Published in Chem Biol on August 25, 2008
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell (2011) 6.74
Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling. Cell Cycle (2011) 1.54
Functional selectivity of EGF family peptide growth factors: implications for cancer. Pharmacol Ther (2008) 1.52
Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system. J Biol Chem (2009) 1.36
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy. Proc Natl Acad Sci U S A (2012) 1.12
Crosstalk and competition in signaling networks. Biophys J (2012) 1.03
Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors. Biol Psychiatry (2012) 1.02
Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors. PLoS One (2012) 1.01
Protein microarrays: novel developments and applications. Pharm Res (2010) 1.00
Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. J Biol Chem (2012) 0.92
Quantifying protein-protein interactions in high throughput using protein domain microarrays. Nat Protoc (2010) 0.91
Quantifying oncogenic phosphotyrosine signaling networks through systems biology. Curr Opin Genet Dev (2010) 0.91
Carboxyl-group footprinting maps the dimerization interface and phosphorylation-induced conformational changes of a membrane-associated tyrosine kinase. Mol Cell Proteomics (2011) 0.91
Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements. PLoS Biol (2010) 0.91
Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected. Mol Cell Proteomics (2013) 0.90
ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells. Lab Invest (2010) 0.90
TNF-α converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Am J Physiol Gastrointest Liver Physiol (2011) 0.87
The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis. Am J Pathol (2014) 0.87
Phosphotyrosine recognition domains: the typical, the atypical and the versatile. Cell Commun Signal (2012) 0.86
ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. Carcinogenesis (2015) 0.84
ErbB receptors and their growth factor ligands in pediatric intestinal inflammation. Pediatr Res (2013) 0.82
The application of modular protein domains in proteomics. FEBS Lett (2012) 0.82
Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling. J Neurochem (2015) 0.81
Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis. Acta Neuropathol (2014) 0.77
The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist. Biochem J (2012) 0.76
Identification of Posttranslational Modification-Dependent Protein Interactions Using Yeast Surface Displayed Human Proteome Libraries. Methods Mol Biol (2015) 0.76
Interactome of ErbB4 unveiled. Chem Biol (2008) 0.75
Direct coupling of the HER4 intracellular domain (4ICD) and STAT5A signaling is required to induce mammary epithelial cell differentiation. Biochem Biophys Rep (2016) 0.75
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science (1987) 49.88
Untangling the ErbB signalling network. Nat Rev Mol Cell Biol (2001) 28.05
SH2 domains recognize specific phosphopeptide sequences. Cell (1993) 17.28
The structural basis for 14-3-3:phosphopeptide binding specificity. Cell (1997) 10.87
A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature (2005) 5.75
JAK-STAT signaling: from interferons to cytokines. J Biol Chem (2007) 5.28
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol (1994) 5.02
gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science (2001) 4.90
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J (1996) 4.26
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. Oncogene (1995) 4.10
STAT proteins: from normal control of cellular events to tumorigenesis. J Cell Physiol (2003) 3.04
Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. EMBO J (1995) 2.87
The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2. Virology (2001) 2.83
An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science (1994) 2.80
SH2 and PTB domains in tyrosine kinase signaling. Sci STKE (2003) 2.59
Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature (1995) 2.59
The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Endocr Rev (1992) 2.44
The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J Cell Biol (2004) 2.41
Signal transduction and oncogenesis by ErbB/HER receptors. Int J Radiat Oncol Biol Phys (2004) 2.41
Binding specificities and affinities of egf domains for ErbB receptors. FEBS Lett (1999) 2.06
The role of STATs in apoptosis. Curr Mol Med (2002) 2.05
Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis. Oncogene (1998) 2.03
The involvement of ErbB4 with schizophrenia: association and expression studies. Am J Med Genet B Neuropsychiatr Genet (2006) 1.94
Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell (1996) 1.92
ErbB-4: mechanism of action and biology. Exp Cell Res (2003) 1.91
Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma. Cancer Res (1997) 1.91
STAT1 as a key modulator of cell death. Cell Signal (2006) 1.85
Acetylation-dependent signal transduction for type I interferon receptor. Cell (2007) 1.68
Outcome and human epidermal growth factor receptor (HER) 1-4 status in invasive breast carcinomas with proliferation indices evaluated by bromodeoxyuridine labelling. Breast Cancer Res (2004) 1.61
Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. Am J Med Genet B Neuropsychiatr Genet (2006) 1.61
ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease. Clin Cancer Res (2002) 1.58
Signal transduction by epidermal growth factor and heregulin via the kinase-deficient ErbB3 protein. Biochem J (1998) 1.57
A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis. J Biol Chem (2000) 1.55
Absence of HER4 expression predicts recurrence of ductal carcinoma in situ of the breast. Clin Cancer Res (2005) 1.49
STAT-1: a novel regulator of apoptosis. Int J Exp Pathol (2003) 1.43
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure (1994) 1.43
HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers. J Biol Chem (1996) 1.40
Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nat Struct Biol (1996) 1.25
A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R. Mol Biosyst (2008) 1.19
STATs as activators of apoptosis. Trends Cell Biol (1998) 1.16
Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry. Mol Cell Proteomics (2003) 1.08
Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients. Br J Cancer (2004) 1.07
The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients. Br J Cancer (2006) 1.01
Circumventing the problems caused by protein diversity in microarrays: implications for protein interaction networks. J Am Chem Soc (2006) 0.92
Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells. J Biol Chem (2001) 0.83
The epidermal growth factor family has a dual role in deciding the fate of cancer cells. Scand J Clin Lab Invest (2006) 0.81
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol (2006) 12.13
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci U S A (2003) 10.82
Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16
Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci (2012) 6.09
Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell (2012) 5.92
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem (2003) 5.86
