WDR5, a complexed protein.

The super elongation complex (SEC) and MLL in development and disease. Genes Dev (2011) 2.63

Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J Biol Chem (2009) 2.23

Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry (2010) 1.74

H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell (2014) 1.68

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance. Nat Struct Mol Biol (2012) 1.64

Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia. Mol Cell (2014) 1.52

WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Mol Cell (2010) 1.50

Keeping it in the family: diverse histone recognition by conserved structural folds. Crit Rev Biochem Mol Biol (2010) 1.29

X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. Mol Cell (2011) 1.29

Mixed lineage leukemia: a structure-function perspective of the MLL1 protein. FEBS J (2010) 1.28

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes. Mol Cell Biol (2013) 1.27

Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination. Cell (2013) 1.16

Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. Elife (2014) 1.16

Noncoding RNAs and enhancers: complications of a long-distance relationship. Trends Genet (2011) 1.13

Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1. J Biol Chem (2010) 1.12

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J (2013) 1.12

WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Proc Natl Acad Sci U S A (2009) 1.08

Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language". Chembiochem (2010) 1.06

Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci (2016) 1.04

A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer. Mol Cell (2014) 1.02

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex. Genes Dev (2014) 0.99

Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction. J Med Chem (2010) 0.97

ATX1-generated H3K4me3 is required for efficient elongation of transcription, not initiation, at ATX1-regulated genes. PLoS Genet (2012) 0.92

Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications. Mol Cancer (2016) 0.90

Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation. Cell Rep (2013) 0.87

WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2. J Biol Chem (2011) 0.86

Site-specific and regiospecific installation of methylarginine analogues into recombinant histones and insights into effector protein binding. J Am Chem Soc (2013) 0.85

Chromatin modifications sequentially enhance ErbB2 expression in ErbB2-positive breast cancers. Cell Rep (2013) 0.85

Synergistic effect of SRY and its direct target, WDR5, on Sox9 expression. PLoS One (2012) 0.85

The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression. J Genomics (2015) 0.84

Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes. Mol Cell Biol (2013) 0.83

Variants in CUL4B are associated with cerebral malformations. Hum Mutat (2015) 0.82

Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function. Cell Rep (2014) 0.80

WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission. J Biol Chem (2015) 0.79

Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx. Virology (2014) 0.79

WDR5 Expression Is Prognostic of Breast Cancer Outcome. PLoS One (2015) 0.78

Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters. Oncogene (2014) 0.78

The role of WDR5 in silencing human fetal globin gene expression. Haematologica (2012) 0.78

MLL1/WDR5 complex in leukemogenesis and epigenetic regulation. Chin J Cancer (2011) 0.78

Protein and DNA modifications: evolutionary imprints of bacterial biochemical diversification and geochemistry on the provenance of eukaryotic epigenetics. Cold Spring Harb Perspect Biol (2014) 0.77

WDR5 high expression and its effect on tumorigenesis in leukemia. Oncotarget (2016) 0.77

Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. Elife (2016) 0.75

The TrxG Complex Mediates Cytokine Induced De Novo Enhancer Formation in Islets. PLoS One (2015) 0.75

WDR82 Negatively Regulates Cellular Antiviral Response by Mediating TRAF3 Polyubiquitination in Multiple Cell Lines. J Immunol (2015) 0.75

PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407. Cell Death Dis (2017) 0.75

The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry. Nat Commun (2017) 0.75

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation. Nat Commun (2017) 0.75

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86

Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem (2006) 8.66

Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03

The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J (2001) 5.34

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A (2001) 5.19

Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. Curr Opin Cell Biol (2008) 4.25

COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05

Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. Mol Cell (2006) 3.98

Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol (2006) 3.54

Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription. Mol Cell (2005) 2.97

Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol Cell (2005) 2.89

Molecular recognition of histone H3 by the WD40 protein WDR5. Nat Struct Mol Biol (2006) 2.55

Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks. Mol Cell (2009) 2.32

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat Struct Mol Biol (2006) 2.29

Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem (2008) 2.19

CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes. Mol Cell Biol (2008) 2.10

Structural basis for molecular recognition and presentation of histone H3 by WDR5. EMBO J (2006) 2.08

Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Mol Cell (2006) 2.02

ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Nat Struct Mol Biol (2008) 1.90

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket. J Biol Chem (2008) 1.77

Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. J Biol Chem (2008) 1.66

A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex. J Biol Chem (2008) 1.61

Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains. EMBO J (2005) 1.55

Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. J Biol Chem (2009) 1.28

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47

Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13

RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell (2010) 4.99

Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem (2002) 4.75

Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49

Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell (2007) 4.49

An operational definition of epigenetics. Genes Dev (2009) 4.26

Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol (2007) 4.17

COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05

Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82

The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem (2003) 3.81

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66

Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol (2006) 3.54

Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol (2009) 3.26

The language of histone crosstalk. Cell (2010) 3.18

Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell (2009) 2.91

Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol Cell (2005) 2.89

Histone modification: cause or cog? Trends Genet (2011) 2.85

Transcriptional elongation by RNA polymerase II and histone methylation. J Biol Chem (2003) 2.76

