Published in Proc Natl Acad Sci U S A on April 15, 1991
Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol (1993) 10.65
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol (1998) 7.78
Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A (1999) 5.54
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol (1999) 5.06
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol (1994) 5.01
A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol (1998) 4.64
The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J Cell Biol (1993) 4.22
Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments. J Cell Biol (1997) 4.00
A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J Cell Biol (1997) 3.86
Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol (1999) 3.78
Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol (1998) 3.62
Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol (1999) 3.57
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions. Proc Natl Acad Sci U S A (1993) 3.48
Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol (1994) 3.45
Possible involvement of phosphorylation of occludin in tight junction formation. J Cell Biol (1997) 3.35
An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol (1998) 3.04
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J Cell Biol (1998) 2.99
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol (1997) 2.82
COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. J Cell Biol (1997) 2.71
Assembly of the tight junction: the role of diacylglycerol. J Cell Biol (1993) 2.61
Symplekin, a novel type of tight junction plaque protein. J Cell Biol (1996) 2.58
Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2. J Cell Biol (1993) 2.56
Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol (1999) 2.40
Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions. J Cell Biol (1996) 2.37
Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex. J Clin Invest (2008) 2.24
The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J Cell Biol (2003) 2.21
Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest (1995) 2.14
Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol (2001) 2.06
Regulated assembly of tight junctions by protein kinase C. Proc Natl Acad Sci U S A (1995) 2.03
Molecular basis of the core structure of tight junctions. Cold Spring Harb Perspect Biol (2010) 1.87
Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS One (2007) 1.86
The molecular organization of tight junctions. J Cell Biol (1993) 1.81
A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. J Cell Biol (1994) 1.80
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell (2000) 1.76
The altered glomerular filtration slits seen in puromycin aminonucleoside nephrosis and protamine sulfate-treated rats contain the tight junction protein ZO-1. Am J Pathol (1992) 1.66
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell (2008) 1.63
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin. J Cell Biol (1999) 1.59
Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery. Ther Deliv (2011) 1.57
Blood-brain barrier breakdown in septic encephalopathy and brain tumours. J Anat (2002) 1.44
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation. Fluids Barriers CNS (2012) 1.44
Claudin family of proteins and cancer: an overview. J Oncol (2010) 1.42
Discovering the molecular components of intercellular junctions--a historical view. Cold Spring Harb Perspect Biol (2009) 1.39
Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. J Biol Chem (2005) 1.38
Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain. J Cell Biol (1996) 1.36
Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. J Virol (2007) 1.34
Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells. Mol Biol Cell (2002) 1.32
Plugging the leaks. Proc Natl Acad Sci U S A (1999) 1.31
Expression of occludin, tight-junction-associated protein, in human digestive tract. Am J Pathol (1997) 1.28
Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells. J Cell Sci (2005) 1.22
The dual role of zonula occludens (ZO) proteins. J Biomed Biotechnol (2010) 1.19
The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis. J Mammary Gland Biol Neoplasia (2003) 1.18
Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in Madin-Darby canine kidney cells. J Biol Chem (2009) 1.15
Tight junction proteins: from barrier to tumorigenesis. Cancer Lett (2013) 1.14
Human astrocytes/astrocyte-conditioned medium and shear stress enhance the barrier properties of human brain microvascular endothelial cells. Brain Res (2007) 1.11
Apically exposed, tight junction-associated beta1-integrins allow binding and YopE-mediated perturbation of epithelial barriers by wild-type Yersinia bacteria. Infect Immun (2000) 1.09
Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity. Cold Spring Harb Perspect Biol (2009) 1.09
Zona occludens-2 inhibits cyclin D1 expression and cell proliferation and exhibits changes in localization along the cell cycle. Mol Biol Cell (2008) 1.09
Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke. Curr Pharm Des (2012) 1.03
Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein. Mol Cell Biol (2006) 1.01
The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB. Mol Biol Cell (2006) 1.00
Altered expression of ZO-1 and ZO-2 in Sertoli cells and loss of blood-testis barrier integrity in testicular carcinoma in situ. Neoplasia (2006) 0.97
Role of the blood-brain barrier in the formation of brain metastases. Int J Mol Sci (2013) 0.96
ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions. J Cell Sci (2013) 0.96
SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells. Am J Pathol (2006) 0.95
Proteomic and bioinformatic analysis of epithelial tight junction reveals an unexpected cluster of synaptic molecules. Biol Direct (2006) 0.94
New aspects of the molecular constituents of tissue barriers. J Neural Transm (Vienna) (2010) 0.93
Endothelial barriers: from hypothetical pores to membrane proteins. J Anat (2002) 0.93
Histamine, ZO-1 and increased blood-retinal barrier permeability in diabetic retinopathy. Trans Am Ophthalmol Soc (1995) 0.93
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. Mol Biol Cell (2013) 0.93
"You Shall Not Pass"-tight junctions of the blood brain barrier. Front Neurosci (2014) 0.92
Structure, regulation, and pathophysiology of tight junctions in the gastrointestinal tract. Yale J Biol Med (1994) 0.89
ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape. PLoS One (2014) 0.88
Arecoline induced disruption of expression and localization of the tight junctional protein ZO-1 is dependent on the HER 2 expression in human endometrial Ishikawa cells. BMC Cell Biol (2010) 0.87
Tight junctions: from simple barriers to multifunctional molecular gates. Nat Rev Mol Cell Biol (2016) 0.87
Mechanisms of the penetration of blood-borne substances into the brain. Curr Neuropharmacol (2009) 0.86
A novel role for aquaporin-5 in enhancing microtubule organization and stability. PLoS One (2012) 0.85
Identification of new binding partners of the chemosensory signaling protein Gγ13 expressed in taste and olfactory sensory cells. Front Cell Neurosci (2012) 0.84
Tight junction-related barrier contributes to the electrophysiological asymmetry across vocal fold epithelium. PLoS One (2012) 0.81
Bile duct ligation in the rat causes upregulation of ZO-2 and decreased colocalization of claudins with ZO-1 and occludin. Histochem Cell Biol (2008) 0.81
Phosphorylation of zona occludens-2 by protein kinase C epsilon regulates its nuclear exportation. Mol Biol Cell (2009) 0.80
Different reactions of aortic and venular endothelial cell monolayers to histamine on macromolecular permeability: role of cAMP, cytosolic Ca2+ and F-actin. Inflammation (1999) 0.79
Emerging roles of Dlg-like PDZ proteins in the organization of the NMDA-type glutamatergic synapse. J Biochem (1998) 0.79
DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation. Oncotarget (2015) 0.78
The intracellular fate of zonula occludens 2 is regulated by the phosphorylation of SR repeats and the phosphorylation/O-GlcNAcylation of S257. Mol Biol Cell (2013) 0.78
Laminin-111 stimulates proliferation of mouse embryonic stem cells through a reduction of gap junctional intercellular communication via RhoA-mediated Cx43 phosphorylation and dissociation of Cx43/ZO-1/drebrin complex. Stem Cells Dev (2012) 0.78
Beyond cell-cell adhesion: Emerging roles of the tight junction scaffold ZO-2. Tissue Barriers (2013) 0.77
ZO-1 and ZO-2 are required for extra-embryonic endoderm integrity, primitive ectoderm survival and normal cavitation in embryoid bodies derived from mouse embryonic stem cells. PLoS One (2014) 0.76
Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury. PLoS One (2015) 0.76
Ghrelin Attenuates Intestinal Barrier Dysfunction Following Intracerebral Hemorrhage in Mice. Int J Mol Sci (2016) 0.75
Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System. AAPS J (2017) 0.75
Chronic hypoxia down-regulates tight junction protein ZO-2 expression in children with cyanotic congenital heart defect. ESC Heart Fail (2015) 0.75
Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. J Biol Chem (1977) 72.51
Junctional complexes in various epithelia. J Cell Biol (1963) 31.83
Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol (1986) 8.74
Alteration of cell-surface proteins by viral transformation and by proteolysis. Proc Natl Acad Sci U S A (1973) 6.98
Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation. Cell (1983) 6.83
A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide. J Cell Biol (1986) 5.75
Fracture faces of zonulae occludentes from "tight" and "leaky" epithelia. J Cell Biol (1973) 5.45
Structure, biochemistry, and assembly of epithelial tight junctions. Am J Physiol (1987) 4.58
Occluding junction structure-function relationships in a cultured epithelial monolayer. J Cell Biol (1985) 4.21
Cingulin, a new peripheral component of tight junctions. Nature (1988) 3.81
Sorting of an apical plasma membrane glycoprotein occurs before it reaches the cell surface in cultured epithelial cells. J Cell Biol (1984) 3.48
Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells. J Cell Biol (1988) 3.47
The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells. EMBO J (1986) 3.20
Twenty-first Bowditch lecture. The epithelial junction: bridge, gate, and fence. Physiologist (1977) 2.90
A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization. J Cell Biol (1989) 2.84
Integral and peripheral protein composition of the apical and basolateral membrane domains in MDCK cells. J Membr Biol (1989) 2.65
The epithelial tight junction: structure, function and preliminary biochemical characterization. Mol Cell Biochem (1988) 2.33
Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance. J Cell Biol (1988) 2.19
Fractionation of asparagine-linked oligosaccharides by serial lectin-Agarose affinity chromatography. A rapid, sensitive, and specific technique. J Biol Chem (1982) 2.14
Tight junction dynamics: is paracellular transport regulated? Cell (1988) 2.03
Evidence for the lipidic nature of tight junction strands. Nature (1982) 1.96
ZO-1 and cingulin: tight junction proteins with distinct identities and localizations. Am J Physiol (1989) 1.96
ZO-1 mRNA and protein expression during tight junction assembly in Caco-2 cells. J Cell Biol (1989) 1.92
The tight junction does not allow lipid molecules to diffuse from one epithelial cell to the next. Nature (1986) 1.91
A new 400-kD protein from isolated adherens junctions: its localization at the undercoat of adherens junctions and at microfilament bundles such as stress fibers and circumferential bundles. J Cell Biol (1989) 1.61
Expression of cell adhesion molecule E-cadherin in Xenopus embryos begins at gastrulation and predominates in the ectoderm. J Cell Biol (1989) 1.41
The molecular constituents of intercellular junctions. Curr Opin Cell Biol (1989) 1.29
Establishment of tight junctions between cells from different animal species and different sealing capacities. J Membr Biol (1989) 1.22
Cardiac cephalgia: a treatable form of exertional headache. Neurology (1997) 1.67
Search for evidence of herpes simplex virus, type 1, or varicella-zoster virus infection in postmortem brain tissue from schizophrenic patients. Acta Psychiatr Scand (1992) 0.83
Endogenous adenosine delays the onset of hypoxic depolarization in the rat hippocampus in vitro via an action at A1 receptors. Brain Res (1993) 0.80
Repetitive behaviors in schizophrenic patients admitted to an acute-care unit: a replicative study. J Nerv Ment Dis (1993) 0.75
Transient ischemia attenuates neuronal afterdischarges induced in the absence of synaptic transmission. Brain Res (1991) 0.75