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NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer. Hepatology (2015) 0.79

UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation. Oncotarget (2016) 0.78

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Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation. Cell Death Dis (2014) 0.77

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WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway. Cell Death Dis (2017) 0.75

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Acetylation is indispensable for p53 activation. Cell (2008) 5.70

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell (2004) 4.46

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet (2001) 4.23

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat Cell Biol (2006) 4.14

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A (2008) 4.07

A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05

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Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell (2008) 3.38

Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J (2001) 3.37

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO J (1997) 3.34

Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science (2003) 3.21

USP10 regulates p53 localization and stability by deubiquitinating p53. Cell (2010) 3.17

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol (2002) 3.10

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Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature (2004) 2.83

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2. Mol Cell (2005) 2.76

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol Cell Biol (2000) 2.72

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Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J (2007) 2.62

Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function. Mol Cell Biol (2005) 2.55

E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell (2006) 2.50

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A (2005) 2.40

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell (2006) 2.32

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci U S A (2006) 2.20

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell (2005) 2.17

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol Cell (2004) 2.16

C-terminal ubiquitination of p53 contributes to nuclear export. Mol Cell Biol (2001) 2.09

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J (2007) 2.07

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Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther (2009) 1.66

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. J Biol Chem (2004) 1.66

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FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26

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Identification and comparative analysis of the Eriocheir sinensis microRNA transcriptome response to Spiroplasma eriocheiris infection using a deep sequencing approach. Fish Shellfish Immunol (2011) 1.06

New insights into p53 activation. Cell Res (2010) 1.06

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04

Potential roles of N-glycosylation in cell adhesion. Glycoconj J (2012) 1.04

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Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. Mol Biol Cell (2008) 1.03

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. J Virol (2009) 1.03

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SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02

SIRT1: Regulator of p53 Deacetylation. Genes Cancer (2013) 1.01

p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol (2012) 1.00

Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem (2011) 1.00

To be, or not to be: functional dilemma of p53 metabolic regulation. Curr Opin Oncol (2014) 1.00

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A critical role for noncoding 5S rRNA in regulating Mdmx stability. Mol Cell (2011) 0.98

RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. Proc Natl Acad Sci U S A (2010) 0.98

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Mechanistic studies of MDM2-mediated ubiquitination in p53 regulation. J Biol Chem (2007) 0.94

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