Published in Am J Respir Crit Care Med on March 05, 2009
Asthma and allergic inflammation. Cell (2010) 2.21
An update on the genetics of atopic dermatitis: scratching the surface in 2009. J Allergy Clin Immunol (2010) 1.73
No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity. PLoS One (2015) 1.38
Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. J Allergy Clin Immunol (2009) 1.23
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun (2015) 1.21
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes. Hum Mol Genet (2012) 1.18
Expression analysis of asthma candidate genes during human and murine lung development. Respir Res (2011) 1.16
Analyses of shared genetic factors between asthma and obesity in children. J Allergy Clin Immunol (2010) 1.13
A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. Am J Respir Crit Care Med (2009) 1.12
Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study. J Allergy Clin Immunol (2014) 1.10
Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations. J Allergy Clin Immunol (2011) 1.03
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PLoS One (2012) 0.99
The interaction of glutathione S-transferase M1-null variants with tobacco smoke exposure and the development of childhood asthma. Clin Exp Allergy (2009) 0.96
Update in asthma 2009. Am J Respir Crit Care Med (2010) 0.96
Loss-of-function of inositol polyphosphate-4-phosphatase reversibly increases the severity of allergic airway inflammation. Nat Commun (2012) 0.93
Epistatic effects of multiple receptor genes on pathophysiology of asthma - its limits and potential for clinical application. Med Sci Monit (2014) 0.93
Similarities in features of autism and asthma and a possible link to acetaminophen use. Med Hypotheses (2009) 0.89
Genetic polymorphisms and associated susceptibility to asthma. Int J Gen Med (2013) 0.89
Poor reproducibility of allergic rhinitis SNP associations. PLoS One (2013) 0.88
Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes. J Allergy Clin Immunol (2012) 0.88
Identification of ATPAF1 as a novel candidate gene for asthma in children. J Allergy Clin Immunol (2011) 0.86
The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis. Allergy Asthma Immunol Res (2014) 0.84
Genetic studies of the etiology of asthma. Proc Am Thorac Soc (2011) 0.84
Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility. Clin Exp Allergy (2013) 0.84
Investigating highly replicated asthma genes as candidate genes for allergic rhinitis. BMC Med Genet (2013) 0.82
Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Med Genet (2010) 0.81
Genetic variation of ITGB3 is associated with asthma in Chinese Han children. PLoS One (2013) 0.81
Vitamin D in asthma and future perspectives. Drug Des Devel Ther (2013) 0.80
Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population. Pediatr Allergy Immunol Pulmonol (2011) 0.80
A genome-wide association study of total serum and mite-specific IgEs in asthma patients. PLoS One (2013) 0.80
Copy number variation genotyping using family information. BMC Bioinformatics (2013) 0.80
In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther (2012) 0.79
(Too) great expectations: the challenges in replicating asthma disease genes. Am J Respir Crit Care Med (2009) 0.79
Assessing the validity of asthma associations for eight candidate genes and age at diagnosis effects. PLoS One (2013) 0.78
SOCS3 dictates the transition of divergent time-phased events in granulocyte TNF-α signaling. Cell Mol Immunol (2013) 0.76
Asthma-snapshot or motion picture? Front Genet (2013) 0.76
Stronger evidence for replication of NPPA using genome-wide genotyping data. Am J Respir Crit Care Med (2010) 0.75
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The International HapMap Project. Nature (2003) 73.65
The structure of haplotype blocks in the human genome. Science (2002) 50.88
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Replication validity of genetic association studies. Nat Genet (2001) 16.30
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
Evaluating coverage of genome-wide association studies. Nat Genet (2006) 11.40
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Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun (2006) 4.14
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet (2001) 2.61
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med (2004) 2.24
ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am J Respir Crit Care Med (2008) 2.18
Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland. Am J Respir Crit Care Med (2001) 1.89
Calibrating the performance of SNP arrays for whole-genome association studies. PLoS Genet (2008) 1.86
A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J Allergy Clin Immunol (2008) 1.65
Comprehensive testing of positionally cloned asthma genes in two populations. Am J Respir Crit Care Med (2007) 1.32
Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection. Hum Genet (2007) 1.26
T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. Am J Respir Crit Care Med (2005) 1.18
Case-control association studies for the genetics of complex respiratory diseases. Am J Respir Cell Mol Biol (2000) 1.16
TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. Am J Respir Crit Care Med (2004) 1.14
Genetic and environment in asthma: the answer of twin studies. Eur Respir J (1999) 1.10
Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations. Am J Respir Crit Care Med (2005) 1.00
Association of IL4R gene polymorphisms with asthma in Chinese populations. Hum Mutat (2007) 0.91
Galaxy: a web-based genome analysis tool for experimentalists. Curr Protoc Mol Biol (2010) 17.00
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Extracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system. BMC Med Inform Decis Mak (2006) 9.98
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75
PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet (2008) 4.66
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med (2009) 4.64
Family-based designs in the age of large-scale gene-association studies. Nat Rev Genet (2006) 4.59
Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med (2005) 4.34
Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19
Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol (2004) 4.17
Instrumenting the health care enterprise for discovery research in the genomic era. Genome Res (2009) 4.13
Design of a national distributed health data network. Ann Intern Med (2009) 4.09
GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med (2012) 3.98
Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol (2007) 3.97
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 3.92
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr (2007) 3.89
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
A generalized linear mixed models approach for detecting incident clusters of disease in small areas, with an application to biological terrorism. Am J Epidemiol (2004) 3.71
Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol (2010) 3.54
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr (2007) 3.40
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30
Distributed health data networks: a practical and preferred approach to multi-institutional evaluations of comparative effectiveness, safety, and quality of care. Med Care (2010) 3.29
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet (2005) 3.24
A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet (2011) 3.13
Rapid diagnosis of smear-negative tuberculosis by bronchoalveolar lavage enzyme-linked immunospot. Am J Respir Crit Care Med (2006) 3.12
Genetic model testing and statistical power in population-based association studies of quantitative traits. Genet Epidemiol (2007) 2.95
The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med (2007) 2.91
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med (2008) 2.61
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet (2009) 2.56
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet (2008) 2.53
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52
Estimating the number of unseen variants in the human genome. Proc Natl Acad Sci U S A (2009) 2.47
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Automated identification of acute hepatitis B using electronic medical record data to facilitate public health surveillance. PLoS One (2008) 2.45
Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet (2007) 2.45
Uric acid and the development of hypertension: the normative aging study. Hypertension (2006) 2.45
Obesity and asthma. Am J Respir Crit Care Med (2006) 2.43