Published in Am J Respir Crit Care Med on April 19, 2007
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med (2014) 2.28
Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet (2012) 2.24
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.72
Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. COPD (2010) 1.60
Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet (2009) 1.52
Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. Am J Respir Crit Care Med (2010) 1.36
Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation. Int J Chron Obstruct Pulmon Dis (2011) 1.34
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 1.21
Genome-wide association study of smoking behaviours in patients with COPD. Thorax (2011) 1.18
The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol (2011) 1.17
Pulmonary epithelium, cigarette smoke, and chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2007) 1.15
An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity. Hum Mol Genet (2008) 1.15
Lung function and airway diseases. Nat Genet (2010) 1.15
Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One (2011) 1.11
Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation. Respir Res (2010) 1.10
Updates on the COPD gene list. Int J Chron Obstruct Pulmon Dis (2012) 1.08
Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2010) 1.04
Measurement of the airway surface liquid volume with simple light refraction microscopy. Am J Respir Cell Mol Biol (2011) 1.04
α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts. Chest (2010) 1.02
Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. Am J Respir Cell Mol Biol (2009) 0.98
Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases. BMC Med Genet (2010) 0.96
Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet (2013) 0.92
National Emphysema Treatment Trial state of the art: genetics of emphysema. Proc Am Thorac Soc (2008) 0.92
Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. Chest (2008) 0.91
PLAUR polymorphisms and lung function in UK smokers. BMC Med Genet (2009) 0.91
Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2010) 0.90
Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. Am J Respir Crit Care Med (2010) 0.89
Cigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1/GGPPS/MAPK signaling. Am J Pathol (2010) 0.89
Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. Respir Med (2008) 0.88
SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development. Am J Respir Crit Care Med (2011) 0.88
Systemic steroid exposure is associated with differential methylation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 0.87
Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes. BMC Pulm Med (2013) 0.84
Integrative genomics of chronic obstructive pulmonary disease. Biochem Biophys Res Commun (2014) 0.82
Absence of association between SERPINE2 genetic polymorphisms and chronic obstructive pulmonary disease in Han Chinese: a case-control cohort study. BMC Med Genet (2009) 0.82
DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. Respir Res (2014) 0.82
Systems biology approaches to identify developmental bases for lung diseases. Pediatr Res (2013) 0.82
Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome. Mol Reprod Dev (2015) 0.82
Association of SERPINE2 with asthma. Chest (2011) 0.81
Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression. Lab Invest (2014) 0.81
SERPINE2 polymorphisms and chronic obstructive pulmonary disease. J Korean Med Sci (2009) 0.80
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. Respir Res (2014) 0.80
On the follow-up of genome-wide association studies: an overall test for the most promising SNPs. Genet Epidemiol (2011) 0.79
Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations. Respir Res (2016) 0.79
SERPINE2 haplotype as a risk factor for panlobular type of emphysema. BMC Med Genet (2011) 0.78
Markers of early disease and prognosis in COPD. Int J Chron Obstruct Pulmon Dis (2009) 0.78
Genetic determinants of chronic obstructive pulmonary disease in South Indian male smokers. PLoS One (2014) 0.78
Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks. Hum Hered (2014) 0.77
Identifying a Deletion Affecting Total Lung Capacity Among Subjects in the COPDGene Study Cohort. Genet Epidemiol (2015) 0.76
The association of SERPINE2 gene with COPD in a Chinese Han population. Yonsei Med J (2011) 0.75
SERPINE2 and COPD. Am J Respir Crit Care Med (2007) 0.75
Chronic obstructive pulmonary disease: towards pharmacogenetics. Genome Med (2009) 0.75
Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma. Hum Mol Genet (2017) 0.75
Hemizygous Deletion on Chromosome 3p26.1 Is Associated with Heavy Smoking among African American Subjects in the COPDGene Study. PLoS One (2016) 0.75
Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. Am J Respir Cell Mol Biol (2017) 0.75
Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med (2010) 15.07
Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet (2003) 10.97
International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet (2007) 10.12
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature (2011) 4.92
Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75
PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68
Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19
GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med (2012) 3.98
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 3.92
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest (2010) 3.91
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med (2011) 3.58
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30
LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study. Lancet Neurol (2008) 2.85
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52
Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma. J Allergy Clin Immunol (2006) 2.49
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS Biol (2007) 2.35
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29
Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate. Am J Respir Crit Care Med (2009) 2.27
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med (2004) 2.24
Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet (2012) 2.24
The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19
Conformational pathology of the serpins: themes, variations, and therapeutic strategies. Annu Rev Biochem (2009) 2.19
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18
Body mass index, weight gain, and other determinants of lung function decline in adult asthma. J Allergy Clin Immunol (2009) 2.16
Post-bronchodilator spirometry reference values in adults and implications for disease management. Am J Respir Crit Care Med (2006) 2.15
A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol (2004) 2.15
Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes. Am J Respir Crit Care Med (2014) 2.14
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet (2004) 2.14
Alpha1-antitrypsin deficiency--a model for conformational diseases. N Engl J Med (2002) 2.11
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med (2009) 2.10
Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med (2013) 2.09
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol (2005) 2.08
A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD (2012) 2.07
Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis. Am J Respir Cell Mol Biol (2013) 2.06
Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med (2011) 2.06
Association between conformational mutations in neuroserpin and onset and severity of dementia. Lancet (2002) 2.02
Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.99
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.98
Effect of reducing indoor air pollution on women's respiratory symptoms and lung function: the RESPIRE Randomized Trial, Guatemala. Am J Epidemiol (2009) 1.95
Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med (2007) 1.94
A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered (2003) 1.89
Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. J Allergy Clin Immunol (2007) 1.88
Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med (2012) 1.85
Endoplasmic reticulum dysfunction in neurological disease. Lancet Neurol (2013) 1.83
Asthma control in Europe: a real-world evaluation based on an international population-based study. J Allergy Clin Immunol (2007) 1.83
Pet-keeping in childhood and adult asthma and hay fever: European community respiratory health survey. J Allergy Clin Immunol (2003) 1.83
Gender differences in COPD: are women more susceptible to smoking effects than men? Thorax (2010) 1.82
CT metrics of airway disease and emphysema in severe COPD. Chest (2009) 1.81
Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med (2012) 1.80
Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med (2014) 1.80
Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.79