Published in Mol Cell Biol on February 22, 2010
Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization. Neuron (2013) 1.83
JNK regulates FoxO-dependent autophagy in neurons. Genes Dev (2011) 1.45
Nuclear and cytosolic JNK signalling in neurons. Nat Rev Neurosci (2014) 1.17
The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation. Dev Neurobiol (2012) 1.10
Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology. J Cell Biol (2011) 1.09
WNT signaling in neuronal maturation and synaptogenesis. Front Cell Neurosci (2013) 1.01
Signaling by the TGFβ superfamily. Cold Spring Harb Perspect Biol (2013) 0.99
Molecular profiles of pyramidal neurons in the superior temporal cortex in schizophrenia. J Neurogenet (2014) 0.99
miR-7 and miR-153 protect neurons against MPP(+)-induced cell death via upregulation of mTOR pathway. Front Cell Neurosci (2014) 0.93
Bmp7 functions via a polarity mechanism to promote cloacal septation. PLoS One (2012) 0.91
An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan. Aging Cell (2012) 0.90
Cadherin-6B stimulates an epithelial mesenchymal transition and the delamination of cells from the neural ectoderm via LIMK/cofilin mediated non-canonical BMP receptor signaling. Dev Biol (2012) 0.86
Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation. Mol Cell Proteomics (2014) 0.82
The Wnt and BMP families of signaling morphogens at the vertebrate neuromuscular junction. Int J Mol Sci (2011) 0.82
JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships. Microbiol Mol Biol Rev (2016) 0.81
c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress. J Biol Chem (2010) 0.81
BMP signaling in telencephalic neural cell specification and maturation. Front Cell Neurosci (2013) 0.80
Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal (2016) 0.80
Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling. J Neurosci (2013) 0.79
Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development. Development (2013) 0.79
Frizzled-5 receptor is involved in neuronal polarity and morphogenesis of hippocampal neurons. PLoS One (2013) 0.79
Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases. Mol Syst Biol (2015) 0.78
In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells. Mol Neurodegener (2016) 0.78
JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination. Front Cell Neurosci (2014) 0.77
Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons. Mol Cell Neurosci (2015) 0.75
Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons. Biochem Biophys Res Commun (2015) 0.75
BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells. Sci Rep (2016) 0.75
Bone morphogenetic protein signaling in vertebrate motor neurons and neuromuscular communication. Front Cell Neurosci (2015) 0.75
Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol (2005) 11.18
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol (2003) 7.74
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Signal transduction by the TGF-beta superfamily. Science (2002) 5.61
High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science (2000) 5.20
Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci (2009) 4.13
wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. Neuron (2002) 3.79
Dendritic anomalies in disorders associated with mental retardation. Cereb Cortex (2000) 3.69
Neural induction, the default model and embryonic stem cells. Nat Rev Neurosci (2002) 3.53
Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell (2009) 3.50
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med (2003) 3.45
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci (2007) 3.31
Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev (2006) 3.30
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Proc Natl Acad Sci U S A (2000) 2.97
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol (1995) 2.80
The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function. Neuron (2002) 2.79
Establishment of axon-dendrite polarity in developing neurons. Annu Rev Neurosci (2009) 2.73
Microtubule stabilization specifies initial neuronal polarization. J Cell Biol (2008) 2.60
Breaking the neuronal sphere: regulation of the actin cytoskeleton in neuritogenesis. Nat Rev Neurosci (2002) 2.51
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J Cell Biol (2003) 2.51
JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell (2003) 2.45
BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol (2000) 2.40
Activated c-Jun N-terminal kinase is required for axon formation. J Neurosci (2006) 2.22
Bone morphogenetic protein signalling and vertebrate nervous system development. Nat Rev Neurosci (2005) 1.97
LIM Kinase1 controls synaptic stability downstream of the type II BMP receptor. Neuron (2005) 1.84
Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science (2005) 1.81
Molecular control of cortical dendrite development. Annu Rev Neurosci (2002) 1.79
Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules. Nat Neurosci (2007) 1.73
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO J (2004) 1.70
JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. J Cell Biol (2006) 1.69
DCX, a new mediator of the JNK pathway. EMBO J (2004) 1.67
BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol (2007) 1.66
Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J Neurosci (2005) 1.54
The role of the cytoskeleton during neuronal polarization. Curr Opin Neurobiol (2008) 1.49
Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. Hum Mol Genet (2003) 1.44
The JIP1 scaffold protein regulates axonal development in cortical neurons. Curr Biol (2008) 1.40
Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons. J Neurosci (2000) 1.25
New insights into the molecular mechanisms specifying neuronal polarity in vivo. Curr Opin Neurobiol (2008) 1.25
The bright side of JNKs-Multitalented mediators in neuronal sprouting, brain development and nerve fiber regeneration. Prog Neurobiol (2006) 1.20
Signaling mechanisms underlying dendrite formation. Curr Opin Neurobiol (2003) 1.18
Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morphogenetic protein type II receptor. Chest (2008) 1.11
Specific activities of individual c-Jun N-terminal kinases in the brain. Neuroscience (2009) 1.07
Dendrites. Genes Dev (2001) 1.03
GSK3beta-mediated phosphorylation of the microtubule-associated protein 2C (MAP2C) prevents microtubule bundling. Eur J Cell Biol (2000) 0.99
Dendritic and synaptic pathology in mental retardation. Pediatr Neurol (1991) 0.99
Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension. Respir Res (2001) 0.98
The yin-yang of dendrite morphology: unity of actin and microtubules. Mol Neurobiol (2008) 0.97
More than just synaptic building blocks: scaffolding proteins of the post-synaptic density regulate dendritic patterning. J Neurochem (2007) 0.96
Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Mol Syst Biol (2009) 0.94
Tau-mediated process outgrowth is differentially altered by the expression of MAP2b and MAP2c in Sf9 cells. Cell Motil Cytoskeleton (1999) 0.78
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
MAP kinases in the immune response. Annu Rev Immunol (2001) 7.62
Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell (2008) 7.47
The JNK signal transduction pathway. Curr Opin Cell Biol (2007) 5.86
Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol (2003) 5.38
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc Natl Acad Sci U S A (2007) 5.36
