Published in J Biol Chem on June 19, 2006
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res (2008) 3.15
DNA polymerases and cancer. Nat Rev Cancer (2011) 3.05
DNA interstrand crosslink repair in mammalian cells: step by step. Crit Rev Biochem Mol Biol (2010) 1.82
Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antioxid Redox Signal (2010) 1.65
Low-fidelity DNA synthesis by human DNA polymerase theta. Nucleic Acids Res (2008) 1.65
A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol. Proc Natl Acad Sci U S A (2007) 1.56
DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol (2009) 1.47
The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism. J Biol Chem (2011) 1.43
Human DNA polymerase θ grasps the primer terminus to mediate DNA repair. Nat Struct Mol Biol (2015) 1.27
An overview of Y-Family DNA polymerases and a case study of human DNA polymerase η. Biochemistry (2014) 1.23
DNA polymerase POLQ and cellular defense against DNA damage. DNA Repair (Amst) (2012) 1.21
Pathways for repairing and tolerating the spectrum of oxidative DNA lesions. Cancer Lett (2012) 1.20
How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis. Nat Struct Mol Biol (2015) 1.17
A unique error signature for human DNA polymerase nu. DNA Repair (Amst) (2006) 1.16
Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links. Chem Res Toxicol (2010) 1.12
Translesion DNA synthesis and mutagenesis in eukaryotes. Cold Spring Harb Perspect Biol (2013) 1.09
Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links. Biochemistry (2009) 1.06
Rapid induction of chromatin-associated DNA mismatch repair proteins after MNNG treatment. DNA Repair (Amst) (2008) 1.01
Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity. Nucleic Acids Res (2010) 1.00
Mechanisms of base substitution mutagenesis in cancer genomes. Genes (Basel) (2014) 0.98
DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken. J Cell Biol (2010) 0.96
Mutator phenotypes due to DNA replication infidelity. Semin Cancer Biol (2010) 0.93
Multiple functions of DNA polymerases. CRC Crit Rev Plant Sci (2007) 0.92
A strategy for the expression of recombinant proteins traditionally hard to purify. Anal Biochem (2012) 0.91
A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells. J Biol Chem (2014) 0.90
Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs. Nat Commun (2013) 0.89
Kinetic analysis of the unique error signature of human DNA polymerase ν. Biochemistry (2011) 0.86
Inhibitory effects of glycyrrhetinic Acid on DNA polymerase and inflammatory activities. Evid Based Complement Alternat Med (2011) 0.86
3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain. Mar Drugs (2009) 0.85
Base excision repair facilitates a functional relationship between Guanine oxidation and histone demethylation. Antioxid Redox Signal (2013) 0.84
Translesion DNA synthesis in the context of cancer research. Cancer Cell Int (2011) 0.82
Anti-cancer gallotannin penta-O-galloyl-beta-D-glucose is a nanomolar inhibitor of select mammalian DNA polymerases. Biochem Pharmacol (2010) 0.82
DNA polymerase θ (POLQ), double-strand break repair, and cancer. DNA Repair (Amst) (2016) 0.81
Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases. Chem Res Toxicol (2012) 0.81
The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions. DNA Repair (Amst) (2013) 0.81
REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ. Nucleic Acids Res (2015) 0.80
Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine. J Nucleic Acids (2010) 0.78
Conserved Overlapping Gene Arrangement, Restricted Expression, and Biochemical Activities of DNA Polymerase ν (POLN). J Biol Chem (2015) 0.78
Oral administration of monogalactosyl diacylglycerol from spinach inhibits colon tumor growth in mice. Exp Ther Med (2012) 0.78
Human DNA Polymerase ν Catalyzes Correct and Incorrect DNA Synthesis with High Catalytic Efficiency. J Biol Chem (2015) 0.78
Eukaryotic DNA Polymerases in Homologous Recombination. Annu Rev Genet (2016) 0.78
A transposon-derived DNA polymerase from Entamoeba histolytica displays intrinsic strand displacement, processivity and lesion bypass. PLoS One (2012) 0.77
Effects of intermediates between vitamins K(2) and K(3) on mammalian DNA polymerase inhibition and anti-inflammatory activity. Int J Mol Sci (2011) 0.77
A nuclear family A DNA polymerase from Entamoeba histolytica bypasses thymine glycol. PLoS Negl Trop Dis (2010) 0.77
DNA Polymerases η and ζ Combine to Bypass O(2)-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens. Chem Res Toxicol (2016) 0.77
The relationship between the molecular structure of natural acetogenins and their inhibitory activities which affect DNA polymerase, DNA topoisomerase and human cancer cell growth. Exp Ther Med (2010) 0.76
A putative Leishmania DNA polymerase theta protects the parasite against oxidative damage. Nucleic Acids Res (2016) 0.75
Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair. PLoS Genet (2017) 0.75
Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet (2017) 0.75
N(2) -Substituted 2'-Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ. Angew Chem Int Ed Engl (2017) 0.75
