1
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
2
|
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.
|
Arthritis Rheum
|
2003
|
10.65
|
3
|
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
Nat Genet
|
2012
|
7.59
|
4
|
Lung cancer susceptibility locus at 5p15.33.
|
Nat Genet
|
2008
|
5.99
|
5
|
Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies.
|
Am J Clin Nutr
|
2009
|
5.79
|
6
|
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
|
Nat Genet
|
2012
|
5.48
|
7
|
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
|
Nat Genet
|
2009
|
5.14
|
8
|
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
|
Nat Genet
|
2010
|
4.89
|
9
|
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
Nat Genet
|
2012
|
4.73
|
10
|
Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition.
|
J Natl Cancer Inst
|
2005
|
4.45
|
11
|
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
Nat Genet
|
2012
|
4.37
|
12
|
Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries.
|
Int J Cancer
|
2004
|
4.10
|
13
|
Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
|
J Natl Cancer Inst
|
2010
|
3.98
|
14
|
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
|
PLoS Med
|
2011
|
3.94
|
15
|
Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study.
|
Lancet
|
2003
|
3.53
|
16
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
17
|
Consumption of vegetables and fruits and risk of breast cancer.
|
JAMA
|
2005
|
3.02
|
18
|
Prostate specific antigen for early detection of prostate cancer: longitudinal study.
|
BMJ
|
2009
|
3.00
|
19
|
Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC).
|
Int J Cancer
|
2004
|
2.96
|
20
|
Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition.
|
Am J Clin Nutr
|
2009
|
2.93
|
21
|
Common variants associated with plasma triglycerides and risk for coronary artery disease.
|
Nat Genet
|
2013
|
2.92
|
22
|
Prospective study of hyperglycemia and cancer risk.
|
Diabetes Care
|
2007
|
2.89
|
23
|
Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).
|
Int J Cancer
|
2006
|
2.89
|
24
|
Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer.
|
J Clin Oncol
|
2013
|
2.87
|
25
|
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
|
PLoS Genet
|
2013
|
2.83
|
26
|
A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis.
|
Arthritis Res Ther
|
2004
|
2.72
|
27
|
Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study.
|
BMJ
|
2010
|
2.66
|
28
|
Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study.
|
J Natl Cancer Inst
|
2011
|
2.63
|
29
|
Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.
|
Hum Mol Genet
|
2009
|
2.58
|
30
|
Smoking and risk for amyotrophic lateral sclerosis: analysis of the EPIC cohort.
|
Ann Neurol
|
2009
|
2.56
|
31
|
Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition.
|
Am J Clin Nutr
|
2008
|
2.53
|
32
|
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.
|
JAMA
|
2008
|
2.52
|
33
|
Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC).
|
Am J Clin Nutr
|
2008
|
2.35
|
34
|
Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies.
|
Ann Intern Med
|
2008
|
2.33
|
35
|
Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis.
|
Arthritis Rheum
|
2010
|
2.29
|
36
|
Validation and calibration of food-frequency questionnaire measurements in the Northern Sweden Health and Disease cohort.
|
Public Health Nutr
|
2002
|
2.10
|
37
|
Plasma bilirubin and UGT1A1*28 are not protective factors against first-time myocardial infarction in a prospective, nested case-referent setting.
|
Circ Cardiovasc Genet
|
2010
|
2.06
|
38
|
[High-fat diet intake can be questioned].
|
Lakartidningen
|
2008
|
2.05
|
39
|
Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition.
|
Gut
|
2011
|
2.03
|
40
|
Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study.
|
Am J Clin Nutr
|
2012
|
1.98
|
41
|
High remaining risk in poorly treated hypertension: the 'rule of halves' still exists.
|
J Hypertens
|
2002
|
1.89
|
42
|
Combining 33 genetic variants with prostate-specific antigen for prediction of prostate cancer: longitudinal study.
|
Int J Cancer
|
2011
|
1.86
|
43
|
Adherence to the World Cancer Research Fund/American Institute for Cancer Research guidelines and risk of death in Europe: results from the European Prospective Investigation into Nutrition and Cancer cohort study1,4.
|
Am J Clin Nutr
|
2013
|
1.84
|
44
|
Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (me-can): analysis of six prospective cohorts.
|
PLoS Med
|
2009
|
1.83
|
45
|
Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.
|
Cancer Res
|
2010
|
1.82
|
46
|
The role of smoking and diet in explaining educational inequalities in lung cancer incidence.
|
J Natl Cancer Inst
|
2009
|
1.81
|
47
|
Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition.
|
BMC Med
|
2013
|
1.77
|
48
|
Body mass index and the risk for Crohn's disease and ulcerative colitis: data from a European Prospective Cohort Study (The IBD in EPIC Study).
|
Am J Gastroenterol
|
2013
|
1.77
|
49
|
Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.
|
PLoS Genet
|
2010
|
1.74
|
50
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
51
|
Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study.
|
J Clin Oncol
|
2012
|
1.70
|
52
|
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
|
PLoS Genet
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2011
|
1.68
|
53
|
Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort.
|
Am J Clin Nutr
|
2012
|
1.66
|
54
|
Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis.
|
Clin Cancer Res
|
2005
|
1.66
|
55
|
Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition.
|
Am J Epidemiol
|
2012
|
1.65
|
56
|
Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis.
|
Arthritis Res Ther
|
2011
|
1.64
|
57
|
Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).
|
Cancer Lett
|
2011
|
1.62
|
58
|
Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition.
|
Am J Clin Nutr
|
2012
|
1.61
|
59
|
EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries.
|
Eur J Epidemiol
|
2007
|
1.59
|
60
|
Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition.
