Göran Hallmans

Author PubWeight™ 452.35‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
2 Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003 10.65
3 Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2012 7.59
4 Lung cancer susceptibility locus at 5p15.33. Nat Genet 2008 5.99
5 Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr 2009 5.79
6 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet 2012 5.48
7 Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 2009 5.14
8 A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 2010 4.89
9 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet 2012 4.73
10 Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J Natl Cancer Inst 2005 4.45
11 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012 4.37
12 Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer 2004 4.10
13 Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2010 3.98
14 Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med 2011 3.94
15 Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet 2003 3.53
16 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
17 Consumption of vegetables and fruits and risk of breast cancer. JAMA 2005 3.02
18 Prostate specific antigen for early detection of prostate cancer: longitudinal study. BMJ 2009 3.00
19 Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC). Int J Cancer 2004 2.96
20 Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2009 2.93
21 Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 2013 2.92
22 Prospective study of hyperglycemia and cancer risk. Diabetes Care 2007 2.89
23 Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Int J Cancer 2006 2.89
24 Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. J Clin Oncol 2013 2.87
25 Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet 2013 2.83
26 A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis. Arthritis Res Ther 2004 2.72
27 Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study. BMJ 2010 2.66
28 Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study. J Natl Cancer Inst 2011 2.63
29 Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet 2009 2.58
30 Smoking and risk for amyotrophic lateral sclerosis: analysis of the EPIC cohort. Ann Neurol 2009 2.56
31 Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2008 2.53
32 Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA 2008 2.52
33 Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Clin Nutr 2008 2.35
34 Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies. Ann Intern Med 2008 2.33
35 Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis. Arthritis Rheum 2010 2.29
36 Validation and calibration of food-frequency questionnaire measurements in the Northern Sweden Health and Disease cohort. Public Health Nutr 2002 2.10
37 Plasma bilirubin and UGT1A1*28 are not protective factors against first-time myocardial infarction in a prospective, nested case-referent setting. Circ Cardiovasc Genet 2010 2.06
38 [High-fat diet intake can be questioned]. Lakartidningen 2008 2.05
39 Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition. Gut 2011 2.03
40 Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study. Am J Clin Nutr 2012 1.98
41 High remaining risk in poorly treated hypertension: the 'rule of halves' still exists. J Hypertens 2002 1.89
42 Combining 33 genetic variants with prostate-specific antigen for prediction of prostate cancer: longitudinal study. Int J Cancer 2011 1.86
43 Adherence to the World Cancer Research Fund/American Institute for Cancer Research guidelines and risk of death in Europe: results from the European Prospective Investigation into Nutrition and Cancer cohort study1,4. Am J Clin Nutr 2013 1.84
44 Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (me-can): analysis of six prospective cohorts. PLoS Med 2009 1.83
45 Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res 2010 1.82
46 The role of smoking and diet in explaining educational inequalities in lung cancer incidence. J Natl Cancer Inst 2009 1.81
47 Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition. BMC Med 2013 1.77
48 Body mass index and the risk for Crohn's disease and ulcerative colitis: data from a European Prospective Cohort Study (The IBD in EPIC Study). Am J Gastroenterol 2013 1.77
49 Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus. PLoS Genet 2010 1.74
50 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
51 Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study. J Clin Oncol 2012 1.70