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 5.28
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 5.01
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
How Saccharomyces responds to nutrients. Annu Rev Genet (2008) 3.92
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet (2013) 3.87
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A (2005) 3.68
Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell (2009) 3.50
Mechanism of p38 MAP kinase activation in vivo. Genes Dev (2003) 3.36
The JNK signal transduction pathway. Curr Opin Genet Dev (2002) 3.35
Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell (2006) 3.32
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol (2005) 3.14
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12
Targeting JNK for therapeutic benefit: from junk to gold? Nat Rev Drug Discov (2003) 3.11
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Use of aldosterone antagonists in heart failure. JAMA (2009) 3.00
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem (2005) 2.74
Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells (2009) 2.71
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science (2008) 2.67
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev (2004) 2.51
A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A (2003) 2.47
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem (2002) 2.45
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell (2007) 2.43
A semisynthetic epitope for kinase substrates. Nat Methods (2007) 2.40
JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell (2003) 2.39
Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock. Circ Res (2009) 2.38
A genetically encoded fluorescent sensor of ERK activity. Proc Natl Acad Sci U S A (2008) 2.34
JNK2 is a positive regulator of the cJun transcription factor. Mol Cell (2006) 2.32
Race/ethnicity, quality of care, and outcomes in ischemic stroke. Circulation (2010) 2.32
Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice. J Biol Chem (2002) 2.23
Prevention of steatosis by hepatic JNK1. Cell Metab (2009) 2.20
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol (2007) 2.17
Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell (2008) 2.16
Age-related differences in characteristics, performance measures, treatment trends, and outcomes in patients with ischemic stroke. Circulation (2010) 2.15
Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol (2010) 2.12
Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation (2008) 2.09
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity (2007) 2.07
The role of JNK in the development of hepatocellular carcinoma. Genes Dev (2011) 2.07
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 2.05
Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes. Circulation (2012) 2.03
Characteristics, performance measures, and in-hospital outcomes of the first one million stroke and transient ischemic attack admissions in get with the guidelines-stroke. Circ Cardiovasc Qual Outcomes (2010) 2.02
Regulation of the immune response by stress-activated protein kinases. Immunol Rev (2009) 2.00
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature (2004) 1.99
Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol (2005) 1.97
CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell (2012) 1.97
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat Neurosci (2009) 1.95
Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. J Neurosci (2004) 1.94
The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids. J Biol Chem (2006) 1.94
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc Natl Acad Sci U S A (2005) 1.91
Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation. Oncogene (2004) 1.90
Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med (2009) 1.89
DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem (2005) 1.89
Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor. J Am Coll Cardiol (2006) 1.89
Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J Exp Med (2006) 1.88
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A (2012) 1.88
Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem (2003) 1.83
A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun. EMBO J (2003) 1.83
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut (2006) 1.82
JNK regulates autocrine expression of TGF-beta1. Mol Cell (2004) 1.81
Quality of care for atrial fibrillation among patients hospitalized for heart failure. J Am Coll Cardiol (2009) 1.81
Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. Cancer Res (2007) 1.81
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol (2005) 1.80
Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 1.79
Strategies used by hospitals to improve speed of tissue-type plasminogen activator treatment in acute ischemic stroke. Stroke (2014) 1.76
Foxh1 is essential for development of the anterior heart field. Dev Cell (2004) 1.74
Role of JNK in tumor development. Cell Cycle (2003) 1.71
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO J (2004) 1.70
Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell (2007) 1.69
JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. J Cell Biol (2006) 1.69
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. J Neurosci Res (2009) 1.68
Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A (2007) 1.67
Function, attachment and synthesis of lipoic acid in Escherichia coli. Adv Microb Physiol (2005) 1.66
Temporal trends and predictors in the use of aldosterone antagonists post-acute myocardial infarction. J Am Coll Cardiol (2012) 1.65
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64
Risk of MDM2 SNP309 alone or in combination with the p53 codon 72 polymorphism in acute myeloid leukemia. Leuk Res (2009) 1.64
Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. J Exp Med (2002) 1.61
Conformational flexibility facilitates self-assembly of complex DNA nanostructures. Proc Natl Acad Sci U S A (2008) 1.60
Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J Cell Sci (2008) 1.60
Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol (2012) 1.59
Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. Gastroenterology (2012) 1.58
Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection. Clin Diagn Lab Immunol (2004) 1.58
c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol (2003) 1.58
Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure. Circ Heart Fail (2010) 1.57
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol (2009) 1.56
IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci (2008) 1.56
Bilateral inhibition of gamma-aminobutyric acid type A receptor function within the basolateral amygdala blocked propofol-induced amnesia and activity-regulated cytoskeletal protein expression inhibition in the hippocampus. Anesthesiology (2008) 1.54
Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J Neurosci (2005) 1.54
Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol (2005) 1.53
Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem (2002) 1.52
Aberrant expression of TSC2 gene in the newly diagnosed acute leukemia. Leuk Res (2009) 1.52
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep (2002) 1.52
Water stress-responsive genes in loblolly pine (Pinus taeda) roots identified by analyses of expressed sequence tag libraries. Tree Physiol (2006) 1.51