Published in PLoS One on February 27, 2009
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Gene--environment-wide association studies: emerging approaches. Nat Rev Genet (2010) 6.10
Pathway analysis by adaptive combination of P-values. Genet Epidemiol (2009) 4.48
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet (2010) 3.91
Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst (2010) 3.18
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res (2009) 2.63
Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. Hum Mol Genet (2009) 2.22
Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. Int J Epidemiol (2009) 1.97
Replication in genome-wide association studies. Stat Sci (2009) 1.89
Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. Int J Epidemiol (2011) 1.61
Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med (2014) 1.57
Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. Nicotine Tob Res (2011) 1.51
Nicotine response genetics in the zebrafish. Proc Natl Acad Sci U S A (2009) 1.45
Genetic architecture of cancer and other complex diseases: lessons learned and future directions. Carcinogenesis (2011) 1.39
Genome-wide association studies in cancer--current and future directions. Carcinogenesis (2009) 1.39
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes Brain Behav (2010) 1.35
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. Trends Pharmacol Sci (2009) 1.35
From men to mice: CHRNA5/CHRNA3, smoking behavior and disease. Nicotine Tob Res (2012) 1.31
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. Twin Res Hum Genet (2010) 1.30
SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study. Nucleic Acids Res (2010) 1.29
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circ Cardiovasc Genet (2011) 1.26
Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. Pharmacogenet Genomics (2013) 1.24
AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats. Neuropsychopharmacology (2012) 1.22
Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. Nicotine Tob Res (2012) 1.22
Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. PLoS One (2010) 1.21
TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. Biol Psychiatry (2010) 1.21
Genome-wide association study of lung function decline in adults with and without asthma. J Allergy Clin Immunol (2012) 1.20
Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. J Natl Cancer Inst (2010) 1.19
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. Hum Genet (2011) 1.19
The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy. J Neurosci (2010) 1.19
Genome-wide association study of smoking behaviours in patients with COPD. Thorax (2011) 1.18
Detecting genetic interactions for quantitative traits with U-statistics. Genet Epidemiol (2011) 1.13
Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Carcinogenesis (2010) 1.12
Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One (2011) 1.11
The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Prog Neurobiol (2010) 1.09
Function and regulation of TRP family channels in C. elegans. Pflugers Arch (2009) 1.09
Meta-analysis of 15 genome-wide linkage scans of smoking behavior. Biol Psychiatry (2010) 1.08
Dopamine genes and nicotine dependence in treatment-seeking and community smokers. Neuropsychopharmacology (2009) 1.04
Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. Am J Clin Nutr (2012) 0.99
Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study. PLoS One (2011) 0.98
GENES AS INSTRUMENTS FOR STUDYING RISK BEHAVIOR EFFECTS: AN APPLICATION TO MATERNAL SMOKING AND OROFACIAL CLEFTS. Health Serv Outcomes Res Methodol (2011) 0.98
Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. Addict Biol (2010) 0.97
The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. Cancer Epidemiol Biomarkers Prev (2014) 0.97
Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample. Mol Psychiatry (2013) 0.96
Family history is a risk factor for COPD. Chest (2011) 0.96
Association of CHRNA4 polymorphisms with smoking behavior in two populations. Am J Med Genet B Neuropsychiatr Genet (2011) 0.96
Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers. Neuropsychopharmacology (2010) 0.94
Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. Hum Genet (2012) 0.92
Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster. Behav Genet (2011) 0.90
In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression. PLoS One (2011) 0.90
Pharmacological stress is required for the anti-alcohol effect of the α3β4* nAChR partial agonist AT-1001. Neuropharmacology (2015) 0.90
A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. Cancer Epidemiol Biomarkers Prev (2011) 0.88
Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population. PLoS One (2011) 0.88
Smoking and body weight: evidence using genetic instruments. Econ Hum Biol (2011) 0.88
Will chronic e-cigarette use cause lung disease? Am J Physiol Lung Cell Mol Physiol (2015) 0.87