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Am J Clin Nutr
|
2008
|
1.57
|
61
|
No association of consumption of animal foods with risk of ovarian cancer.
|
Cancer Epidemiol Biomarkers Prev
|
2007
|
1.55
|
62
|
Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC).
|
J Natl Cancer Inst
|
2006
|
1.55
|
63
|
Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women.
|
Int J Cancer
|
2004
|
1.52
|
64
|
PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease.
|
Arthritis Res Ther
|
2006
|
1.51
|
65
|
Nordic biological specimen banks as basis for studies of cancer causes and control--more than 2 million sample donors, 25 million person years and 100,000 prospective cancers.
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Acta Oncol
|
2007
|
1.51
|
66
|
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.
|
PLoS Genet
|
2013
|
1.51
|
67
|
Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population.
|
J Nutr
|
2008
|
1.49
|
68
|
Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition.
|
Int J Cancer
|
2007
|
1.49
|
69
|
Plasma leptin and colorectal cancer risk: a prospective study in Northern Sweden.
|
Oncol Rep
|
2003
|
1.48
|
70
|
Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
|
Am J Clin Nutr
|
2011
|
1.48
|
71
|
Epidemiology of Kaposi's Sarcoma herpesvirus (HHV8) in Västerbotten County, Sweden.
|
J Med Virol
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2006
|
1.47
|
72
|
Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis.
|
Arthritis Rheum
|
2013
|
1.46
|
73
|
Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
|
Am J Clin Nutr
|
2009
|
1.45
|
74
|
Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden.
|
Cancer Causes Control
|
2002
|
1.44
|
75
|
A population-based prospective study of Chlamydia trachomatis infection and cervical carcinoma.
|
Int J Cancer
|
2002
|
1.43
|
76
|
Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.
|
Carcinogenesis
|
2006
|
1.43
|
77
|
High levels of circulating insulin-like growth factor-I increase prostate cancer risk: a prospective study in a population-based nonscreened cohort.
|
J Clin Oncol
|
2004
|
1.41
|
78
|
Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study.
|
Am J Clin Nutr
|
2007
|
1.40
|
79
|
Estrogen receptor alpha gene polymorphisms and first-ever intracerebral hemorrhage.
|
Cerebrovasc Dis
|
2007
|
1.39
|
80
|
Metabolic syndrome and breast cancer in the me-can (metabolic syndrome and cancer) project.
|
Cancer Epidemiol Biomarkers Prev
|
2010
|
1.37
|
81
|
Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study.
|
Int J Cancer
|
2005
|
1.37
|
82
|
Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts.
|
Am J Clin Nutr
|
2004
|
1.35
|
83
|
Plasma leptin and breast cancer risk: a prospective study in northern Sweden.
|
Breast Cancer Res Treat
|
2004
|
1.35
|
84
|
Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition.
|
Am J Epidemiol
|
2010
|
1.34
|
85
|
An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
|
PLoS One
|
2013
|
1.33
|
86
|
Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC).
|
Cancer Causes Control
|
2007
|
1.33
|
87
|
Dietary patterns among older Europeans: the EPIC-Elderly study.
|
Br J Nutr
|
2005
|
1.33
|
88
|
Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC).
|
Int J Cancer
|
2007
|
1.33
|
89
|
Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer.
|
Int J Cancer
|
2004
|
1.33
|
90
|
Anthropometry, physical activity, and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition.
|
Cancer Epidemiol Biomarkers Prev
|
2006
|
1.32
|
91
|
Body mass index and cancer: results from the Northern Sweden Health and Disease Cohort.
|
Int J Cancer
|
2006
|
1.31
|
92
|
Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies.
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J Natl Cancer Inst
|
2012
|
1.31
|
93
|
Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition.
|
Am J Clin Nutr
|
2008
|
1.30
|
94
|
Fatty acid profile of the erythrocyte membrane preceding development of Type 2 diabetes mellitus.
|
Nutr Metab Cardiovasc Dis
|
2007
|
1.30
|
95
|
Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition.
|
Am J Clin Nutr
|
2008
|
1.27
|
96
|
Abdominal and gynoid fat mass are associated with cardiovascular risk factors in men and women.
|
J Clin Endocrinol Metab
|
2008
|
1.26
|
97
|
Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk.
|
Diabetes
|
2009
|
1.25
|
98
|
Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden.
|
Arthritis Res Ther
|
2011
|
1.25
|
99
|
Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC).
|
Int J Cancer
|
2006
|
1.25
|
100
|
Genetic variation in glutathione-related genes and body burden of methylmercury.
|
Environ Health Perspect
|
2008
|
1.24
|
101
|
Circulating levels of insulin-like growth factor-I and risk of ovarian cancer.
|
Int J Cancer
|
2002
|
1.24
|
102
|
Body size and risk of differentiated thyroid carcinomas: findings from the EPIC study.
|
Int J Cancer
|
2012
|
1.23
|
103
|
The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition.
|
Cancer Epidemiol Biomarkers Prev
|
2007
|
1.23
|
104
|
Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).
|
Am J Epidemiol
|
2009
|
1.23
|
105
|
Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.
