Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.

PubWeight™: 4.31‹?› | Rank: Top 1%

🔗 View Article (PMC 350560)

Published in Mol Cell Biol on March 01, 2004

Authors

Yannick Doyon1, William Selleck, William S Lane, Song Tan, Jacques Côté

Author Affiliations

1: Laval University Cancer Research Center, Hôtel-Dieu de Québec, Quebec City, Quebec G1R 2J6, Canada.

Articles citing this

(truncated to the top 100)

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell (2009) 8.69

Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40

ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res (2011) 4.91

Identification of multiple distinct Snf2 subfamilies with conserved structural motifs. Nucleic Acids Res (2006) 4.64

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A (2005) 4.24

Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell (2006) 3.87

A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol (2005) 3.04

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol (2007) 3.03

Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A (2004) 2.80

Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast. Genes Dev (2006) 2.73

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. Mutat Res (2008) 2.31

The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3. Mol Cell Biol (2006) 2.29

p21 transcription is regulated by differential localization of histone H2A.Z. Genes Dev (2007) 2.21

The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken. Nucleic Acids Res (2005) 2.08

Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes. Cell (2013) 2.04

MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Mol Cell Biol (2010) 2.03

Telomeric heterochromatin boundaries require NuA4-dependent acetylation of histone variant H2A.Z in Saccharomyces cerevisiae. Genes Dev (2006) 2.01

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol (2008) 1.89

Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87

The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol (2004) 1.80

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol (2010) 1.80

ATP-dependent chromatin remodeling factors and DNA damage repair. Mutat Res (2007) 1.78

Tip60: connecting chromatin to DNA damage signaling. Cell Cycle (2010) 1.73

The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. Genes Dev (2005) 1.70

Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage. Mol Cell Biol (2008) 1.66

Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol (2008) 1.65

Chromatin dynamics and the repair of DNA double strand breaks. Cell Cycle (2011) 1.63

Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. Neurology (2010) 1.63

RVB1/RVB2: running rings around molecular biology. Mol Cell (2009) 1.62

Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. EMBO J (2006) 1.59

Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc Natl Acad Sci U S A (2010) 1.57

Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J Mol Biol (2008) 1.57

Catalytic mechanism of a MYST family histone acetyltransferase. Biochemistry (2007) 1.57

Physical and functional HAT/HDAC interplay regulates protein acetylation balance. J Biomed Biotechnol (2010) 1.55

Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54

Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans. PLoS Genet (2006) 1.47

Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex. Cell Cycle (2014) 1.45

Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants. Mol Cell Biol (2008) 1.39

The 2q23.1 microdeletion syndrome: clinical and behavioural phenotype. Eur J Hum Genet (2009) 1.39

MRG15 regulates embryonic development and cell proliferation. Mol Cell Biol (2005) 1.35

Physiological roles of class I HDAC complex and histone demethylase. J Biomed Biotechnol (2010) 1.33

NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex. J Biol Chem (2010) 1.32

GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation. Mol Cell Biol (2006) 1.32

ANP32E is a histone chaperone that removes H2A.Z from chromatin. Nature (2014) 1.32

Sequence and comparative genomic analysis of actin-related proteins. Mol Biol Cell (2005) 1.28

AID-dependent histone acetylation is detected in immunoglobulin S regions. J Exp Med (2006) 1.26

Molecular basis of the interaction of Saccharomyces cerevisiae Eaf3 chromo domain with methylated H3K36. J Biol Chem (2008) 1.26

MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem (2009) 1.26

2q23.1 microdeletion identified by array comparative genomic hybridisation: an emerging phenotype with Angelman-like features? J Med Genet (2008) 1.25

Functional characterization of the OFD1 protein reveals a nuclear localization and physical interaction with subunits of a chromatin remodeling complex. Mol Biol Cell (2007) 1.25

PHD fingers: epigenetic effectors and potential drug targets. Mol Interv (2009) 1.21

MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks. J Cell Sci (2010) 1.20

NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b). EMBO Rep (2008) 1.18

The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex. Mol Cell Biol (2005) 1.18

Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. J Neurosci (2010) 1.17

SEF, a new protein required for flowering repression in Arabidopsis, interacts with PIE1 and ARP6. Plant Physiol (2006) 1.16