From smoking to lung cancer: the CHRNA5/A3/B4 connection. Oncogene (2010) 0.87
A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood. Cancer Prev Res (Phila) (2014) 0.86
Genome-wide association study of smoking behaviours among Bangladeshi adults. J Med Genet (2014) 0.85
Genetic basis of delay discounting in frequent gamblers: examination of a priori candidates and exploration of a panel of dopamine-related loci. Brain Behav (2014) 0.85
Functional characterization of AT-1001, an α3β4 nicotinic acetylcholine receptor ligand, at human α3β4 and α4β2 nAChR. Nicotine Tob Res (2014) 0.84
Genetic analyses of smoking initiation, persistence, quantity, and age-at-onset of regular cigarette use in Brazilian families: the Baependi Heart Study. BMC Med Genet (2012) 0.84
Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. Genes Brain Behav (2015) 0.84
Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. Mol Psychiatry (2015) 0.83
A flexible Bayesian model for studying gene-environment interaction. PLoS Genet (2012) 0.83
C. elegans TRP channels. Adv Exp Med Biol (2011) 0.83
Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort. Am J Med Genet B Neuropsychiatr Genet (2012) 0.83
Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults. Nicotine Tob Res (2013) 0.82
Determining the causes and consequences of nicotine dependence: emerging genetic research methods. Curr Psychiatry Rep (2014) 0.82
Smoking and psychopathology increasingly associated in recent birth cohorts. Drug Alcohol Depend (2013) 0.82
A genetic instrumental variables analysis of the effects of prenatal smoking on birth weight: evidence from two samples. Biodemography Soc Biol (2011) 0.82
Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex. Cell Mol Life Sci (2014) 0.82
Personalized medicine and tobacco-related health disparities: is there a role for genetics? Ann Fam Med (2011) 0.80
NCK2 is significantly associated with opiates addiction in African-origin men. ScientificWorldJournal (2013) 0.80
Pharmacogenetics of chronic obstructive pulmonary disease: challenges and opportunities. Pharmacogenomics (2010) 0.80
Variants in the 15q24/25 locus associate with lung function decline in active smokers. PLoS One (2013) 0.80
A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction. Sci Rep (2016) 0.80
Variants in multiple genes polymorphism association analysis of COPD in the Chinese Li population. Int J Chron Obstruct Pulmon Dis (2015) 0.79
Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian population. Eur J Hum Genet (2011) 0.79
Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD. PLoS One (2012) 0.79
Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung Cancer (2016) 0.78
Translational research in nicotine dependence. Cold Spring Harb Perspect Med (2013) 0.77
New mechanisms and perspectives in nicotine withdrawal. Neuropharmacology (2014) 0.77
Are adolescents with ADHD interested in genetic testing for nicotine addiction susceptibility? Int J Environ Res Public Health (2010) 0.77
Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study. Biomed Res Int (2015) 0.77
Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study. PLoS One (2012) 0.77
Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine. Neurosci Lett (2013) 0.77
Familial aggregation of tobacco use behaviors among Amish men. Nicotine Tob Res (2014) 0.77
Large scale association analysis for drug addiction: results from SNP to gene. ScientificWorldJournal (2012) 0.76
A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study. Behav Brain Funct (2011) 0.76
High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice. Biochem Pharmacol (2015) 0.76
Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents. PLoS One (2014) 0.76
Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California. Am J Epidemiol (2011) 0.76
The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism. Psychopharmacology (Berl) (2013) 0.76
Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. Am J Med Genet B Neuropsychiatr Genet (2016) 0.75
Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. Genes (Basel) (2016) 0.75
The Impact of Cigarette Quitting during Pregnancy on Other Prenatal Health Behaviors. Rev Econ Househ (2013) 0.75
Combined genotype and haplotype tests for region-based association studies. BMC Genomics (2013) 0.75
A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment. Drug Alcohol Depend (2016) 0.75
Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey. BMC Public Health (2015) 0.75
Narrative review of genes, environment, and cigarettes. Ann Med (2016) 0.75
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Quantifying heterogeneity in a meta-analysis. Stat Med (2002) 83.16
Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet (1999) 23.67
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature (2008) 18.21
