PubRank

Ruth J F Loos

Author PubWeight™ 479.37‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007 37.88
2 Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010 28.21
3 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010 23.08
4 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2008 22.35
5 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010 20.01
6 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
7 Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet 2008 16.92
8 Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011 13.25
9 Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009 12.44
10 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012 11.09
11 Variants in MTNR1B influence fasting glucose levels. Nat Genet 2008 10.85
12 Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 2010 8.89
13 Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 2010 8.55
14 Correlates of physical activity: why are some people physically active and others not? Lancet 2012 8.19
15 Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010 7.94
16 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010 6.66
17 LDL-cholesterol concentrations: a genome-wide association study. Lancet 2008 6.44
18 The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet 2012 6.15
19 Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 2009 5.81
20 Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med 2014 5.47
21 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet 2012 4.73
22 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012 4.37
23 Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr 2006 4.24
24 Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genet 2009 4.24
25 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 2014 4.13
26 Genome-wide association study identifies five loci associated with lung function. Nat Genet 2009 4.10
27 Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol 2010 4.08
28 Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes 2010 4.07
29 Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med 2011 3.94
30 Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med 2016 3.88
31 Genetic loci influencing kidney function and chronic kidney disease. Nat Genet 2010 3.75
32 Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet 2011 3.40
33 Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet 2010 3.37
34 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 2013 3.25
35 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
36 Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 2011 3.18
37 New gene functions in megakaryopoiesis and platelet formation. Nature 2011 3.14
38 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet 2012 3.04
39 Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet 2011 3.03
40 Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 2013 2.92
41 Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes 2007 2.83
42 Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet 2013 2.83
43 FTO genotype is associated with phenotypic variability of body mass index. Nature 2012 2.77
44 Seventy-five genetic loci influencing the human red blood cell. Nature 2012 2.77
45 Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr 2009 2.74
46 Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet 2011 2.73
47 Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 2013 2.73
48 CUBN is a gene locus for albuminuria. J Am Soc Nephrol 2011 2.70
49 Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes 2008 2.46
50 Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Med 2010 2.25
51 Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet 2010 2.24
52 Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet 2009 2.22
53 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011 2.21
54 Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am J Clin Nutr 2009 2.14
55 A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet 2009 2.09
56 Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med 2011 2.07
57 Variability in the heritability of body mass index: a systematic review and meta-regression. Front Endocrinol (Lausanne) 2012 1.94
58 New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet 2012 1.90
59 Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Med 2010 1.88
60 A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet 2013 1.82
61 Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nat Genet 2011 1.77
62 Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 2013 1.72
63 Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nat Genet 2013 1.72
64 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
65 Lack of evidence for the role of human adenovirus-36 in obesity in a European cohort. Obesity (Silver Spring) 2009 1.70
66 Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. Diabetes 2010 1.70
67 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet 2012 1.52
68 Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med 2012 1.49
69 A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes 2012 1.47
70 Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Dis Model Mech 2011 1.40
71 Trend in obesity prevalence in European adult cohort populations during follow-up since 1996 and their predictions to 2015. PLoS One 2011 1.40
72 Association between birth weight and visceral fat in adults. Am J Clin Nutr 2010 1.35
73 Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr 2013 1.35
74 Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes 2011 1.31
75 Developments in obesity genetics in the era of genome-wide association studies. J Nutrigenet Nutrigenomics 2011 1.30
76 Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study. Hum Mol Genet 2009 1.28
77 Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study. Am J Clin Nutr 2012 1.26
78 Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk. Cancer Epidemiol Biomarkers Prev 2012 1.26
79 Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies. Acta Diabetol 2008 1.25
80 Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes 2013 1.25
81 Associations between the pubertal timing-related variant in LIN28B and BMI vary across the life course. J Clin Endocrinol Metab 2010 1.21
82 Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet 2009 1.18
83 Progress in the genetics of common obesity: size matters. Curr Opin Lipidol 2008 1.18
84 Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Hum Mol Genet 2009 1.13
85 A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample. PLoS One 2011 1.13
86 Advances in exercise, fitness, and performance genomics in 2010. Med Sci Sports Exerc 2011 1.12
87 Progress in the genetics of common obesity and type 2 diabetes. Expert Rev Mol Med 2010 1.12
88 Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. Am J Clin Nutr 2011 1.10
