Published in N Engl J Med on December 21, 2006
Hospital-acquired infections due to gram-negative bacteria. N Engl J Med (2010) 6.61
Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogens. Clin Infect Dis (2011) 3.20
Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ (2007) 2.44
The importance of the first complication: understanding failure to rescue after emergent surgery in the elderly. J Am Coll Surg (2014) 2.11
Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis (2016) 2.08
Ventilator-associated pneumonia in the ICU. Crit Care (2014) 1.82
Prompting physicians to address a daily checklist and process of care and clinical outcomes: a single-site study. Am J Respir Crit Care Med (2011) 1.77
Diagnosis of ventilator-associated pneumonia: a systematic review of the literature. Crit Care (2008) 1.76
Clinical practice guidelines for hospital-acquired pneumonia and ventilator-associated pneumonia in adults. Can J Infect Dis Med Microbiol (2008) 1.68
Adult patients with nosocomial pneumonia: epidemiology, diagnosis, and treatment. Dtsch Arztebl Int (2013) 1.65
Ventilator-associated pneumonia with or without toothbrushing: a randomized controlled trial. Eur J Clin Microbiol Infect Dis (2012) 1.64
Guidelines for diagnosis and management of community- and hospital-acquired pneumonia in adults: Joint ICS/NCCP(I) recommendations. Lung India (2012) 1.40
Ventilator-associated Pneumonia caused by commensal oropharyngeal Flora; [corrected] a retrospective Analysis of a prospectively collected Database. BMC Pulm Med (2015) 1.39
Enhanced protein-energy provision via the enteral route in critically ill patients: a single center feasibility trial of the PEP uP protocol. Crit Care (2010) 1.18
Recommended design features of future clinical trials of antibacterial agents for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Clin Infect Dis (2010) 1.16
Implications of endotracheal tube biofilm in ventilator-associated pneumonia response: a state of concept. Crit Care (2012) 1.14
Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study. Crit Care (2011) 1.09
Suspected ventilator-associated respiratory infection in severely ill patients: a prospective observational study. Crit Care (2013) 1.04
Comparison of bronchoscopic and non-bronchoscopic techniques for diagnosis of ventilator associated pneumonia. Indian J Crit Care Med (2011) 0.99
The Japanese guidelines for the management of sepsis. J Intensive Care (2014) 0.99
Multiple lung abscesses caused by Actinomyces graevenitzii mimicking acute pulmonary coccidioidomycosis. J Clin Microbiol (2012) 0.94
Diagnosis of ventilator-associated pneumonia. N Engl J Med (2006) 0.89
Temporal trends of ventilator-associated pneumonia incidence and the effect of implementing health-care bundles in a suburban community. Chest (2013) 0.88
A national survey of the diagnosis and management of suspected ventilator-associated pneumonia. BMJ Open Respir Res (2014) 0.87
Quality indicators for ICU: ISCCM guidelines for ICUs in India. Indian J Crit Care Med (2009) 0.87
Mild hypoglycemia is independently associated with increased risk of mortality in patients with sepsis: a 3-year retrospective observational study. Crit Care (2012) 0.87
Diagnosis of ventilator-associated pneumonia. N Engl J Med (2007) 0.84
Infectious complications of cardiac surgery: a clinical review. J Cardiothorac Vasc Anesth (2012) 0.83
Diagnosis of ventilator-associated pneumonia. N Engl J Med (2007) 0.82
How to treat VAP due to MDR pathogens in ICU patients. BMC Infect Dis (2014) 0.81
Composition and dynamics of the respiratory tract microbiome in intubated patients. Microbiome (2016) 0.81
Quantitative cultures of bronchoscopically obtained specimens should be performed for optimal management of ventilator-associated pneumonia. J Clin Microbiol (2013) 0.81
Identifying missed opportunities to curtail antimicrobial therapy for presumed ventilator-associated pneumonia using the clinical pulmonary infection score. Can J Hosp Pharm (2009) 0.79
Impact of Candida species on clinical outcomes in patients with suspected ventilator-associated pneumonia. Can Respir J (2011) 0.79
Endotracheal aspirate and bronchoalveolar lavage fluid analysis: interchangeable diagnostic modalities in suspected ventilator-associated pneumonia? J Clin Microbiol (2014) 0.79
Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia: a threshold-finding prospective observational study. Crit Care (2014) 0.79
Is bronchoalveolar lavage with quantitative cultures a useful tool for diagnosing ventilator-associated pneumonia? Crit Care (2007) 0.78
Quantitative culture of endotracheal aspirate and BAL fluid samples in the management of patients with ventilator-associated pneumonia: a randomized clinical trial. J Bras Pneumol (2015) 0.77
