Published in Science on May 26, 2005
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A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A (2008) 33.65
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet (2005) 17.07
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell (2009) 11.10
Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev (2006) 11.04
The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem (2008) 10.08
Characterization of microRNA expression profiles in normal human tissues. BMC Genomics (2007) 8.01
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell (2008) 7.26
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miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell (2008) 6.59
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Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A (2006) 6.19
Muscle-specific microRNA miR-206 promotes muscle differentiation. J Cell Biol (2006) 5.78
Reciprocal actions of REST and a microRNA promote neuronal identity. Proc Natl Acad Sci U S A (2006) 5.78
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res (2007) 5.67
A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. Genome Res (2006) 5.23
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microRNA modulation of circadian-clock period and entrainment. Neuron (2007) 4.49
MicroRNAs in cancer. Annu Rev Pathol (2009) 4.47
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth. Genes Dev (2005) 4.34
A microRNA imparts robustness against environmental fluctuation during development. Cell (2009) 4.08
TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol (2009) 4.05
MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Genes Dev (2007) 4.01
Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate. Nat Genet (2007) 3.77
A microRNA catalog of the developing chicken embryo identified by a deep sequencing approach. Genome Res (2008) 3.74
Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat Genet (2009) 3.72
The expression profile of microRNAs in mouse embryos. Nucleic Acids Res (2006) 3.49
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ (2009) 3.43
Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron (2010) 3.37
MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24
MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature (2010) 3.18
MicroRNA expression in the adult mouse central nervous system. RNA (2008) 3.12
Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Genome Res (2007) 3.11
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A (2008) 3.10
MicroRNAs: regulators of gene expression and cell differentiation. Blood (2006) 3.08
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol (2007) 3.05
Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biol (2007) 3.04
MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nat Genet (2008) 3.01
MicroRNAs and the advent of vertebrate morphological complexity. Proc Natl Acad Sci U S A (2008) 3.00
Many families of C. elegans microRNAs are not essential for development or viability. Curr Biol (2010) 2.90
The expansion of the metazoan microRNA repertoire. BMC Genomics (2006) 2.80
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 2.79
MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev (2010) 2.70
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69
Suppression of cell growth and invasion by miR-205 in breast cancer. Cell Res (2009) 2.65
MicroRNA-206: the skeletal muscle-specific myomiR. Biochim Biophys Acta (2008) 2.64
Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proc Natl Acad Sci U S A (2005) 2.62
Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci U S A (2009) 2.61
MIR-206 regulates connexin43 expression during skeletal muscle development. Nucleic Acids Res (2006) 2.59
Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Res (2006) 2.58
The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis. RNA Biol (2009) 2.56
Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity. Genome Res (2008) 2.52
Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol (2008) 2.51
Pattern formation via small RNA mobility. Genes Dev (2009) 2.50
MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation. Exp Cell Res (2008) 2.46
Differences in vertebrate microRNA expression. Proc Natl Acad Sci U S A (2006) 2.45
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes Dev (2009) 2.41
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation. J Clin Invest (2009) 2.36
Ancient animal microRNAs and the evolution of tissue identity. Nature (2010) 2.35
Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis. Genes Dev (2008) 2.34
MicroRNAs as novel regulators of angiogenesis. Circ Res (2009) 2.33
Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression. Proc Natl Acad Sci U S A (2009) 2.28
microRNAs reveal the interrelationships of hagfish, lampreys, and gnathostomes and the nature of the ancestral vertebrate. Proc Natl Acad Sci U S A (2010) 2.25
A 3'-untranslated region (3'UTR) induces organ adhesion by regulating miR-199a* functions. PLoS One (2009) 2.24
miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood (2008) 2.21
Site-specific DICER and DROSHA RNA products control the DNA-damage response. Nature (2012) 2.20
Uncovering growth-suppressive MicroRNAs in lung cancer. Clin Cancer Res (2009) 2.19
Evidence for a microRNA expansion in the bilaterian ancestor. Dev Genes Evol (2006) 2.11
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08
Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron (2008) 2.07
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MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum (2009) 1.99
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MicroRNA let-7: an emerging next-generation cancer therapeutic. Curr Oncol (2010) 1.90
Cell-cell contact globally activates microRNA biogenesis. Proc Natl Acad Sci U S A (2009) 1.89
MiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A. Mol Biol Cell (2010) 1.89
MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. PLoS One (2009) 1.88
MicroRNAs in the Hox network: an apparent link to posterior prevalence. Nat Rev Genet (2008) 1.87
Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Genes Dev (2009) 1.84
The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One (2011) 1.81
microRNA-138 modulates cardiac patterning during embryonic development. Proc Natl Acad Sci U S A (2008) 1.80
MicroRNA miR-328 regulates zonation morphogenesis by targeting CD44 expression. PLoS One (2008) 1.80
Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis. Nat Commun (2011) 1.80
MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons. J Neurosci (2008) 1.78
