Innate immune sensing of HIV-1 by dendritic cells.

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science (2013) 3.61

A Blueprint for HIV Vaccine Discovery. Cell Host Microbe (2012) 3.27

Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem (2013) 1.76

CD169-mediated trafficking of HIV to plasma membrane invaginations in dendritic cells attenuates efficacy of anti-gp120 broadly neutralizing antibodies. PLoS Pathog (2015) 1.45

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis. EMBO J (2014) 1.16

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. J Virol (2013) 1.09

HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation. J Biol Chem (2013) 1.01

Endogenous retroviruses and the development of cancer. J Immunol (2014) 0.97

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1. Cell (2015) 0.94

Interactions between HIV-1 and the cell-autonomous innate immune system. Cell Host Microbe (2014) 0.86

CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination. J Infect Dis (2014) 0.85

HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms. J Virol (2014) 0.85

Safeguard against DNA sensing: the role of TREX1 in HIV-1 infection and autoimmune diseases. Front Microbiol (2014) 0.84

Dendritic cell-lymphocyte cross talk downregulates host restriction factor SAMHD1 and stimulates HIV-1 replication in dendritic cells. J Virol (2014) 0.84

Mouse knockout models for HIV-1 restriction factors. Cell Mol Life Sci (2014) 0.83

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization. J Am Chem Soc (2014) 0.83

A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Biomol Screen (2015) 0.82

HIV-1 vaginal transmission: cell-free or cell-associated virus? Am J Reprod Immunol (2014) 0.81

Characterization of HIV-1 infection and innate sensing in different types of primary human monocyte-derived macrophages. Mediators Inflamm (2013) 0.80

Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile α Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors. J Biol Chem (2015) 0.79

Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells. J Virol (2015) 0.78

Development of human dendritic cells and their role in HIV infection: antiviral immunity versus HIV transmission. Front Microbiol (2013) 0.77

A Chimeric HIV-1 gp120 Fused with Vaccinia Virus 14K (A27) Protein as an HIV Immunogen. PLoS One (2015) 0.77

Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells. Cell Rep (2015) 0.77

Sindbis Virus Can Exploit a Host Antiviral Protein To Evade Immune Surveillance. J Virol (2016) 0.76

Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion. J Immunol (2016) 0.76

Optimization of human dendritic cell sample preparation for mass spectrometry-based proteomic studies. Anal Biochem (2015) 0.75

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3. Nat Immunol (2016) 0.75

Keeping your armour intact: how HIV-1 evades detection by the innate immune system: HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS. Bioessays (2014) 0.75

HIV fusion in Dendritic cells mainly occurs at the surface and is limited by low CD4 levels. J Virol (2017) 0.75

A molecular dynamics simulation study decodes the early stage of the disassembly process abolishing the human SAMHD1 function. J Comput Aided Mol Des (2017) 0.75

Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling. EMBO J (2017) 0.75

The innate immune roles of host factors TRIM5α and Cyclophilin A on HIV-1 replication. Med Microbiol Immunol (2015) 0.75

Pathogen recognition and innate immunity. Cell (2006) 44.14

Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med (2009) 28.62

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature (2006) 20.00

The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature (2004) 17.56

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med (2006) 13.15

Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial. Lancet (2012) 12.41

Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature (2007) 11.73

Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity (2007) 10.83

Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature (2009) 9.51

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature (2011) 9.30

HIV preferentially infects HIV-specific CD4+ T cells. Nature (2002) 9.28

IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol (2010) 8.97

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med (2001) 8.60

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med (2009) 8.45

Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature (2011) 7.92

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature (2012) 7.76

GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature (1992) 7.41

Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1. Nature (2004) 7.10

Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain. Proc Natl Acad Sci U S A (2005) 6.85

Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci U S A (2006) 6.82

Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature (2005) 6.78

Visualization of the intracellular behavior of HIV in living cells. J Cell Biol (2002) 6.59

Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity (2012) 6.29

TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature (2011) 6.29

Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science (2003) 6.22

SLAM (CDw150) is a cellular receptor for measles virus. Nature (2000) 6.07

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response. Nat Genet (2009) 5.84

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol (2012) 5.71

Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science (1992) 5.61

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature (2010) 5.45

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol (2011) 5.34

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature (2011) 5.28

Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection. Nat Genet (2006) 5.26