89 Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study. Diabetes 2009 1.05
90 Heritability of objectively assessed daily physical activity and sedentary behavior. Am J Clin Nutr 2013 1.02
91 Mendelian Randomisation Study of Childhood BMI and Early Menarche. J Obes 2011 0.99
92 Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans. PLoS One 2011 0.98
93 MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai. BMC Med Genet 2010 0.98
94 Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans. Hum Genet 2011 0.98
95 Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations. Diabetes 2008 0.97
96 Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. Hum Mol Genet 2013 0.97
97 Advances in exercise, fitness, and performance genomics in 2011. Med Sci Sports Exerc 2012 0.97
98 Twin-specific intrauterine 'growth' charts based on cross-sectional birthweight data. Twin Res Hum Genet 2008 0.95
99 Advances in exercise, fitness, and performance genomics in 2012. Med Sci Sports Exerc 2013 0.93
100 Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population. PLoS One 2010 0.92
101 Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies. Diabetes 2007 0.90
102 RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans. J Lipid Res 2009 0.89
103 Genome-wide meta-analysis of common variant differences between men and women. Hum Mol Genet 2012 0.88
104 Identification of a novel percent mammographic density locus at 12q24. Hum Mol Genet 2012 0.88
105 Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI. Hum Mol Genet 2012 0.87
106 PGC-1alpha gene and physical activity in type 2 diabetes mellitus. Exerc Sport Sci Rev 2006 0.87
107 Association between FTO variant and change in body weight and its interaction with dietary factors: the DiOGenes study. Obesity (Silver Spring) 2012 0.87
108 Advances in exercise, fitness, and performance genomics in 2013. Med Sci Sports Exerc 2014 0.87
109 Genetic and environmental influences on blood pressure variability: a study in twins. J Hypertens 2013 0.86
110 No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes 2012 0.86
111 Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes. J Nutrigenet Nutrigenomics 2010 0.85
112 Growth in peak aerobic power during adolescence. Med Sci Sports Exerc 2004 0.85
113 Genetic and environmental determination of tracking in static strength during adolescence. J Appl Physiol (1985) 2005 0.85
114 Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS). Obesity (Silver Spring) 2009 0.85
115 Epidemiological study designs to investigate gene-behavior interactions in the context of human obesity. Obesity (Silver Spring) 2008 0.85
116 A latent variable partial least squares path modeling approach to regional association and polygenic effect with applications to a human obesity study. PLoS One 2012 0.85
117 Twin birth weight standards. Neonatology 2007 0.84
118 Obesity-susceptibility loci and their influence on adiposity-related traits in transition from adolescence to adulthood--the HUNT study. PLoS One 2012 0.84
119 Curves of placental weights of live-born twins. Twin Res Hum Genet 2006 0.84
120 Genetics of maximally attained lung function: a role for leptin? Respir Med 2011 0.83
121 Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study. Am J Clin Nutr 2012 0.83
122 Genetic predisposition to an adverse lipid profile limits the improvement in total cholesterol in response to weight loss. Obesity (Silver Spring) 2013 0.83
123 Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals. Diabetologia 2014 0.82
124 Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study. PLoS One 2011 0.82
125 The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals. J Appl Physiol (1985) 2008 0.81
126 MC4R marker associated with stature in children and young adults: a longitudinal study. J Pediatr Endocrinol Metab 2005 0.80
127 Clustering of metabolic risk factors in young adults: genes and environment. Atherosclerosis 2008 0.80
128 NOS3 variants, physical activity, and blood pressure in the European Youth Heart Study. Am J Hypertens 2011 0.80
129 Genetic and environmental determination of tracking in subcutaneous fat distribution during adolescence. Am J Clin Nutr 2007 0.80
130 Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study. Br J Nutr 2013 0.80
131 Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring) 2014 0.80
132 Genetics: genome-wide risk profiles - will they change your life(style)? Nat Rev Endocrinol 2011 0.79
133 Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort. Genet Res (Camb) 2011 0.79
134 Determinants of infant growth in four age windows: a twin study. J Pediatr 2010 0.79
135 Do genetic factors contribute to the relation between education and metabolic risk factors in young adults? A twin study. Eur J Public Health 2012 0.79
136 Genetic and environmental factors in associations between infant growth and adult cardiometabolic risk profile in twins. Am J Clin Nutr 2013 0.79
137 Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure. Am J Hypertens 2008 0.77
138 Changes in genetic and environmental effects on growth during infancy. Am J Clin Nutr 2011 0.77
139 The contribution of prenatal environment and genetic factors to the association between birth weight and adult grip strength. PLoS One 2011 0.77
140 Advances in Exercise, Fitness, and Performance Genomics in 2015. Med Sci Sports Exerc 2016 0.77
141 Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat. Genes Nutr 2012 0.77
142 Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: linkage of candidate genes using two sib-pair based variance components analyses. Twin Res Hum Genet 2008 0.77
143 Retrospective determination of chorion type in twins using a simple questionnaire. Twin Res 2003 0.77
144 Gender mix: does it modify birthweight--outcome association? Paediatr Perinat Epidemiol 2005 0.76
145 Dietary factors impact on the association between CTSS variants and obesity related traits. PLoS One 2012 0.76
146 Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet 2016 0.75
147 Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight. Genes Nutr 2014 0.75
148 Lack of association between PCK1 polymorphisms and obesity, physical activity, and fitness in European Youth Heart Study (EYHS). Obesity (Silver Spring) 2010 0.75
149 No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits. Am J Clin Nutr 2010 0.75
150 New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circ Cardiovasc Genet 2017 0.75
151 Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 2017 0.75
152 Genetic and environmental causes of tracking in explosive strength during adolescence. Behav Genet 2005 0.75
153 Corrigendum: Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Nat Commun 2015 0.75
154 Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep 2017 0.75