Pyrimidine Nucleobase Radical Reactivity in DNA and RNA. Radiat Phys Chem Oxf Engl 1993 (2016) 0.75
Mutagenic Bypass of an Oxidized Abasic Lesion-Induced DNA Interstrand Cross-Link Analogue by Human Translesion Synthesis DNA Polymerases. Biochemistry (2015) 0.75
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell (2005) 3.85
DNA polymerases and cancer. Nat Rev Cancer (2011) 3.05
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell (2008) 2.47
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity. Nature (2004) 2.40
The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair. DNA Repair (Amst) (2007) 2.26
ERCC1 and non-small-cell lung cancer. N Engl J Med (2007) 2.22
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Cell (2011) 2.16
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. Mol Cell (2006) 2.13
High-efficiency bypass of DNA damage by human DNA polymerase Q. EMBO J (2004) 2.07
Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. Cancer Res (2009) 2.03
DNA polymerase zeta (pol zeta) in higher eukaryotes. Cell Res (2008) 2.02
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Mol Cell Biol (2004) 1.85
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Mol Cell (2006) 1.79
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res (2003) 1.76
Translesion synthesis by human DNA polymerase eta across thymine glycol lesions. Biochemistry (2002) 1.71
Low-fidelity DNA synthesis by human DNA polymerase theta. Nucleic Acids Res (2008) 1.65
Loss of DNA polymerase zeta causes chromosomal instability in mammalian cells. Cancer Res (2006) 1.60
Crystal structure of the DNA repair enzyme ultraviolet damage endonuclease. Structure (2007) 1.59
Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. Mol Cell Biol (2005) 1.58
DNA repair: from molecular mechanism to human disease. DNA Repair (Amst) (2006) 1.56
Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions. J Biol Chem (2004) 1.53
A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair (Amst) (2002) 1.53
POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308. J Biol Chem (2003) 1.53
Fate of DNA replication fork encountering a single DNA lesion during oriC plasmid DNA replication in vitro. Genes Cells (2003) 1.48
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Proc Natl Acad Sci U S A (2010) 1.48
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J Biol Chem (2007) 1.44
DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct. DNA Repair (Amst) (2007) 1.39
DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA. J Biol Chem (2005) 1.38
Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning. Mol Cell (2009) 1.37
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes. Proc Natl Acad Sci U S A (2009) 1.36
A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308. J Biol Chem (2001) 1.36
Identification of cryptochrome DASH from vertebrates. Genes Cells (2004) 1.36
Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines. Int J Cancer (2004) 1.34
Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution. Nat Biotechnol (2004) 1.34
Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damage. Mol Cell Biol (2004) 1.31
An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress. J Biol Chem (2003) 1.30
The XPC-HR23B complex displays high affinity and specificity for damaged DNA in a true-equilibrium fluorescence assay. Biochemistry (2002) 1.26
XPA protein as a limiting factor for nucleotide excision repair and UV sensitivity in human cells. DNA Repair (Amst) (2006) 1.25
DNA polymerase POLQ and cellular defense against DNA damage. DNA Repair (Amst) (2012) 1.21
Polymorphisms in the human XPD (ERCC2) gene, DNA repair capacity and cancer susceptibility: an appraisal. DNA Repair (Amst) (2005) 1.16
A unique error signature for human DNA polymerase nu. DNA Repair (Amst) (2006) 1.16
DDB complexities. DNA Repair (Amst) (2003) 1.16
REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo. Nucleic Acids Res (2008) 1.15
Loss of DNA polymerase zeta enhances spontaneous tumorigenesis. Cancer Res (2010) 1.15
Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair. Nucleic Acids Res (2003) 1.14
Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts. J Mol Biol (2010) 1.12
DNA polymerases and somatic hypermutation of immunoglobulin genes. EMBO Rep (2005) 1.12
Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links. Chem Res Toxicol (2010) 1.12
In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation. Mol Cell Biol (2007) 1.06
Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions. PLoS Genet (2010) 1.06
DNA polymerase zeta is required for proliferation of normal mammalian cells. Nucleic Acids Res (2012) 1.05
Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase. EMBO J (2003) 1.05
A role for DNA polymerase beta in mutagenic UV lesion bypass. J Biol Chem (2002) 1.04
Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota. DNA Repair (Amst) (2003) 1.03
Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation. Radiat Res (2009) 1.03
Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivo. Mutat Res (2005) 1.03