The interplay of histone modifications - writers that read. EMBO Rep (2015) 1.15

SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol (2012) 1.15

Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex. Biochemistry (2007) 1.14

X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivity. Genetics (2004) 1.13

In vitro nuclear interactome of the HIV-1 Tat protein. Retrovirology (2009) 1.13

Structural insight into histone recognition by the ING PHD fingers. Curr Drug Targets (2009) 1.11

Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation. FEBS Lett (2007) 1.11

Genome recognition by MYC. Cold Spring Harb Perspect Med (2014) 1.10

Reviewing the current classification of inhibitor of growth family proteins. Cancer Sci (2009) 1.09

Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. Mol Cell Biol (2005) 1.09

The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol (2008) 1.09

MicroRNA markers for the diagnosis of pancreatic and biliary-tract cancers. PLoS One (2015) 1.08

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity. Genes Dev (2013) 1.08

MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans. Development (2007) 1.06

PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis. Neoplasia (2009) 1.06

Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers. Gene (2009) 1.05

Epigenetic virtues of chromodomains. Crit Rev Biochem Mol Biol (2011) 1.03

Chaperone-like activity of the AAA+ proteins Rvb1 and Rvb2 in the assembly of various complexes. Philos Trans R Soc Lond B Biol Sci (2013) 1.03

Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation. Mol Cell Biol (2011) 1.03

Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infection. PLoS Pathog (2014) 1.03

Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone. Proc Natl Acad Sci U S A (2010) 1.03

H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. Nucleic Acids Res (2012) 1.03

The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair. Mol Cell Biol (2006) 1.01

MYSTs mark chromatin for chromosomal functions. Curr Opin Cell Biol (2008) 0.99

The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression. Mol Cell Biol (2010) 0.99

Where splicing joins chromatin. Nucleus (2011) 0.98

BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere. Mol Biol Cell (2004) 0.98

X-chromosome targeting and dosage compensation are mediated by distinct domains in MSL-3. EMBO Rep (2006) 0.98

Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development. Mol Cell Biol (2006) 0.97

Hdac6 regulates Tip60-p400 function in stem cells. Elife (2013) 0.96

Recombinant protein complex expression in E. coli. Curr Protoc Protein Sci (2008) 0.95

Histone H4 acetylation differentially modulates arginine methylation by an in Cis mechanism. J Biol Chem (2011) 0.95

Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin. Genetics (2006) 0.95

Catalytic-site mutations in the MYST family histone Acetyltransferase Esa1. Genetics (2008) 0.95

Histone target selection within chromatin: an exemplary case of teamwork. Genes Dev (2014) 0.95

MRG15, a component of HAT and HDAC complexes, is essential for proliferation and differentiation of neural precursor cells. J Neurosci Res (2009) 0.94

Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. Mol Cell Biol (2011) 0.94

Solution structure of the mSin3A PAH2-Pf1 SID1 complex: a Mad1/Mxd1-like interaction disrupted by MRG15 in the Rpd3S/Sin3S complex. J Mol Biol (2011) 0.94

Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells. Cell Cycle (2015) 0.93

Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation. Mol Cell Biol (2007) 0.92

Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway. Mol Cell Biol (2013) 0.91

The genetic control of growth rate: a systems biology study in yeast. BMC Syst Biol (2012) 0.91

Genetic suppressors of Caenorhabditis elegans pha-4/FoxA identify the predicted AAA helicase ruvb-1/RuvB. Genetics (2007) 0.90

Regulation of septin dynamics by the Saccharomyces cerevisiae lysine acetyltransferase NuA4. PLoS One (2011) 0.90

Articles cited by this

Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature (2002) 45.19

The tandem affinity purification (TAP) method: a general procedure of protein complex purification. Methods (2001) 15.37

Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69

Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes. Cell (2002) 7.10

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell (2000) 6.70

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet (2000) 5.72

Histone H2A variants H2AX and H2AZ. Curr Opin Genet Dev (2002) 5.11

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell (2001) 4.73

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes. Nature (1998) 4.68

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell (1998) 4.52

Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair. Nature (2002) 4.18

NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J (1999) 4.14

Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Mol Cell (2000) 3.80

Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol (1999) 3.57

The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB. Trends Biochem Sci (1996) 3.55

