insights into protein arginine symmetric dimethylation by PRMT5. Proc Natl Acad Sci U S A (2011) 1.14

Epigenetic reprogramming and development: a unique heterochromatin organization in the preimplantation mouse embryo. Brief Funct Genomics (2010) 1.11

Histone modifiers in cancer: friends or foes? Genes Cancer (2011) 1.10

Chatting histone modifications in mammals. Brief Funct Genomics (2010) 1.10

A type III protein arginine methyltransferase from the protozoan parasite Trypanosoma brucei. J Biol Chem (2009) 1.06

Histone demethylases and cancer. Adv Cancer Res (2009) 1.05

Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program. PLoS One (2013) 1.04

Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2. Nat Struct Mol Biol (2009) 1.03

The bromodomain: from epigenome reader to druggable target. Biochim Biophys Acta (2014) 1.02

Regulation of flowering time by the protein arginine methyltransferase AtPRMT10. EMBO Rep (2007) 1.01

Histone modifications and chromatin dynamics: a focus on filamentous fungi. FEMS Microbiol Rev (2008) 1.01

Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs. J Biol Chem (2011) 1.00

A combinatorial H4 tail library for exploring the histone code. Biochemistry (2008) 0.99

Chemical biology of protein arginine modifications in epigenetic regulation. Chem Rev (2015) 0.99

The dynamic stress-induced "O-GlcNAc-ome" highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways. Amino Acids (2010) 0.98

Joining the dots: from chromatin remodeling to neuronal plasticity. Curr Opin Neurobiol (2010) 0.97

Protein arginine methylation in parasitic protozoa. Eukaryot Cell (2011) 0.97

Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease. J Mol Neurosci (2008) 0.96

Transcription-coupled deposition of histone modifications during MHC class II gene activation. Nucleic Acids Res (2007) 0.95

Potential role for PADI-mediated histone citrullination in preimplantation development. BMC Dev Biol (2012) 0.95

Epigenetics-beyond the genome in alcoholism. Alcohol Res (2012) 0.94

TbPRMT6 is a type I protein arginine methyltransferase that contributes to cytokinesis in Trypanosoma brucei. Eukaryot Cell (2010) 0.94

Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. Gastroenterology (2014) 0.93

Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei. Eukaryot Cell (2007) 0.92

Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor γ2 (PPARγ2) and its target genes during adipogenesis. Mol Endocrinol (2012) 0.91

Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis. Prog Neurobiol (2008) 0.91

A transient kinetic analysis of PRMT1 catalysis. Biochemistry (2011) 0.91

The association between H3K4me3 and antisense transcription. Genomics Proteomics Bioinformatics (2012) 0.88

An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nat Neurosci (2016) 0.87

A methyltransferase-independent function for Rmt3 in ribosomal subunit homeostasis. J Biol Chem (2009) 0.86

Extensive and varied modifications in histone H2B of wild-type and histone deacetylase 1 mutant Neurospora crassa. Biochemistry (2010) 0.85

Frequent SOCS3 and 3OST2 promoter methylation and their epigenetic regulation in endometrial carcinoma. Am J Cancer Res (2014) 0.84

Investigation of the molecular origins of protein-arginine methyltransferase I (PRMT1) product specificity reveals a role for two conserved methionine residues. J Biol Chem (2011) 0.84

A lesson learned from the H3.3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo? Cell Cycle (2013) 0.84

Modern approaches for investigating epigenetic signaling pathways. J Appl Physiol (1985) (2010) 0.84

Repression of cardiac phospholamban gene expression is mediated by thyroid hormone receptor-{alpha}1 and involves targeted covalent histone modifications. Endocrinology (2010) 0.82

A novel mechanism of antagonism between ATP-dependent chromatin remodeling complexes regulates RNR3 expression. Mol Cell Biol (2009) 0.82

Expression, purification, crystallization and preliminary crystallographic study of isolated modules of the mouse coactivator-associated arginine methyltransferase 1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.82

A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3. Nucleic Acids Res (2008) 0.81

Loss of CARM1 is linked to reduced HuR function in replicative senescence. BMC Mol Biol (2013) 0.81

A remodeled protein arginine methyltransferase 1 (PRMT1) generates symmetric dimethylarginine. J Biol Chem (2014) 0.80

Entamoeba histolytica: protein arginine transferase 1a methylates arginine residues and potentially modify the H4 histone. Parasit Vectors (2015) 0.80

Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage. Glia (2015) 0.80

Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice. BMC Musculoskelet Disord (2016) 0.80

A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72. J Biol Chem (2012) 0.79

Epigenetics in preimplantation mammalian development. Theriogenology (2016) 0.78

Mechanisms of epigenetic regulation of leukemia onset and progression. Adv Immunol (2013) 0.77

Defining the chromatin landscape in demyelinating disorders. Neurobiol Dis (2009) 0.77

