Molecular principles of hair follicle induction and morphogenesis.

A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell (2009) 5.40

Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell (2008) 5.02

Scratching the surface of skin development. Nature (2007) 4.61

Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27

Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92

Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev (2005) 3.67

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat Cell Biol (2008) 3.07

Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development (2009) 2.82

Lhx2 maintains stem cell character in hair follicles. Science (2006) 2.78

Skin stem cells: rising to the surface. J Cell Biol (2008) 2.66

BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev (2008) 2.41

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17

Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev (2006) 2.10

Paracrine TGF-β signaling counterbalances BMP-mediated repression in hair follicle stem cell activation. Cell Stem Cell (2012) 1.99

Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96

More than one way to skin . . . Genes Dev (2008) 1.95

Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development (2012) 1.89

Review of hair follicle dermal cells. J Dermatol Sci (2010) 1.72

Hair follicle dermal papilla cells at a glance. J Cell Sci (2011) 1.72

Generation of the primary hair follicle pattern. Proc Natl Acad Sci U S A (2006) 1.72

Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis. Mol Cell Biol (2006) 1.58

Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. J Invest Dermatol (2012) 1.48

In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators. Nat Cell Biol (2014) 1.35

Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development (2008) 1.32

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell (2007) 1.31

MicroRNA-mediated control in the skin. Cell Death Differ (2009) 1.30

An essential role for dermal primary cilia in hair follicle morphogenesis. J Invest Dermatol (2008) 1.22

Hairy tale of signaling in hair follicle development and cycling. Semin Cell Dev Biol (2012) 1.22

Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals. J Cell Physiol (2008) 1.21

Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle. J Cell Biol (2005) 1.20

Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development (2011) 1.15

Exploiting the keratin 17 gene promoter to visualize live cells in epithelial appendages of mice. Mol Cell Biol (2005) 1.14

Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis. J Invest Dermatol (2012) 1.13

Building epithelial tissues from skin stem cells. Cold Spring Harb Symp Quant Biol (2008) 1.12

Wnt signaling in skin development, homeostasis, and disease. Cold Spring Harb Perspect Biol (2013) 1.11

Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev (2013) 1.10

Heterogeneity and plasticity of epidermal stem cells. Development (2014) 1.08

A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia. Hum Genet (2008) 1.06

Forming patterns in development without morphogen gradients: scattered differentiation and sorting out. Cold Spring Harb Perspect Biol (2009) 1.06

Dissecting the bulge in hair regeneration. J Clin Invest (2012) 1.03

KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development (2009) 1.03

Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation. Dev Biol (2013) 1.02

TGF-β family signaling in stem cells. Biochim Biophys Acta (2012) 1.01

p53/p63/p73 in the epidermis in health and disease. Cold Spring Harb Perspect Med (2014) 1.01

Involvement of the Edar signaling in the control of hair follicle involution (catagen). Am J Pathol (2006) 1.01

Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation. J Cell Biol (2010) 1.00

Wnt signaling in skin organogenesis. Organogenesis (2008) 1.00

Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol (2011) 0.99

Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes. Am J Pathol (2005) 0.97

Signaling involved in hair follicle morphogenesis and development. Int J Mol Sci (2014) 0.97

The cycling hair follicle as an ideal systems biology research model. Exp Dermatol (2010) 0.95

Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering. Expert Opin Biol Ther (2013) 0.95

Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. J Invest Dermatol (2012) 0.93

Discovery of cashmere goat (Capra hircus) microRNAs in skin and hair follicles by Solexa sequencing. BMC Genomics (2013) 0.93

Genome-wide linkage analysis of an autosomal recessive hypotrichosis identifies a novel P2RY5 mutation. Genomics (2008) 0.92

Wound healing and skin regeneration. Cold Spring Harb Perspect Med (2015) 0.91

Exploring differentially expressed genes by RNA-Seq in cashmere goat (Capra hircus) skin during hair follicle development and cycling. PLoS One (2013) 0.91

Wls is expressed in the epidermis and regulates embryonic hair follicle induction in mice. PLoS One (2012) 0.90

