Published in Epigenetics on July 01, 2011
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Factors underlying variable DNA methylation in a human community cohort. Proc Natl Acad Sci U S A (2012) 3.20
Recommendations for the design and analysis of epigenome-wide association studies. Nat Methods (2013) 2.19
Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PLoS One (2012) 1.89
Age-associated epigenetic drift: implications, and a case of epigenetic thrift? Hum Mol Genet (2013) 1.76
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet (2012) 1.47
Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression. Mod Pathol (2014) 1.16
Epigenomics in environmental health. Front Genet (2011) 1.02
Interindividual variability and co-regulation of DNA methylation differ among blood cell populations. Epigenetics (2012) 1.00
From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? Clin Epigenetics (2015) 0.98
Identification of an epigenetic profile classifier that is associated with survival in head and neck cancer. Cancer Res (2012) 0.94
Influence of environmental exposure on human epigenetic regulation. J Exp Biol (2015) 0.93
Association of DNA methylation with age, gender, and smoking in an Arab population. Clin Epigenetics (2015) 0.93
Postnatal development- and age-related changes in DNA-methylation patterns in the human genome. Nucleic Acids Res (2012) 0.89
LINE-1 DNA methylation, smoking and risk of Parkinson's disease. J Parkinsons Dis (2012) 0.88
Fetal epigenetic programming of adipokines. Adipocyte (2013) 0.87
Associations between serum perfluoroalkyl acids and LINE-1 DNA methylation. Environ Int (2013) 0.86
An integrated epigenetic and transcriptomic analysis reveals distinct tissue-specific patterns of DNA methylation associated with atopic dermatitis. J Invest Dermatol (2014) 0.86
Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth. Epigenetics (2014) 0.84
DNA methylation signature of human fetal alcohol spectrum disorder. Epigenetics Chromatin (2016) 0.80
Quantitative leukocyte BDNF promoter methylation analysis in bipolar disorder. Int J Bipolar Disord (2013) 0.77
Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease. Clin Epigenetics (2017) 0.75
Does epigenetic drift contribute to age-related increases in breast cancer risk? Epigenomics (2014) 0.75
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
Epigenetics in cancer. N Engl J Med (2008) 17.36
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 12.33
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet (2006) 10.47
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet (1994) 8.34
A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol (2008) 7.95
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet (2009) 7.07
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project. PLoS Biol (2004) 4.96
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res (2008) 4.84
DNA hypomethylation and human diseases. Biochim Biophys Acta (2006) 4.31
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev (2008) 3.93
Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Bioinformatics (2008) 3.89
Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol (2009) 3.05
Implications of LINE1 methylation for bladder cancer risk in women. Clin Cancer Res (2010) 2.10
Age-related DNA methylation changes in normal human prostate tissues. Clin Cancer Res (2007) 2.02
Global, comparative analysis of tissue-specific promoter CpG methylation. Genomics (2007) 2.01
Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci U S A (1996) 1.99
Causes and consequences of DNA hypomethylation in human cancer. Biochem Cell Biol (2005) 1.94
The role of epigenetics in aging and age-related diseases. Ageing Res Rev (2009) 1.89
Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake. PLoS Genet (2010) 1.74
Epigenetics and atherosclerosis. Biochim Biophys Acta (2009) 1.72
Aging, DNA methylation and cancer. Crit Rev Oncol Hematol (1999) 1.70
Epigenetics and cardiovascular disease. Nat Rev Cardiol (2010) 1.68
Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences. Physiol Genomics (2010) 1.67
DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker. Mol Biotechnol (2010) 1.54
Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle. Diabetologia (2008) 1.50
Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Res (2010) 1.47
Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia. Cancer Sci (2006) 1.33
Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features. BMC Cancer (2010) 1.32
Identification of methylated genes associated with aggressive bladder cancer. PLoS One (2010) 1.27
Safety assessment of personal care products/cosmetics and their ingredients. Toxicol Appl Pharmacol (2009) 1.24
Occupational, environmental, and life-style factors associated with the risk of hematolymphopoietic malignancies in women. Am J Ind Med (1999) 1.23
DNA methylation as a universal biomarker. Expert Rev Mol Diagn (2010) 1.18
Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2. Carcinogenesis (2003) 1.16
DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements. J Nutr (2002) 1.14
Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA. Mutat Res (1989) 1.07
Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted. PLoS One (2010) 1.05
