Published in Protein Sci on August 18, 2011
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PoPMuSiC, rationally designing point mutations in protein structures. Bioinformatics (2002) 1.06
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Functional insights from the distribution and role of homopeptide repeat-containing proteins. Genome Res (2005) 1.70
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The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment. Structure (2003) 1.61
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Molecular gymnastics: serpin structure, folding and misfolding. Curr Opin Struct Biol (2006) 1.47
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Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem (2010) 1.32
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The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J Biol Chem (2005) 1.21
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The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. J Biol Chem (2005) 1.20
Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions. Proteins (2013) 1.20
Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein. Biochemistry (2008) 1.18
Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation. J Biol Chem (2002) 1.17
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Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3. Biochem Biophys Res Commun (2004) 1.14
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The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates. PLoS Pathog (2010) 1.10
Kinetic instability of the serpin Z alpha1-antitrypsin promotes aggregation. J Mol Biol (2009) 1.10
Specificity and phenetic relationships of iron- and manganese-containing superoxide dismutases on the basis of structure and sequence comparisons. J Biol Chem (2003) 1.09
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Acid Denaturation of alpha1-antitrypsin: characterization of a novel mechanism of serpin polymerization. J Mol Biol (2002) 1.06
Different conformational changes within the F-helix occur during serpin folding, polymerization, and proteinase inhibition. Biochemistry (2004) 1.06
Antithrombin: in control of coagulation. Int J Biochem Cell Biol (2004) 1.03
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Human embryonic stem cell models of Huntington disease. Reprod Biomed Online (2009) 0.99
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Evidence that interaction between conserved residues in transmembrane helices 2, 3, and 7 are crucial for human VPAC1 receptor activation. Mol Pharmacol (2010) 0.99
Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease. J Mol Biol (2004) 0.98
Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide. Biophys J (2007) 0.98
The first peptides: the evolutionary transition between prebiotic amino acids and early proteins. J Theor Biol (2009) 0.98
The N terminus of the serpin, tengpin, functions to trap the metastable native state. EMBO Rep (2007) 0.97
A conserved cysteine residue is involved in disulfide bond formation between plant plasma membrane aquaporin monomers. Biochem J (2012) 0.96
Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases. Biochemistry (2002) 0.96
Sequence-structure signals of 3D domain swapping in proteins. J Mol Biol (2003) 0.96
Purification of polyglutamine proteins. Methods Enzymol (2006) 0.94
The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes. J Biol Chem (2009) 0.94
Probing the role of the F-helix in serpin stability through a single tryptophan substitution. Biochemistry (2002) 0.94
X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation. EMBO J (2006) 0.94
Probing the energetic and structural role of amino acid/nucleobase cation-pi interactions in protein-ligand complexes. J Biol Chem (2002) 0.94
Physical characterization of serpin conformations. Methods (2004) 0.93
Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species. J Biol Chem (2008) 0.93
The structural impact of a polyglutamine tract is location-dependent. Biophys J (2008) 0.93
A protein family under 'stress' - serpin stability, folding and misfolding. Front Biosci (2005) 0.93
DNA accelerates the inhibition of human cathepsin V by serpins. J Biol Chem (2007) 0.92
Production of recombinant serpins in Escherichia coli. Methods (2004) 0.92
Expression, purification and characterization of recombinant Z alpha(1)-antitrypsin--the most common cause of alpha(1)-antitrypsin deficiency. Protein Expr Purif (2009) 0.91
Serpin polymerization and its role in disease--the molecular basis of alpha1-antitrypsin deficiency. IUBMB Life (2009) 0.91
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The structure of H-2K(b) and K(bm8) complexed to a herpes simplex virus determinant: evidence for a conformational switch that governs T cell repertoire selection and viral resistance. J Immunol (2004) 0.90
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Structural change in β-sheet A of Z α(1)-antitrypsin is responsible for accelerated polymerization and disease. J Mol Biol (2011) 0.90
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The REFOLD database: a tool for the optimization of protein expression and refolding. Nucleic Acids Res (2006) 0.89
Protein stability: a single recorded mutation aids in predicting the effects of other mutations in the same amino acid site. Bioinformatics (2011) 0.89
The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition. J Biol Chem (2004) 0.88
Development of novel statistical potentials describing cation-pi interactions in proteins and comparison with semiempirical and quantum chemistry approaches. J Chem Inf Model (2006) 0.88
Thermostability of salt bridges versus hydrophobic interactions in proteins probed by statistical potentials. J Chem Inf Model (2007) 0.88
A structural basis for loop C-sheet polymerization in serpins. J Mol Biol (2008) 0.87
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Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap. J Biol Chem (2007) 0.86
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Free-energy calculations of protein-ligand cation-pi and amino-pi interactions: from vacuum to proteinlike environments. J Am Chem Soc (2003) 0.86
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Conformational properties of the disease-causing Z variant of α1-antitrypsin revealed by theory and experiment. Biophys J (2012) 0.85
Thermo- and mesostabilizing protein interactions identified by temperature-dependent statistical potentials. Biophys J (2010) 0.85
Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis. J Biol Chem (2008) 0.85