Published in Annu Rev Cell Dev Biol on January 01, 2007
Serum microRNAs are promising novel biomarkers. PLoS One (2008) 8.69
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet (2008) 5.83
Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res (2010) 5.29
Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. Proc Natl Acad Sci U S A (2009) 5.13
The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution. Nat Struct Mol Biol (2008) 4.88
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71
Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs. RNA (2008) 4.53
MicroRNA functions in stress responses. Mol Cell (2010) 4.46
Predicting effective microRNA target sites in mammalian mRNAs. Elife (2015) 4.30
A microRNA imparts robustness against environmental fluctuation during development. Cell (2009) 4.08
Deadenylation is a widespread effect of miRNA regulation. RNA (2008) 3.98
Integration of microRNA miR-122 in hepatic circadian gene expression. Genes Dev (2009) 3.64
Posttranscriptional crossregulation between Drosha and DGCR8. Cell (2009) 3.54
Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet (2011) 3.36
Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol Cell (2008) 3.23
Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20
MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell (2010) 3.18
Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe (2008) 3.14
MicroRNA expression in the adult mouse central nervous system. RNA (2008) 3.12
Molecular architecture of a miRNA-regulated 3' UTR. RNA (2008) 3.11
Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing. Proc Natl Acad Sci U S A (2008) 3.03
MicroRNA sponges: progress and possibilities. RNA (2010) 2.96
Serum microRNAs as non-invasive biomarkers for cancer. Mol Cancer (2010) 2.95
MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol (2009) 2.89
Genetics of circadian rhythms in Mammalian model organisms. Adv Genet (2011) 2.80
miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc Natl Acad Sci U S A (2009) 2.74
Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev (2009) 2.73
Experimental validation of miRNA targets. Methods (2008) 2.57
MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer (2009) 2.57
The miR-144/451 locus is required for erythroid homeostasis. J Exp Med (2010) 2.54
MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev (2010) 2.51
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis. Nat Rev Mol Cell Biol (2011) 2.51
DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A (2008) 2.49
CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. Mol Cell (2009) 2.38
The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA (2009) 2.37
The evolution of RNAi as a defence against viruses and transposable elements. Philos Trans R Soc Lond B Biol Sci (2009) 2.35
MicroRNAs as novel regulators of angiogenesis. Circ Res (2009) 2.33
Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms. Nat Methods (2009) 2.32
Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins. EMBO J (2009) 2.32
MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler Thromb Vasc Biol (2011) 2.31
Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes. Pharmacol Rev (2012) 2.31
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms. Cell Commun Signal (2009) 2.27
miRanalyzer: an update on the detection and analysis of microRNAs in high-throughput sequencing experiments. Nucleic Acids Res (2011) 2.25
Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas. J Virol (2009) 2.20
Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA (2009) 2.15
Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures. Mol Cell (2010) 2.12
Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailers. PLoS One (2010) 2.12
Temporal regulation of metamorphic processes in Drosophila by the let-7 and miR-125 heterochronic microRNAs. Curr Biol (2008) 2.11
The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury. Physiol Genomics (2012) 2.08
SNPs in human miRNA genes affect biogenesis and function. RNA (2009) 2.08
Inhibition of microRNA function by antimiR oligonucleotides. Silence (2012) 2.02
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. EMBO J (2013) 2.01
MicroRNAs in the Drosophila bithorax complex. Genes Dev (2008) 1.99
MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways. Oncogene (2010) 1.97
Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation. PLoS Genet (2009) 1.96
Reprogramming mRNA translation during stress. Curr Opin Cell Biol (2008) 1.92
Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc Natl Acad Sci U S A (2012) 1.91
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding. Nat Struct Mol Biol (2012) 1.91
Retracted Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun (2008) 1.91
MiR-210--micromanager of the hypoxia pathway. Trends Mol Med (2010) 1.90
microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer (2010) 1.90
The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines. Cancer Res (2009) 1.88
Assessing the human immune system through blood transcriptomics. BMC Biol (2010) 1.86
