Published in Mech Dev on August 29, 2009
Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Res Ther (2013) 1.57
Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression. Arthritis Rheum (2010) 1.13
Foxa1 and Foxa2 are required for formation of the intervertebral discs. PLoS One (2013) 0.92
Notochord Cells in Intervertebral Disc Development and Degeneration. J Dev Biol (2016) 0.84
Position-dependent plasticity of distinct progenitor types in the primitive streak. Elife (2016) 0.83
Mixl1 localizes to putative axial stem cell reservoirs and their posterior descendants in the mouse embryo. Gene Expr Patterns (2014) 0.81
Generation of knock-in mice that express nuclear enhanced green fluorescent protein and tamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci. Genesis (2013) 0.81
Notochordal cell-derived therapeutic strategies for discogenic back pain. Global Spine J (2013) 0.81
Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development (2015) 0.80
Isolation and characterization of node/notochord-like cells from mouse embryonic stem cells. Stem Cells Dev (2011) 0.79
Adriamycin-Induced Models of VACTERL Association. Mol Syndromol (2013) 0.78
Oestrogen and parathyroid hormone alleviate lumbar intervertebral disc degeneration in ovariectomized rats and enhance Wnt/β-catenin pathway activity. Sci Rep (2016) 0.75
Cell signaling pathways related to pain receptors in the degenerated disk. Global Spine J (2013) 0.75
Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
A guide to choosing fluorescent proteins. Nat Methods (2005) 18.55
A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res (2003) 12.94
Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54
Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nat Biotechnol (2004) 10.60
Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (2001) 9.00
Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun (1997) 7.87
Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A (2003) 7.60
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41
Expression pattern of the mouse T gene and its role in mesoderm formation. Nature (1990) 4.97
A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development (2002) 4.13
HNF-3 beta is essential for node and notochord formation in mouse development. Cell (1994) 4.08
A novel ES cell line, TT2, with high germline-differentiating potency. Anal Biochem (1993) 3.79
Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell (1994) 3.71
Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development (1993) 3.63
Targeting genes for self-excision in the germ line. Genes Dev (1999) 3.59
Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities. Proc Natl Acad Sci U S A (2002) 3.46
A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. J Cell Biol (1986) 3.06
Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev (1999) 2.94
Mouse gastrulation: the formation of a mammalian body plan. Mech Dev (1997) 2.68
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development (2004) 2.45
Development of 2A peptide-based strategies in the design of multicistronic vectors. Expert Opin Biol Ther (2005) 2.31
Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos. Mech Dev (2007) 2.29
Tcf3: a transcriptional regulator of axis induction in the early embryo. Development (2003) 2.26
Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm. Dev Cell (2002) 2.14
The molecular nature of the zebrafish tail organizer. Nature (2003) 1.96
Beta-catenin, MAPK and Smad signaling during early Xenopus development. Development (2002) 1.95
Regionally specific induction by the Spemann-Mangold organizer. Nat Rev Genet (2004) 1.92
Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev (2003) 1.91
The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Development (2001) 1.83
Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development (2005) 1.76
Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol (2007) 1.75
Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol (2008) 1.59
Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms. Dev Cell (2007) 1.59
Induction of a second neural axis by the mouse node. Development (1994) 1.58
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev (2001) 1.54
The T genes in embryogenesis. Trends Genet (1994) 1.53
Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip. Development (1993) 1.52
Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Dev Biol (2005) 1.52
Axial progenitors with extensive potency are localised to the mouse chordoneural hinge. Development (2002) 1.42
Two distinct sources for a population of maturing axial progenitors. Development (2007) 1.41
Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development (2005) 1.38
System for tamoxifen-inducible expression of cre-recombinase from the Foxa2 locus in mice. Dev Dyn (2008) 1.37
Cell proliferation in mammalian gastrulation: the ventral node and notochord are relatively quiescent. Dev Dyn (1996) 1.37
Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements. Genes Cells (1996) 1.37
Cell fate and morphogenetic movement in the late mouse primitive streak. Mech Dev (1996) 1.29
Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. Development (2005) 1.20
The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev (2004) 1.17
ang is a novel gene expressed in early neuroectoderm, but its null mutant exhibits no obvious phenotype. Gene Expr Patterns (2004) 1.16
Notochord patterning of the endoderm. Dev Biol (2001) 1.11
The role of BMP signaling in outgrowth and patterning of the Xenopus tail bud. Dev Biol (2001) 1.07
GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen. Genesis (2007) 1.07
Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor. Development (2005) 1.00
Genetic patterning of the developing mouse tail at the time of posterior neuropore closure. Dev Dyn (1997) 0.93
Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm. Development (2008) 0.92
The vertebrate tail bud: three germ layers from one tissue. Anat Embryol (Berl) (1992) 0.91
Lineage and functional analyses of the mouse organizer. Cold Spring Harb Symp Quant Biol (1997) 0.89
A developmental pathway controlling outgrowth of the Xenopus tail bud. Development (1999) 0.89
Identification of essential sequence motifs in the node/notochord enhancer of Foxa2 (Hnf3beta) gene that are conserved across vertebrate species. Mech Dev (2001) 0.89
The node of the mouse embryo. Curr Biol (2000) 0.86
Identification of the mammalian Not gene via a phylogenomic approach. Gene Expr Patterns (2004) 0.82
Distribution pattern of HNF-3beta proteins in developing embryos of two mammalian species, the house shrew and the mouse. Dev Growth Differ (1997) 0.79
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell (2002) 15.20
Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A (2003) 7.87
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet (2010) 6.81
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell (2009) 5.19
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell (2006) 4.89
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A (2005) 4.25
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell (2006) 4.13
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell (2007) 3.74
Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development (2004) 3.25
Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice. Development (2007) 3.06
Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science (2012) 3.01
Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc Natl Acad Sci U S A (2002) 2.99
Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development (2005) 2.98
Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development (2008) 2.98
Hippo pathway regulation by cell morphology and stress fibers. Development (2011) 2.94
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell (2008) 2.89
Functional genetic analysis of mouse chromosome 11. Nature (2003) 2.87
Conserved role of nanos proteins in germ cell development. Science (2003) 2.86
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A (2005) 2.82
Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol (2006) 2.75
Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J (2011) 2.75
Requirement of Bmpr1a for Müllerian duct regression during male sexual development. Nat Genet (2002) 2.75
Generation of Bmpr/Alk3 conditional knockout mice. Genesis (2002) 2.71
Periostin is essential for cardiac healing after acute myocardial infarction. J Exp Med (2008) 2.68
Triggering neural differentiation of ES cells by subtype switching of importin-alpha. Nat Cell Biol (2006) 2.64
Distinct functions for Bmp signaling in lip and palate fusion in mice. Development (2005) 2.46
Functional analysis of chicken Sox2 enhancers highlights an array of diverse regulatory elements that are conserved in mammals. Dev Cell (2003) 2.43
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development (2007) 2.40
Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos. Mech Dev (2007) 2.29
The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature (2005) 2.29
Cell lineage in mammalian craniofacial mesenchyme. Mech Dev (2008) 2.24
Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev Cell (2002) 2.24
Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. Nature (2004) 2.16
A mechanism for gene-environment interaction in the etiology of congenital scoliosis. Cell (2012) 2.08
Cord blood stem cell therapy for acquired immune deficiency syndrome. Stem Cells Dev (2010) 2.06
Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2. Development (2010) 2.05
Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis. Genes Dev (2004) 2.04
Prevalence and risk factors for cornea guttata in the Reykjavik Eye Study. Ophthalmology (2006) 2.03
Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev (2002) 2.01
Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol (2004) 2.00
New terminology for intrauterine endometrial samples: a group study by the Japanese Society of Clinical Cytology. Acta Cytol (2012) 1.99
Regulatory divergence modifies limb length between mammals. Genes Dev (2008) 1.96
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature (2005) 1.94
Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. Am J Hum Genet (2003) 1.88
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
Sox proteins: regulators of cell fate specification and differentiation. Development (2013) 1.82
Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells. Ann N Y Acad Sci (2004) 1.80
Cell-specific knockout of steroidogenic factor 1 reveals its essential roles in gonadal function. Mol Endocrinol (2004) 1.79
Developmental genetics of the female reproductive tract in mammals. Nat Rev Genet (2003) 1.78
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A (2004) 1.77
Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development (2003) 1.76
DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev (2006) 1.76
DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell (2006) 1.75
Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development (2002) 1.73
Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development (2003) 1.73
Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol Cell Biol (2007) 1.72
Retracted Regulation of NF-kappaB circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis. J Biol Chem (2010) 1.71
Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol (2007) 1.66
A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes. Mech Dev (2004) 1.65
The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. Science (2009) 1.65
Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller glial cell development. J Comp Neurol (2008) 1.65
Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development (2007) 1.65
Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. Dev Cell (2005) 1.63
Increased disk size in glaucomatous eyes vs normal eyes in the Reykjavik eye study. Am J Ophthalmol (2003) 1.62
Granulosa cell-specific inactivation of follistatin causes female fertility defects. Mol Endocrinol (2003) 1.62
Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling. J Biol Chem (2004) 1.62
β-Catenin is essential for Müllerian duct regression during male sexual differentiation. Development (2011) 1.62
Wt1 negatively regulates beta-catenin signaling during testis development. Development (2008) 1.61
Periostin is an extracellular matrix protein required for eruption of incisors in mice. Biochem Biophys Res Commun (2006) 1.61
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci U S A (2007) 1.60
Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol (2008) 1.59
BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development (2006) 1.59
Developmental potential and behavior of tetraploid cells in the mouse embryo. Dev Biol (2005) 1.56
Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev (2003) 1.55
Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling. J Am Soc Nephrol (2011) 1.55
Racial differences of lens transparency properties with aging and prevalence of age-related cataract applying a WHO classification system. Ophthalmic Res (2005) 1.55
Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes Dev (2008) 1.55
Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables. Am J Ophthalmol (2009) 1.55
The impact of hypertriglyceridemia on prostate cancer development in patients aged ≥60 years. BJU Int (2011) 1.54
Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses. Proc Natl Acad Sci U S A (2010) 1.54
Impaired angiogenesis in aminopeptidase N-null mice. Proc Natl Acad Sci U S A (2007) 1.53
Efficient identification of regulatory sequences in the chicken genome by a powerful combination of embryo electroporation and genome comparison. Mech Dev (2004) 1.53
Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol Cell Biol (2004) 1.53
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev (2006) 1.52
Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum (2007) 1.51
The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proc Natl Acad Sci U S A (2006) 1.51
Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development. Cancer Res (2005) 1.51
Cosmic radiation increases the risk of nuclear cataract in airline pilots: a population-based case-control study. Arch Ophthalmol (2005) 1.51
Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature (2011) 1.50
Stratification of the flexor retinaculum and the course and distribution of the ulnar, median, and palmar digital nerves: an anatomical study. Clin Anat (2004) 1.48
Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus. Circ Res (2005) 1.48
Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo. Dev Biol (2002) 1.47
Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons. Genesis (2010) 1.46
Generation of viable male and female mice from two fathers. Biol Reprod (2010) 1.46
Development of bat flight: morphologic and molecular evolution of bat wing digits. Proc Natl Acad Sci U S A (2006) 1.45
Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol (2005) 1.42