New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMC 2613165)

Published in J Cereb Blood Flow Metab on September 10, 2008

Authors

Xiao-Hong Zhu1, Nanyin Zhang, Yi Zhang, Kâmil Uğurbil, Wei Chen

Author Affiliations

1: Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. zhu@cmrr.umn.edu

Articles citing this

Fueling and imaging brain activation. ASN Neuro (2012) 1.04

Quantitative fMRI and oxidative neuroenergetics. Neuroimage (2012) 0.98

Intracellular redox state revealed by in vivo (31) P MRS measurement of NAD(+) and NADH contents in brains. Magn Reson Med (2013) 0.95

Astrocytic energetics during excitatory neurotransmission: What are contributions of glutamate oxidation and glycolysis? Neurochem Int (2013) 0.94

Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice. Neuroimage (2012) 0.93

Magnetic resonance spectroscopy studies of human metabolism. Diabetes (2011) 0.89

In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field. Prog Nucl Magn Reson Spectrosc (2011) 0.87

Insights from neuroenergetics into the interpretation of functional neuroimaging: an alternative empirical model for studying the brain's support of behavior. J Cereb Blood Flow Metab (2014) 0.87

Field dependence study of in vivo brain (31) P MRS up to 16.4 T. NMR Biomed (2014) 0.85

Evidence for the importance of measuring total brain activity in neuroimaging. Proc Natl Acad Sci U S A (2011) 0.84

Non-invasive measurement of cerebral oxygen metabolism in the mouse brain by ultra-high field (17)O MR spectroscopy. J Cereb Blood Flow Metab (2013) 0.83

Computational approaches for understanding energy metabolism. Wiley Interdiscip Rev Syst Biol Med (2013) 0.83

Noninvasive functional imaging of cerebral blood volume with vascular-space-occupancy (VASO) MRI. NMR Biomed (2013) 0.81

Role of ongoing, intrinsic activity of neuronal populations for quantitative neuroimaging of functional magnetic resonance imaging-based networks. Brain Connect (2011) 0.80

Impact of "noncaloric" activity-related factors on the predisposition to obesity in children. Risk Manag Healthc Policy (2010) 0.79

Animal models and high field imaging and spectroscopy. Dialogues Clin Neurosci (2013) 0.79

Non-invasive assessment of neonatal brain oxygen metabolism: A review of newly available techniques. Early Hum Dev (2014) 0.78

Cortical network models of impulse firing in the resting and active states predict cortical energetics. Proc Natl Acad Sci U S A (2015) 0.77

In vivo(17)O MRS imaging - Quantitative assessment of regional oxygen consumption and perfusion rates in living brain. Anal Biochem (2016) 0.76

In vivo measurement of CBF using ¹⁷O NMR signal of metabolically produced H₂¹⁷O as a perfusion tracer. Magn Reson Med (2012) 0.76

Articles cited by this

Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med (1995) 42.32

Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci (2007) 27.23

Neuronal oscillations in cortical networks. Science (2004) 19.57

Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A (1990) 17.55

Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci U S A (1992) 16.64

Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A (1992) 14.96

An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab (2001) 11.01

Nonoxidative glucose consumption during focal physiologic neural activity. Science (1988) 9.59

Brain work and brain imaging. Annu Rev Neurosci (2006) 6.99

Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J (1993) 6.52

Time course EPI of human brain function during task activation. Magn Reson Med (1992) 6.35

Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci U S A (1998) 6.02

Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses. Nat Neurosci (2005) 5.83

Modeling the hemodynamic response to brain activation. Neuroimage (2004) 5.15

Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1. Nat Neurosci (2006) 4.67

Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography. J Nucl Med (1984) 4.30

Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain. Neuron (2002) 3.92

Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci U S A (1999) 3.44

Neuronal-glial glucose oxidation and glutamatergic-GABAergic function. J Cereb Blood Flow Metab (2006) 2.88

Origin of negative blood oxygenation level-dependent fMRI signals. J Cereb Blood Flow Metab (2002) 2.34

Inhibition and brain work. Neuron (2007) 2.22

Determination of relative CMRO2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation. Magn Reson Med (1999) 2.06

Development of (17)O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field. Proc Natl Acad Sci U S A (2002) 1.85

Effect of alpha-chloralose, halothane, pentobarbital and nitrous oxide anesthesia on metabolic coupling in somatosensory cortex of rat. Acta Anaesthesiol Scand (1992) 1.77

Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. NMR Biomed (2001) 1.69

The effect of mental arithmetic on cerebral circulation and metabolism. J Clin Invest (1955) 1.68

Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI. Proc Natl Acad Sci U S A (2002) 1.62

What makes brain neurons run? Science (1997) 1.57

Analysis of oxygen metabolism implies a neural origin for the negative BOLD response in human visual cortex. Neuroimage (2006) 1.53

Tightly coupled brain activity and cerebral ATP metabolic rate. Proc Natl Acad Sci U S A (2008) 1.53

Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (2003) 1.47

In vivo 17O NMR approaches for brain study at high field. NMR Biomed (2005) 1.31

Vibratory stimulation increases and decreases the regional cerebral blood flow and oxidative metabolism: a positron emission tomography (PET) study. Acta Neurol Scand (1992) 1.30

A BOLD search for baseline. Neuroimage (2007) 1.26

In vivo measurement of cerebral oxygen consumption and blood flow using 17O magnetic resonance imaging. Magn Reson Med (1991) 1.26

Quantification of cerebral blood flow and oxygen metabolism with 3-dimensional PET and 15O: validation by comparison with 2-dimensional PET. J Nucl Med (2007) 1.16

Simplified methods for calculating cerebral metabolic rate of oxygen based on 17O magnetic resonance spectroscopic imaging measurement during a short 17O2 inhalation. J Cereb Blood Flow Metab (2004) 1.10