52 A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet 2011 1.68
53 Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr 2012 1.66
54 Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis. Clin Cancer Res 2005 1.66
55 Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition. Am J Epidemiol 2012 1.65
56 Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis. Arthritis Res Ther 2011 1.64
57 Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Cancer Lett 2011 1.62
58 Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2012 1.61
59 EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries. Eur J Epidemiol 2007 1.59
60 Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2008 1.57
61 No association of consumption of animal foods with risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev 2007 1.55
62 Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2006 1.55
63 Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women. Int J Cancer 2004 1.52
64 PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease. Arthritis Res Ther 2006 1.51
65 Nordic biological specimen banks as basis for studies of cancer causes and control--more than 2 million sample donors, 25 million person years and 100,000 prospective cancers. Acta Oncol 2007 1.51
66 Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet 2013 1.51
67 Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population. J Nutr 2008 1.49
68 Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 2007 1.49
69 Plasma leptin and colorectal cancer risk: a prospective study in Northern Sweden. Oncol Rep 2003 1.48
70 Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr 2011 1.48
71 Epidemiology of Kaposi's Sarcoma herpesvirus (HHV8) in Västerbotten County, Sweden. J Med Virol 2006 1.47
72 Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum 2013 1.46
73 Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr 2009 1.45
74 Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden. Cancer Causes Control 2002 1.44
75 A population-based prospective study of Chlamydia trachomatis infection and cervical carcinoma. Int J Cancer 2002 1.43
76 Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. Carcinogenesis 2006 1.43
77 High levels of circulating insulin-like growth factor-I increase prostate cancer risk: a prospective study in a population-based nonscreened cohort. J Clin Oncol 2004 1.41
78 Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study. Am J Clin Nutr 2007 1.40
79 Estrogen receptor alpha gene polymorphisms and first-ever intracerebral hemorrhage. Cerebrovasc Dis 2007 1.39
80 Metabolic syndrome and breast cancer in the me-can (metabolic syndrome and cancer) project. Cancer Epidemiol Biomarkers Prev 2010 1.37
81 Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. Int J Cancer 2005 1.37
82 Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. Am J Clin Nutr 2004 1.35
83 Plasma leptin and breast cancer risk: a prospective study in northern Sweden. Breast Cancer Res Treat 2004 1.35
84 Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. Am J Epidemiol 2010 1.34
85 An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population. PLoS One 2013 1.33
86 Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes Control 2007 1.33
87 Dietary patterns among older Europeans: the EPIC-Elderly study. Br J Nutr 2005 1.33
88 Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 2007 1.33
89 Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer. Int J Cancer 2004 1.33
90 Anthropometry, physical activity, and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 2006 1.32
91 Body mass index and cancer: results from the Northern Sweden Health and Disease Cohort. Int J Cancer 2006 1.31
92 Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies. J Natl Cancer Inst 2012 1.31
93 Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2008 1.30
94 Fatty acid profile of the erythrocyte membrane preceding development of Type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis 2007 1.30
95 Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2008 1.27
96 Abdominal and gynoid fat mass are associated with cardiovascular risk factors in men and women. J Clin Endocrinol Metab 2008 1.26
97 Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk. Diabetes 2009 1.25
98 Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden. Arthritis Res Ther 2011 1.25
99 Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 2006 1.25
100 Genetic variation in glutathione-related genes and body burden of methylmercury. Environ Health Perspect 2008 1.24