Transcriptional Gene Silencing (TGS) via the RNAi Machinery in HIV-1 Infections. Biology (Basel) (2012) 0.77

A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs. Neurotox Res (2014) 0.77

Identification and characterization of PKF118-310 as a KDM4A inhibitor. Epigenetics (2016) 0.77

Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase. J Biol Chem (2015) 0.76

The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis. Clin Epigenetics (2016) 0.76

Diversity and Divergence of Dinoflagellate Histone Proteins. G3 (Bethesda) (2015) 0.75

Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene. PLoS One (2012) 0.75

KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation. PLoS Pathog (2017) 0.75

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73

Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73

Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86

Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79

Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69

Epigenetics: a landscape takes shape. Cell (2007) 8.29

MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17

Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91

Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature (2002) 7.54

Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell (2003) 6.44

Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (2013) 6.29

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27

Extraction, purification and analysis of histones. Nat Protoc (2007) 6.25

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12

Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol (2006) 5.99

Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80

RNA meets chromatin. Genes Dev (2005) 5.66

PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59

Human PAD4 regulates histone arginine methylation levels via demethylimination. Science (2004) 5.46

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43

Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol (2009) 5.27

Binary switches and modification cassettes in histone biology and beyond. Nature (2003) 4.75

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73

Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol (2002) 4.50

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13

Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell (2006) 3.87

Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem (2006) 3.84

Gene silencing: trans-histone regulatory pathway in chromatin. Nature (2002) 3.77

Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat Genet (2001) 3.63

Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37

Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23

Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena. Cell (2002) 3.16

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature (2009) 3.13

Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell (2008) 3.09

Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Genes Dev (2007) 2.81

Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell (2011) 2.68

Histone H3 variants and their potential role in indexing mammalian genomes: the "H3 barcode hypothesis". Proc Natl Acad Sci U S A (2006) 2.68

ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature (2010) 2.65

Chromatin remodeling and cancer, Part I: Covalent histone modifications. Trends Mol Med (2007) 2.60

Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription. J Biol Chem (2003) 2.48

Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol Cell (2007) 2.47

Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell (2010) 2.44

Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism. Curr Biol (2002) 2.44

Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc Natl Acad Sci U S A (2007) 2.43

Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol (2004) 2.43

KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell (2013) 2.34

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. Mutat Res (2008) 2.31

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat Struct Mol Biol (2006) 2.29

RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes Dev (2007) 2.26

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol Cell (2010) 2.25

The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast. Mol Cell (2005) 2.19

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol (2011) 2.18

Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc Natl Acad Sci U S A (2003) 2.16

Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae. Cell (2005) 2.15

Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Mol Cell Biol (2008) 2.05

Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Genes Dev (2006) 2.05

Operating on chromatin, a colorful language where context matters. J Mol Biol (2011) 2.00

New functions for an old variant: no substitute for histone H3.3. Curr Opin Genet Dev (2010) 1.93

Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Proc Natl Acad Sci U S A (2005) 1.91

Proteome-wide prediction of acetylation substrates. Proc Natl Acad Sci U S A (2009) 1.81

Polycomb Group proteins: an evolutionary perspective. Trends Genet (2007) 1.79

Cancer. New epigenetic drivers of cancers. Science (2011) 1.73

Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10. Mol Cell (2006) 1.72

Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons. J Cell Sci (2003) 1.70

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proc Natl Acad Sci U S A (2010) 1.68

DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature (2012) 1.65

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes. Proc Natl Acad Sci U S A (2011) 1.65

Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. Mol Cell Biol (2002) 1.63

Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling. Trends Mol Med (2007) 1.59

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes Dev (2008) 1.51

Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. J Biol Chem (2006) 1.50

Phosphorylation of histone H2B at DNA double-strand breaks. J Exp Med (2004) 1.49

The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved. Chromosoma (2004) 1.47

Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. Proc Natl Acad Sci U S A (2002) 1.46

An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol Cell (2012) 1.43

Histone variants in metazoan development. Dev Cell (2010) 1.42

Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae. Curr Biol (2005) 1.41

Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. J Biol Chem (2009) 1.38

Taking LSD 1 to a new high. Cell (2005) 1.34

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. Cancer Discov (2012) 1.33

Histone regulation in the CNS: basic principles of epigenetic plasticity. Neuropsychopharmacology (2012) 1.33

Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry. J Proteome Res (2004) 1.33

Dynamic alterations of specific histone modifications during early murine development. J Cell Sci (2004) 1.30

Modifications of human histone H3 variants during mitosis. Biochemistry (2005) 1.29

Analysis of histones in Xenopus laevis. I. A distinct index of enriched variants and modifications exists in each cell type and is remodeled during developmental transitions. J Biol Chem (2008) 1.26

Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila. Mol Cell Proteomics (2006) 1.26

Beyond the double helix: writing and reading the histone code. Novartis Found Symp (2004) 1.25

RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction. Cell Rep (2013) 1.22