Computational analysis of signaling patterns in single cells.

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Single-cell approaches for molecular classification of endocrine tumors. Curr Opin Oncol (2016) 0.75

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42

BIND: the Biomolecular Interaction Network Database. Nucleic Acids Res (2003) 18.75

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Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science (2004) 8.44

Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature (2008) 7.60

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature (2009) 7.24

Variability and memory of protein levels in human cells. Nature (2006) 6.15

Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol (2002) 6.05

Intrinsic disorder in cell-signaling and cancer-associated proteins. J Mol Biol (2002) 5.64

Dynamic proteomics of individual cancer cells in response to a drug. Science (2008) 5.43

Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27

Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59

Physicochemical modelling of cell signalling pathways. Nat Cell Biol (2006) 4.34

Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science (2009) 4.14

Intrinsically disordered proteins in human diseases: introducing the D2 concept. Annu Rev Biophys (2008) 3.98

Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol (1998) 3.88

Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell (2008) 3.88

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature (2014) 3.86

Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A (2000) 3.74

The cell-cycle state of stem cells determines cell fate propensity. Cell (2013) 3.50

The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol Cell (2009) 3.38

Population context determines cell-to-cell variability in endocytosis and virus infection. Nature (2009) 3.37

p53 dynamics control cell fate. Science (2012) 3.30

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis. Genes Dev (1994) 3.10

Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 2.70

Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61

Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science (2013) 2.56

Dynamics and variability of ERK2 response to EGF in individual living cells. Mol Cell (2009) 2.42

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40

The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell (2013) 2.37

Cooperative binding of tetrameric p53 to DNA. J Mol Biol (2004) 2.26

Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell (2013) 2.22

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14

Pulsed feedback defers cellular differentiation. PLoS Biol (2012) 2.13

The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13

Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 2.11

Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell (2012) 2.11

Measuring and modeling apoptosis in single cells. Cell (2011) 2.10

Prediction of disordered regions in proteins based on the meta approach. Bioinformatics (2008) 2.09

Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02

Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3. J Biol Chem (2002) 1.96

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92

A noisy paracrine signal determines the cellular NF-kappaB response to lipopolysaccharide. Sci Signal (2009) 1.91

Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol (2013) 1.91

Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol Cell (2012) 1.91

Functional roles of pulsing in genetic circuits. Science (2013) 1.84

Impulse control: temporal dynamics in gene transcription. Cell (2011) 1.79

Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis. Curr Biol (2010) 1.73

Fold-change detection and scalar symmetry of sensory input fields. Proc Natl Acad Sci U S A (2010) 1.67

Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Oncogene (2001) 1.53

Imaging the coordination of multiple signalling activities in living cells. Nat Rev Mol Cell Biol (2011) 1.47

Dynamic response diversity of NFAT isoforms in individual living cells. Mol Cell (2012) 1.28

Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks. PLoS Comput Biol (2008) 1.26

Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding. Protein Sci (2013) 1.23

Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes. Biochem J (2013) 1.21

Design and optimization of genetically encoded fluorescent biosensors: GTPase biosensors. Methods Cell Biol (2008) 1.20

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53. Nucleic Acids Res (2010) 1.20

Fold change of nuclear NF-κB determines TNF-induced transcription in single cells. Mol Cell (2014) 1.16

Activation and control of p53 tetramerization in individual living cells. Proc Natl Acad Sci U S A (2013) 1.12

Cellular ras and cyclin D1 are required during different cell cycle periods in cycling NIH 3T3 cells. Mol Cell Biol (1999) 1.11

Visualizing dynamic activities of signaling enzymes using genetically encodable FRET-based biosensors from designs to applications. Methods Enzymol (2012) 1.07

Ragged spiking of free calcium in ADP-stimulated human platelets: regulation of puff-like calcium signals in vitro and ex vivo. J Physiol (2001) 1.07

The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol (2013) 1.02

Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes. Mol Biol Cell (2013) 0.97

Confluence-induced cell cycle exit involves pre-mitotic CDK inhibition by p27(Kip1) and cyclin D1 downregulation. Cell Cycle (2008) 0.90

Controlling low rates of cell differentiation through noise and ultrahigh feedback. Science (2014) 0.90

Live-cell fluorescence imaging. Methods Cell Biol (2013) 0.86

Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells. PLoS Genet (2014) 0.81

Tight control of hypoxia-inducible factor-α transient dynamics is essential for cell survival in hypoxia. J Biol Chem (2014) 0.81

Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock. Biomed Res Int (2014) 0.76

Heterogeneity of sister cell fates. Nat Rev Mol Cell Biol (2013) 0.76