Published in J Biol Chem on July 14, 2011
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The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature (2002) 3.48
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Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep (2008) 2.35
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Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin. J Cell Biol (2008) 2.18
ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Oncogene (2007) 2.12
A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem (2007) 2.09
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell (2009) 2.07
Multiple functions of MRN in end-joining pathways during isotype class switching. Nat Struct Mol Biol (2009) 2.05
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ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci Signal (2010) 1.86
Chk2 activation dependence on Nbs1 after DNA damage. Mol Cell Biol (2001) 1.85
Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Mol Cell (2007) 1.77
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol Cell (2009) 1.70
Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks. J Biol Chem (2004) 1.66
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MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med (2009) 1.50
Rapid activation of ATM on DNA flanking double-strand breaks. Nat Cell Biol (2007) 1.49
53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J (2009) 1.47
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J Biol Chem (2007) 1.39
The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage. J Biol Chem (1999) 1.34
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med (2007) 1.32
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm. J Biol Chem (2004) 1.28
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol (2008) 1.24
Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J Cell Biol (2005) 1.24
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Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res (2006) 1.19
Biological imaging of heavy charged-particle tracks. Radiat Res (2003) 1.17
CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1. Nucleic Acids Res (2010) 1.16
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NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J Cell Sci (2007) 1.14
Spatiotemporal analysis of DNA repair using charged particle radiation. Mutat Res (2009) 1.11
Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem (2010) 1.07
Live cell imaging of heavy-ion-induced radiation responses by beamline microscopy. Radiat Res (2005) 1.06
The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer. Mutat Res (2008) 0.97
PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst) (2009) 0.90
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11
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Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23
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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet (2009) 6.04
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet (2010) 5.48
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Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Nat Genet (2006) 5.12
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Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst (2010) 4.54
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. Nat Genet (2005) 4.13
Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Science (2008) 4.04
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell (2007) 3.86
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet (2010) 3.86
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet (2011) 3.74
Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet (2010) 3.57
Dominant negative ATM mutations in breast cancer families. J Natl Cancer Inst (2002) 3.46
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet (2013) 3.42
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet (2011) 3.07
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol (2008) 3.07
Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium. Cancer Epidemiol Biomarkers Prev (2008) 3.05
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol (2007) 2.92
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Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet (2011) 2.72
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem (2006) 2.66
Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders. PLoS Genet (2012) 2.65
Identification of the Fanconi anemia complementation group I gene, FANCI. Cell Oncol (2007) 2.50
Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J (2011) 2.46
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell (2010) 2.36
Involvement of human MOF in ATM function. Mol Cell Biol (2005) 2.30
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Mol Cell (2007) 2.30
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
Proapoptotic BID is an ATM effector in the DNA-damage response. Cell (2005) 2.21
Nonsense mutation p.Q548X in BLM, the gene mutated in Bloom's syndrome, is associated with breast cancer in Slavic populations. Breast Cancer Res Treat (2012) 2.19
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia. Am J Hum Genet (2013) 2.15
Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks. Nat Struct Mol Biol (2010) 2.14
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break. Cell (2008) 2.11
Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer. Nat Genet (2002) 2.11
The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing. Clin Cancer Res (2011) 2.09
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FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway. EMBO J (2007) 2.00
Involvement of novel autophosphorylation sites in ATM activation. EMBO J (2006) 1.94
The ATM protein kinase and cellular redox signaling: beyond the DNA damage response. Trends Biochem Sci (2011) 1.91
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet (2013) 1.88
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. J Biol Chem (2007) 1.80
Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Mol Cell (2007) 1.77
Functional consequences of ATM sequence variants for chromosomal radiosensitivity. Genes Chromosomes Cancer (2004) 1.76
ATM signaling and genomic stability in response to DNA damage. Mutat Res (2005) 1.75
A new type of mutation causes a splicing defect in ATM. Nat Genet (2002) 1.74
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin. Nucleic Acids Res (2011) 1.72
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Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype. Am J Hum Genet (2007) 1.67
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Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. EMBO J (2007) 1.65
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Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res (2005) 1.65
Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks. Cell Cycle (2011) 1.63
Aprataxin, a novel protein that protects against genotoxic stress. Hum Mol Genet (2004) 1.60
Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage. J Cell Biol (2007) 1.59
Association of ESR1 gene tagging SNPs with breast cancer risk. Hum Mol Genet (2009) 1.58
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Nonclassical splicing mutations in the coding and noncoding regions of the ATM Gene: maximum entropy estimates of splice junction strengths. Hum Mutat (2004) 1.53
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