Published in Trends Genet on May 28, 2014
Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging. Science (2015) 2.10
Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxid Redox Signal (2015) 1.09
Renal protective effect of sirtuin 1. J Diabetes Res (2014) 1.05
The Mitochondrial Basis of Aging. Mol Cell (2016) 1.02
Transcriptional and epigenetic regulation of autophagy in aging. Autophagy (2015) 0.97
The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects. Vet Pathol (2015) 0.91
H3K36 methylation promotes longevity by enhancing transcriptional fidelity. Genes Dev (2015) 0.89
Metabolic regulation of histone post-translational modifications. ACS Chem Biol (2015) 0.87
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming. Dis Model Mech (2014) 0.84
Genetics of aging, health, and survival: dynamic regulation of human longevity related traits. Front Genet (2015) 0.82
SIRTain regulators of premature senescence and accelerated aging. Protein Cell (2015) 0.82
Genetic variation in Sirtuin 1 (SIRT1) is associated with lipid profiles but not with longevity in Ashkenazi Jews. Transl Res (2014) 0.82
Biochemical Genetic Pathways that Modulate Aging in Multiple Species. Cold Spring Harb Perspect Med (2015) 0.81
Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation. Mol Cell Proteomics (2015) 0.80
Key proteins and pathways that regulate lifespan. J Biol Chem (2017) 0.79
Review: Metabolic Regulation of Inflammation in Osteoarthritis. Arthritis Rheumatol (2017) 0.78
Role of NAD(+) and mitochondrial sirtuins in cardiac and renal diseases. Nat Rev Nephrol (2017) 0.78
Cellular ageing mechanisms in osteoarthritis. Mamm Genome (2016) 0.78
SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease. J Lifestyle Med (2014) 0.78
SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation. PLoS One (2015) 0.78
Adaptive response to chronic mild ethanol stress involves ROS, sirtuins and changes in chromosome dosage in wine yeasts. Oncotarget (2016) 0.78
Contribution of mitochondrial oxidative stress to hypertension. Curr Opin Nephrol Hypertens (2016) 0.77
Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead. J Clin Med (2014) 0.76
Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction. PLoS One (2016) 0.75
Relationships between rDNA, Nop1 and Sir complex in biotechnologically relevant distillery yeasts. Arch Microbiol (2016) 0.75
SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation. Aging (Albany NY) (2016) 0.75
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders. Neurochem Res (2016) 0.75
How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data. N Am Actuar J (2016) 0.75
SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation. Cell Death Differ (2016) 0.75
SirT1 activator represses the transcription of TNF‑α in THP‑1 cells of a sepsis model via deacetylation of H4K16. Mol Med Rep (2016) 0.75
Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2. Basic Res Cardiol (2016) 0.75
Neuroprotective Functions for the Histone Deacetylase SIRT6. Cell Rep (2017) 0.75
Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein. Methods Mol Biol (2016) 0.75
Characterization and mutational analysis of a nicotinamide mononucleotide deamidase from Agrobacterium tumefaciens showing high thermal stability and catalytic efficiency. PLoS One (2017) 0.75
Resveratrol Induces Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Neuron-Like Cells. Stem Cells Int (2017) 0.75
Deregulation of CRTCs in Aging and Age-Related Disease Risk. Trends Genet (2017) 0.75
Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1. Proc Natl Acad Sci U S A (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
The hallmarks of aging. Cell (2013) 14.29
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun (2000) 9.09
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell (2007) 8.94
Extrachromosomal rDNA circles--a cause of aging in yeast. Cell (1997) 8.68
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell (2005) 6.79
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol (2005) 6.34
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell (2009) 6.09
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
Life span of individual yeast cells. Nature (1959) 5.81
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell (2010) 5.73
Deaths: preliminary data for 2011. Natl Vital Stat Rep (2012) 5.62
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem (2010) 5.43
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell (2010) 5.40
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab (2005) 5.39
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res (2007) 5.23
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab (2009) 5.02
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell (2013) 4.85
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem (2005) 4.80
2013 Alzheimer's disease facts and figures. Alzheimers Dement (2013) 4.75
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease. Circulation (2003) 4.43
Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin. Nat Genet (2002) 4.36
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest (2009) 4.29
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell (2010) 4.19
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
HST2 mediates SIR2-independent life-span extension by calorie restriction. Science (2005) 4.12
The sirtuin SIRT6 regulates lifespan in male mice. Nature (2012) 4.07
Angiogenesis: a team effort coordinated by notch. Dev Cell (2009) 4.05
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell (2009) 4.01
Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci U S A (2000) 3.94
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2007) 3.94
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell (2011) 3.71
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest (2005) 3.66
SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One (2008) 3.66
Retracted SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell (2010) 3.58
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature (2013) 3.46
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell (1999) 3.46
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab (2011) 3.38
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell (2010) 3.33
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell (2006) 3.26
Reactive oxygen species in cancer. Free Radic Res (2010) 3.20
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics (2005) 3.19
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem (2006) 3.18
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A (2002) 3.18
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab (2012) 3.18
Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron (2010) 3.15
The polarisome is required for segregation and retrograde transport of protein aggregates. Cell (2010) 3.13
SIRT6 promotes DNA repair under stress by activating PARP1. Science (2011) 2.99
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun (2010) 2.97
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96
Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell (2006) 2.95
Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med (2010) 2.94
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J Clin Invest (2010) 2.92
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab (2010) 2.89
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat Med (2011) 2.87
The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell (2012) 2.78
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp Gerontol (2003) 2.77
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science (2010) 2.74
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell (2013) 2.70
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature (2011) 2.60
Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell (2012) 2.54
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature (2013) 2.52
Caloric restriction. Mol Aspects Med (2011) 2.50
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature (2011) 2.47
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A (2011) 2.41
For Certain, SIRT4 Activities! Trends Biochem Sci (2017) 0.75
Cycling around Lysine Modifications. Trends Biochem Sci (2017) 0.75