101 Circulating levels of insulin-like growth factor-I and risk of ovarian cancer. Int J Cancer 2002 1.24
102 Body size and risk of differentiated thyroid carcinomas: findings from the EPIC study. Int J Cancer 2012 1.23
103 The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev 2007 1.23
104 Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Epidemiol 2009 1.23
105 Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC. Cancer Epidemiol Biomarkers Prev 2011 1.21
106 Insulin resistance is inversely related to prostate cancer: a prospective study in Northern Sweden. Int J Cancer 2007 1.21
107 Vitamin D as a protective factor in multiple sclerosis. Neurology 2012 1.21
108 Intake of whole grain in Scandinavia: intake, sources and compliance with new national recommendations. Scand J Public Health 2011 1.21
109 Fruit and vegetable consumption and prospective weight change in participants of the European Prospective Investigation into Cancer and Nutrition-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home, and Obesity study. Am J Clin Nutr 2011 1.21
110 Polymorphisms in glutathione-related genes affect methylmercury retention. Arch Environ Health 2004 1.20
111 Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study. Diabetes 2010 1.20
112 Is the association with fiber from foods in colorectal cancer confounded by folate intake? Cancer Epidemiol Biomarkers Prev 2005 1.20
113 Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European ppulations. Cancer Epidemiol Biomarkers Prev 2012 1.20
114 Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer. Carcinogenesis 2012 1.20
115 Serum B vitamin levels and risk of lung cancer. JAMA 2010 1.20
116 The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study. Breast Cancer Res Treat 2008 1.19
117 Anthropometric measures, physical activity, and risk of glioma and meningioma in a large prospective cohort study. Cancer Prev Res (Phila) 2011 1.18
118 Epstein-Barr virus antibodies and vitamin D in prospective multiple sclerosis biobank samples. Mult Scler 2013 1.18
119 Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. Cancer Causes Control 2012 1.17
120 Circulating levels of sex steroid hormones and risk of ovarian cancer. Int J Cancer 2003 1.17
121 Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study. Cancer Epidemiol Biomarkers Prev 2010 1.16
122 TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study. Cancer Res 2006 1.16
123 Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Haematologica 2008 1.16
124 Social inequalities and mortality in Europe--results from a large multi-national cohort. PLoS One 2012 1.16
125 Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Hum Mol Genet 2010 1.16
126 Fruits and vegetables and lung cancer: Findings from the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 2004 1.16
127 Associations among 25-year trends in diet, cholesterol and BMI from 140,000 observations in men and women in Northern Sweden. Nutr J 2012 1.15
128 Metabolic syndrome and risks of colon and rectal cancer: the European prospective investigation into cancer and nutrition study. Cancer Prev Res (Phila) 2011 1.15
129 Fruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer 2006 1.15
130 Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study. Am J Clin Nutr 2010 1.15
131 Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 2009 1.14
132 Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can). Cancer Causes Control 2011 1.14
133 Plasma insulin, IGF-binding proteins-1 and -2 and risk of colorectal cancer: a prospective study in northern Sweden. Int J Cancer 2003 1.13
134 Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. Cancer Epidemiol Biomarkers Prev 2009 1.13
135 PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3). Carcinogenesis 2009 1.13
136 Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research. Environ Health Perspect 2013 1.13
137 High levels of circulating testosterone are not associated with increased prostate cancer risk: a pooled prospective study. Int J Cancer 2004 1.12
138 Body size and risk of prostate cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 2008 1.12
139 Cohort Profile: The Metabolic syndrome and Cancer project (Me-Can). Int J Epidemiol 2009 1.12
140 Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium. Cancer Epidemiol Biomarkers Prev 2010 1.11
141 Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach. Int J Cancer 2009 1.11
142 Metabolic risk factors and cervical cancer in the metabolic syndrome and cancer project (Me-Can). Gynecol Oncol 2012 1.11
