PubRank

Rudolf Jaenisch

Author PubWeight™ 942.46‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007 65.18
2 A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006 48.80
3 Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 2009 35.48
4 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005 34.93
5 Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 2008 30.29
6 In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007 28.24
7 Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 2006 28.21
8 Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 2006 25.90
9 One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 2013 24.00
10 A chromatin landmark and transcription initiation at most promoters in human cells. Cell 2007 23.41
11 Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 2007 21.58
12 Dissecting direct reprogramming through integrative genomic analysis. Nature 2008 16.47
13 Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 2008 16.38
14 Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A 2010 15.13
15 Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 2009 13.02
16 Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 2007 12.41
17 Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol 2009 12.40
18 Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 2008 12.29
19 Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2008 12.29
20 Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol 2011 11.76
21 Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell 2008 10.68
22 Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 2005 9.84
23 Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A 2004 9.33
24 DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet 2007 9.25
25 HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 2003 9.12
26 Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol 2007 9.04
27 Induction of tumors in mice by genomic hypomethylation. Science 2003 8.86
28 Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 2009 8.71
29 Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res 2005 8.69
30 Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 2003 8.48
31 c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell 2007 8.46
32 YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 2007 8.11
33 One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell 2013 7.99
34 A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol 2008 7.91
35 Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A 2008 7.52
36 Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 2012 7.17
37 HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009 6.96
38 Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis 2006 6.64
39 Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 2011 6.56
40 Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003 6.02
41 Chromosomal silencing and localization are mediated by different domains of Xist RNA. Nat Genet 2002 5.51
42 Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell 2008 5.40
43 Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell 2007 5.29
44 Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell 2010 5.13
45 Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A 2010 5.00
46 The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 2006 4.74
47 Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells 2008 4.67
48 Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell 2010 4.59
49 Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 2002 4.56
50 Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell 2011 4.52
51 Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A 2005 4.52
52 Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A 2008 4.48
53 Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell 2008 4.43
54 Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol 2008 4.41
55 Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell 2010 4.32
56 Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature 2002 4.16
57 Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res 2010 3.94
58 Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell 2009 3.92
59 H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell 2008 3.90
60 DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet 2009 3.73
61 Nuclear reprogramming and pluripotency. Nature 2006 3.68
62 Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res 2013 3.50
63 Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 2009 3.42
64 Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell 2013 3.31
65 Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. Cell Stem Cell 2011 3.31
66 DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One 2007 3.30
67 Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci U S A 2002 3.29
68 Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. Proc Natl Acad Sci U S A 2009 3.23
69 Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development 2003 3.22
70 Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater 2010 3.11
71 Reprogramming of human peripheral blood cells to induced pluripotent stem cells. Cell Stem Cell 2010 3.08
72 Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells 2006 3.07
73 Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell 2009 3.03
74 Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev 2008 2.99
75 Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Science 2004 2.93
76 Mice cloned from olfactory sensory neurons. Nature 2004 2.90
77 Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc Natl Acad Sci U S A 2004 2.87
78 Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci U S A 2010 2.85
79 Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A 2009 2.80
80 Rapid generation of inducible mouse mutants. Nucleic Acids Res 2003 2.77
81 Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev 2004 2.75
82 Molecular control of pluripotency. Curr Opin Genet Dev 2006 2.75
83 Characterization of a highly variable eutherian microRNA gene. RNA 2005 2.72
84 Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 2013 2.61
85 Microfluidic control of cell pairing and fusion. Nat Methods 2009 2.58
86 Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. N Engl J Med 2003 2.50
87 Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med 2010 2.50
88 Transgenic mice with defined combinations of drug-inducible reprogramming factors. Nat Biotechnol 2009 2.46
89 Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res 2009 2.44
90 Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev 2007 2.34
91 Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A 2009 2.30
92 Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2. Proc Natl Acad Sci U S A 2007 2.27
93 Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Mol Cell Biol 2002 2.24
94 Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell 2005 2.17
95 ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. Proc Natl Acad Sci U S A 2006 2.16
96 Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer. Cell Stem Cell 2007 2.14
97 Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice. Biol Psychiatry 2005 2.14
98 Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci U S A 2005 2.11
99 Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion. Mol Cell 2013 2.10
100 Mechanisms and models of somatic cell reprogramming. Nat Rev Genet 2013 2.09
101 Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci U S A 2002 2.05
102 Generation of iPSCs from cultured human malignant cells. Blood 2010 1.99
103 Stem cells. Setting standards for human embryonic stem cells. Science 2003 1.95
104 Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell 2011 1.95
105 Single-gene transgenic mouse strains for reprogramming adult somatic cells. Nat Methods 2009 1.92
106 Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan. Dev Dyn 2007 1.81
107 Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 2007 1.81
108 Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell 2013 1.80
109 The pluripotency regulator Oct4: a role in somatic stem cells? Cell Cycle 2008 1.79