Clinical course and spectrum of intensive care unit patients reactivating herpes simplex-1 virus: a retrospective analysis. Indian J Crit Care Med (2008) 0.76
Characteristics and outcomes of anti-infective de-escalation during health care-associated intra-abdominal infections. Crit Care (2016) 0.76
Ventilator-associated pneumonia: problems with diagnosis and therapy. Best Pract Res Clin Anaesthesiol (2008) 0.76
Antibiotic Utilization Patterns in Patients with Ventilator-Associated Pneumonia: A Canadian Context. Can J Infect Dis Med Microbiol (2016) 0.75
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial. Trials (2015) 0.75
Clinical course and complications following diagnostic bronchoalveolar lavage in critically ill mechanically ventilated patients. BMC Pulm Med (2015) 0.75
Storage of bronchoalveolar lavage fluid and accuracy of microbiologic diagnostics in the ICU: a prospective observational study. Crit Care (2013) 0.75
Use of different diagnostic methods for ventilator-associated pneumonia did not affect mortality or targeted antibiotic use. ACP J Club (2007) 0.75
Empirical antibiotic therapy for pneumonia in intensive care units: a multicentre, retrospective analysis of potentially pathogenic microorganisms identified by endotracheal aspirates cultures. Eur J Clin Microbiol Infect Dis (2015) 0.75
Reactive oxygen species measure for rapid detection of infection in fluids. Ann Intensive Care (2016) 0.75
The effect of using blood culture bottle of bronchoalveolar larvage fluid in pneumonia. BMC Infect Dis (2016) 0.75
Critical care nephrology: Core Curriculum 2009. Am J Kidney Dis (2009) 0.75
Influence of bronchoscopy on the diagnosis of and outcomes from ventilator-associated pneumonia. Surg Infect (Larchmt) (2014) 0.75
Incidence of ventilator-associated pneumonia in Australasian intensive care units: use of a consensus-developed clinical surveillance checklist in a multisite prospective audit. BMJ Open (2015) 0.75
The simple and the simpler in pneumonia diagnosis. Crit Care (2007) 0.75
Diagnostic techniques for ventilator-associated pneumonia: conflicting results from two trials. Crit Care (2009) 0.75
Diagnosis of ventilator-associated pneumonia. N Engl J Med (2007) 0.75
Bilateral versus unilateral bronchoalveolar lavage for the diagnosis of ventilator-associated pneumonia. Surg Infect (Larchmt) (2012) 0.75
Diagnostic Value of Endotracheal Aspirates Sonication on Ventilator-Associated Pneumonia Microbiologic Diagnosis. Microorganisms (2017) 0.75
One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med (2003) 11.77
Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med (2011) 9.96
A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med (2013) 8.94
Transfusion strategies for patients in pediatric intensive care units. N Engl J Med (2007) 7.21
Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69
High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med (2013) 6.56
Clinical consequences of red cell storage in the critically ill. Transfusion (2006) 3.57
Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med (2006) 3.06
The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis. Crit Care Med (2015) 2.85
Fluids after cardiac surgery: a pilot study of the use of colloids versus crystalloids. Crit Care Med (2010) 2.82
The Very Elderly Admitted to ICU: A Quality Finish? Crit Care Med (2015) 2.77
Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One (2012) 2.75
One-Year Outcomes in Caregivers of Critically Ill Patients. N Engl J Med (2016) 2.73
Acute rehabilitation practices in critically ill children: a multicenter study. Pediatr Crit Care Med (2014) 2.71
Clinician predictions of intensive care unit mortality. Crit Care Med (2004) 2.65
Age of transfused blood in critically ill adults. N Engl J Med (2015) 2.52
Nonleg venous thrombosis in critically ill adults: a nested prospective cohort study. JAMA Intern Med (2014) 2.36
Red blood cell transfusion thresholds in pediatric patients with sepsis. Pediatr Crit Care Med (2011) 2.35
Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest (2013) 2.24
Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials. Am J Respir Crit Care Med (2012) 2.15
Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia. Ann Intern Med (2004) 1.97
Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia. Crit Care Med (2008) 1.94
Survey of interventions for the prevention and treatment of acute respiratory distress syndrome. Crit Care Med (2004) 1.90
Multiple organ dysfunction: baseline and serial component scores. Crit Care Med (2001) 1.88
Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada. Can J Anaesth (2010) 1.78