143 Glycosylated hemoglobin and risk of colorectal cancer in men and women, the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 2008 1.11
144 Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis. Breast Cancer Res Treat 2006 1.10
145 Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Carcinogenesis 2006 1.10
146 Prostate stem-cell antigen gene is associated with diffuse and intestinal gastric cancer in Caucasians: results from the EPIC-EURGAST study. Int J Cancer 2011 1.10
147 Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition study. Cancer Epidemiol Biomarkers Prev 2008 1.10
148 Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). Carcinogenesis 2008 1.10
149 Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. Breast Cancer Res Treat 2006 1.10
150 Prospective study on metabolic factors and risk of prostate cancer. Cancer 2012 1.09
151 Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden. Stroke 2010 1.09
152 Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer. Cancer Lett 2008 1.09
153 One-carbon metabolism and prostate cancer risk: prospective investigation of seven circulating B vitamins and metabolites. Cancer Epidemiol Biomarkers Prev 2009 1.07
154 Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels. J Clin Endocrinol Metab 2007 1.06
155 Alcohol intake and risk of coronary heart disease in younger, middle-aged, and older adults. Circulation 2010 1.05
156 Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden. Br J Nutr 2007 1.05
157 Variety in fruit and vegetable consumption and the risk of lung cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 2010 1.05
158 Blood pressure and risk of cancer incidence and mortality in the Metabolic Syndrome and Cancer Project. Hypertension 2012 1.04
159 One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study. Cancer Causes Control 2009 1.04
160 Smoking and lymphoma risk in the European prospective investigation into cancer and nutrition. Am J Epidemiol 2008 1.03
161 Metabolic factors and the risk of pancreatic cancer: a prospective analysis of almost 580,000 men and women in the Metabolic Syndrome and Cancer Project. Cancer Epidemiol Biomarkers Prev 2010 1.03
162 t(14;18) Translocation: A predictive blood biomarker for follicular lymphoma. J Clin Oncol 2014 1.02
163 Plasma vitamin B12 concentrations and the risk of colorectal cancer: a nested case-referent study. Int J Cancer 2008 1.02
164 Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression. Genes Chromosomes Cancer 2010 1.02
165 Total and high-molecular weight adiponectin and risk of colorectal cancer: the European Prospective Investigation into Cancer and Nutrition Study. Carcinogenesis 2012 1.02
166 Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study. Cancer Causes Control 2010 1.01
167 Interleukin promoter polymorphisms and prognosis in colorectal cancer. Carcinogenesis 2008 1.01
168 Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. J Agric Food Chem 2008 1.00
169 Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiol Biomarkers Prev 2010 1.00
170 Low levels of IgM antibodies against phosphorylcholine predict development of acute myocardial infarction in a population-based cohort from northern Sweden. Eur J Cardiovasc Prev Rehabil 2009 1.00
171 Risk of endometrial cancer in relationship to cigarette smoking: results from the EPIC study. Int J Cancer 2007 0.99
172 Metabolic factors and the risk of colorectal cancer in 580,000 men and women in the metabolic syndrome and cancer project (Me-Can). Cancer 2010 0.99
173 Metabolic syndrome and endometrial carcinoma. Am J Epidemiol 2010 0.99
174 Smoking as a risk factor for multiple sclerosis. Mult Scler 2012 0.99
175 Human papillomavirus 16, 18, and 33 infections and risk of prostate cancer: a Nordic nested case-control study. Cancer Epidemiol Biomarkers Prev 2005 0.99
176 Blood pressure and other metabolic syndrome factors and risk of brain tumour in the large population-based Me-Can cohort study. J Hypertens 2012 0.98
177 Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev 2005 0.98
178 More distinct food intake patterns among women than men in northern Sweden: a population-based survey. Nutr J 2009 0.98
179 Total serum cholesterol and cancer incidence in the Metabolic syndrome and Cancer Project (Me-Can). PLoS One 2013 0.98
180 Intake of whole grains in Scandinavia is associated with healthy lifestyle, socio-economic and dietary factors. Public Health Nutr 2011 0.98