Epithelial Skin Biology: Three Decades of Developmental Biology, a Hundred Questions Answered and a Thousand New Ones to Address. Curr Top Dev Biol (2016) 0.89

Biochemistry of epidermal stem cells. Biochim Biophys Acta (2012) 0.88

Molecular basis of hypohidrotic ectodermal dysplasia: an update. J Appl Genet (2015) 0.88

Matrix metalloproteinase-9 is involved in the regulation of hair canal formation. J Invest Dermatol (2010) 0.88

Expression of RNA-binding protein Musashi in hair follicle development and hair cycle progression. Am J Pathol (2006) 0.88

Towards an integrated experimental-theoretical approach for assessing the mechanistic basis of hair and feather morphogenesis. Interface Focus (2012) 0.87

A splice variant in KRT71 is associated with curly coat phenotype of Selkirk Rex cats. Sci Rep (2013) 0.87

Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia. Am J Pathol (2007) 0.87

Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in the P2RY5 gene. Exp Dermatol (2008) 0.87

Glucocorticoid receptors, epidermal homeostasis and hair follicle differentiation. Dermatoendocrinol (2011) 0.87

MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway. J Cell Biol (2014) 0.87

Differential expression of A-type and B-type lamins during hair cycling. PLoS One (2009) 0.84

Dermal papilla cells induce keratinocyte tubulogenesis in culture. Histochem Cell Biol (2010) 0.84

Stem cells in ectodermal development. J Mol Med (Berl) (2012) 0.84

Activating β-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity. FEBS J (2016) 0.83

A miR image of stem cells and their lineages. Curr Top Dev Biol (2012) 0.82

Differentiation of the sebaceous gland. Dermatoendocrinol (2009) 0.82

Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ (2012) 0.81

Bioengineering the hair follicle. Organogenesis (2007) 0.81

Deciphering principles of morphogenesis from temporal and spatial patterns on the integument. Dev Dyn (2015) 0.81

E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity. J Biol Chem (2010) 0.81

Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice. PLoS One (2010) 0.80

Modeling AEC-New approaches to study rare genetic disorders. Am J Med Genet A (2014) 0.80

Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development. Stem Cell Rev (2014) 0.79

Exploring Differentially Expressed Genes and Natural Antisense Transcripts in Sheep (Ovis aries) Skin with Different Wool Fiber Diameters by Digital Gene Expression Profiling. PLoS One (2015) 0.79

Expression of nucleosomal protein HMGN1 in the cycling mouse hair follicle. Gene Expr Patterns (2009) 0.79

Two waves of anisotropic growth generate enlarged follicles in the spiny mouse. Evodevo (2014) 0.79

Rho GTPases in embryonic development. Small GTPases (2014) 0.79

Derivation of hair-inducing cell from human pluripotent stem cells. PLoS One (2015) 0.79

Mesenchymal stem cells with modification of junctional adhesion molecule a induce hair formation. Stem Cells Transl Med (2014) 0.78

Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development (2015) 0.78

Ontogeny and Homeostasis of Adult Epithelial Skin Stem Cells. Stem Cell Rev (2012) 0.78

iRhom2 mutation leads to aberrant hair follicle differentiation in mice. PLoS One (2014) 0.78

Patterning skin by planar cell polarity: the multi-talented hair designer. Exp Dermatol (2012) 0.78

The M4 muscarinic acetylcholine receptor plays a key role in the control of murine hair follicle cycling and pigmentation. Life Sci (2007) 0.78

Epidermal stem cells and skin tissue engineering in hair follicle regeneration. World J Stem Cells (2015) 0.78

Early epithelial signaling center governs tooth budding morphogenesis. J Cell Biol (2016) 0.77

An Integrated Analysis of MicroRNA and mRNA Expression Profiles to Identify RNA Expression Signatures in Lambskin Hair Follicles in Hu Sheep. PLoS One (2016) 0.77

Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ. Dermatoendocrinol (2009) 0.76

SNP Discovery from Transcriptome of Cashmere Goat Skin. Asian-Australas J Anim Sci (2015) 0.76

