Published in Trends Cell Biol on January 22, 2008
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Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma. Cell Death Dis (2013) 0.89
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Adverse effects of reduced oxygen tension on the proliferative capacity of rat kidney and insulin-secreting cell lines involve DNA damage and stress responses. Exp Cell Res (2008) 0.78
Inflammation contributes to NKX3.1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression. J Inflamm (Lond) (2015) 0.77
Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-small Cell Lung Cancer. Cancer Discov (2017) 0.75
Insulin-Like Growth Factor-1-Mediated DNA Repair in Irradiated Salivary Glands Is Sirtuin-1 Dependent. J Dent Res (2016) 0.75
The Deacetylase SIRT1 Regulates the Replication Properties of Human Papillomavirus 16 E1 and E2. J Virol (2017) 0.75
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol (2009) 2.65
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med (2012) 2.58
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci (2010) 2.24
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One (2009) 2.07
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Development of calorie restriction mimetics as a prolongevity strategy. Ann N Y Acad Sci (2004) 1.92
Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol (2008) 1.87
Mitochondrial biogenesis and healthy aging. Exp Gerontol (2008) 1.85
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res (2008) 1.75
Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol (2010) 1.73
SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71
Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Ageing Dev (2009) 1.69
Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension (2009) 1.63
Age-associated learning and memory deficits in two mouse versions of the Stone T-maze. Neurobiol Aging (2012) 1.55
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J (2009) 1.52
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell (2013) 1.48
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Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol (2011) 1.42
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med (2012) 1.42
Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett (2008) 1.36
Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc Natl Acad Sci U S A (2006) 1.35
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem (2011) 1.35
Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab (2012) 1.35
RAP1 protects from obesity through its extratelomeric role regulating gene expression. Cell Rep (2013) 1.31
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2012) 1.29
Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med (2006) 1.28
Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). J Alzheimers Dis (2006) 1.27
RNA-binding protein HuD controls insulin translation. Mol Cell (2012) 1.25
The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion (2007) 1.25
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Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. Am J Physiol Heart Circ Physiol (2011) 1.22
FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest (2013) 1.21
A regulatory role for microRNA 33* in controlling lipid metabolism gene expression. Mol Cell Biol (2013) 1.21
MicroRNA 33 regulates glucose metabolism. Mol Cell Biol (2013) 1.19
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab (2013) 1.14
Perinatal exercise improves glucose homeostasis in adult offspring. Am J Physiol Endocrinol Metab (2012) 1.13
Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging. J Gerontol A Biol Sci Med Sci (2012) 1.09
Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males. PLoS One (2008) 1.07
Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev (2006) 1.06
SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell (2013) 1.06
Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis. PLoS One (2011) 1.05
Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet. Diabetes (2013) 1.04
The plasma membrane redox system in aging. Ageing Res Rev (2006) 1.03
Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats. Toxicol Appl Pharmacol (2009) 1.03
Aging biology and novel targets for drug discovery. J Gerontol A Biol Sci Med Sci (2011) 1.01
Bioenergetics of aging and calorie restriction. Ageing Res Rev (2006) 1.01
The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontology (2006) 1.00
Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction. Aging (Albany NY) (2013) 1.00
Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. J Neurochem (2007) 1.00
Dietary activators of Sirt1. Mol Cell Endocrinol (2008) 0.98
Mitochondrial protection by resveratrol. Exerc Sport Sci Rev (2011) 0.98
Mitochondrial metabolic reprogramming induced by calorie restriction. Antioxid Redox Signal (2012) 0.98
In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets. PLoS One (2008) 0.97
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell (2014) 0.94
The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster. Age (Dordr) (2011) 0.93
Effects of calorie restriction on cardioprotection and cardiovascular health. J Mol Cell Cardiol (2011) 0.93
Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling. Behav Brain Res (2008) 0.92
Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts. J Gerontol A Biol Sci Med Sci (2010) 0.90
Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells. J Immunol (2013) 0.90
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell (2009) 0.90
Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction. Mol Cell Endocrinol (2008) 0.89
A patent review of sirtuin activators: an update. Expert Opin Ther Pat (2012) 0.89
Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis. PLoS One (2009) 0.89
Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Exp Gerontol (2007) 0.85
Caloric restriction modulates insulin receptor signaling in liver and skeletal muscle of rat. Nutrition (2005) 0.85
Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Exp Gerontol (2008) 0.85
Alterations of ultrastructural and fission/fusion markers in hepatocyte mitochondria from mice following calorie restriction with different dietary fats. J Gerontol A Biol Sci Med Sci (2013) 0.84
Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats. J Gerontol A Biol Sci Med Sci (2011) 0.84
The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction. Aging Cell (2011) 0.84
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An unSIRTain role in longevity. Nat Med (2011) 0.82
Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators. J Gerontol A Biol Sci Med Sci (2013) 0.81
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The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice. Exp Neurol (2010) 0.81
The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats. J Gerontol A Biol Sci Med Sci (2013) 0.80
Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids. Neurobiol Aging (2012) 0.80
17α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice. J Alzheimers Dis (2011) 0.80
Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2. Antioxid Redox Signal (2014) 0.80
Effects of aging and calorie restriction on rat skeletal muscle glycogen synthase and glycogen phosphorylase. Exp Gerontol (2009) 0.79
Effect of calorie restriction and refeeding on skin wound healing in the rat. Age (Dordr) (2011) 0.79
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Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat. Ann N Y Acad Sci (2004) 0.79
Utilizing calorie restriction to evaluate the role of sirtuins in healthspan and lifespan of mice. Methods Mol Biol (2013) 0.79