181 Fish consumption and myocardial infarction: a second prospective biomarker study from northern Sweden. Am J Clin Nutr 2010 0.97
182 A potential inverse association between insulin-like growth factor I and hypertension in a cross-sectional study. Ann Epidemiol 2006 0.97
183 Defining the genomic signature of the parous breast. BMC Med Genomics 2012 0.97
184 Adherence to a healthy diet according to the World Health Organization guidelines and all-cause mortality in elderly adults from Europe and the United States. Am J Epidemiol 2014 0.97
185 Stroke and plasma markers of milk fat intake--a prospective nested case-control study. Nutr J 2009 0.97
186 Cereal alkylresorcinols are absorbed by humans. J Nutr 2003 0.97
187 The effects of commuting activity and occupational and leisure time physical activity on risk of myocardial infarction. Eur J Cardiovasc Prev Rehabil 2006 0.97
188 Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case-control study. Br J Nutr 2004 0.97
189 The effect of occasional smoking on smoking-related cancers: in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes Control 2006 0.96
190 Metabolic syndrome and risk of bladder cancer: prospective cohort study in the metabolic syndrome and cancer project (Me-Can). Int J Cancer 2011 0.96
191 Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk. Carcinogenesis 2009 0.96
192 Recruiting high-risk individuals to a diabetes prevention program: how hard can it be? Diabetes Care 2007 0.96
193 Temporal reliability of cytokines and growth factors in EDTA plasma. BMC Res Notes 2010 0.95
194 Circulating levels of 25-hydroxyvitamin D and risk of breast cancer: a nested case-control study. Breast Cancer Res 2013 0.95
195 Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 2006 0.95
196 Effects of heavy endurance physical exercise on inflammatory markers in non-athletes. Atherosclerosis 2009 0.95
197 Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition cohort. Am J Epidemiol 2007 0.95
198 Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580,000 subjects within the Me-Can project. BMC Cancer 2014 0.95
199 Dietary glycemic index and glycemic load and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Clin Nutr 2012 0.95
200 Risk factors for cancers of unknown primary site: Results from the prospective EPIC cohort. Int J Cancer 2014 0.94
201 Nonlinear relationship of insulin-like growth factor (IGF)-I and IGF-I/IGF-binding protein-3 ratio with indices of adiposity and plasma insulin concentrations (Sweden). Cancer Causes Control 2002 0.94
202 A randomized lifestyle intervention with 5-year follow-up in subjects with impaired glucose tolerance: pronounced short-term impact but long-term adherence problems. Scand J Public Health 2009 0.94
203 Increased glucose levels are associated with episodic memory in nondiabetic women. Diabetes 2007 0.94
204 Trends in food intakes in Swedish adults 1986-1999: findings from the Northern Sweden MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease) Study. Public Health Nutr 2005 0.94
205 Macronutrient composition of the diet and prospective weight change in participants of the EPIC-PANACEA study. PLoS One 2013 0.94
206 Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer. Am J Obstet Gynecol 2003 0.93
207 Prediagnostic levels of carcinoembryonic antigen and CA 242 in colorectal cancer: a matched case-control study. Dis Colon Rectum 2003 0.93
208 Effect of long-term storage on hormone measurements in samples from pregnant women: the experience of the Finnish Maternity Cohort. Acta Oncol 2007 0.93
209 Rye whole grain and bran intake compared with refined wheat decreases urinary C-peptide, plasma insulin, and prostate specific antigen in men with prostate cancer. J Nutr 2010 0.93
210 Cigarette smoking and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study. Clin Gastroenterol Hepatol 2010 0.93
211 Smoking and risk of coronary heart disease in younger, middle-aged, and older adults. Am J Public Health 2013 0.92
212 Human chorionic gonadotropin and alpha-fetoprotein concentrations in pregnancy and maternal risk of breast cancer: a nested case-control study. Am J Epidemiol 2008 0.92
213 Menstrual and reproductive factors, exogenous hormone use, and gastric cancer risk in a cohort of women from the European Prospective Investigation Into Cancer and Nutrition. Am J Epidemiol 2010 0.92
214 Chlamydial antibodies and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2005 0.92