Personal hair dye use and cancer: a systematic literature review and evaluation of exposure assessment in studies published since 1992. J Toxicol Environ Health B Crit Rev (2007) 1.03
Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma. Int J Cancer (2009) 1.02
Identification of disease-associated DNA methylation in intestinal tissues from patients with inflammatory bowel disease. Clin Genet (2010) 0.98
Bladder cancer risk and personal hair dye use. Int J Cancer (2004) 0.92
Age-dependent alterations in mRNA level and promoter methylation of collagen alpha1(I) gene in human periodontal ligament. Mech Ageing Dev (1999) 0.92
Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver. Mutat Res (1996) 0.91
A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions. Carcinogenesis (2008) 0.91
Hair dye use and occupational exposure to organic solvents as risk factors for myelodysplastic syndrome. Leuk Res (1999) 0.89
Hair-color products and risk for non-Hodgkin's lymphoma: a population-based study in the San Francisco bay area. Am J Public Health (1998) 0.88
CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer. Cancer Res (2009) 0.86
A review of biomonitoring studies measuring genotoxicity in humans exposed to hair dyes. Mutagenesis (2009) 0.79
DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics (2012) 9.31
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet (2009) 7.07
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet (2009) 5.13
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. N Engl J Med (2015) 5.03
New common variants affecting susceptibility to basal cell carcinoma. Nat Genet (2009) 4.15
Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev (2007) 4.01
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet (2010) 3.93
Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Bioinformatics (2008) 3.89
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst (2010) 3.18
MicroRNA responses to cellular stress. Cancer Res (2006) 3.13
The landscape of recombination in African Americans. Nature (2011) 3.06
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res (2007) 2.93
DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma. J Natl Cancer Inst (2010) 2.87
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet (2009) 2.76
Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. J Natl Cancer Inst (2007) 2.68
Reference-free cell mixture adjustments in analysis of DNA methylation data. Bioinformatics (2014) 2.61
Population- and community-based recruitment of African Americans and Latinos: the San Francisco Bay Area Lung Cancer Study. Am J Epidemiol (2003) 2.52
Rice consumption and urinary arsenic concentrations in U.S. children. Environ Health Perspect (2012) 2.44
Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin. J Natl Cancer Inst (2006) 2.40
A case-control study of smoking and bladder cancer risk: emergent patterns over time. J Natl Cancer Inst (2009) 2.40
Arsenic, organic foods, and brown rice syrup. Environ Health Perspect (2012) 2.37
Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls. Int J Epidemiol (2009) 2.32
Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res (2012) 2.29
A let-7 microRNA-binding site polymorphism in the KRAS 3' UTR is associated with reduced survival in oral cancers. Carcinogenesis (2009) 2.28
Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res (2002) 2.20
Recommendations for the design and analysis of epigenome-wide association studies. Nat Methods (2013) 2.19
MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma. Clin Cancer Res (2009) 2.13
Implications of LINE1 methylation for bladder cancer risk in women. Clin Cancer Res (2010) 2.10
Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis (2005) 2.08
Which fish should I eat? Perspectives influencing fish consumption choices. Environ Health Perspect (2012) 2.06
Rice consumption contributes to arsenic exposure in US women. Proc Natl Acad Sci U S A (2011) 2.03
Nightshift work and genome-wide DNA methylation. Chronobiol Int (2014) 2.01
Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer. Cancer Res (2013) 1.99
Genome-wide association study of glioma and meta-analysis. Hum Genet (2012) 1.96
Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma. Carcinogenesis (2009) 1.94
Selenium and colorectal adenoma: results of a pooled analysis. J Natl Cancer Inst (2004) 1.93
DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer. J Clin Oncol (2011) 1.92
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene (2004) 1.82
Toxicity testing in the 21st century: a vision and a strategy. J Toxicol Environ Health B Crit Rev (2010) 1.81
Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis. Epigenetics (2013) 1.79
Human papillomavirus 16 and head and neck squamous cell carcinoma. Int J Cancer (2007) 1.78
History of allergies among adults with glioma and controls. Int J Cancer (2002) 1.78
Distinct germ line polymorphisms underlie glioma morphologic heterogeneity. Cancer Genet (2011) 1.77
Lung cancer in a U.S. population with low to moderate arsenic exposure. Environ Health Perspect (2009) 1.77
Epigenetics in the placenta. Am J Reprod Immunol (2009) 1.77
Biomarkers of HPV in head and neck squamous cell carcinoma. Cancer Res (2012) 1.76
Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers. Cancer Epidemiol Biomarkers Prev (2012) 1.76