110 Blimp1 expression predicts embryonic stem cell development in vitro. Curr Biol 2011 1.76
111 Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Science 2010 1.74
112 Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts. Nature 2005 1.68
113 New advances in iPS cell research do not obviate the need for human embryonic stem cells. Cell Stem Cell 2007 1.68
114 Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs. Cell Stem Cell 2013 1.67
115 Nuclear cloning of embryonal carcinoma cells. Proc Natl Acad Sci U S A 2004 1.61
116 Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription. Cell 2013 1.61
117 Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome. J Cell Biol 2004 1.57
118 Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation. Nat Biotechnol 2002 1.57
119 Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro. FASEB J 2009 1.52
120 Somatic cell nuclear transfer and derivation of embryonic stem cells in the mouse. Methods 2008 1.46
121 Two-step imprinted X inactivation: repeat versus genic silencing in the mouse. Mol Cell Biol 2010 1.46
122 X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proc Natl Acad Sci U S A 2012 1.46
123 Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes. J Immunol 2007 1.41
124 Derivation and manipulation of murine embryonic stem cells. Methods Mol Biol 2009 1.40
125 Medicine. iPSC disease modeling. Science 2012 1.36
126 Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol Cell Biol 2006 1.35
127 Nuclear transplantation: lessons from frogs and mice. Curr Opin Cell Biol 2002 1.34
128 Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation. Mol Cell Biol 2006 1.34
129 DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. Clin Cancer Res 2009 1.33
130 Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors. Cell Stem Cell 2012 1.33
131 Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proc Natl Acad Sci U S A 2011 1.33
132 SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state. PLoS Genet 2013 1.32
133 De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state. Genes Dev 2011 1.32
134 A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. PLoS Genet 2011 1.31
135 At most three ES cells contribute to the somatic lineages of chimeric mice and of mice produced by ES-tetraploid complementation. Dev Biol 2004 1.30
136 Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET. Genome Biol 2008 1.29
137 Mammalian nuclear transfer. Dev Dyn 2006 1.27
138 TALEN-mediated editing of the mouse Y chromosome. Nat Biotechnol 2013 1.26
139 Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression. Proc Natl Acad Sci U S A 2011 1.26
140 Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions. Proc Natl Acad Sci U S A 2011 1.25
141 Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization. Genes Dev 2003 1.25
142 Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. J Neurosci 2002 1.24
143 Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer. J Clin Invest 2011 1.23
144 Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist. J Cell Sci 2002 1.22
145 Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest 2004 1.22
146 X-chromosome inactivation during spermatogenesis is regulated by an Xist/Tsix-independent mechanism in the mouse. Genesis 2002 1.20
147 Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development 2013 1.19
148 TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proc Natl Acad Sci U S A 2013 1.19
149 Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. J Neurobiol 2006 1.18
150 Nanoparticles for gene transfer to human embryonic stem cell colonies. Nano Lett 2008 1.17
151 Toward eliminating HLA class I expression to generate universal cells from allogeneic donors. Blood 2013 1.17
152 NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. Learn Mem 2006 1.16
153 X chromosome choice occurs independently of asynchronous replication timing. J Cell Biol 2005 1.14
154 T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell. Proc Natl Acad Sci U S A 2010 1.13
155 Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways. Blood 2007 1.10
156 Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. J Neurosci 2008 1.10
157 Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations. Gastroenterology 2008 1.10
158 Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells. FASEB J 2010 1.08
159 Direct in vivo VH to JH rearrangement violating the 12/23 rule. J Exp Med 2005 1.05
160 Epigenetic hierarchy governing Nestin expression. Stem Cells 2009 1.05
161 DNA CpG hypomethylation induces heterochromatin reorganization involving the histone variant macroH2A. J Cell Sci 2005 1.05
162 On the cloning of animals from terminally differentiated cells. Nat Genet 2007 1.03
163 Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility. Cell Physiol Biochem 2009 1.02
164 Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature 2013 1.01
165 Generating iPS cells from MEFS through forced expression of Sox-2, Oct-4, c-Myc, and Klf4. J Vis Exp 2008 1.00
166 Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation. Methods Enzymol 2003 1.00
167 IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells. Proc Natl Acad Sci U S A 2012 0.96
168 Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors. Stem Cells 2011 0.96
169 Nuclear transplantation, embryonic stem cells and the potential for cell therapy. Hematol J 2004 0.95
170 Dnmt3a protects active chromosome domains against cancer-associated hypomethylation. PLoS Genet 2012 0.93
171 Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells. Angew Chem Int Ed Engl 2011 0.91
172 Commentary: isolated stem cells--patentable as cultural artifacts? Stem Cells 2007 0.91
173 Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes. J Immunol 2010 0.91
174 Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. J Vis Exp 2010 0.90
175 Transdifferentiation by defined factors as a powerful research tool to address basic biological questions. Cell Cycle 2012 0.90
176 Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics. Mol Cell Biol 2003 0.88
177 TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexes. J Immunol 2009 0.87
178 Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells 2013 0.85
179 Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev Biol 2004 0.84
180 Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice. J Immunol 2012 0.83
181 Transgene excision has no impact on in vivo integration of human iPS derived neural precursors. PLoS One 2011 0.83
182 Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals. Neurobiol Dis 2002 0.82
183 Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor. Vis Neurosci 2005 0.78
184 Erratum: TET1 is a tumor suppressor of hematopoietic malignancy. Nat Immunol 2015 0.78
185 Flp recombinase regulated lacZ expression at the ROSA26 locus. Genesis 2002 0.78
186 Politically correct human embryonic stem cells? N Engl J Med 2006 0.77
187 Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus. J Cereb Blood Flow Metab 2003 0.77
188 Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells. 1990. J Immunol 2010 0.77
189 Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun 2015 0.76
190 Corrigendum: Hallmarks of pluripotency. Nature 2015 0.75
191 Corrigendum: Failure to replicate the STAP cell phenomenon. Nature 2015 0.75
192 Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency. Cell Stem Cell 2014 0.75
193 Interview with Rudolf Jaenisch, M.D. Rejuvenation Res 2008 0.75
194 Sixteenth Annual Pezcoller Symposium: stem cells and epigenesis in cancer. Cancer Res 2004 0.75
195 An interview with Rudolf Jaenisch. Development 2015 0.75
196 Celebrating 10 years of hESC lines: an interview with Rudolf Jaenisch. Stem Cells 2008 0.75
197 Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation. Semin Cell Dev Biol 2003 0.75
198 Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency. Cell Stem Cell 2014 0.75
199 A conversation with Rudolf Jaenisch. J Clin Invest 2015 0.75