Published in Cell on February 18, 2011
The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol (2011) 2.13
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ (2011) 1.94
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p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer (2013) 1.34
p73 in Cancer. Genes Cancer (2011) 1.33
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p63 the guardian of human reproduction. Cell Cycle (2012) 0.98
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Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level. Elife (2016) 0.90
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Functional interplay between MDM2, p63/p73 and mutant p53. Oncogene (2014) 0.89
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Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins. J Biol Chem (2011) 0.84
Tissue-specific expression of p73 C-terminal isoforms in mice. Cell Cycle (2012) 0.84
Regulation of p63 protein stability via ubiquitin-proteasome pathway. Biomed Res Int (2014) 0.83
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Defying DNA double-strand break-induced death during prophase I meiosis by temporal TAp63α phosphorylation regulation in developing mouse oocytes. Mol Cell Biol (2014) 0.77
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p73 - constitutively open for business. Cell Death Differ (2013) 0.76
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Damage limitation. Elife (2016) 0.75
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p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21
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Structure and functionality of a designed p53 dimer. J Mol Biol (2001) 1.19
Conservation of DNA-binding specificity and oligomerisation properties within the p53 family. BMC Genomics (2009) 1.16
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The C-terminus of p63 contains multiple regulatory elements with different functions. Cell Death Dis (2010) 1.07
A novel approach to analyze membrane proteins by laser mass spectrometry: from protein subunits to the integral complex. J Am Soc Mass Spectrom (2007) 1.05
DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol Cell Biol (2005) 1.04
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Tracing the protectors path from the germ line to the genome. Proc Natl Acad Sci U S A (2010) 0.84
Probing the limits of liquid droplet laser desorption mass spectrometry in the analysis of oligonucleotides and nucleic acids. Rapid Commun Mass Spectrom (2009) 0.83
Selective inhibition of BET bromodomains. Nature (2010) 18.79
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med (2006) 9.68
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Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70
Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep (2009) 5.52
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science (2011) 5.46
Histone recognition and large-scale structural analysis of the human bromodomain family. Cell (2012) 5.15
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med (2010) 4.76
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature (2002) 4.56
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell (2006) 4.51
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc Natl Acad Sci U S A (2006) 4.45
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell (2005) 4.14
p63 protects the female germ line during meiotic arrest. Nature (2006) 3.98
Protein production and purification. Nat Methods (2008) 3.97
Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature (2010) 3.70
On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet (2002) 3.57
Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell (2009) 3.51
Small-molecule inhibition of BRDT for male contraception. Cell (2012) 3.50
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J (2002) 3.42
Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell (2011) 3.36
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell (2002) 3.29
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A (2007) 3.21
Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell (2011) 3.00
Critical residues for structure and catalysis in short-chain dehydrogenases/reductases. J Biol Chem (2002) 2.95
E3-independent monoubiquitination of ubiquitin-binding proteins. Mol Cell (2007) 2.77
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A (2006) 2.73
Bromodomains as therapeutic targets. Expert Rev Mol Med (2011) 2.52
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell (2008) 2.46
Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis. Mol Cell (2009) 2.36
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation. EMBO J (2008) 2.36
Photosystem II core phosphorylation and photosynthetic acclimation require two different protein kinases. Nature (2005) 2.35
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. J Med Chem (2005) 2.34
Targeted cell entry of lentiviral vectors. Mol Ther (2008) 2.34
Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure (2009) 2.33
The (un)targeted cancer kinome. Nat Chem Biol (2010) 2.33
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol (2010) 2.26
Protein import into chloroplasts. Nat Rev Mol Cell Biol (2004) 2.26
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol (2010) 2.22
The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol (2003) 2.17
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Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol (2011) 2.06
Olfactory dysfunction in patients with idiopathic intracranial hypertension. Neurology (2013) 2.04
Spatial organization of transmembrane receptor signalling. EMBO J (2010) 2.03
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
Structure and substrate specificity of the Pim-1 kinase. J Biol Chem (2005) 1.96
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J Biol Chem (2007) 1.92
The bromodomain interaction module. FEBS Lett (2012) 1.92
Low-conductivity buffers for high-sensitivity NMR measurements. J Am Chem Soc (2002) 1.88
p63 and p73 are not required for the development and p53-dependent apoptosis of T cells. Cancer Cell (2004) 1.86
Structure and functional characterization of the atypical human kinase haspin. Proc Natl Acad Sci U S A (2009) 1.85
Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin Cancer Res (2013) 1.84
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica (2010) 1.83
p63 regulates commitment to the prostate cell lineage. Proc Natl Acad Sci U S A (2005) 1.80
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell (2003) 1.78
Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem (2012) 1.76
A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Mol Cell Biol (2002) 1.73
Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth. Cancer Cell (2008) 1.72
Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex. Science (2011) 1.68
In vivo viscoelastic properties of the brain in normal pressure hydrocephalus. NMR Biomed (2010) 1.67
Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature (2008) 1.66
Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nat Neurosci (2007) 1.66
Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex. J Biol Chem (2005) 1.64
Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites. J Med Chem (2012) 1.64
Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. Cancer Res (2007) 1.62
Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science (2006) 1.61
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery. Mol Biosyst (2011) 1.58
Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A (2011) 1.58
Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. Proc Natl Acad Sci U S A (2006) 1.57
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J Med Chem (2012) 1.55
Ruthenium half-sandwich complexes bound to protein kinase Pim-1. Angew Chem Int Ed Engl (2006) 1.54
PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains. Cancer Res (2013) 1.53
Preparative scale expression of membrane proteins in Escherichia coli-based continuous exchange cell-free systems. Nat Protoc (2007) 1.52
Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J Exp Med (2009) 1.52
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron (2004) 1.51
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J (2007) 1.51
UnPAKing the class differences among p21-activated kinases. Trends Biochem Sci (2008) 1.51
Sustained expansion and transgene expression of coagulation factor VIII-transduced cord blood-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol (2003) 1.50
Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest (2009) 1.49
Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33. Biochem J (2011) 1.49
Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice. Blood (2011) 1.48
3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J Med Chem (2011) 1.48
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. J Biol Chem (2013) 1.46
Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans. Trends Mol Med (2002) 1.46
PharmD in Pakistan: a tag or a degree? Am J Pharm Educ (2009) 1.46
Homeobox A9 transcriptionally regulates the EphB4 receptor to modulate endothelial cell migration and tube formation. Circ Res (2004) 1.46
Activation segment exchange: a common mechanism of kinase autophosphorylation? Trends Biochem Sci (2007) 1.45
Structure and regulation of the human Nek2 centrosomal kinase. J Biol Chem (2006) 1.45
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High level cell-free expression and specific labeling of integral membrane proteins. Eur J Biochem (2004) 1.45