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet (2006) 13.16
Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet (2007) 12.27
Design of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Control Clin Trials (2000) 10.99
Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet (2006) 7.90
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry (2008) 6.37
Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev (2004) 4.68
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet (2006) 4.51
A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction (2003) 4.37
Smoking and smoking cessation in relation to mortality in women. JAMA (2008) 3.68
Rank truncated product of P-values, with application to genomewide association scans. Genet Epidemiol (2003) 3.34
Defining nicotine dependence for genetic research: evidence from Australian twins. Psychol Med (2004) 3.26
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet (2008) 3.25
A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence. Psychol Med (2004) 2.98
The genetic determinants of smoking. Chest (2003) 2.88
Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. J Psychoactive Drugs (2000) 2.82
Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Hum Mol Genet (2005) 2.80
Genomics: when the smoke clears ... Nature (2008) 2.72
A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels. Cell (2006) 2.68
Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog Brain Res (2000) 2.58
The genetics of nicotine dependence. Curr Psychiatry Rep (2006) 2.41
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine. Clin Pharmacol Ther (2006) 2.21
The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. J R Soc Med (1996) 1.98
Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. Clin Pharmacol Ther (2005) 1.96
Identifying susceptibility loci for nicotine dependence: 2008 update based on recent genome-wide linkage analyses. Hum Genet (2008) 1.94
A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence. Am J Med Genet A (2004) 1.88
The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial. Pharmacogenomics J (2004) 1.74
Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples. Am J Hum Genet (2007) 1.73
Assessing the function of genetic variants in candidate gene association studies. Nat Rev Genet (2004) 1.70
Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. Am J Med Genet B Neuropsychiatr Genet (2004) 1.67
Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers. Carcinogenesis (2004) 1.65
The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology (2007) 1.61
Monoamine oxidase and cigarette smoking. Neurotoxicology (2003) 1.57
Genetic variability in CYP2A6 and the pharmacokinetics of nicotine. Pharmacogenomics (2007) 1.56
Cigarette smoking. J Natl Cancer Inst (1999) 1.56
A genome-wide search for loci contributing to smoking and alcoholism. Genet Epidemiol (1999) 1.55
Genes and cigarette smoking. Addiction (2008) 1.55
Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokers. J Nucl Med (2005) 1.53
A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease. Neurology (1998) 1.52
Interacting effects of the serotonin transporter gene and neuroticism in smoking practices and nicotine dependence. Mol Psychiatry (2000) 1.44
Dopamine D4 receptors and the risk of cigarette smoking in African-Americans and Caucasians. Cancer Epidemiol Biomarkers Prev (1998) 1.41
An association of CYP2A6 genotype and smoking topography. Nicotine Tob Res (2007) 1.37
Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. Pharmacogenetics (1995) 1.35
Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity. J Neurosci (2007) 1.33
A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. Am J Hum Genet (2006) 1.31
Three haplotypes associated with CYP2A6 phenotypes in Caucasians. Pharmacogenet Genomics (2005) 1.26
A genome-wide screen for nicotine dependence susceptibility loci. Am J Med Genet B Neuropsychiatr Genet (2006) 1.25
Genetics of nicotine dependence and pharmacotherapy. Biochem Pharmacol (2007) 1.21
Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. Am J Med Genet B Neuropsychiatr Genet (2004) 1.21
Linkage analysis of smoking initiation and quantity in Dutch sibling pairs. Pharmacogenomics J (2004) 1.20
Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. Ther Drug Monit (2002) 1.19
Association between polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers. Pharmacogenetics (2000) 1.16
Monoamine oxidase and tobacco dependence. Neurotoxicology (2006) 1.15
The genetics of smoking related behavior: a brief review. Am J Med Sci (2003) 1.15
The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics. Cancer Epidemiol Biomarkers Prev (2007) 1.10
2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels. Am J Physiol Lung Cell Mol Physiol (2005) 1.08
Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample. Mol Psychiatry (2007) 1.08