The Biology and Husbandry of the African Spiny Mouse (Acomys cahirinus) and the Research Uses of a Laboratory Colony. J Am Assoc Lab Anim Sci (2016) 0.76

Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages. Exp Cell Res (2014) 0.76

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature (2010) 2.85

Alopecia areata. N Engl J Med (2012) 2.56

The hair follicle as a dynamic miniorgan. Curr Biol (2009) 2.52

Exploring the "hair growth-wound healing connection": anagen phase promotes wound re-epithelialization. J Invest Dermatol (2010) 2.48

IL-15/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine Growth Factor Rev (2006) 2.29

Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J (2005) 2.23

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17

Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev (2006) 2.10

IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. Nat Med (2007) 2.00

Hair follicle pigmentation. J Invest Dermatol (2005) 1.84

Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol (2006) 1.72

Retracted A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control. EMBO J (2005) 1.72

Neuroimmunology of stress: skin takes center stage. J Invest Dermatol (2006) 1.72

The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling. Bioessays (2006) 1.70

NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development (2006) 1.66

Neuronal plasticity of the "brain-skin connection": stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways. J Mol Med (Berl) (2007) 1.58

Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest (2007) 1.56

Cylindroma as tumor of hair follicle origin. J Invest Dermatol (2006) 1.56

Mast cells are required for normal healing of skin wounds in mice. FASEB J (2006) 1.50

Circadian clock genes contribute to the regulation of hair follicle cycling. PLoS Genet (2009) 1.49

Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol (2008) 1.47

Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche. Exp Dermatol (2008) 1.43

Thyrotropin-releasing hormone selectively stimulates human hair follicle pigmentation. J Invest Dermatol (2011) 1.43

Molecular biology of hair morphogenesis: development and cycling. J Exp Zool B Mol Dev Evol (2003) 1.36

Neuropeptide control mechanisms in cutaneous biology: physiological and clinical significance. J Invest Dermatol (2006) 1.33

Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control. J Invest Dermatol (2003) 1.32

A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. Am J Pathol (2005) 1.27

Migration of melanoblasts into the developing murine hair follicle is accompanied by transient c-Kit expression. J Histochem Cytochem (2002) 1.26

Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia. J Invest Dermatol (2004) 1.24

Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin. Mol Cell Biol (2010) 1.23

Exploring the role of stem cells in cutaneous wound healing. Exp Dermatol (2009) 1.23

Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways. Am J Pathol (2003) 1.22

Developmental timing of hair follicle and dorsal skin innervation in mice. J Comp Neurol (2002) 1.20

The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization. Exp Dermatol (2009) 1.20

Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab (2007) 1.20

Skin as an endocrine organ: implications for its function. Drug Discov Today Dis Mech (2008) 1.19

Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. J Invest Dermatol (2007) 1.18

Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. FASEB J (2003) 1.17

p75 Neurotrophin receptor antagonist retards apoptosis-driven hair follicle involution (catagen). J Invest Dermatol (2003) 1.16

Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses. Eur J Immunol (2003) 1.16

Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab (2008) 1.15

Retracted Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B. J Biol Chem (2002) 1.15

Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development (2011) 1.15

Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit. Proc Natl Acad Sci U S A (2011) 1.13

Hair growth inhibition by psychoemotional stress: a mouse model for neural mechanisms in hair growth control. Exp Dermatol (2006) 1.13

Hair follicle stem cells: walking the maze. Eur J Cell Biol (2007) 1.12

The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am J Pathol (2002) 1.11

How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha. Mol Cell Biol (2008) 1.11

Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control. Bioessays (2007) 1.11

Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo. J Invest Dermatol (2003) 1.10

FOXN1 is critical for onycholemmal terminal differentiation in nude (Foxn1) mice. J Invest Dermatol (2004) 1.10

Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions. Immunity (2009) 1.10

The pathogenesis of primary cicatricial alopecias. Am J Pathol (2010) 1.09

From the brain-skin connection: the neuroendocrine-immune misalliance of stress and itch. Neuroimmunomodulation (2007) 1.07

Activation of transient receptor potential vanilloid-3 inhibits human hair growth. J Invest Dermatol (2011) 1.05

