Published in Ann N Y Acad Sci on June 01, 2010
Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription. Biochemistry (2011) 1.10
Epigenetic virtues of chromodomains. Crit Rev Biochem Mol Biol (2011) 1.03
PALB2: the hub of a network of tumor suppressors involved in DNA damage responses. Biochim Biophys Acta (2014) 1.01
Maintenance of interphase chromosome compaction and homolog pairing in Drosophila is regulated by the condensin cap-h2 and its partner Mrg15. Genetics (2013) 0.89
Structural basis for molecular interactions involving MRG domains: implications in chromatin biology. Structure (2012) 0.88
'Relax and Repair' to restrain aging. Aging (Albany NY) (2011) 0.80
Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers. Cancer Biol Ther (2012) 0.78
A head and neck cancer tumor response-specific gene signature for cisplatin, 5-fluorouracil induction chemotherapy fails with added taxanes. PLoS One (2012) 0.77
Structural Basis for Multi-specificity of MRG Domains. Structure (2015) 0.77
MRG15 is required for pre-mRNA splicing and spermatogenesis. Proc Natl Acad Sci U S A (2016) 0.76
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
The serial cultivation of human diploid cell strains. Exp Cell Res (1961) 25.11
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res (1965) 21.61
Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell (1996) 10.40
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci (1996) 9.84
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature (2006) 8.06
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature (2007) 7.72
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem (2001) 6.85
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J (2001) 6.85
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res (1994) 6.16
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell (1994) 5.00
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science (2004) 4.97
Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol (1996) 4.67
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol (2004) 4.31
The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu Rev Genet (1995) 4.03
Experience-induced neurogenesis in the senescent dentate gyrus. J Neurosci (1998) 3.71
Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci U S A (2004) 3.60
Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J Neurosci (2004) 3.40
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev (1995) 3.29
Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature (2004) 3.25
Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics. Proc Natl Acad Sci U S A (2008) 3.23
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell (2009) 2.99
Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science (1998) 2.88
Replicative senescence: implications for in vivo aging and tumor suppression. Science (1996) 2.83
Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat Cell Biol (2008) 2.71
Restoring production of hippocampal neurons in old age. Nat Neurosci (1999) 2.49
Hippocampal neurogenesis in adult Old World primates. Proc Natl Acad Sci U S A (1999) 2.37
Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. J Biol Chem (2003) 2.36
Mammalian chromodomain proteins: their role in genome organisation and expression. Bioessays (2000) 2.36
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem Biophys Res Commun (2003) 2.27
The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin. Nucleic Acids Res (1995) 2.26
Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain. Exp Neurol (1999) 2.14
Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging Cell (2007) 2.07
Defective limbic system in mice lacking the tailless gene. Nature (1997) 2.05
Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci U S A (2007) 2.05
Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma. J Neurosci (1997) 2.01
Evidence for the recessive nature of cellular immortality. Science (1983) 1.94
Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Cell (2002) 1.81
Chromo-domain proteins: linking chromatin structure to epigenetic regulation. Curr Opin Cell Biol (1998) 1.78
Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. J Neurosci (2007) 1.77
RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. Genes Cells (2007) 1.71
Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Mol Cell Biol (1999) 1.57
Dynamics of neurogenesis in the dentate gyrus of adult rats. Neurosci Lett (2005) 1.55
The window and mechanisms of major age-related decline in the production of new neurons within the dentate gyrus of the hippocampus. Aging Cell (2006) 1.52
Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. Mol Cell Biol (2002) 1.52
Conservation of the MORF4 related gene family: identification of a new chromo domain subfamily and novel protein motif. Gene (2001) 1.49
MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. J Biol Chem (2002) 1.44
Lifelong corticosterone level determines age-related decline in neurogenesis and memory. Neurobiol Aging (2005) 1.39
Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain. J Neurosci (2009) 1.37
The product of the ATM gene is a 370-kDa nuclear phosphoprotein. J Biol Chem (1996) 1.35
Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev (2001) 1.35
MRG15 regulates embryonic development and cell proliferation. Mol Cell Biol (2005) 1.35
NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus. Neurobiol Aging (2002) 1.30
MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem (2009) 1.26
Expression of the transcription factor, tailless, is required for formation of superficial cortical layers. Cereb Cortex (2003) 1.17
MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. J Biol Chem (2001) 1.16
Replicative stress, stem cells and aging. Mech Ageing Dev (2008) 1.14
Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions. Neurosci Res (2009) 1.14
Neural stem cells in the developing and adult brains. J Cell Physiol (2009) 1.11
Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation. FEBS Lett (2007) 1.11
MRG15, a component of HAT and HDAC complexes, is essential for proliferation and differentiation of neural precursor cells. J Neurosci Res (2009) 0.94
The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging. Ann N Y Acad Sci (2007) 0.92
MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. J Biol Chem (2003) 0.90
Assembly of a BAC contig of the complementation group B cell senescence gene candidate region at 4q33-q34.1 and identification of expressed sequences. Genomics (1999) 0.80
Regulation of alternative splicing by histone modifications. Science (2010) 7.98
Activation of innate immune antiviral responses by Nod2. Nat Immunol (2009) 4.19
DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc Natl Acad Sci U S A (2004) 2.51
Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J (2004) 1.54
Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J Biol Chem (2002) 1.50
MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. J Biol Chem (2002) 1.44
p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts. Cancer Res (2006) 1.43
Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. Int J Cancer (2006) 1.42
MRG15 regulates embryonic development and cell proliferation. Mol Cell Biol (2005) 1.35
Microfluidics device for single cell gene expression analysis in Saccharomyces cerevisiae. Yeast (2006) 1.16
Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells. Mol Cell Biol (2006) 1.16
Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation. FEBS Lett (2007) 1.11
Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells. FASEB J (2010) 1.09
Role of IFI 16 in cellular senescence of human fibroblasts. Oncogene (2004) 1.07
Genetics of cellular senescence. Mech Ageing Dev (2002) 1.07
Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice. J Gerontol A Biol Sci Med Sci (2011) 0.99
The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay. Neoplasia (2005) 0.99
Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts. J Biol Chem (2002) 0.97
MRG15, a component of HAT and HDAC complexes, is essential for proliferation and differentiation of neural precursor cells. J Neurosci Res (2009) 0.94
Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. Structure (2006) 0.94
The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging. Ann N Y Acad Sci (2007) 0.92
The genomic organization, promoter position and expression profile of the mouse MRG15 gene. Gene (2002) 0.92
Mortalin: present and prospective. Exp Gerontol (2002) 0.92
MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. J Biol Chem (2003) 0.90
Functional analysis of MRG-1: the ortholog of human MRG15 in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci (2005) 0.85
PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice. Mol Cell Biol (2004) 0.85
The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas. Pathobiol Aging Age Relat Dis (2011) 0.83
Paraneoplastic cerebellar degeneration associated with an onconeural antibody against creatine kinase, brain-type. J Neurol Sci (2013) 0.83
The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway. Exp Cell Res (2009) 0.82
MrgX is not essential for cell growth and development in the mouse. Mol Cell Biol (2005) 0.82
MRG15 activates the cdc2 promoter via histone acetylation in human cells. Exp Cell Res (2011) 0.82
Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor. Stem Cell Res (2011) 0.81
The aging factor in health and disease: the promise of basic research on aging. Aging Clin Exp Res (2004) 0.81
Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster. Exp Gerontol (2010) 0.81
Exploring the link between MORF4L1 and risk of breast cancer. Breast Cancer Res (2011) 0.79
Translational repression of the McKusick-Kaufman syndrome transcript by unique upstream open reading frames encoding mitochondrial proteins with alternative polyadenylation sites. Biochim Biophys Acta (2013) 0.78
Rapid selection of XO embryonic stem cells using Y chromosome-linked GFP transgenic mice. Transgenic Res (2014) 0.76
A single-stage mechanism controls replicative senescence through Sudden Senescence Syndrome. Biogerontology (2002) 0.76
Polyethylene glycol-based homologated ligands for nicotinic acetylcholine receptors. Bioorg Med Chem (2008) 0.75
The role of chromatin reorganization in the process of cellular senescence. Curr Drug Targets (2012) 0.75
Early-senescing human skin fibroblasts do not demonstrate accelerated telomere shortening. J Gerontol A Biol Sci Med Sci (2005) 0.75
[Paraneoplastic cerebellar degeneration with bladder cancer confirmed the existence of an anti-neural antibody: a case report]. Brain Nerve (2013) 0.75