PubRank

Laurie H Glimcher

Author PubWeight™ 325.10‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004 19.08
2 XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 2003 11.17
3 XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008 8.43
4 Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 2007 8.42
5 Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 2002 8.34
6 Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol 2003 7.06
7 XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 2004 6.72
8 T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 2004 6.43
9 Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol 2001 6.30
10 Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 2008 6.02
11 Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med 2004 5.13
12 Homeostasis and inflammation in the intestine. Cell 2010 4.60
13 TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 2010 4.56
14 Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe 2010 4.54
15 Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A 2003 4.47
16 Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 2006 4.46
17 T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol 2002 4.38
18 The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 2008 4.09
19 XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J 2005 3.92
20 Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002 3.91
21 NFATc1 balances quiescence and proliferation of skin stem cells. Cell 2008 3.81
22 Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol 2006 3.70
23 T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 2005 3.65
24 XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res 2004 3.24
25 Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A 2003 3.23
26 The role of Th1/Th2 polarization in mucosal immunity. Nat Med 2002 3.19
27 Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med 2002 3.16
28 Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 2003 3.15
29 BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell 2009 3.07
30 XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev 2009 3.03
31 T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood 2005 2.95
32 Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science 2006 2.70
33 T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol 2010 2.68
34 T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A 2002 2.63
35 The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol Rev 2011 2.50
36 Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell 2009 2.47
37 T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A 2003 2.34
38 NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 2008 2.29
39 A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 2008 2.26
40 Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell 2004 2.20
41 The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev 2003 2.20
42 The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med 2007 2.12
43 Signaling pathways in Th2 development. Immunol Rev 2004 2.10
44 Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A 2010 2.10
45 T-bet in disease. Nat Immunol 2011 2.09
46 The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest 2010 1.98
47 Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron 2012 1.97
48 Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell 2009 1.95
49 The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe 2013 1.91
50 Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. Cell Metab 2012 1.90
51 T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. J Exp Med 2004 1.88
52 Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell 2011 1.87
53 The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A 2009 1.86
54 T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A 2005 1.83
55 T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A 2005 1.82
56 Transcription: tantalizing times for T cells. Cell 2002 1.82
57 Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest 2008 1.81
58 Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia. Circ Cardiovasc Genet 2011 1.78
59 Protein folding stress in neurodegenerative diseases: a glimpse into the ER. Curr Opin Cell Biol 2011 1.77
60 A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 2004 1.77
61 Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med 2010 1.76
62 Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest 2007 1.75
63 Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice. Gastroenterology 2011 1.72
64 XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. J Exp Med 2009 1.71
65 Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin. Dev Biol 2004 1.71
66 The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med 2011 1.70
67 T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol 2013 1.70
68 T-bet, a T-cell-associated transcription factor, is expressed in a subset of B-cell lymphoproliferative disorders. Am J Clin Pathol 2004 1.70
69 The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells. Nat Immunol 2009 1.66
70 IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med 2005 1.64
71 NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proc Natl Acad Sci U S A 2013 1.61
72 Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci U S A 2008 1.60
73 Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci U S A 2011 1.59
74 Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum. Curr Opin Immunol 2010 1.57
75 Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. J Biol Chem 2011 1.55
76 T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma. Hum Pathol 2005 1.52
77 NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells. Nat Immunol 2001 1.51
78 Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest 2011 1.50
79 Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J Clin Invest 2006 1.49
80 TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J 2009 1.46
81 Pillars article: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000. 100: 655-669. J Immunol 2015 1.44