A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1. J Biol Chem (2001) 1.02
Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates. J Biol Chem (2004) 1.01
Elevation of XPA protein level in testis tumor cells without increasing resistance to cisplatin or UV radiation. Mol Carcinog (2008) 1.00
Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity. Nucleic Acids Res (2010) 1.00
Blockage of RNA polymerase II at a cyclobutane pyrimidine dimer and 6-4 photoproduct. Biochem Biophys Res Commun (2004) 0.99
DNA binding properties of human DNA polymerase eta: implications for fidelity and polymerase switching of translesion synthesis. Genes Cells (2004) 0.99
Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses. Proc Natl Acad Sci U S A (2013) 0.97
Lesion bypass by S. cerevisiae Pol ζ alone. DNA Repair (Amst) (2011) 0.95
Quantitative analysis of isolated and clustered DNA damage induced by gamma-rays, carbon ion beams, and iron ion beams. J Radiat Res (2008) 0.94
Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer. Nucleic Acids Res (2004) 0.94
Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant. Genes Cells (2008) 0.94
The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts. DNA Repair (Amst) (2009) 0.93
Human endonuclease V is a ribonuclease specific for inosine-containing RNA. Nat Commun (2013) 0.93
Mammalian 5-formyluracil-DNA glycosylase. 1. Identification and characterization of a novel activity that releases 5-formyluracil from DNA. Biochemistry (2003) 0.93
Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel nucleotides, in different DNA sequence contexts. DNA Repair (Amst) (2005) 0.90
Nucleosomal structure of undamaged DNA regions suppresses the non-specific DNA binding of the XPC complex. DNA Repair (Amst) (2005) 0.90
Synthesis and characterization of oligonucleotides containing 2'-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction. Nucleic Acids Res (2006) 0.89
Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs. Nat Commun (2013) 0.89
Discovery and functional analysis of a 4th electron-transferring tryptophan conserved exclusively in animal cryptochromes and (6-4) photolyases. Chem Commun (Camb) (2015) 0.88
Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha. J Biol Chem (2003) 0.88
Bypass specialists operate together. EMBO J (2009) 0.88
Salicylanilide inhibitors of Toxoplasma gondii. J Med Chem (2012) 0.87
Use of yeast transformation by oligonucleotides to study DNA lesion bypass in vivo. Mutat Res (2002) 0.87
Preferential formation of (5S,6R)-thymine glycol for oligodeoxyribonucleotide synthesis and analysis of drug binding to thymine glycol-containing DNA. Nucleic Acids Res (2006) 0.87
Investigation of the cyclobutane pyrimidine dimer (CPD) photolyase DNA recognition mechanism by NMR analyses. J Biol Chem (2004) 0.87
DNA polymerase iota-dependent translesion replication of uracil containing cyclobutane pyrimidine dimers. DNA Repair (Amst) (2005) 0.86
Assaying for the dual incisions of nucleotide excision repair using DNA with a lesion at a specific site. Methods Mol Biol (2006) 0.86
NMR study of repair mechanism of DNA photolyase by FAD-induced paramagnetic relaxation enhancement. J Biol Chem (2004) 0.86
Human replicative DNA polymerase δ can bypass T-T (6-4) ultraviolet photoproducts on template strands. Genes Cells (2010) 0.86
Biochemical properties and base excision repair complex formation of apurinic/apyrimidinic endonuclease from Pyrococcus furiosus. Nucleic Acids Res (2009) 0.86
Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana. J Nucleic Acids (2010) 0.85
A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae. Nucleic Acids Res (2004) 0.85
UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions. Nucleic Acids Res (2012) 0.85
Spectroscopic analysis of the pyrimidine(6-4)pyrimidone photoproduct: insights into the (6-4) photolyase reaction. Org Biomol Chem (2008) 0.84
Role of the carbonyl group of the (6-4) photoproduct in the (6-4) photolyase reaction. Biochemistry (2009) 0.84
Combining (1)H NMR spectroscopy and chemometrics to identify heparin samples that may possess dermatan sulfate (DS) impurities or oversulfated chondroitin sulfate (OSCS) contaminants. J Pharm Biomed Anal (2010) 0.84
Repair of the (6-4) photoproduct by DNA photolyase requires two photons. Angew Chem Int Ed Engl (2013) 0.84
Chemical synthesis of oligodeoxyribonucleotides containing the Dewar valence isomer of the (6-4) photoproduct and their use in (6-4) photolyase studies. Nucleic Acids Res (2006) 0.83
DNA polymerases eta and kappa are responsible for error-free translesion DNA synthesis activity over a cis-syn thymine dimer in Xenopus laevis oocyte extracts. DNA Repair (Amst) (2005) 0.83
FTIR study of light-dependent activation and DNA repair processes of (6-4) photolyase. Biochemistry (2011) 0.83
Molecular analyses of an unusual translesion DNA polymerase from Methanosarcina acetivorans C2A. J Mol Biol (2010) 0.82
The Gly-952 residue of Saccharomyces cerevisiae DNA polymerase alpha is important in discriminating correct deoxyribonucleotides from incorrect ones. J Biol Chem (2003) 0.82