Published in EMBO J on September 15, 2005
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer (2006) 8.83
Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59
Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer (2009) 4.06
MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer (2013) 3.60
p53 polymorphisms: cancer implications. Nat Rev Cancer (2009) 3.33
The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol (2010) 3.08
Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell (2009) 2.28
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J (2006) 2.11
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
MDMX regulation of p53 response to ribosomal stress. EMBO J (2006) 1.77
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. EMBO J (2006) 1.67
The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation. Cell Cycle (2011) 1.62
Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes Dev (2013) 1.57
Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A (2007) 1.56
ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. EMBO J (2009) 1.56
Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol (2014) 1.54
Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci U S A (2011) 1.51
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J (2006) 1.40
MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination. J Biol Chem (2011) 1.27
Regulation of p53: a collaboration between Mdm2 and Mdmx. Oncotarget (2012) 1.24
The regulation of the p53-mediated stress response by MDM2 and MDM4. Cold Spring Harb Perspect Biol (2010) 1.23
Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4. Cancer Res (2010) 1.23
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Mol Cell Biol (2006) 1.22
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. BMC Cancer (2011) 1.15
p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells. FEBS Lett (2007) 1.14
Functions of MDMX in the modulation of the p53-response. J Biomed Biotechnol (2011) 1.12
Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2. PLoS One (2012) 1.09
Mechanism of p53 stabilization by ATM after DNA damage. Cell Cycle (2010) 1.09
Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation. Cell Cycle (2008) 1.08
DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. Mol Cell Biol (2006) 1.07
Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response. Cancer Res (2009) 1.07
Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. J Biol Chem (2008) 1.06
CHK2 kinase in the DNA damage response and beyond. J Mol Cell Biol (2014) 1.05
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res (2011) 1.04
Regulation of MDMX expression by mitogenic signaling. Mol Cell Biol (2008) 1.01
HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity. J Biol Chem (2010) 1.00
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol Cell Biol (2008) 0.98
Phosphatases in the cellular response to DNA damage. Cell Commun Signal (2010) 0.97
Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells. Int J Mol Sci (2014) 0.96
Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents. Neoplasia (2013) 0.96
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. Proc Natl Acad Sci U S A (2014) 0.95
MDM4 (MDMX) and its Transcript Variants. Curr Genomics (2009) 0.94
The versatile functions of ATM kinase. Biomed J (2014) 0.94
Antiproliferative factor signaling and interstitial cystitis/painful bladder syndrome. Int Neurourol J (2011) 0.94
Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding. Mol Cell Biol (2012) 0.94
Controlling the Mdm2-Mdmx-p53 Circuit. Pharmaceuticals (Basel) (2010) 0.92
Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment. Mar Drugs (2011) 0.91
Mdmx promotes genomic instability independent of p53 and Mdm2. Oncogene (2014) 0.91
Abnormal MDMX degradation in tumor cells due to ARF deficiency. Oncogene (2011) 0.90
Endoplasmic reticulum stress, genome damage, and cancer. Front Oncol (2015) 0.90
AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol (2013) 0.90
MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response. Oncogene (2015) 0.89
MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress. Mol Cell Biol (2012) 0.89
c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation. J Biol Chem (2010) 0.87
Transcriptome analysis of newt lens regeneration reveals distinct gradients in gene expression patterns. PLoS One (2013) 0.87
Regulation of the life cycle of HPVs by differentiation and the DNA damage response. Future Microbiol (2013) 0.87
EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma. Hepatology (2014) 0.87
Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX. Cell Death Differ (2011) 0.86
Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. Apoptosis (2010) 0.86
Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1. World J Biol Chem (2014) 0.84
Autoinhibition of MDMX by intramolecular p53 mimicry. Proc Natl Acad Sci U S A (2015) 0.84
Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage. PLoS Comput Biol (2010) 0.83
Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx. Cell Signal (2012) 0.82
Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene (2012) 0.82
Apoptosis in leukemias: regulation and therapeutic targeting. Cancer Treat Res (2010) 0.81
The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53. Genes Cancer (2012) 0.81
Doxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast cancer cells. Cancer Biol Ther (2014) 0.80
On the intrinsic disorder status of the major players in programmed cell death pathways. F1000Res (2013) 0.79
14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53. J Biol Chem (2010) 0.79
Protecting the genome from mdm2 and mdmx. Genes Cancer (2012) 0.79
Mutation analysis of the MDM4 gene in German breast cancer patients. BMC Cancer (2008) 0.79
p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53. Cell Death Dis (2015) 0.78
Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress. Nucleic Acids Res (2013) 0.78
XI-006 induces potent p53-independent apoptosis in Ewing sarcoma. Sci Rep (2015) 0.78
Drosophila MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis. BMC Mol Biol (2013) 0.78
Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection. Cell Cycle (2012) 0.77
Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53. Oncogene (2016) 0.77
Activation of checkpoint kinase 2 is critical for herpes simplex virus type 1 replication in corneal epithelium. Ophthalmic Res (2014) 0.76
Logical network of genotoxic stress-induced NF-κB signal transduction predicts putative target structures for therapeutic intervention strategies. Adv Appl Bioinform Chem (2009) 0.76
Antitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One-Based Synthetic Small Molecule In Vitro and In Vivo. PLoS One (2015) 0.76
Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding. Proc Natl Acad Sci U S A (2016) 0.76
MDM2 oligomers: antagonizers of the guardian of the genome. Oncogene (2016) 0.76
Coordinate to guard: crosstalk of phosphorylation, sumoylation, and ubiquitylation in DNA damage response. Front Oncol (2012) 0.76
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis. Transl Cancer Res (2016) 0.76
Identification of complex genomic rearrangements in cancers using CouGaR. Genome Res (2016) 0.75
Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila. Aging (Albany NY) (2015) 0.75
Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. Cell Rep (2016) 0.75
Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria. Oncotarget (2016) 0.75
Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice. Proc Natl Acad Sci U S A (2016) 0.75
Functional Activation of Mutant p53 by Platinum Analogs in Cisplatin-resistant Cells is Dependent on Phosphorylation. Mol Cancer Res (2016) 0.75
Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2. PLoS One (2013) 0.75
Structural basis of how stress-induced MDMX phosphorylation activates p53. Oncogene (2015) 0.75
RhoA regulates resistance to irinotecan by regulating membrane transporter and apoptosis signaling in colorectal cancer. Oncotarget (2016) 0.75
SMG7 is a critical regulator of p53 stability and function in DNA damage stress response. Cell Discov (2016) 0.75
DNA damage response is hijacked by human papillomaviruses to complete their life cycle. J Zhejiang Univ Sci B (2017) 0.75
Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model. PLoS One (2015) 0.75
[EEF1A2 inhibits the p53 function in hepatocellular carcinoma via PI3K/AKT/mTOR-dependent stabilization of MDM4]. Pathologe (2014) 0.75
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (1995) 10.18
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell (1998) 8.99
Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell (2003) 7.48
The p53 pathway. J Pathol (1999) 6.79
Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem (1999) 6.14
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev (2000) 5.90
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72
The many substrates and functions of ATM. Nat Rev Mol Cell Biol (2000) 5.46
Mapping of the p53 and mdm-2 interaction domains. Mol Cell Biol (1993) 5.31
p53: death star. Cell (2000) 4.77
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet (2001) 4.23
MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J (1996) 4.13
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J (2004) 3.10
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol (2002) 3.10
MDM2 interacts with MDMX through their RING finger domains. FEBS Lett (1999) 2.98
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. J Biol Chem (1999) 2.92
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem (2002) 2.68
MDM2 promotes ubiquitination and degradation of MDMX. Mol Cell Biol (2003) 2.45
mdmx is a negative regulator of p53 activity in vivo. Cancer Res (2002) 2.40
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms. EMBO Rep (2001) 2.27
Control of p53 ubiquitination and nuclear export by MDM2 and ARF. Cell Growth Differ (2001) 2.05
DNA damage-induced MDMX degradation is mediated by MDM2. J Biol Chem (2003) 2.03
14-3-3 proteins; bringing new definitions to scaffolding. Oncogene (2001) 2.03
Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses. J Biol Chem (2003) 2.02
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage. Proc Natl Acad Sci U S A (2005) 1.97
Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2. J Biol Chem (2003) 1.93
Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53. Cancer Res (2001) 1.92
Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol (2004) 1.85
The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J Biol Chem (2003) 1.84
Mutation of mouse p53 Ser23 and the response to DNA damage. Mol Cell Biol (2002) 1.65
DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms. Mol Cell Biol (2002) 1.53
Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. EMBO J (2002) 1.45
Regulation of p53-MDMX interaction by casein kinase 1 alpha. Mol Cell Biol (2005) 1.41
Questioning the role of checkpoint kinase 2 in the p53 DNA damage response. J Biol Chem (2003) 1.29
Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression. Mol Med (1999) 1.00
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem (2003) 5.86
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell (2006) 5.01
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol (2004) 4.31
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem (2001) 4.21
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95
Ordered phosphorylation governs oscillation of a three-protein circadian clock. Science (2007) 3.78
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem (2002) 3.33
HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol (2003) 3.22
A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol (2005) 3.04
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76
Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (2009) 2.48
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol (2007) 2.47
MDM2 promotes ubiquitination and degradation of MDMX. Mol Cell Biol (2003) 2.45
SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42
Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol (2007) 2.41
Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev (2003) 2.30
MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. J Biol Chem (2006) 2.20
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci U S A (2011) 2.17
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev (2006) 2.15
The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem (2004) 2.11
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem (2004) 2.05
System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol (2008) 1.97
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev (2010) 1.95
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J (2005) 1.85
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83
Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80
Direct identification of PTEN phosphorylation sites. FEBS Lett (2002) 1.80
MDMX regulation of p53 response to ribosomal stress. EMBO J (2006) 1.77
An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell (2003) 1.76
Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem (2005) 1.76
Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res (2007) 1.76
Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75
Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions. J Am Chem Soc (2009) 1.72
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest (2012) 1.71
Expression and gene polymorphisms of interleukin 28B and hepatitis B virus infection in a Chinese Han population. Liver Int (2011) 1.70
Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem (2008) 1.68
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. EMBO J (2006) 1.67
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J Mol Med (Berl) (2012) 1.67
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem (2002) 1.67
Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol (2008) 1.64
MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem (2009) 1.63
The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation. Cell Cycle (2011) 1.62
Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA (2005) 1.59
Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56
ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. EMBO J (2009) 1.56
The Association of Biomolecular Resource Facilities Proteomics Research Group 2006 study: relative protein quantitation. Mol Cell Proteomics (2007) 1.53
DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms. Mol Cell Biol (2002) 1.53
Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell (2005) 1.52
p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem (2009) 1.48
Adiponectin is positively associated with insulin resistance in subjects with type 2 diabetic nephropathy and effects of angiotensin II type 1 receptor blocker losartan. Nephrol Dial Transplant (2009) 1.44
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43
Regulation of p53-MDMX interaction by casein kinase 1 alpha. Mol Cell Biol (2005) 1.41
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol (2011) 1.35
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem (2009) 1.33
Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res (2008) 1.32
Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways. J Biol Chem (2004) 1.32
Regulation of E2F1 function by the nuclear corepressor KAP1. J Biol Chem (2007) 1.31
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J Biol Chem (2009) 1.31
Inhibition of SUV39H1 methyltransferase activity by DBC1. J Biol Chem (2009) 1.31
Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc Natl Acad Sci U S A (2009) 1.30
Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology (2003) 1.29
MDM2-ARF complex regulates p53 sumoylation. Oncogene (2003) 1.29
Characterization and cloning of T24, a Taenia solium antigen diagnostic for cysticercosis. Mol Biochem Parasitol (2006) 1.28
Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J Biol Chem (2009) 1.27
IL28B genetic variation is associated with spontaneous clearance of hepatitis C virus, treatment response, serum IL-28B levels in Chinese population. PLoS One (2012) 1.25
RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection. Blood (2006) 1.24
Systematic review and meta-analysis of laparoscopy-assisted and open total gastrectomy for gastric cancer. World J Gastroenterol (2013) 1.24
Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism. J Biol Chem (2005) 1.23
ABRF-PRG04: differentiation of protein isoforms. J Biomol Tech (2007) 1.22
Peptidase substrates via global peptide profiling. Nat Chem Biol (2008) 1.22
Biochemical characterization of symbiosome membrane proteins from Medicago truncatula root nodules. Electrophoresis (2004) 1.20
Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc Natl Acad Sci U S A (2012) 1.20
Short-term surgical and long-term survival outcomes after laparoscopic distal gastrectomy with D2 lymphadenectomy for gastric cancer. BMC Gastroenterol (2014) 1.17
N-terminal truncation of antiapoptotic MCL1, but not G2/M-induced phosphorylation, is associated with stabilization and abundant expression in tumor cells. J Biol Chem (2007) 1.17
A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. Sci Signal (2013) 1.17
SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol (2012) 1.15
Systematic review and meta-analysis of laparoscopic and open gastrectomy for advanced gastric cancer. World J Surg Oncol (2013) 1.15
Phosphorylation of SNAP-23 in activated human platelets. J Biol Chem (2003) 1.15
The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Mol Cell Biol (2010) 1.14
Rescue of mutant p53 transcription function by ellipticine. Oncogene (2003) 1.14
A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3'-end formation. Mol Cell Biol (2010) 1.13
Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation. J Am Chem Soc (2005) 1.13
NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function. Nat Cell Biol (2002) 1.12
Totally laparoscopic distal gastrectomy with D2 lymphadenectomy and Billroth II gastrojejunostomy for gastric cancer: short- and medium-term results of 139 consecutive cases from a single institution. Int J Med Sci (2013) 1.11
Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol (2011) 1.11