Revisiting transfusion practices in critically ill patients. Crit Care Med (2005) 1.78
Determination of neurologic prognosis and clinical decision making in adult patients with severe traumatic brain injury: a survey of Canadian intensivists, neurosurgeons, and neurologists. Crit Care Med (2013) 1.72
Mortality associated with withdrawal of life-sustaining therapy for patients with severe traumatic brain injury: a Canadian multicentre cohort study. CMAJ (2011) 1.72
A randomized trial of daily awakening in critically ill patients managed with a sedation protocol: a pilot trial. Crit Care Med (2008) 1.71
Vasopressin in pediatric vasodilatory shock: a multicenter randomized controlled trial. Am J Respir Crit Care Med (2009) 1.71
Implementation of clinical practice guidelines for ventilator-associated pneumonia: a multicenter prospective study. Crit Care Med (2013) 1.68
Patient safety, resident well-being and continuity of care with different resident duty schedules in the intensive care unit: a randomized trial. CMAJ (2015) 1.65
Research recruitment practices and critically ill patients. A multicenter, cross-sectional study (the Consent Study). Am J Respir Crit Care Med (2013) 1.63
Cost-effectiveness of dalteparin vs unfractionated heparin for the prevention of venous thromboembolism in critically ill patients. JAMA (2014) 1.60
In-house, overnight physician staffing: a cross-sectional survey of Canadian adult and pediatric intensive care units. Crit Care Med (2006) 1.60
Screening and prevention of venous thromboembolism in critically ill patients: a decision analysis and economic evaluation. Am J Respir Crit Care Med (2011) 1.58
Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. Crit Care Med (2015) 1.58
Survey on transfusion practices of pediatric intensivists. Pediatr Crit Care Med (2002) 1.55
The association of vitamin D status with pediatric critical illness. Pediatrics (2012) 1.53
Resuscitating patients with early severe sepsis: a Canadian multicentre observational study. Can J Anaesth (2007) 1.52
Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study. J Crit Care (2005) 1.50
Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. Kidney Int (2015) 1.47
Physicians declining patient enrollment in a critical care trial: a case study in thromboprophylaxis. Intensive Care Med (2013) 1.46
The clinical impact and preventability of ventilator-associated conditions in critically ill patients who are mechanically ventilated. Chest (2013) 1.46
Survey of determination of death after cardiac arrest by intensive care physicians. Crit Care Med (2012) 1.46
Nonbeneficial treatment Canada: definitions, causes, and potential solutions from the perspective of healthcare practitioners*. Crit Care Med (2015) 1.45
Barriers and facilitators of thromboprophylaxis for medical-surgical intensive care unit patients: a multicenter survey. J Crit Care (2014) 1.44
Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients. Crit Care Med (2016) 1.44
Heparin-induced thrombocytopenia in the critically ill: interpreting the 4Ts test in a randomized trial. J Crit Care (2014) 1.42
Cardiac arrhythmias associated with severe traumatic brain injury and hypothermia therapy. Pediatr Crit Care Med (2010) 1.42
Coenrollment in a randomized trial of high-frequency oscillation: prevalence, patterns, predictors, and outcomes*. Crit Care Med (2015) 1.41
Characteristics and Outcomes of Eligible Nonenrolled Patients in a Mechanical Ventilation Trial of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med (2015) 1.39
A survey of Canadian intensivists' resuscitation practices in early septic shock. Crit Care (2007) 1.37
Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT study. Arch Intern Med (2008) 1.28
Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients? J Trauma (2004) 1.25
Hypothermia therapy after pediatric cardiac arrest. Circulation (2009) 1.19
Ventilator-associated pneumonia caused by multidrug-resistant organisms or Pseudomonas aeruginosa: prevalence, incidence, risk factors, and outcomes. J Crit Care (2008) 1.18
REducing Deaths due to OXidative Stress (The REDOXS Study): Rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically-ill patients. Proc Nutr Soc (2006) 1.12
A prospective multicenter study of adrenal function in critically ill children. Am J Respir Crit Care Med (2010) 1.10
Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT-AKI): study protocol for a randomized controlled trial. Trials (2013) 1.07
The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients. Crit Care (2001) 1.07
Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysis. Crit Care Med (2010) 1.05
Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial. JPEN J Parenter Enteral Nutr (2014) 1.02
Burden of illness in venous thromboembolism in critical care: a multicenter observational study. J Crit Care (2005) 1.01
The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients. J Crit Care (2010) 1.00
The RECOVER Program: Disability Risk Groups and 1-Year Outcome after 7 or More Days of Mechanical Ventilation. Am J Respir Crit Care Med (2016) 1.00
Ventilator-associated pneumonia: Improving outcomes through guideline implementation. J Crit Care (2008) 1.00
Hypothermia pediatric head injury trial: the value of a pretrial clinical evaluation phase. Dev Neurosci (2006) 1.00
Investigator-led clinical research consortia: the Canadian Critical Care Trials Group. Crit Care Med (2009) 0.99
Epidemiology and management of atrial fibrillation in medical and noncardiac surgical adult intensive care unit patients. J Crit Care (2012) 0.97
Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors. Crit Care (2008) 0.96
The adequacy of timely empiric antibiotic therapy for ventilator-associated pneumonia: an important determinant of outcome. J Crit Care (2011) 0.96
The value of pretest probability and modified clinical pulmonary infection score to diagnose ventilator-associated pneumonia. J Crit Care (2008) 0.93
Clinically important venous thromboembolism in pediatric critical care: a Canadian survey. J Crit Care (2005) 0.91
Correlates of clinical failure in ventilator-associated pneumonia: insights from a large, randomized trial. J Crit Care (2008) 0.90
The safety of targeted antibiotic therapy for ventilator-associated pneumonia: a multicenter observational study. J Crit Care (2008) 0.89
The occurrence and impact of bacterial organisms complicating critical care illness associated with 2009 influenza A(H1N1) infection. Chest (2013) 0.89
Video-laryngoscopy versus direct laryngoscopy in critically ill patients: a pilot randomized trial. Can J Anaesth (2012) 0.89
Blood pressure targets for vasopressor therapy: a systematic review. Shock (2015) 0.89
Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: a post hoc analysis of the Hypothermia Pediatric Head Injury Trial. Dev Neurosci (2011) 0.89
Clinician perspectives on protocols designed to minimize sedation. J Crit Care (2014) 0.88
Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock: a pilot randomized, controlled trial. J Crit Care (2011) 0.86
Barriers to feeding critically ill patients: a multicenter survey of critical care nurses. J Crit Care (2012) 0.86
Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: a randomized clinical trial. Ann Surg (2010) 0.86
Clinically important deep vein thrombosis in the intensive care unit: a survey of intensivists. Crit Care (2004) 0.86
A study of consent for participation in a non-therapeutic study in the pediatric intensive care population. J Med Ethics (2013) 0.86
Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trial. Can J Anaesth (2008) 0.85
Levels of care in the intensive care unit: a research program. Am J Crit Care (2006) 0.85
Implementation and Evaluation of a Wiki Involving Multiple Stakeholders Including Patients in the Promotion of Best Practices in Trauma Care: The WikiTrauma Interrupted Time Series Protocol. JMIR Res Protoc (2015) 0.85
Improving the provision of enteral nutrition in the intensive care unit: a description of a multifaceted intervention tailored to overcome local barriers. Nutr Clin Pract (2013) 0.84
Utility of Gram stain in the clinical management of suspected ventilator-associated pneumonia. Secondary analysis of a multicenter randomized trial. J Crit Care (2008) 0.83
Thromboprophylaxis patterns and determinants in critically ill patients: a multicenter audit. Crit Care (2014) 0.83
Persistent organ dysfunction plus death: a novel, composite outcome measure for critical care trials. Crit Care (2011) 0.83
Development and psychometric properties of a questionnaire to assess barriers to feeding critically ill patients. Implement Sci (2013) 0.82
Rates and determinants of informed consent: a case study of an international thromboprophylaxis trial. J Crit Care (2012) 0.82
Heparin-induced thrombocytopenia in medical surgical critical illness. Chest (2013) 0.82
Functional recovery following critical illness in children: the "wee-cover" pilot study. Pediatr Crit Care Med (2015) 0.82
Noninvasive therapy with helium-oxygen for severe bronchiolitis. J Pediatr (2005) 0.81
The PRECISE RCT: evolution of an early septic shock fluid resuscitation trial. Transfus Med Rev (2012) 0.80
TryCYCLE: A Prospective Study of the Safety and Feasibility of Early In-Bed Cycling in Mechanically Ventilated Patients. PLoS One (2016) 0.80