215 Trends in lifestyle 1986-99 in a 25- to 64-year-old population of the Northern Sweden MONICA project. Scand J Public Health Suppl 2003 0.92
216 Folate, vitamin B12, and risk of ischemic and hemorrhagic stroke: a prospective, nested case-referent study of plasma concentrations and dietary intake. Stroke 2005 0.92
217 Metabolic risk factors and ovarian cancer in the Metabolic Syndrome and Cancer project. Int J Epidemiol 2011 0.92
218 Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev 2007 0.92
219 Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer. Cancer Epidemiol 2012 0.92
220 Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin. Thromb Res 2008 0.91
221 Time trends in burdens of cadmium, lead, and mercury in the population of northern Sweden. Environ Res 2005 0.91
222 Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition. Haematologica 2008 0.91
223 Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Carcinogenesis 2011 0.91
224 Reduced risk of myocardial infarction related to active commuting: inflammatory and haemostatic effects are potential major mediating mechanisms. Eur J Cardiovasc Prev Rehabil 2010 0.90
225 Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes Control 2007 0.90
226 Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction. Eur J Cardiovasc Prev Rehabil 2004 0.90
227 Human immunoglobulin G levels of viruses and associated glioma risk. Cancer Causes Control 2011 0.90
228 Circulating enterolactone and prostate cancer risk: a Nordic nested case-control study. Int J Cancer 2002 0.90
229 Haemostatic and inflammatory markers are independently associated with myocardial infarction in men and women. Thromb Res 2011 0.90
230 Genetic polymorphism of chemokine receptors CCR2 and CCR5 in Swedish cervical cancer patients. Anticancer Res 2006 0.90
231 End-stage renal disease and low level exposure to lead, cadmium and mercury; a population-based, prospective nested case-referent study in Sweden. Environ Health 2013 0.89
232 Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. Breast Cancer Res Treat 2009 0.89
233 Characterization of a genomic signature of pregnancy identified in the breast. Cancer Prev Res (Phila) 2011 0.89
234 Consumption of meat and fish and risk of lung cancer: results from the European Prospective Investigation into Cancer and Nutrition. Cancer Causes Control 2011 0.89
235 Fruits and vegetables and prostate cancer: no association among 1104 cases in a prospective study of 130544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 2004 0.89
236 Metabolic factors associated with risk of renal cell carcinoma. PLoS One 2013 0.89
237 Insulin-like growth factor-II methylation status in lymphocyte DNA and colon cancer risk in the Northern Sweden Health and Disease cohort. Cancer Res 2009 0.89
238 Prostate cancer, prostate cancer death, and death from other causes, among men with metabolic aberrations. Epidemiology 2014 0.89
239 Endogenous steroid hormone levels in early pregnancy and risk of testicular cancer in the offspring: a nested case-referent study. Int J Cancer 2009 0.88
240 An incident case-referent study on plasma enterolactone and breast cancer risk. Eur J Nutr 2002 0.88
241 Reproducibility of plasma alkylresorcinols during a 6-week rye intervention study in men with prostate cancer. J Nutr 2009 0.88
242 Maternal Epstein-Barr virus and cytomegalovirus infections and risk of testicular cancer in the offspring: a nested case-control study. APMIS 2008 0.88
243 Pooled cohort study on height and risk of cancer and cancer death. Cancer Causes Control 2013 0.88
244 Known glioma risk loci are associated with glioma with a family history of brain tumours -- a case-control gene association study. Int J Cancer 2012 0.88
245 Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. J Nutr 2013 0.88
246 Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study. Int J Cancer 2010 0.88
247 Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 2010 0.88
248 IGF-I, IGFBP-3 and breast cancer in young women: a pooled re-analysis of three prospective studies. Eur J Cancer Prev 2005 0.87
249 Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC). Mutagenesis 2011 0.87
250 Prospective study of plasma enterolactone and prostate cancer risk (Sweden). Cancer Causes Control 2004 0.87
251 Circulating vitamin d and risk of epithelial ovarian cancer. J Oncol 2009 0.87
252 The Mediterranean diet score and mortality are inversely associated in adults living in the subarctic region. J Nutr 2012 0.87
253 Alcohol consumption and the risk for prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev 2008 0.87
