Published in J Cell Biochem on June 01, 2005
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell (2010) 4.99
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature (2007) 4.35
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. Curr Opin Cell Biol (2008) 4.25
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Annu Rev Biochem (2012) 3.61
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol (2009) 3.26
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Res (2010) 2.37
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol (2008) 2.34
Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination. Cell (2011) 2.30
Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24
DNA topoisomerase II, genotoxicity, and cancer. Mutat Res (2007) 1.95
The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell (2005) 1.94
Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet (2011) 1.58
SRA-domain proteins required for DRM2-mediated de novo DNA methylation. PLoS Genet (2008) 1.57
Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci U S A (2006) 1.54
Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1. Mol Cell Biol (2009) 1.18
The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res (2012) 1.15
Histone demethylases and cancer. Adv Cancer Res (2009) 1.05
The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. Blood (2011) 1.02
A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans. PLoS Genet (2011) 0.99
The structure of the FYR domain of transforming growth factor beta regulator 1. Protein Sci (2010) 0.95
DPY30 regulates pathways in cellular senescence through ID protein expression. EMBO J (2013) 0.92
Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1). Epigenetics Chromatin (2010) 0.86
Trithorax group protein Oryza sativa Trithorax1 controls flowering time in rice via interaction with early heading date3. Plant Physiol (2014) 0.86
Genomic hallmarks of genes involved in chromosomal translocations in hematological cancer. PLoS Comput Biol (2012) 0.83
Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation. PLoS One (2012) 0.83
hSET1: a novel approach for colon cancer therapy. Biochem Pharmacol (2009) 0.83
Absent, small or homeotic 2-like protein (ASH2L) enhances the transcription of the estrogen receptor α gene through GATA-binding protein 3 (GATA3). J Biol Chem (2014) 0.81
Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report. Leukemia (2013) 0.80
Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. G3 (Bethesda) (2015) 0.77
The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer. Biochim Biophys Acta (2017) 0.76
Writing, erasing and reading histone lysine methylations. Exp Mol Med (2017) 0.75
Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults. BMC Genomics (2017) 0.75
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell (2010) 4.99
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem (2002) 4.75
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49
Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell (2007) 4.49
An operational definition of epigenetics. Genes Dev (2009) 4.26
Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol (2007) 4.17
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem (2003) 3.81
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol (2006) 3.54
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol (2009) 3.26
The language of histone crosstalk. Cell (2010) 3.18
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell (2009) 2.91
Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol Cell (2005) 2.89
Histone modification: cause or cog? Trends Genet (2011) 2.85
Transcriptional elongation by RNA polymerase II and histone methylation. J Biol Chem (2003) 2.76
The super elongation complex (SEC) and MLL in development and disease. Genes Dev (2011) 2.63
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev (2010) 2.53
Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell (2011) 2.53
Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. J Biol Chem (2006) 2.45
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol (2008) 2.34
Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell (2007) 2.29
Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24
Cse4 is part of an octameric nucleosome in budding yeast. Mol Cell (2009) 2.23
A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat Struct Mol Biol (2008) 2.22
The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell (2010) 2.06
The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol (2007) 2.05
Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev (2012) 2.04
The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS. Mol Cell (2005) 1.99
Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription. J Biol Chem (2009) 1.94
Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol (2007) 1.89
The super elongation complex (SEC) family in transcriptional control. Nat Rev Mol Cell Biol (2012) 1.78
A site to remember: H3K36 methylation a mark for histone deacetylation. Mutat Res (2007) 1.77
Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC). Genes Dev (2011) 1.77
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer (2010) 1.77
ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc Natl Acad Sci U S A (2005) 1.69
The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54
Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci U S A (2006) 1.54
Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. J Cell Biol (2009) 1.52
WDR5, a complexed protein. Nat Struct Mol Biol (2009) 1.51
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol Cell (2005) 1.51
Ctk complex-mediated regulation of histone methylation by COMPASS. Mol Cell Biol (2006) 1.50
The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output. Mol Cell Biol (2012) 1.49
Leaving a mark: the many footprints of the elongating RNA polymerase II. Curr Opin Genet Dev (2006) 1.46
Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Mol Genet Genomics (2006) 1.42
The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. Mol Cell Biol (2013) 1.35
dELL is an essential RNA polymerase II elongation factor with a general role in development. Proc Natl Acad Sci U S A (2002) 1.34
The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation. Cell (2012) 1.33
Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol (2008) 1.32
Dot1 and histone H3K79 methylation in natural telomeric and HM silencing. Mol Cell (2011) 1.32
The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol (2010) 1.32
Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb. Cell Cycle (2006) 1.31
Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL. Proc Natl Acad Sci U S A (2008) 1.30
Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123. Genes Dev (2011) 1.30
Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol (2007) 1.26
Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage. J Biol Chem (2005) 1.23
Cross-talking histones: implications for the regulation of gene expression and DNA repair. Biochem Cell Biol (2005) 1.22
SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci (2013) 1.22
The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells. Nat Struct Mol Biol (2013) 1.21
The JARID2-PRC2 duality. Genes Dev (2010) 1.18
Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1. Mol Cell Biol (2009) 1.18
Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation. Nat Cell Biol (2005) 1.15
Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human. Proc Natl Acad Sci U S A (2011) 1.12
Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol Cell Biol (2012) 1.10
Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1. Genes Dev (2012) 1.09
Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A. J Biol Chem (2004) 1.08
Global proteomic analysis of S. cerevisiae (GPS) to identify proteins required for histone modifications. Methods Enzymol (2004) 1.07
The little elongation complex regulates small nuclear RNA transcription. Mol Cell (2011) 1.06
Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL. Mol Cell Biol (2003) 1.04
Histone demethylation by hydroxylation: chemistry in action. ACS Chem Biol (2006) 1.01
In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development. Mol Cell Biol (2004) 1.01
Transcriptional elongation checkpoint control in development and disease. Genes Dev (2013) 0.98
SnapShot: Histone lysine methylase complexes. Cell (2012) 0.92
Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation. Genes Dev (2014) 0.91
Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster. Mol Cell Biol (2005) 0.90
Developmental biology. Histone cross-talk in stem cells. Science (2009) 0.88
The curious case of bivalent marks. Dev Cell (2009) 0.87
Drosophila SETs its sights on cancer: Trr/MLL3/4 COMPASS-like complexes in development and disease. Mol Cell Biol (2013) 0.87
The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Mol Cell (2013) 0.86
Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche. Development (2013) 0.86
A conserved patch near the C terminus of histone H4 is required for genome stability in budding yeast. Mol Cell Biol (2011) 0.85
The A, B, Gs of silencing. Genes Dev (2007) 0.84
Posttranslational modifications of histones by methylation. Adv Protein Chem (2004) 0.81
Packing for the germy: the role of histone H4 Ser1 phosphorylation in chromatin compaction and germ cell development. Genes Dev (2006) 0.81
Structural basis for H3K4 trimethylation by yeast Set1/COMPASS. Adv Enzyme Regul (2009) 0.79
Transcriptional blackjack with p21. Genes Dev (2006) 0.78
Guided by COMPASS on a journey through chromosome segregation. Nat Struct Mol Biol (2005) 0.78
Medicine. (Poly)combing the pediatric cancer genome for answers. Science (2013) 0.77
Preparation and assay of RNA polymerase II elongation factors elongin and ELL. Methods Enzymol (2003) 0.77
A histone modifier's ill-gotten copy gains. Cell (2013) 0.76
Global proteomic analysis of Saccharomyces cerevisiae identifies molecular pathways of histone modifications. Methods Mol Biol (2009) 0.76