Human cellular restriction factors that target HIV-1 replication. BMC Med (2009) 1.86
Vigilance and validation: Keys to success in RNAi screening. ACS Chem Biol (2010) 1.85
Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes (2008) 1.85
Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Genes Dev (2009) 1.84
The role of incoherent microRNA-mediated feedforward loops in noise buffering. PLoS Comput Biol (2011) 1.84
Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps. Nat Struct Mol Biol (2009) 1.83
Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury. J Am Soc Nephrol (2010) 1.82
Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2010) 1.81
Micro RNAs of Epstein-Barr virus promote cell cycle progression and prevent apoptosis of primary human B cells. PLoS Pathog (2010) 1.80
Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila. RNA (2009) 1.80
microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila. Genes Dev (2007) 1.80
MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum (2010) 1.78
The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proc Natl Acad Sci U S A (2008) 1.76
DNA methylation in development and human disease. Mutat Res (2008) 1.74
Control of metastatic progression by microRNA regulatory networks. Nat Cell Biol (2013) 1.73
Evolution under canalization and the dual roles of microRNAs: a hypothesis. Genome Res (2009) 1.72
Dicer1 is essential for female fertility and normal development of the female reproductive system. Endocrinology (2008) 1.71
MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol (2009) 1.71
Mechanisms of deadenylation-dependent decay. Wiley Interdiscip Rev RNA (2010) 1.69
MicroRNA profiling and head and neck cancer. Comp Funct Genomics (2009) 1.68
Identification of cis- and trans-regulatory variation modulating microRNA expression levels in human fibroblasts. Genome Res (2010) 1.67
Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk. Nat Immunol (2011) 1.67
MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}. J Biol Chem (2010) 1.67
The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Curr Biol (2011) 1.66
Correlation of expression profiles between microRNAs and mRNA targets using NCI-60 data. BMC Genomics (2009) 1.66
MicroRNAs shape the neuronal landscape. Neuron (2012) 1.64
Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis. Sleep (2010) 1.64
Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis. J Cell Biol (2010) 1.63
Adenylation of maternally inherited microRNAs by Wispy. Mol Cell (2014) 1.63
A survey of small RNAs in human sperm. Hum Reprod (2011) 1.62
Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs. Proc Natl Acad Sci U S A (2010) 1.62
IGF-II is regulated by microRNA-125b in skeletal myogenesis. J Cell Biol (2011) 1.62
Development of microRNA therapeutics is coming of age. EMBO Mol Med (2014) 1.60
Principles of microRNA-target recognition. PLoS Biol (2005) 23.70
bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell (2003) 22.14
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Cell (2005) 15.38
Identification of Drosophila MicroRNA targets. PLoS Biol (2003) 12.72
Isolation of microRNA targets by miRNP immunopurification. RNA (2007) 5.50
Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev Cell (2002) 4.85
The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Cell (2007) 4.00
The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell (2006) 3.81
Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Mol Cell Biol (2006) 3.80
Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev Cell (2005) 2.81
On the mechanism of wing size determination in fly development. Proc Natl Acad Sci U S A (2007) 2.62
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature (2008) 2.54
MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev (2010) 2.51
Temporal reciprocity of miRNAs and their targets during the maternal-to-zygotic transition in Drosophila. Curr Biol (2008) 2.47
A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands. Genes Dev (2008) 2.45
Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab (2008) 2.32
4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev (2005) 2.28
Drosophila lacking microRNA miR-278 are defective in energy homeostasis. Genes Dev (2006) 2.26
Regulation of tissue growth through nutrient sensing. Annu Rev Genet (2009) 2.18
HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient. Dev Cell (2002) 2.03
Connecting proliferation and apoptosis in development and disease. Nat Rev Mol Cell Biol (2004) 1.97
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev (2007) 1.83
microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila. Genes Dev (2007) 1.80
Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development. Development (2003) 1.72
Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity. Dev Cell (2004) 1.69
The bantam gene regulates Drosophila growth. Genetics (2002) 1.62
MicroRNAs in neurodegeneration. Curr Opin Neurobiol (2008) 1.62
Drosophila Melted modulates FOXO and TOR activity. Dev Cell (2005) 1.59
Short-range cell interactions and cell survival in the Drosophila wing. Dev Cell (2002) 1.57