Systematic identification of novel protein domain families associated with nuclear functions. Genome Res (2002) 3.50

The diverse functions of histone acetyltransferase complexes. Trends Genet (2003) 3.35

MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep (2003) 3.24

ESA1 is a histone acetyltransferase that is essential for growth in yeast. Proc Natl Acad Sci U S A (1998) 3.19

Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science (2001) 3.17

The p400 complex is an essential E1A transformation target. Cell (2001) 3.05

Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell (2003) 2.99

A modular polycistronic expression system for overexpressing protein complexes in Escherichia coli. Protein Expr Purif (2001) 2.97

The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. Nature (1998) 2.86

An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. Mol Cell (2000) 2.84

Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation. Mol Cell (2003) 2.74

Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell (2000) 2.41

Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes. Mol Cell (2002) 2.33

Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev (2003) 2.30

Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology (1996) 2.12

Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60. J Biol Chem (1997) 2.12

The constantly changing face of chromatin. Sci Aging Knowledge Environ (2003) 2.02

DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc Natl Acad Sci U S A (2001) 2.00

Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. J Biol Chem (1999) 1.97

The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation. J Biol Chem (2000) 1.92

Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes. EMBO J (2000) 1.92

Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. EMBO J (2002) 1.81

The MYST family of histone acetyltransferases. Curr Top Microbiol Immunol (2003) 1.69

BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Mol Cell Biol (2002) 1.69

The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex. J Biol Chem (2002) 1.68

The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes. Development (2001) 1.66

Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Mol Cell Biol (2001) 1.62

Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes. Mol Cell Biol (2002) 1.59

Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Mol Cell Biol (1999) 1.57

Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. Mol Cell Biol (2002) 1.52

NuA4 subunit Yng2 function in intra-S-phase DNA damage response. Mol Cell Biol (2002) 1.51

Different HATS of the ING1 gene family. Trends Cell Biol (2002) 1.45

Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. Mol Cell Biol (2003) 1.44

A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. Oncogene (2003) 1.40

Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity. EMBO J (2003) 1.35

Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I. Hum Mol Genet (1997) 1.34

Control of class II gene transcription during in vitro nucleosome assembly. Methods Cell Biol (1991) 1.28

Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. Mol Cell Biol (2003) 1.21

Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. Oncogene (2002) 1.19

RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. J Biol Chem (2000) 1.17

MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. J Biol Chem (2001) 1.16

Regulation of cAMP-responsive element-binding protein-mediated transcription by the SNF2/SWI-related protein, SRCAP. J Biol Chem (2001) 1.14

Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein. J Biol Chem (1997) 1.02

Opposite role of yeast ING family members in p53-dependent transcriptional activation. J Biol Chem (2003) 1.02

PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. Mol Cell Biol (2001) 1.01

Targeted disruption of the GAS41 gene encoding a putative transcription factor indicates that GAS41 is essential for cell viability. J Biol Chem (2002) 1.00

Purification of a histone deacetylase complex from Xenopus laevis: preparation of substrates and assay procedures. Methods Enzymol (1999) 0.91

p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers. Mol Endocrinol (1999) 0.89

A SWI2/SNF2-type ATPase/helicase protein, mDomino, interacts with myeloid zinc finger protein 2A (MZF-2A) to regulate its transcriptional activity. Genes Cells (2003) 0.89

Forced expression of YL-1 protein suppresses the anchorage-independent growth of Kirsten sarcoma virus-transformed NIH3T3 cells. Exp Cell Res (1995) 0.86

Articles by these authors

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature (2006) 9.30

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem (2003) 5.86

Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell (2006) 5.01

Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Mol Cell (2004) 4.17

HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95

Ordered phosphorylation governs oscillation of a three-protein circadian clock. Science (2007) 3.78

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71

Meta-analysis of traditional Chinese patent medicine for ischemic stroke. Stroke (2007) 3.46

The diverse functions of histone acetyltransferase complexes. Trends Genet (2003) 3.35

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem (2002) 3.33

HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol (2003) 3.22

A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol (2005) 3.04

The highly conserved and multifunctional NuA4 HAT complex. Curr Opin Genet Dev (2004) 3.03