Serum response factor micromanaging cardiogenesis. Curr Opin Cell Biol (2007) 1.77
Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Genes Dev (2009) 1.77
MiR-10 represses HoxB1a and HoxB3a in zebrafish. PLoS One (2008) 1.76
MicroRNAs in gene regulation: when the smallest governs it all. J Biomed Biotechnol (2006) 1.76
Neural stem cell self-renewal. Crit Rev Oncol Hematol (2007) 1.76
Context-dependent functions of specific microRNAs in neuronal development. Neural Dev (2010) 1.74
Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression. Genes Dev (2013) 1.74
The expanding transcriptome: the genome as the 'Book of Sand'. EMBO J (2006) 1.73
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
The diverse functions of microRNAs in animal development and disease. Dev Cell (2006) 15.62
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39
LNA-mediated microRNA silencing in non-human primates. Nature (2008) 11.45
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science (2009) 10.30
Treatment of HCV infection by targeting microRNA. N Engl J Med (2013) 9.91
The zebrafish reference genome sequence and its relationship to the human genome. Nature (2013) 8.52
Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol (2004) 7.33
MicroRNA function in animal development. FEBS Lett (2005) 6.93
In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nat Methods (2006) 6.67
Diversity of microRNAs in human and chimpanzee brain. Nat Genet (2006) 6.57
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31
The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell (2005) 5.90
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res (2007) 5.67
Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr Biol (2002) 5.66
Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res (2007) 5.62
Secondary siRNAs result from unprimed RNA synthesis and form a distinct class. Science (2006) 5.49
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer. Cancer Res (2007) 5.25
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A (2008) 5.24
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol (2003) 5.07
The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet (2003) 4.97
RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA (2005) 4.91
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Concern Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic Acids Res (2004) 4.50
Limitations and possibilities of small RNA digital gene expression profiling. Nat Methods (2009) 4.34
Approaches to microRNA discovery. Nat Genet (2006) 4.32
Diagnostic and prognostic microRNAs in stage II colon cancer. Cancer Res (2008) 4.20
Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi. Nature (2003) 4.09
Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes. Nucleic Acids Res (2004) 3.97
A micrococcal nuclease homologue in RNAi effector complexes. Nature (2003) 3.67
Efficient target-selected mutagenesis in zebrafish. Genome Res (2003) 3.61
The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell (2009) 3.60
A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature (2013) 3.52
LNA-modified oligonucleotides mediate specific inhibition of microRNA function. Gene (2006) 3.49
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol (2009) 3.44
Mapping determinants of gene expression plasticity by genetical genomics in C. elegans. PLoS Genet (2006) 3.39
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol Cell (2008) 3.37
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell (2006) 3.26
Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries. Nucleic Acids Res (2010) 3.23
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev (2004) 3.21
MicroRNA expression in the adult mouse central nervous system. RNA (2008) 3.12
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol (2007) 3.05
Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J Clin Invest (2010) 3.04
Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biol (2007) 3.04
Many families of C. elegans microRNAs are not essential for development or viability. Curr Biol (2010) 2.90
The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature (2003) 2.89
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci U S A (2004) 2.89
MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest (2010) 2.87
Evolutionary flux of canonical microRNAs and mirtrons in Drosophila. Nat Genet (2010) 2.84
Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification. Nat Protoc (2007) 2.80
Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer Res (2009) 2.80
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev (2003) 2.76
Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Res (2009) 2.68
miR-200b mediates post-transcriptional repression of ZFHX1B. RNA (2007) 2.67
Target-selected inactivation of the zebrafish rag1 gene. Science (2002) 2.60
Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Res (2006) 2.58
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J (2002) 2.56
Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system. Neuron (2005) 2.54
Differences in vertebrate microRNA expression. Proc Natl Acad Sci U S A (2006) 2.45
Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline. Hum Mol Genet (2011) 2.43
Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics. Nat Biotechnol (2003) 2.37
Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes Dev (2008) 2.35
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
The engulfment process of programmed cell death in caenorhabditis elegans. Annu Rev Cell Dev Biol (2004) 2.27
Gene expression: long-term gene silencing by RNAi. Nature (2006) 2.27
Genetic variation in the zebrafish. Genome Res (2006) 2.22
miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood (2008) 2.21
Uncovering growth-suppressive MicroRNAs in lung cancer. Clin Cancer Res (2009) 2.19
Camels and zebrafish, viruses and cancer: a microRNA update. Hum Mol Genet (2005) 2.18
Dicers at RISC; the mechanism of RNAi. Cell (2004) 2.14
Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol Cell Biol (2003) 2.13
The genetics of RNA silencing. Annu Rev Genet (2002) 2.10
Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron (2008) 2.07
Homologous gene targeting in Caenorhabditis elegans by biolistic transformation. Nucleic Acids Res (2004) 2.06
MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo. Proc Natl Acad Sci U S A (2011) 2.05
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2009) 2.03
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet (2008) 2.03
Inhibition of microRNA function by antimiR oligonucleotides. Silence (2012) 2.02