Study of tricarboxylic acid cycle flux changes in human visual cortex during hemifield visual stimulation using (1)H-[(13)C] MRS and fMRI. Magn Reson Med (2001) 1.08

Noninvasive and three-dimensional imaging of CMRO(2) in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison study. J Cereb Blood Flow Metab (2006) 1.07

Cerebral oxygen utilization analyzed by the use of oxygen-17 and its nuclear magnetic resonance. Biochem Biophys Res Commun (1990) 0.97

Simultaneous oxygenation and perfusion imaging study of functional activity in primary visual cortex at different visual stimulation frequency: quantitative correlation between BOLD and CBF changes. Magn Reson Med (1998) 0.97

Time-related increase of oxygen utilization in continuously activated human visual cortex. Neuroimage (2002) 0.96

A comparison of the cerebrovascular and metabolic effects of halothane and isoflurane in the cat. Anesthesiology (1984) 0.91

Spectroscopic imaging of circular voxels with a two-dimensional Fourier-series window technique. J Magn Reson B (1994) 0.91

Articles by these authors

A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78

Galaxy: a platform for interactive large-scale genome analysis. Genome Res (2005) 35.75

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet (2005) 29.45

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40

Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31

A genome-wide association study of global gene expression. Nat Genet (2007) 22.98

Global quantification of mammalian gene expression control. Nature (2011) 22.36

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature (2010) 18.63

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37

The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol (2005) 12.70

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44

Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53

Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36

Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17

Role of histone H3 lysine 27 methylation in X inactivation. Science (2003) 9.85

Role of histone H2A ubiquitination in Polycomb silencing. Nature (2004) 9.48

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47

Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol (2010) 9.35

Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res (2007) 8.41

The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev (2004) 7.89

Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much? J Clin Oncol (2004) 7.36

Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med (2011) 7.16

Cubic AgPb(m)SbTe(2+m): bulk thermoelectric materials with high figure of merit. Science (2004) 7.07

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol Cell (2004) 6.90

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71

Hydrogen-bonded ferroelectrics based on metal-organic coordination. J Am Chem Soc (2009) 6.69

JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet (2006) 6.65

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature (2011) 6.48

Altered histone acetylation is associated with age-dependent memory impairment in mice. Science (2010) 6.38

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell (2005) 6.29

Regulation of histone methylation by demethylimination and demethylation. Nat Rev Mol Cell Biol (2007) 6.13

A framework for collaborative analysis of ENCODE data: making large-scale analyses biologist-friendly. Genome Res (2007) 5.97

A human snoRNA with microRNA-like functions. Mol Cell (2008) 5.84

miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83

hDOT1L links histone methylation to leukemogenesis. Cell (2005) 5.83

Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev (2003) 5.77

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell (2006) 5.54

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol (2002) 5.53

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature (2006) 5.51

Multiband multislice GE-EPI at 7 tesla, with 16-fold acceleration using partial parallel imaging with application to high spatial and temporal whole-brain fMRI. Magn Reson Med (2010) 5.42

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet (2002) 5.38

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Hum Mol Genet (2007) 5.28

Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep (2006) 5.19

Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum (2005) 5.18

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol (2006) 5.16

Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J Clin Oncol (2004) 5.12

Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature (2003) 5.04

Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA (2003) 4.88

Deep sequencing reveals 50 novel genes for recessive cognitive disorders. Nature (2011) 4.85

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83

Supramolecular bola-like ferroelectric: 4-methoxyanilinium tetrafluoroborate-18-crown-6. J Am Chem Soc (2011) 4.73

Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell (2009) 4.71

Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science (2010) 4.60

Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science (2006) 4.54

Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49

Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol (2008) 4.45

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev (2011) 4.45

Dialysis facility ownership and epoetin dosing in patients receiving hemodialysis. JAMA (2007) 4.40

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature (2005) 4.39

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

Subtypes of breast cancer show preferential site of relapse. Cancer Res (2008) 4.38

Ligand configurational entropy and protein binding. Proc Natl Acad Sci U S A (2007) 4.33

Diisopropylammonium chloride: a ferroelectric organic salt with a high phase transition temperature and practical utilization level of spontaneous polarization. Adv Mater (2011) 4.30

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol (2008) 4.30

Transmit and receive transmission line arrays for 7 Tesla parallel imaging. Magn Reson Med (2005) 4.25

Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol (2013) 4.19

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16

Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science (2011) 4.12

Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr Biol (2002) 4.12

Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung. Cancer Res (2006) 4.11

Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood (2005) 4.10

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev (2011) 4.09

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev (2002) 4.07

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet (2011) 4.04

Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres. Nature (2012) 4.00

Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci U S A (2007) 3.92

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. J Neurosci (2005) 3.92

Estimating accuracy of RNA-Seq and microarrays with proteomics. BMC Genomics (2009) 3.87

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat Struct Mol Biol (2008) 3.80

The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell (2007) 3.79

Hierarchical recruitment of polycomb group silencing complexes. Mol Cell (2004) 3.73

A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet (2008) 3.71

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell (2007) 3.68

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64

Intradiscal injection therapy for degenerative chronic discogenic low back pain with end plate Modic changes. Spine J (2010) 3.55

Array CGH identifies reciprocal 16p13.1 duplications and deletions that predispose to autism and/or mental retardation. Hum Mutat (2007) 3.52

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50

TET enzymes, TDG and the dynamics of DNA demethylation. Nature (2013) 3.49

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet (2007) 3.39

Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell (2006) 3.39

The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet (2013) 3.39

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37

Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet (2004) 3.33

E2-2 protein and Fuchs's corneal dystrophy. N Engl J Med (2010) 3.31

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev (2007) 3.31