82 IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J Immunol 2010 1.43
83 Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production. J Immunol 2005 1.41
84 Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci U S A 2007 1.39
85 Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J Biol Chem 2005 1.39
86 XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum. Gastroenterology 2010 1.37
87 Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. Hum Mol Genet 2012 1.36
88 T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells. J Immunol 2002 1.34
89 Asthmatic changes in mice lacking T-bet are mediated by IL-13. Int Immunol 2005 1.32
90 Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol 2012 1.32
91 T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol 2008 1.32
92 Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection. J Immunol 2005 1.32
93 T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity. J Immunol 2006 1.31
94 IRE1α activation protects mice against acetaminophen-induced hepatotoxicity. J Exp Med 2012 1.30
95 TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A 2004 1.30
96 The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells. Proc Natl Acad Sci U S A 2005 1.30
97 The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nat Cell Biol 2010 1.29
98 Intersection of the unfolded protein response and hepatic lipid metabolism. Cell Mol Life Sci 2009 1.24
99 Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development. Dev Biol 2003 1.23
100 T-bet, a Th1 transcription factor regulates the expression of Tim-3. Eur J Immunol 2010 1.21
101 Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products. J Virol 2005 1.19
102 T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. Am J Respir Crit Care Med 2005 1.18
103 T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function. J Immunol 2009 1.16
104 XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells. J Exp Med 2005 1.16
105 T-bet regulates metastasis rate in a murine model of primary prostate cancer. Cancer Res 2004 1.14
106 Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest 2013 1.14
107 Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system. J Clin Invest 2004 1.12
108 Endoplasmic reticulum stress in immunity. Annu Rev Immunol 2014 1.12
109 Mitogen-activated protein kinase pathways in osteoblasts. Annu Rev Cell Dev Biol 2013 1.11
110 A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2. Mol Cell 2002 1.10
111 Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. J Exp Med 2009 1.08
112 Gout: new insights into an old disease. J Clin Invest 2006 1.07
113 Differential expression of T-bet, a T-box transcription factor required for Th1 T-cell development, in peripheral T-cell lymphomas. Am J Clin Pathol 2003 1.06
114 Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A 2009 1.06
115 Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani. J Immunol 2006 1.06
116 Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc Natl Acad Sci U S A 2008 1.05
117 Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells. J Exp Med 2004 1.05
118 Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection. J Clin Invest 2011 1.05
119 Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities. J Allergy Clin Immunol 2004 1.04
120 Dampening of death pathways by schnurri-2 is essential for T-cell development. Nature 2011 1.02
121 HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A 2008 1.02
122 Distal regions of the human IFNG locus direct cell type-specific expression. J Immunol 2010 0.99
123 MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J Clin Invest 2011 0.97
124 A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding. Hum Mol Genet 2003 0.96
125 Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue. J Exp Med 2007 0.94
126 Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3. Proc Natl Acad Sci U S A 2010 0.93
127 After GWAS: mice to the rescue? Curr Opin Immunol 2012 0.91
128 Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma. J Allergy Clin Immunol 2008 0.90
129 Protective role of nuclear factor of activated T cells 2 in CD8+ long-lived memory T cells in an allergy model. J Allergy Clin Immunol 2008 0.90
130 Control of bone resorption in mice by Schnurri-3. Proc Natl Acad Sci U S A 2012 0.90
131 Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus. Proc Natl Acad Sci U S A 2011 0.90
132 The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. J Exp Med 2013 0.89
133 Schnurri-3: a key regulator of postnatal skeletal remodeling. Adv Exp Med Biol 2007 0.89
134 Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo. Proc Natl Acad Sci U S A 2002 0.88
135 NFATc1 in inflammatory and musculoskeletal conditions. Adv Exp Med Biol 2010 0.88
136 XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy. Autophagy 2009 0.86
137 Protein homeostasis networks in physiology and disease. Curr Opin Cell Biol 2011 0.85
138 NIP45 controls the magnitude of the type 2 T helper cell response. Proc Natl Acad Sci U S A 2010 0.85
139 Lentivirus delivery of shRNA constructs into osteoblasts. Methods Mol Biol 2008 0.84
140 T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships. Cytokine 2009 0.83
141 TAK1 mediates BMP signaling in cartilage. Ann N Y Acad Sci 2010 0.83
142 An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells. Gastroenterology 2004 0.80
143 Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin. J Control Release 2013 0.79
144 Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice. Ann N Y Acad Sci 2003 0.78
145 Schnurri-3 is an essential regulator of osteoblast function and adult bone mass. Ann Rheum Dis 2007 0.78
146 Regulation of bone formation and immune cell development by Schnurri proteins. Adv Exp Med Biol 2010 0.76
147 It's a good year for Blimp-1 (and plasma cells). Immunity 2003 0.75
148 Turning down the system: counter-regulatory mechanisms in bone and adaptive immunity. Immunol Rev 2005 0.75
149 Editorial overview. Curr Opin Immunol 2010 0.75
150 William Erwin Paul (1936-2015). Cell 2015 0.75