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Cancer Epidemiol Biomarkers Prev
|
2011
|
1.21
|
106
|
Insulin resistance is inversely related to prostate cancer: a prospective study in Northern Sweden.
|
Int J Cancer
|
2007
|
1.21
|
107
|
Vitamin D as a protective factor in multiple sclerosis.
|
Neurology
|
2012
|
1.21
|
108
|
Intake of whole grain in Scandinavia: intake, sources and compliance with new national recommendations.
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Scand J Public Health
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2011
|
1.21
|
109
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Fruit and vegetable consumption and prospective weight change in participants of the European Prospective Investigation into Cancer and Nutrition-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home, and Obesity study.
|
Am J Clin Nutr
|
2011
|
1.21
|
110
|
Polymorphisms in glutathione-related genes affect methylmercury retention.
|
Arch Environ Health
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2004
|
1.20
|
111
|
Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.
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Diabetes
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2010
|
1.20
|
112
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Is the association with fiber from foods in colorectal cancer confounded by folate intake?
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Cancer Epidemiol Biomarkers Prev
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2005
|
1.20
|
113
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Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European ppulations.
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Cancer Epidemiol Biomarkers Prev
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2012
|
1.20
|
114
|
Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
|
Carcinogenesis
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2012
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1.20
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115
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Serum B vitamin levels and risk of lung cancer.
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JAMA
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2010
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1.20
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116
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The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study.
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Breast Cancer Res Treat
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2008
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1.19
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117
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Anthropometric measures, physical activity, and risk of glioma and meningioma in a large prospective cohort study.
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Cancer Prev Res (Phila)
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2011
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1.18
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118
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Epstein-Barr virus antibodies and vitamin D in prospective multiple sclerosis biobank samples.
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Mult Scler
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2013
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1.18
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119
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Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium.
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Cancer Causes Control
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2012
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1.17
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120
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Circulating levels of sex steroid hormones and risk of ovarian cancer.
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Int J Cancer
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2003
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1.17
|
121
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Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study.
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Cancer Epidemiol Biomarkers Prev
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2010
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1.16
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122
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TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study.
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Cancer Res
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2006
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1.16
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123
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Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
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Haematologica
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2008
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1.16
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124
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Social inequalities and mortality in Europe--results from a large multi-national cohort.
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PLoS One
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2012
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1.16
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125
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Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.
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Hum Mol Genet
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2010
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1.16
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126
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Fruits and vegetables and lung cancer: Findings from the European Prospective Investigation into Cancer and Nutrition.
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Int J Cancer
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2004
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1.16
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127
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Associations among 25-year trends in diet, cholesterol and BMI from 140,000 observations in men and women in Northern Sweden.
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Nutr J
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2012
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1.15
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128
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Metabolic syndrome and risks of colon and rectal cancer: the European prospective investigation into cancer and nutrition study.
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Cancer Prev Res (Phila)
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2011
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1.15
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129
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Fruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and nutrition (EPIC).
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Int J Cancer
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2006
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1.15
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130
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Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study.
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Am J Clin Nutr
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2010
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1.15
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131
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Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition.
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Int J Cancer
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2009
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1.14
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132
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Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can).
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Cancer Causes Control
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2011
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1.14
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133
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Plasma insulin, IGF-binding proteins-1 and -2 and risk of colorectal cancer: a prospective study in northern Sweden.
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Int J Cancer
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2003
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1.13
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134
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Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations.
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Cancer Epidemiol Biomarkers Prev
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2009
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1.13
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135
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PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3).
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Carcinogenesis
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2009
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1.13
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136
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Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research.
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Environ Health Perspect
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2013
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1.13
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137
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High levels of circulating testosterone are not associated with increased prostate cancer risk: a pooled prospective study.
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Int J Cancer
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2004
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1.12
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138
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Body size and risk of prostate cancer in the European prospective investigation into cancer and nutrition.
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Cancer Epidemiol Biomarkers Prev
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2008
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1.12
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139
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Cohort Profile: The Metabolic syndrome and Cancer project (Me-Can).
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Int J Epidemiol
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2009
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1.12
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140
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Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium.
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Cancer Epidemiol Biomarkers Prev
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2010
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1.11
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141
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Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach.
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Int J Cancer
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2009
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1.11
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142
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Metabolic risk factors and cervical cancer in the metabolic syndrome and cancer project (Me-Can).
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Gynecol Oncol
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2012
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1.11
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143
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Glycosylated hemoglobin and risk of colorectal cancer in men and women, the European prospective investigation into cancer and nutrition.
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Cancer Epidemiol Biomarkers Prev
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