The super elongation complex (SEC) and MLL in development and disease. Genes Dev (2011) 2.63

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev (2010) 2.53

Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell (2011) 2.53

Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. J Biol Chem (2006) 2.45

Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol (2008) 2.34

Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell (2007) 2.29

Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24

Cse4 is part of an octameric nucleosome in budding yeast. Mol Cell (2009) 2.23

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat Struct Mol Biol (2008) 2.22

The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell (2010) 2.06

The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol (2007) 2.05

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev (2012) 2.04

The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS. Mol Cell (2005) 1.99

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription. J Biol Chem (2009) 1.94

Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol (2007) 1.89

A COMPASS in the voyage of defining the role of trithorax/MLL-containing complexes: linking leukemogensis to covalent modifications of chromatin. J Cell Biochem (2005) 1.88

The super elongation complex (SEC) family in transcriptional control. Nat Rev Mol Cell Biol (2012) 1.78

A site to remember: H3K36 methylation a mark for histone deacetylation. Mutat Res (2007) 1.77

Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC). Genes Dev (2011) 1.77

Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer (2010) 1.77

ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc Natl Acad Sci U S A (2005) 1.69

The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54

Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci U S A (2006) 1.54

Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. J Cell Biol (2009) 1.52

Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol Cell (2005) 1.51

Ctk complex-mediated regulation of histone methylation by COMPASS. Mol Cell Biol (2006) 1.50

The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output. Mol Cell Biol (2012) 1.49

Leaving a mark: the many footprints of the elongating RNA polymerase II. Curr Opin Genet Dev (2006) 1.46

Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Mol Genet Genomics (2006) 1.42

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. Mol Cell Biol (2013) 1.35

dELL is an essential RNA polymerase II elongation factor with a general role in development. Proc Natl Acad Sci U S A (2002) 1.34

The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation. Cell (2012) 1.33

Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol (2008) 1.32

Dot1 and histone H3K79 methylation in natural telomeric and HM silencing. Mol Cell (2011) 1.32

The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol (2010) 1.32

Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb. Cell Cycle (2006) 1.31

Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL. Proc Natl Acad Sci U S A (2008) 1.30

Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123. Genes Dev (2011) 1.30

Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol (2007) 1.26

Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage. J Biol Chem (2005) 1.23

Cross-talking histones: implications for the regulation of gene expression and DNA repair. Biochem Cell Biol (2005) 1.22

SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci (2013) 1.22

The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells. Nat Struct Mol Biol (2013) 1.21

The JARID2-PRC2 duality. Genes Dev (2010) 1.18

Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1. Mol Cell Biol (2009) 1.18

Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation. Nat Cell Biol (2005) 1.15

Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human. Proc Natl Acad Sci U S A (2011) 1.12

Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol Cell Biol (2012) 1.10

Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1. Genes Dev (2012) 1.09

Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A. J Biol Chem (2004) 1.08

Global proteomic analysis of S. cerevisiae (GPS) to identify proteins required for histone modifications. Methods Enzymol (2004) 1.07

The little elongation complex regulates small nuclear RNA transcription. Mol Cell (2011) 1.06

Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL. Mol Cell Biol (2003) 1.04

Histone demethylation by hydroxylation: chemistry in action. ACS Chem Biol (2006) 1.01

In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development. Mol Cell Biol (2004) 1.01

Transcriptional elongation checkpoint control in development and disease. Genes Dev (2013) 0.98

SnapShot: Histone lysine methylase complexes. Cell (2012) 0.92

Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation. Genes Dev (2014) 0.91

Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster. Mol Cell Biol (2005) 0.90

Developmental biology. Histone cross-talk in stem cells. Science (2009) 0.88

The curious case of bivalent marks. Dev Cell (2009) 0.87

Drosophila SETs its sights on cancer: Trr/MLL3/4 COMPASS-like complexes in development and disease. Mol Cell Biol (2013) 0.87

The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Mol Cell (2013) 0.86

Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche. Development (2013) 0.86

A conserved patch near the C terminus of histone H4 is required for genome stability in budding yeast. Mol Cell Biol (2011) 0.85

The A, B, Gs of silencing. Genes Dev (2007) 0.84

Posttranslational modifications of histones by methylation. Adv Protein Chem (2004) 0.81

Packing for the germy: the role of histone H4 Ser1 phosphorylation in chromatin compaction and germ cell development. Genes Dev (2006) 0.81

Structural basis for H3K4 trimethylation by yeast Set1/COMPASS. Adv Enzyme Regul (2009) 0.79

Guided by COMPASS on a journey through chromosome segregation. Nat Struct Mol Biol (2005) 0.78

Transcriptional blackjack with p21. Genes Dev (2006) 0.78

Medicine. (Poly)combing the pediatric cancer genome for answers. Science (2013) 0.77

Preparation and assay of RNA polymerase II elongation factors elongin and ELL. Methods Enzymol (2003) 0.77

Global proteomic analysis of Saccharomyces cerevisiae identifies molecular pathways of histone modifications. Methods Mol Biol (2009) 0.76

A histone modifier's ill-gotten copy gains. Cell (2013) 0.76