254 Inverse relation between dietary intake of naturally occurring plant sterols and serum cholesterol in northern Sweden. Am J Clin Nutr 2008 0.87
255 Long-term temporal trends in cardiovascular and metabolic risk factors. Wien Klin Wochenschr 2009 0.87
256 Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiol Biomarkers Prev 2011 0.87
257 Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer. Cancer Res 2010 0.86
258 No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes 2012 0.86
259 Nuclear magnetic resonance-based metabolomics enable detection of the effects of a whole grain rye and rye bran diet on the metabolic profile of plasma in prostate cancer patients. J Nutr 2011 0.85
260 Genetic variants in hormone-related genes and risk of breast cancer. PLoS One 2013 0.85
261 CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Eur J Cancer 2008 0.85
262 Herpes simplex virus and risk of cervical cancer: a longitudinal, nested case-control study in the nordic countries. Am J Epidemiol 2002 0.85
263 No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 2006 0.85
264 Ecological-level associations between highly processed food intakes and plasma phospholipid elaidic acid concentrations: results from a cross-sectional study within the European prospective investigation into cancer and nutrition (EPIC). Nutr Cancer 2011 0.85
265 Insulin-like growth factor I in pregnancy and maternal risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2006 0.84
266 Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. Eur J Cancer 2008 0.84
267 Physical activity and lymphoid neoplasms in the European Prospective Investigation into Cancer and nutrition (EPIC). Eur J Cancer 2010 0.84
268 Smoking, secondhand smoke, and cotinine levels in a subset of EPIC cohort. Cancer Epidemiol Biomarkers Prev 2011 0.84
269 A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus. J Med Genet 2013 0.84
270 Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can). Cancer Causes Control 2012 0.84
271 Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2009 0.84
272 Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study. Environ Health 2011 0.84
273 Smoking and body mass index as risk factors for subtypes of cancer of unknown primary. Int J Cancer 2014 0.84
274 Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study. Inflamm Bowel Dis 2016 0.83
275 Serum follicle-stimulating hormone and risk of epithelial ovarian cancer in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2003 0.83
276 A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 2009 0.83
277 Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can). Ann Hematol 2012 0.83
278 Hip fracture risk and cadmium in erythrocytes: a nested case-control study with prospectively collected samples. Calcif Tissue Int 2013 0.83
279 Adiposity, mediating biomarkers and risk of colon cancer in the European prospective investigation into cancer and nutrition study. Int J Cancer 2013 0.82
280 Reported food intake and distribution of body fat: a repeated cross-sectional study. Nutr J 2006 0.82
281 Iron biomarkers in plasma, HFE genotypes, and the risk for colorectal cancer in a prospective setting. Dis Colon Rectum 2012 0.81
282 Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo. Exp Biol Med (Maywood) 2005 0.81
283 Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition. Int J Cancer 2012 0.81
284 Smoking status, snus use, and variation at the CHRNA5-CHRNA3-CHRNB4 locus in relation to obesity: the GLACIER study. Am J Epidemiol 2013 0.81
285 Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). PLoS One 2011 0.81
286 Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer: a nested case-control study. Eur J Cancer Prev 2006 0.81
287 Maternal smoking during pregnancy and testicular cancer in the sons: a nested case-control study and a meta-analysis. Eur J Cancer 2009 0.81
288 Estimation and selection of complex covariate effects in pooled nested case-control studies with heterogeneity. Biostatistics 2013 0.81
289 Vitamin A and systemic inflammation as protective factors in multiple sclerosis. Mult Scler 2013 0.80
290 Circulating enterolactone and risk of endometrial cancer. Int J Cancer 2006 0.80
291 Variety in vegetable and fruit consumption and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 2010 0.80
292 Evaluation of plant sterol intake estimated with the Northern Sweden FFQ. Public Health Nutr 2012 0.80
293 Hemostatic factors as risk markers for intracerebral hemorrhage: a prospective incident case-referent study. Stroke 2004 0.79