A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature (2005) 5.75
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40
Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci U S A (2008) 5.08
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell (2006) 5.01
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol Cell Proteomics (2005) 4.33
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol (2004) 4.31
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol (2006) 4.25
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95
Ordered phosphorylation governs oscillation of a three-protein circadian clock. Science (2007) 3.78
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71
Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum. Mol Cell Proteomics (2006) 3.56
PDZ domain binding selectivity is optimized across the mouse proteome. Science (2007) 3.47
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem (2002) 3.33
HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol (2003) 3.22
Global identification of modular cullin-RING ligase substrates. Cell (2011) 3.13
Profiling of UV-induced ATM/ATR signaling pathways. Proc Natl Acad Sci U S A (2007) 3.12
Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One (2011) 3.10
A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol (2005) 3.04
Peptidomic discovery of short open reading frame-encoded peptides in human cells. Nat Chem Biol (2012) 2.95
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. Front Mol Neurosci (2013) 2.79
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76
An optimized fluorescent probe for visualizing glutamate neurotransmission. Nat Methods (2013) 2.75
Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells. Proc Natl Acad Sci U S A (2010) 2.74
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Sci Signal (2010) 2.64
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell (2010) 2.59
The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella. J Cell Biol (2009) 2.55
A proteomics approach for the identification and cloning of monoclonal antibodies from serum. Nat Biotechnol (2012) 2.51
Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (2009) 2.48
SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42
Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol (2007) 2.41
Single-molecule transition-state analysis of RNA folding. Proc Natl Acad Sci U S A (2003) 2.31
Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev (2003) 2.30
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J (2005) 2.29
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast. Proc Natl Acad Sci U S A (2010) 2.23
Marine cloud brightening. Philos Trans A Math Phys Eng Sci (2012) 2.23
Mass spectrometry based targeted protein quantification: methods and applications. J Proteome Res (2009) 2.20
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev (2006) 2.15
Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors. Sci Transl Med (2010) 2.13
The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13
Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements. Mol Cell Proteomics (2005) 2.12
Tunable signal processing through modular control of transcription factor translocation. Science (2013) 2.11
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem (2004) 2.05
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev (2010) 1.95
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93
Predicting PDZ domain-peptide interactions from primary sequences. Nat Biotechnol (2008) 1.86
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83
Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80
Direct identification of PTEN phosphorylation sites. FEBS Lett (2002) 1.80
An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell (2003) 1.76
Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem (2005) 1.76
Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75
Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem (2008) 1.68
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem (2002) 1.67
Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. Blood (2006) 1.65
Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol (2008) 1.64
Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nat Methods (2013) 1.60
Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA (2005) 1.59
Collecting and organizing systematic sets of protein data. Nat Rev Mol Cell Biol (2006) 1.58
Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56
ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. EMBO J (2009) 1.56
A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions. Chem Biol (2011) 1.55
High throughput proteome screening for biomarker detection. Mol Cell Proteomics (2005) 1.54
The Association of Biomolecular Resource Facilities Proteomics Research Group 2006 study: relative protein quantitation. Mol Cell Proteomics (2007) 1.53
Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell (2005) 1.52
State-based discovery: a multidimensional screen for small-molecule modulators of EGF signaling. Nat Methods (2006) 1.50
Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease. J Biol Chem (2011) 1.48
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43
Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins. J Am Soc Mass Spectrom (2005) 1.41
Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. J Am Chem Soc (2006) 1.40
Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci U S A (2003) 1.36
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol (2011) 1.35
Absolute quantification of protein and post-translational modification abundance with stable isotope-labeled synthetic peptides. Nat Protoc (2011) 1.34
Dissecting protein function and signaling using protein microarrays. Curr Opin Chem Biol (2009) 1.34
Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res (2008) 1.32
Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc Natl Acad Sci U S A (2009) 1.30
In vitro cytotoxic activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrug-resistant cancer cells. J Nat Prod (2002) 1.30
Long-lived electron capture dissociation product ions experience radical migration via hydrogen abstraction. J Am Soc Mass Spectrom (2006) 1.29
Characterization and cloning of T24, a Taenia solium antigen diagnostic for cysticercosis. Mol Biochem Parasitol (2006) 1.28
Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J Biol Chem (2009) 1.27
ABRF-PRG04: differentiation of protein isoforms. J Biomol Tech (2007) 1.22
Peptidase substrates via global peptide profiling. Nat Chem Biol (2008) 1.22
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification. Nat Biotechnol (2009) 1.21
Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels. Proc Natl Acad Sci U S A (2014) 1.21
Biochemical characterization of symbiosome membrane proteins from Medicago truncatula root nodules. Electrophoresis (2004) 1.20
Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer. Cancer Res (2012) 1.20
A new hybrid electrospray Fourier transform mass spectrometer: design and performance characteristics. Rapid Commun Mass Spectrom (2006) 1.20
Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc Natl Acad Sci U S A (2012) 1.20