Genomic screen for loci associated with tobacco usage in Mission Indians. BMC Med Genet (2006) 1.06
Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. Mol Psychiatry (2006) 1.02
The role of the serotonin transporter gene in cigarette smoking. Cancer Epidemiol Biomarkers Prev (1998) 1.01
Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. Hum Genet (2006) 1.01
Coronary heart disease and body mass index: a systematic review of the evidence from larger prospective cohort studies. Semin Vasc Med (2002) 0.99
A case-control study on cigarette, alcohol, and coffee consumption preceding Parkinson's disease. Neuroepidemiology (2003) 0.97
Integrative study designs--next step in the evolution of molecular epidemiology? Cancer Epidemiol Biomarkers Prev (2007) 0.97
Association between monoamine oxidase gene polymorphisms and smoking behaviour in Chinese males. Int J Neuropsychopharmacol (2005) 0.95
A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families. Hum Hered (2004) 0.93
Genome-wide linkage scan to identify Loci for age at first cigarette in Dutch sibling pairs. Behav Genet (2005) 0.92
Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk. Biochem Biophys Res Commun (2005) 0.89
Smoking behavior and related cancers: the role of CYP2A6 polymorphisms. Curr Opin Mol Ther (2007) 0.87
Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior. Pharmacogenet Genomics (2007) 0.87
Monoamine oxidase polymorphisms and smoking behaviour in Japanese. Pharmacogenetics (2003) 0.87
Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial. Nicotine Tob Res (2007) 0.85
Nicotine metabolism and CYP2D6 phenotype in smokers. Cancer Epidemiol Biomarkers Prev (2001) 0.85
A genome-wide linkage scan for body mass index on Framingham Heart Study families. BMC Genet (2003) 0.84
Genome-wide linkage analysis for smoking-related regions, with replication in two ethnically diverse populations. Nicotine Tob Res (2007) 0.83
A functional polymorphism in the promoter region of the monoamine oxidase A gene is associated with the cigarette smoking quantity in alcohol-dependent heavy smokers. Neuropsychobiology (2006) 0.83
Linkage for platelet monoamine oxidase (MAO) activity: results from a replication sample. Alcohol Clin Exp Res (2002) 0.83
Association of the serotonin transporter gene, neuroticism and smoking behaviours. J Hum Genet (2008) 0.81
Monoamine oxidase B polymorphism, cigarette smoking and risk of Parkinson's disease: a study in an Asian population. Am J Med Genet B Neuropsychiatr Genet (2003) 0.79
Should we consider gene x environment interaction in the hunt for quantitative trait loci? Genet Epidemiol (2001) 0.78
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst (2004) 19.00
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Replicating genotype-phenotype associations. Nature (2007) 16.11
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Statistics in medicine--reporting of subgroup analyses in clinical trials. N Engl J Med (2007) 12.55
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat Genet (2010) 9.07
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
Incidental meniscal findings on knee MRI in middle-aged and elderly persons. N Engl J Med (2008) 8.40
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet (2009) 8.39
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Genetic risk prediction--are we there yet? N Engl J Med (2009) 7.30
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr (2002) 6.96
Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet (2010) 6.60
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22
Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16
Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Performance of common genetic variants in breast-cancer risk models. N Engl J Med (2010) 5.79
A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med (2004) 5.68
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet (2009) 5.62
Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses' health study. Obstet Gynecol (2009) 5.59
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet (2013) 5.58
A twist code determines the onset of osteoblast differentiation. Dev Cell (2004) 5.40
The Diesel Exhaust in Miners study: a nested case-control study of lung cancer and diesel exhaust. J Natl Cancer Inst (2012) 5.27
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet (2005) 5.01
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Quality control and quality assurance in genotypic data for genome-wide association studies. Genet Epidemiol (2010) 4.83
ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst (2009) 4.72
SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes. Nucleic Acids Res (2006) 4.63
A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PLoS Genet (2008) 4.57
Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst (2010) 4.54
Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet (2010) 4.51