294 Androgens and prostate cancer risk: a prospective study. Prostate 2007 0.79
295 Challenges in estimating the validity of dietary acrylamide measurements. Eur J Nutr 2012 0.79
296 Plasma folate, but not homocysteine, is associated with Apolipoprotein A1 levels in a non-fortified population. Lipids Health Dis 2013 0.79
297 Risk of invasive cervical cancer associated with polymorphic HLA DR/DQ haplotypes. Int J Cancer 2002 0.79
298 Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke. Clin Chem Lab Med 2011 0.79
299 A structural equation modelling approach to explore the role of B vitamins and immune markers in lung cancer risk. Eur J Epidemiol 2013 0.79
300 Risk of ovarian cancer in relation to prediagnostic levels of C-peptide, insulin-like growth factor binding proteins-1 and -2 (USA, Sweden, Italy). Cancer Causes Control 2003 0.78
301 Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4. Cancer Causes Control 2013 0.78
302 Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change. Obes Facts 2011 0.78
303 High-titer GAD65 autoantibodies detected in adult diabetes patients using a high efficiency expression vector and cold GAD65 displacement. Autoimmunity 2010 0.78
304 Low-carbohydrate, high-protein diet score and risk of incident cancer; a prospective cohort study. Nutr J 2013 0.78
305 Exploring dietary patterns, obesity and sources of bias: the Västerbotten Intervention Programme (VIP). Public Health Nutr 2012 0.78
306 Components of One-carbon Metabolism Other than Folate and Colorectal Cancer Risk. Epidemiology 2016 0.77
307 The interface of population-based cancer registries and biobanks in etiological and clinical research--current and future perspectives. Acta Oncol 2010 0.77
308 Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European Prospective Cohort Investigation. Inflamm Bowel Dis 2016 0.77
309 Carbohydrate intake in the etiology of Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 2014 0.77
310 Iron stores and HFE genotypes are not related to increased risk of first-time myocardial infarction: a prospective nested case-referent study. Int J Cardiol 2010 0.77
311 Mis-reporting, previous health status and health status of family may seriously bias the association between food patterns and disease. Nutr J 2010 0.77
312 Prediagnostic circulating parathyroid hormone concentration and colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort. Cancer Epidemiol Biomarkers Prev 2011 0.77
313 Fish consumption and subsequent change in body weight in European women and men. Br J Nutr 2012 0.77
314 Bilirubin and UGT1A1*28 are not associated with lower risk for ischemic stroke in a prospective nested case-referent setting. Cerebrovasc Dis 2010 0.76
315 Prevalence of systemic immunoreactivity to Aggregatibacter actinomycetemcomitans leukotoxin in relation to the incidence of myocardial infarction. BMC Infect Dis 2011 0.76
316 Polymorphisms of IL-1beta, IL-1Ra, and TNF-alpha genes: a nested case-control study of their association with risk for stroke. J Stroke Cerebrovasc Dis 2007 0.76
317 The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. BMC Cancer 2010 0.75
318 Circulating soluble Fas levels and risk of ovarian cancer. BMC Cancer 2003 0.75
319 [Dietary fibers in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study]. Ugeskr Laeger 2004 0.75
320 Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study. Diabetologia 2015 0.75
321 New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circ Cardiovasc Genet 2017 0.75
322 [The researcher, the society and partiality]. Lakartidningen 2008 0.75
323 Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years. Blood Coagul Fibrinolysis 2009 0.75
324 Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC). Inflamm Bowel Dis 2017 0.75
325 Prospective study on soluble thrombomodulin and von Willebrand factor and the risk of ischemic and hemorrhagic stroke. Thromb Haemost 2002 0.75
326 [Final reply to the debate on diet: alarming that extreme diets are marketed in health care]. Lakartidningen 2008 0.75
327 Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition. J Cancer Res Clin Oncol 2010 0.75
328 Dietary intake of naturally occurring plant sterols is related to a lower risk of a first myocardial infarction in men but not in women in northern Sweden. J Nutr 2013 0.75
329 [Population studies are needed--also LifeGene!]. Lakartidningen 2012 0.75
330 Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 2017 0.75