Published in Development on November 01, 1996
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol (2002) 10.95
Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J (2006) 3.26
Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev Cell (2009) 2.60
A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development (2009) 2.55
Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev (1998) 2.51
Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J Clin Invest (2000) 2.42
Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell (1997) 2.09
Planar polarization of node cells determines the rotational axis of node cilia. Nat Cell Biol (2010) 1.83
Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest (2006) 1.63
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Wnt signaling and pulmonary fibrosis. Am J Pathol (2003) 1.41
Comparative mechanisms of branching morphogenesis in diverse systems. J Mammary Gland Biol Neoplasia (2006) 1.39
Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol (2007) 1.33
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Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development (2009) 1.24
Defining and redefining the nephron progenitor population. Pediatr Nephrol (2011) 1.23
TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol (2007) 1.22
The RET-glial cell-derived neurotrophic factor (GDNF) pathway stimulates migration and chemoattraction of epithelial cells. J Cell Biol (1998) 1.22
Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells. J Biol Chem (2004) 1.22
Motor neurons with axial muscle projections specified by Wnt4/5 signaling. Neuron (2009) 1.22
SOX7 and SOX18 are essential for cardiogenesis in Xenopus. Dev Dyn (2005) 1.17
Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros. J Clin Invest (1999) 1.14
SOX9 controls epithelial branching by activating RET effector genes during kidney development. Hum Mol Genet (2011) 1.13
Wnt5a and Wnt11 are essential for second heart field progenitor development. Development (2012) 1.08
Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals. Mol Cell Biol (2010) 1.02
Wnt11-R signaling regulates a calcium sensitive EMT event essential for dorsal fin development of Xenopus. Dev Biol (2006) 0.99
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Wnt signaling in kidney development and disease. Organogenesis (2008) 0.98
Noncanonical Wnt11 signaling and cardiomyogenic differentiation. Trends Cardiovasc Med (2008) 0.96
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Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome. PLoS One (2010) 0.93
Intracellular and extracellular regulation of ureteric bud morphogenesis. J Anat (2001) 0.93
Stimulatory and inhibitory signaling molecules that regulate renal branching morphogenesis. Pediatr Nephrol (2008) 0.93
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The lectin Dolichos biflorus agglutinin is a sensitive indicator of branching morphogenetic activity in the developing mouse metanephric collecting duct system. J Anat (2007) 0.90
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The murine allantois: a model system for the study of blood vessel formation. Blood (2012) 0.87
Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol (2011) 0.87
A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development. PLoS One (2011) 0.86
Coordination of kidney organogenesis by Wnt signaling. Pediatr Nephrol (2014) 0.85
Aggregated P19 mouse embryonal carcinoma cells as a simple in vitro model to study the molecular regulations of mesoderm formation and axial elongation morphogenesis. Genesis (2009) 0.85
Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development. Glycoconj J (2003) 0.85
Genetic regulation of patterned tubular branching in Drosophila. Proc Natl Acad Sci U S A (2006) 0.83
Temporal changes in expression of FoxA1 and Wnt7A in isolated adult human alveolar epithelial cells enhanced by heparin. Anat Rec (Hoboken) (2010) 0.83
Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development. Dev Biol (2014) 0.82
Branching morphogenesis. Circ Res (2009) 0.82
Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development (2015) 0.80
Planar cell polarity signaling pathway in congenital heart diseases. J Biomed Biotechnol (2011) 0.80
The regulation of apoptosis in kidney development: implications for nephron number and pattern? Front Pediatr (2014) 0.79
Node retraction during patterning of the urinary collecting duct system. J Anat (2014) 0.79
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Signaling during Kidney Development. Cells (2015) 0.78
The ureteric bud epithelium: morphogenesis and roles in metanephric kidney patterning. Mol Reprod Dev (2015) 0.77
Stem cells and the formation of the myocardium in the vertebrate embryo. Anat Rec A Discov Mol Cell Evol Biol (2004) 0.77
TROP2 expressed in the trunk of the ureteric duct regulates branching morphogenesis during kidney development. PLoS One (2011) 0.76
LDL Receptor-Related Protein 6 Modulates Ret Proto-Oncogene Signaling in Renal Development and Cystic Dysplasia. J Am Soc Nephrol (2015) 0.76
Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner. PLoS One (2013) 0.76
Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling. J Cell Biol (2016) 0.75
Different populations of Wnt-containing vesicles are individually released from polarized epithelial cells. Sci Rep (2016) 0.75
A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia. Hum Mol Genet (2015) 0.75
Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol (1998) 10.58
Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (2001) 9.00
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development (2000) 8.07
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41
Fate of the mammalian cardiac neural crest. Development (2000) 6.79