A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors. FASEB J (2005) 1.03

A guide to assessing damage response pathways of the hair follicle: lessons from cyclophosphamide-induced alopecia in mice. J Invest Dermatol (2005) 1.03

The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells (2011) 1.03

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. J Immunol (2009) 1.03

Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp Dermatol (2008) 1.03

TRP channels as novel players in the pathogenesis and therapy of itch. Biochim Biophys Acta (2007) 1.02

Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture. Exp Dermatol (2009) 1.02

Prolactin and the skin: a dermatological perspective on an ancient pleiotropic peptide hormone. J Invest Dermatol (2008) 1.01

Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. Am J Pathol (2004) 1.01

Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice. Am J Pathol (2008) 1.01

Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition. J Mol Med (Berl) (2005) 1.01

Vanilloid receptor-1 (VR1) is widely expressed on various epithelial and mesenchymal cell types of human skin. J Invest Dermatol (2004) 1.01

Autoimmune disease induction in a healthy human organ: a humanized mouse model of alopecia areata. J Invest Dermatol (2012) 1.00

Immunology of the human nail apparatus: the nail matrix is a site of relative immune privilege. J Invest Dermatol (2005) 0.99

The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends Pharmacol Sci (2009) 0.99

Towards the development of a simplified long-term organ culture method for human scalp skin and its appendages under serum-free conditions. Exp Dermatol (2007) 0.99

Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology. J Invest Dermatol (2008) 0.99

'Fish matters': the relevance of fish skin biology to investigative dermatology. Exp Dermatol (2010) 0.99

The hair follicle as an estrogen target and source. Endocr Rev (2006) 0.99

Learning from nudity: lessons from the nude phenotype. Exp Dermatol (2005) 0.99

Sebocytes, multifaceted epithelial cells: lipid production and holocrine secretion. Int J Biochem Cell Biol (2009) 0.98

Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling. Am J Pathol (2004) 0.98

Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin. FASEB J (2007) 0.98

Kit is expressed by epithelial cells in vivo. J Invest Dermatol (2003) 0.98

Probing the effects of stress mediators on the human hair follicle: substance P holds central position. Am J Pathol (2007) 0.97

A practical guide for the study of human and murine sebaceous glands in situ. Exp Dermatol (2013) 0.97

Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes. Am J Pathol (2005) 0.97

Neurotrophins in skin biology and pathology. J Invest Dermatol (2006) 0.97

An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic? Exp Dermatol (2010) 0.96

A human folliculoid microsphere assay for exploring epithelial- mesenchymal interactions in the human hair follicle. J Invest Dermatol (2008) 0.96

Zinc as an ambivalent but potent modulator of murine hair growth in vivo- preliminary observations. Exp Dermatol (2005) 0.96

Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor. Am J Pathol (2004) 0.95

Thyrotropin releasing hormone (TRH): a new player in human hair-growth control. FASEB J (2009) 0.95

The cycling hair follicle as an ideal systems biology research model. Exp Dermatol (2010) 0.95

Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche. J Pathol (2013) 0.95

Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin. J Invest Dermatol (2008) 0.95

Plasticity and cytokinetic dynamics of the hair follicle mesenchyme during the hair growth cycle: implications for growth control and hair follicle transformations. J Investig Dermatol Symp Proc (2003) 0.95

Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1. J Invest Dermatol (2011) 0.94

Retracted Mast cells express novel functional IL-15 receptor alpha isoforms. J Immunol (2003) 0.94

Endocannabinoids limit excessive mast cell maturation and activation in human skin. J Allergy Clin Immunol (2012) 0.94

Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones. Endocrinology (2010) 0.94

Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: an update. J Dermatol Sci (2012) 0.93

Melatonin and the hair follicle. J Pineal Res (2008) 0.93

Human epithelial hair follicle stem cells and their progeny: current state of knowledge, the widening gap in translational research and future challenges. Bioessays (2014) 0.93

Interleukin-15 stimulates macrophages to activate CD4+ T cells: a role in the pathogenesis of rheumatoid arthritis? Immunology (2008) 0.93