Towards a complete description of the microRNA complement of animal genomes. Genome Biol (2003) 1.49
Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth. Genes Dev (2004) 1.38
Identification of novel Drosophila melanogaster microRNAs. PLoS One (2007) 1.28
Recombinase-mediated cassette exchange provides a versatile platform for gene targeting: knockout of miR-31b. Genetics (2009) 1.26
Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Proc Natl Acad Sci U S A (2009) 1.26
Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis. PLoS Biol (2010) 1.26
MAP4K3 regulates body size and metabolism in Drosophila. Dev Biol (2010) 1.24
On the role of glypicans in the process of morphogen gradient formation. Dev Biol (2006) 1.18
TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells. BMC Cancer (2008) 1.18
A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway. Genetics (2005) 1.14
Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe. Genes Dev (2010) 1.10
Drosophila miR-124 regulates neuroblast proliferation through its target anachronism. Development (2012) 1.04
MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet (2011) 1.03
Gain-of-function screen for genes that affect Drosophila muscle pattern formation. PLoS Genet (2005) 1.02
Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan. Dev Dyn (2005) 1.01
The Drosophila sterile-20 kinase slik controls cell proliferation and apoptosis during imaginal disc development. PLoS Biol (2003) 1.00
Distal antenna and distal antenna related encode nuclear proteins containing pipsqueak motifs involved in antenna development in Drosophila. Development (2003) 0.99
Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing. Development (2011) 0.99
A naturally occurring alternative product of the mastermind locus that represses notch signalling. Mech Dev (2002) 0.98
Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. Curr Biol (2012) 0.98
Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complex. Development (2004) 0.98
A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing. Development (2003) 0.98
Repression of Teashirt marks the initiation of wing development. Development (2002) 0.97
The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. EMBO J (2010) 0.97
Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. Genes Dev (2012) 0.97
molting defective is required for ecdysone biosynthesis. Dev Biol (2005) 0.97
MicroRNA transgene overexpression complements deficiency-based modifier screens in Drosophila. Genetics (2011) 0.96
Drosophila egghead encodes a beta 1,4-mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for brainiac. J Biol Chem (2002) 0.94
Protocols for use of homologous recombination gene targeting to produce microRNA mutants in Drosophila. Methods Mol Biol (2011) 0.94
Not miR-ly muscular: microRNAs and muscle development. Genes Dev (2005) 0.92
Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivo. J Biol Chem (2004) 0.92
Structural insights into the Notch-modifying glycosyltransferase Fringe. Nat Struct Mol Biol (2006) 0.92
The Drosophila gene brainiac encodes a glycosyltransferase putatively involved in glycosphingolipid synthesis. J Biol Chem (2002) 0.91
ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation. Genes Dev (2013) 0.90
The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs. Cell Metab (2012) 0.90
Spatial and temporal regulation of the homeotic selector gene Antennapedia is required for the establishment of leg identity in Drosophila. Dev Biol (2004) 0.89
An evaluation of the efficacy of a cyclosporine-based dry eye therapy when used with marketed artificial tears as supportive therapy in dry eye. Eye Contact Lens (2006) 0.89
Glycosphingolipids with extended sugar chain have specialized functions in development and behavior of Drosophila. Dev Biol (2007) 0.89
Osa modulates the expression of Apterous target genes in the Drosophila wing. Mech Dev (2004) 0.87
Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster. G3 (Bethesda) (2013) 0.86
Perspective: follow the money: the implications of medical schools' funds flow models. Acad Med (2012) 0.85
Drosophila Minus is required for cell proliferation and influences Cyclin E turnover. Genes Dev (2009) 0.84
The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth. Biol Open (2013) 0.83
miR-989 is required for border cell migration in the Drosophila ovary. PLoS One (2013) 0.82
miR-124 controls male reproductive success in Drosophila. Elife (2013) 0.82
Glycosphingolipids control the extracellular gradient of the Drosophila EGFR ligand Gurken. Development (2009) 0.81
TORCing up metabolic control in the brain. Cell Metab (2008) 0.80
Time is of the essence: microRNAs and age-associated neurodegeneration. Cell Res (2012) 0.80
Ligand-binding and signaling properties of the Ax[M1] form of Notch. Mech Dev (2005) 0.79
Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11. Glycoconj J (2010) 0.78
Notch signaling: filopodia dynamics confer robustness. Curr Biol (2010) 0.76
Developmental biology: long-range signalling by touch. Nature (2003) 0.75
The secret life of Smoothened. Dev Cell (2003) 0.75