A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76

Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol (2012) 2.76

Cellular machineries for chromosomal DNA repair. Genes Dev (2004) 2.66

Structure of RCC1 chromatin factor bound to the nucleosome core particle. Nature (2010) 2.61

Role for miR-204 in human pulmonary arterial hypertension. J Exp Med (2011) 2.60

Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylation. J Biol Chem (2001) 2.50

Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (2009) 2.48

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol (2005) 2.48

Comparison of affinity tags for protein purification. Protein Expr Purif (2005) 2.45

SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42

Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol (2007) 2.41

Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes. Mol Cell (2002) 2.33

Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev (2003) 2.30

The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling. Mol Cell (2003) 2.29

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J (2005) 2.29

Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev (2006) 2.15

The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13

Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin. Mol Cell (2007) 2.07

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem (2004) 2.05

System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol (2008) 1.97

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev (2010) 1.95

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol (2008) 1.89

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83

Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80

Direct identification of PTEN phosphorylation sites. FEBS Lett (2002) 1.80

The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol (2004) 1.80

An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell (2003) 1.76

Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem (2005) 1.76

Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75

Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem (2008) 1.68

DNA methylation increases nucleosome compaction and rigidity. J Am Chem Soc (2010) 1.67

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem (2002) 1.67

Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol (2008) 1.64

The pST44 polycistronic expression system for producing protein complexes in Escherichia coli. Protein Expr Purif (2005) 1.62

Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA (2005) 1.59

HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail. Mol Cell (2009) 1.58

Catalytic mechanism of a MYST family histone acetyltransferase. Biochemistry (2007) 1.57

Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. EMBO J (2009) 1.56

Histone chaperones: modulators of chromatin marks. Mol Cell (2011) 1.56

The Association of Biomolecular Resource Facilities Proteomics Research Group 2006 study: relative protein quantitation. Mol Cell Proteomics (2007) 1.53

Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell (2005) 1.52

The Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex requires the Enhancer of Polycomb A domain and chromodomain to acetylate nucleosomes. Mol Cell Biol (2005) 1.52

Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation. EMBO J (2004) 1.46

Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. J Biol Chem (2005) 1.46

Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4. Mol Cell Biol (2005) 1.46

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43

Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants. Mol Cell Biol (2008) 1.39

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol (2011) 1.35

Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension. Circulation (2011) 1.33

Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling. Proc Natl Acad Sci U S A (2006) 1.32

NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex. J Biol Chem (2010) 1.32

Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res (2008) 1.32

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc Natl Acad Sci U S A (2009) 1.30

MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J (2011) 1.29

Characterization and cloning of T24, a Taenia solium antigen diagnostic for cysticercosis. Mol Biochem Parasitol (2006) 1.28

Connection between histone H2A variants and chromatin remodeling complexes. Biochem Cell Biol (2009) 1.28

Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat Struct Mol Biol (2012) 1.27

The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide. Proteins (2008) 1.27

Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J Biol Chem (2009) 1.27

Histone modifications in response to DNA damage. Mutat Res (2007) 1.25

ABRF-PRG04: differentiation of protein isoforms. J Biomol Tech (2007) 1.22

Peptidase substrates via global peptide profiling. Nat Chem Biol (2008) 1.22

SAGA binds TBP via its Spt8 subunit in competition with DNA: implications for TBP recruitment. EMBO J (2006) 1.21

Biochemical characterization of symbiosome membrane proteins from Medicago truncatula root nodules. Electrophoresis (2004) 1.20

Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc Natl Acad Sci U S A (2012) 1.20

MYST-family histone acetyltransferases: beyond chromatin. Cell Mol Life Sci (2010) 1.19

Epigenetic modifications in double-strand break DNA damage signaling and repair. Clin Cancer Res (2010) 1.18

Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP. Hum Mol Genet (2013) 1.17

Histone H3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms. Nucleic Acids Res (2011) 1.17

N-terminal truncation of antiapoptotic MCL1, but not G2/M-induced phosphorylation, is associated with stabilization and abundant expression in tumor cells. J Biol Chem (2007) 1.17

Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes. J Mol Biol (2003) 1.16

SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol (2012) 1.15