Dendritic cells in a mature age. Nat Rev Immunol (2006) 5.03

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J Clin Invest (2005) 5.00

Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction. J Virol (2005) 4.64

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol (2010) 4.58

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med (2009) 4.27

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells. Nat Med (2012) 4.27

Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat Immunol (2005) 4.22

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus. Nature (2002) 4.20

Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell (1994) 4.04

Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity (2011) 3.74

SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells. Retrovirology (2007) 3.51

Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity (2008) 3.48

Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell (2010) 3.42

Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection. PLoS Pathog (2012) 3.35

Successful transmission of a retrovirus depends on the commensal microbiota. Science (2011) 3.34

Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. PLoS Pathog (2008) 3.27

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe (2012) 3.23

Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. J Biol Chem (2011) 3.21

Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J Virol (2004) 3.12

Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J Biol Chem (2004) 3.10

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity. Hum Mol Genet (2009) 3.07

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction. PLoS Pathog (2008) 2.72

Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol (2009) 2.70

Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur J Immunol (2008) 2.59

The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection. J Virol (2009) 2.57

Human immunodeficiency virus type 1 population genetics and adaptation in newly infected individuals. J Virol (2008) 2.56

HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1. Proc Natl Acad Sci U S A (2007) 2.50

Best practices in dengue surveillance: a report from the Asia-Pacific and Americas Dengue Prevention Boards. PLoS Negl Trop Dis (2010) 2.45

Hexagonal assembly of a restricting TRIM5alpha protein. Proc Natl Acad Sci U S A (2010) 2.40

Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection. J Pediatr (2003) 2.38

HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc Natl Acad Sci U S A (2004) 2.38

Immunology and the elusive AIDS vaccine. Nature (2010) 2.26

Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages. J Biol Chem (2012) 2.25

With a little help from a friend: increasing HIV transduction of monocyte-derived dendritic cells with virion-like particles of SIV(MAC). Gene Ther (2006) 2.24

HIV superinfection. J Infect Dis (2005) 2.20

Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases. J Virol (2005) 2.17

The interaction of HIV with dendritic cells: outcomes and pathways. Trends Immunol (2007) 2.03

Natural SIV hosts: showing AIDS the door. Science (2012) 2.03

DCs and NK cells: critical effectors in the immune response to HIV-1. Nat Rev Immunol (2011) 1.98

Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells. J Virol (2005) 1.97

DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation. Blood (2003) 1.89

Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells. J Virol (2011) 1.85

Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1. PLoS Biol (2012) 1.79

Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells. J Virol (2006) 1.77

High levels of transduction of human dendritic cells with optimized SIV vectors. Mol Ther (2002) 1.73

Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages. J Biol Chem (2010) 1.70

HIV-2: the forgotten AIDS virus. Trends Microbiol (2008) 1.66

Revisiting immune exhaustion during HIV infection. Curr HIV/AIDS Rep (2011) 1.62

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape. PLoS Pathog (2012) 1.61

Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer. Blood (2006) 1.58

Features of the dendritic cell lineage. Immunol Rev (2010) 1.58

Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo. Proc Natl Acad Sci U S A (2011) 1.56

RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. J Virol (2010) 1.55

A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1-derived lentiviral vectors. Nat Protoc (2011) 1.54

Cyclophilin, TRIM5, and innate immunity to HIV-1. Curr Opin Microbiol (2006) 1.48

Innate immune sensing of retroviral infection via Toll-like receptor 7 occurs upon viral entry. Immunity (2011) 1.42

HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation. Blood (2004) 1.42

Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+ T helper cells and CD4+ CD25hi T regulatory cells. Eur J Immunol (2005) 1.42

Human Trim5α has additional activities that are uncoupled from retroviral capsid recognition. Virology (2010) 1.40

Myd88 is required for an antibody response to retroviral infection. PLoS Pathog (2009) 1.35

Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12. EMBO J (2000) 1.34

Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon. Retrovirology (2011) 1.32

Progress in the rational design of an AIDS vaccine. Philos Trans R Soc Lond B Biol Sci (2011) 1.28

CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction. PLoS Pathog (2012) 1.28

An autoimmune disease prevented by anti-retroviral drugs. Retrovirology (2011) 1.25