Malignant glioma: genetics and biology of a grave matter. Genes Dev (2001) 6.78
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature (1994) 6.57
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. Biotechniques (2003) 5.49
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol (1995) 5.36
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72
Sonic hedgehog regulates growth and morphogenesis of the tooth. Development (2000) 4.71
Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J Clin Invest (1997) 4.51
Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron (2000) 4.17
Female development in mammals is regulated by Wnt-4 signalling. Nature (1999) 4.13
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87
Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol Cell Biol (2000) 3.84
Defects in enteric innervation and kidney development in mice lacking GDNF. Nature (1996) 3.82
Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77
Hedgehog signals regulate multiple aspects of gastrointestinal development. Development (2000) 3.77
Antibody-dependent cell-mediated cytotoxicity due to a "null" lymphoid cell. Nat New Biol (1973) 3.68
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development (1993) 3.66
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30
Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol (1998) 3.29
Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell (1987) 3.29
T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev (1999) 3.13
Wnt signalling required for expansion of neural crest and CNS progenitors. Nature (1997) 3.11
Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature (1999) 3.06
Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development (1998) 2.90
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell (2001) 2.84
The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78
A local Wnt-3a signal is required for development of the mammalian hippocampus. Development (2000) 2.75
Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature (1995) 2.73
Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development (1994) 2.73
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature (1999) 2.69
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell (2001) 2.65
Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol (1996) 2.59
Characterization of the antibody-dependent cytotoxic cell. A non-phagocytic monocyte? Clin Exp Immunol (1973) 2.53
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Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron (1999) 2.50
Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest (2001) 2.49
Cytotoxicity mediated by human Fc receptors for IgG. Immunol Today (1989) 2.47
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature (1995) 2.46
A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development (1987) 2.44
Regulation of pancreas development by hedgehog signaling. Development (2000) 2.43
Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development (2000) 2.39
Differential transformation of mammary epithelial cells by Wnt genes. Mol Cell Biol (1994) 2.37
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development (2001) 2.37
BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development (2001) 2.37
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Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev (1995) 2.22
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Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev (1998) 2.02
Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci (1999) 2.02
Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol (1997) 2.02
Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development (1991) 2.02
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development (1992) 1.99
The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol (2001) 1.98
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev (1990) 1.97
Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev (1996) 1.94
Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature (1998) 1.94
Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis. Dev Dyn (2000) 1.93
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev (1996) 1.92
Wnt5 is required for tail formation in the zebrafish embryo. Cold Spring Harb Symp Quant Biol (1997) 1.91
Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature (1996) 1.91
Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes. J Exp Med (1990) 1.89
CpG island methylation in colorectal adenomas. Am J Pathol (2001) 1.88
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell (2001) 1.88
Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol Cell Biol (1992) 1.88
Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol (2001) 1.77
Impact of cabazitaxel on 2-year survival and palliation of tumour-related pain in men with metastatic castration-resistant prostate cancer treated in the TROPIC trial. Ann Oncol (2013) 1.76
Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol (1998) 1.73
Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res (1994) 1.72
Polymorphonuclear leukocyte function triggered through the high affinity Fc receptor for monomeric IgG. J Immunol (1987) 1.72
Induced expression of syndecan in healing wounds. J Cell Biol (1991) 1.67
Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes Dev (1996) 1.65
Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag. J Immunol (1992) 1.65
Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur J Immunol (2001) 1.63
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. Neurology (2010) 1.63
Hedgehog signaling is required for pituitary gland development. Development (2001) 1.62
Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides. Mucosal Immunol (2012) 1.62