Homeostasis and inflammation in the intestine.

Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71

Gut microbiota composition correlates with diet and health in the elderly. Nature (2012) 6.94

Metabolic reconstruction for metagenomic data and its application to the human microbiome. PLoS Comput Biol (2012) 6.27

Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med (2011) 4.78

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci U S A (2010) 4.35

Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Science (2011) 3.62

Targeting the unfolded protein response in disease. Nat Rev Drug Discov (2013) 3.37

The role of retinoic acid in tolerance and immunity. Immunity (2011) 3.16

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest (2013) 2.96

Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab (2014) 2.44

The immune system and the gut microbiota: friends or foes? Nat Rev Immunol (2010) 2.38

The impact of perinatal immune development on mucosal homeostasis and chronic inflammation. Nat Rev Immunol (2011) 2.29

Programming dendritic cells to induce T(H)2 and tolerogenic responses. Nat Immunol (2010) 2.29

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22

Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded? Diabetes Care (2010) 2.22

Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest (2011) 2.09

IgT, a primitive immunoglobulin class specialized in mucosal immunity. Nat Immunol (2010) 2.03

Metagenomics and personalized medicine. Cell (2011) 2.00

Microbiota restoration: natural and supplemented recovery of human microbial communities. Nat Rev Microbiol (2010) 1.89

The human microbiome and its potential importance to pediatrics. Pediatrics (2012) 1.74

Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions. Curr Biol (2012) 1.67

Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog (2012) 1.52

Exploring host-microbiota interactions in animal models and humans. Genes Dev (2013) 1.51

B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity (2012) 1.47

DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest (2015) 1.45

Stress, inflammation, and defense of homeostasis. Mol Cell (2014) 1.44

Chapter 12: Human microbiome analysis. PLoS Comput Biol (2012) 1.44

Pregnancy outcome and risk of celiac disease in offspring: a nationwide case-control study. Gastroenterology (2011) 1.44

The role of the immune system in governing host-microbe interactions in the intestine. Nat Immunol (2013) 1.41

The effects of TLR activation on T-cell development and differentiation. Clin Dev Immunol (2012) 1.33

The biodiversity hypothesis and allergic disease: world allergy organization position statement. World Allergy Organ J (2013) 1.32

Gene-environment interactions in chronic inflammatory disease. Nat Immunol (2011) 1.30

Fecal microbiota transplantation: indications, methods, evidence, and future directions. Curr Gastroenterol Rep (2013) 1.30

Drosophila melanogaster as a model for human intestinal infection and pathology. Dis Model Mech (2011) 1.29

Crohn's disease: NOD2, autophagy and ER stress converge. Gut (2011) 1.27

The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology (2013) 1.27

Evolution of inflammatory diseases. Curr Biol (2012) 1.27

The gut as a sensory organ. Nat Rev Gastroenterol Hepatol (2013) 1.26

The potter's wheel: the host's role in sculpting its microbiota. Cell Mol Life Sci (2011) 1.25

The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? Am J Physiol Gastrointest Liver Physiol (2011) 1.22

Immunomodulatory dietary polysaccharides: a systematic review of the literature. Nutr J (2010) 1.20

The impact of probiotics and prebiotics on the immune system. Nat Rev Immunol (2012) 1.19

Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis. Inflamm Bowel Dis (2011) 1.18

Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. Am J Physiol Gastrointest Liver Physiol (2012) 1.18

Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2. Cell Host Microbe (2012) 1.17

Contribution of gut bacteria to liver pathobiology. Gastroenterol Res Pract (2010) 1.07

Integration of UPRER and oxidative stress signaling in the control of intestinal stem cell proliferation. PLoS Genet (2014) 1.06

Promoting longevity by maintaining metabolic and proliferative homeostasis. J Exp Biol (2014) 1.05

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis. Proc Natl Acad Sci U S A (2011) 1.04

Role of Th17 Cells in the Pathogenesis of Human IBD. ISRN Inflamm (2014) 1.04

Genes and environment: how will our concepts on the pathophysiology of IBD develop in the future? Dig Dis (2010) 1.03

Inside the mucosal immune system. PLoS Biol (2012) 1.03

Emerging actions of the nuclear receptor LRH-1 in the gut. Biochim Biophys Acta (2010) 1.01

Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. Gut Microbes (2013) 1.01

The role of gut microbiota on insulin resistance. Nutrients (2013) 0.99

Regulatory immune cells in regulation of intestinal inflammatory response to microbiota. Mucosal Immunol (2015) 0.98

Microbial community profiling of human saliva using shotgun metagenomic sequencing. PLoS One (2014) 0.98

Predominant effect of host genetics on levels of Lactobacillus johnsonii bacteria in the mouse gut. Appl Environ Microbiol (2011) 0.98

Altered enteric microbiota ecology in interleukin 10-deficient mice during development and progression of intestinal inflammation. Gut Microbes (2013) 0.97

GM-CSF: a role in immune and inflammatory reactions in the intestine. Expert Rev Gastroenterol Hepatol (2010) 0.96

PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response. PLoS One (2011) 0.96

Fecal microbiome analysis as a diagnostic test for diverticulitis. Eur J Clin Microbiol Infect Dis (2014) 0.96

Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving Forward. Front Microbiol (2011) 0.96

Neonatal immune adaptation of the gut and its role during infections. Clin Dev Immunol (2013) 0.95

Long-term differential changes in mouse intestinal metabolomics after γ and heavy ion radiation exposure. PLoS One (2014) 0.95

Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease. Front Immunol (2014) 0.95

Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice. BMC Med Genomics (2012) 0.92

Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases. BMC Immunol (2012) 0.91

ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis. Autophagy (2013) 0.90

Genetically determined epithelial dysfunction and its consequences for microflora-host interactions. Cell Mol Life Sci (2011) 0.90

Endoplasmic reticulum stress in intestinal epithelial cell function and inflammatory bowel disease. Gastroenterol Res Pract (2015) 0.90

The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium. Mucosal Immunol (2014) 0.90

Chitin microparticles for the control of intestinal inflammation. Inflamm Bowel Dis (2012) 0.90

Cellular and molecular basis of intestinal barrier dysfunction in the irritable bowel syndrome. Gut Liver (2012) 0.89

Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction. Proc Natl Acad Sci U S A (2012) 0.89

Metabolism: Host and microbes in a pickle. Nature (2010) 0.89

Immune responses to gut microbiota-commensals and pathogens. Gut Microbes (2010) 0.89

PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress. PLoS Genet (2015) 0.88

Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction. PLoS One (2012) 0.88

The role of the intestinal context in the generation of tolerance and inflammation. Clin Dev Immunol (2011) 0.88

Probiotics, nuclear receptor signaling, and anti-inflammatory pathways. Gastroenterol Res Pract (2011) 0.88

Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination. Immune Netw (2012) 0.88

Soluble CD83 ameliorates experimental colitis in mice. Mucosal Immunol (2014) 0.88

Natural genome diversity of AI-2 quorum sensing in Escherichia coli: conserved signal production but labile signal reception. Genome Biol Evol (2013) 0.88

Characterization of the Gut Microbiome Using 16S or Shotgun Metagenomics. Front Microbiol (2016) 0.87

Cytopenia and leukocyte recovery shape cytokine fluctuations after myeloablative allogeneic hematopoietic stem cell transplantation. Haematologica (2011) 0.87

Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion. Nutr Res Pract (2015) 0.87

Restoring the gut microbiome for the treatment of inflammatory bowel diseases. World J Gastroenterol (2014) 0.87

Intestinal antimicrobial peptides during homeostasis, infection, and disease. Front Immunol (2012) 0.86

Impairment of cellular immunity is associated with overexpression of heat shock protein 70 in neonatal pigs with intrauterine growth retardation. Cell Stress Chaperones (2012) 0.86

Blood microbiota dysbiosis is associated with the onset of cardiovascular events in a large general population: the D.E.S.I.R. study. PLoS One (2013) 0.86

Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease. J Biol Chem (2011) 0.86

Aging of the mammalian gastrointestinal tract: a complex organ system. Age (Dordr) (2013) 0.86

Guidelines on the use of extracorporeal photopheresis. J Eur Acad Dermatol Venereol (2014) 0.85

Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. PLoS One (2012) 0.85

Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases. Am J Physiol Gastrointest Liver Physiol (2014) 0.84

Activation of Immune and Defense Responses in the Intestinal Mucosa by Outer Membrane Vesicles of Commensal and Probiotic Escherichia coli Strains. Front Microbiol (2016) 0.83

Contribution of TLR signaling to the pathogenesis of colitis-associated cancer in inflammatory bowel disease. World J Gastroenterol (2014) 0.83

Differential intestinal M-cell gene expression response to gut commensals. Immunology (2012) 0.83

Chemistry meets biology in colitis-associated carcinogenesis. Free Radic Res (2013) 0.83

A core gut microbiome in obese and lean twins. Nature (2008) 52.30

An obesity-associated gut microbiome with increased capacity for energy harvest. Nature (2006) 44.35

The human microbiome project. Nature (2007) 28.53

IL-17 and Th17 Cells. Annu Rev Immunol (2009) 23.02

Evolution of mammals and their gut microbes. Science (2008) 21.40

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08

Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell (2006) 18.83

The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med (2009) 16.02

Topographical and temporal diversity of the human skin microbiome. Science (2009) 15.96

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14

Systems biology: a brief overview. Science (2002) 14.69

A microbial symbiosis factor prevents intestinal inflammatory disease. Nature (2008) 13.15

Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature (2008) 12.45

Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe (2008) 11.97

Origin and physiological roles of inflammation. Nature (2008) 11.68

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol (2001) 11.07

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science (2000) 10.98

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84

Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science (2006) 9.95

Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Cell (2006) 9.64

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet (2008) 9.52

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol (2004) 9.42

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol (2004) 8.45

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell (2007) 8.42

ATP drives lamina propria T(H)17 cell differentiation. Nature (2008) 8.02

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A (2008) 7.43

Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34

Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature (2007) 7.17

Microbial community profiling for human microbiome projects: Tools, techniques, and challenges. Genome Res (2009) 7.12

Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science (2009) 6.07

RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol (2008) 5.91

Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity (2008) 5.82

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A (2008) 5.78

Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont. Cell Host Microbe (2008) 5.39

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol (2008) 5.18

A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med (2000) 5.11

A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10

Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05

Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? Nat Immunol (2004) 4.58

Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science (2009) 4.45

Aire. Annu Rev Immunol (2009) 4.43

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med (2008) 4.24

A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol (2009) 4.19

Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell Host Microbe (2007) 3.88

Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol (2006) 3.85

Regulatory T cells in the control of host-microorganism interactions (*). Annu Rev Immunol (2009) 3.82

Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol (2009) 3.80

MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med (2007) 3.79

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol (2003) 3.69

Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat Immunol (2009) 3.60

Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity (2007) 3.58

The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity (2009) 3.58

Shotgun metaproteomics of the human distal gut microbiota. ISME J (2008) 3.43

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS One (2008) 3.36

Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science (2005) 3.32

The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity (2008) 3.19

Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system. Nat Med (2007) 2.98

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest (2008) 2.88

Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev Immunol (2009) 2.82

Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity (2004) 2.79

Gut commensal bacteria direct a protective immune response against Toxoplasma gondii. Cell Host Microbe (2009) 2.67

JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med (2007) 2.63

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. J Clin Invest (2007) 2.55

The role of stromal stem cells in tissue regeneration and wound repair. Science (2009) 2.51

Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology (2008) 2.42

Endotoxin tolerance: A review. Crit Care Med (2002) 2.33

Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen. Nat Med (1999) 2.17

Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model. Inflamm Bowel Dis (2003) 2.09

Do symbiotic bacteria subvert host immunity? Nat Rev Microbiol (2009) 2.07

Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes. J Immunol (2007) 2.05

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. J Exp Med (2009) 2.02

Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity. Gastroenterology (2008) 2.00

The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med (2006) 1.96

Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell (2009) 1.95

Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food Chem Toxicol (2003) 1.93

Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe (2009) 1.91

Dendritic cells in intestinal homeostasis and disease. J Clin Invest (2009) 1.83

Epithelial tight junctions in intestinal inflammation. Ann N Y Acad Sci (2009) 1.81

IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med (2006) 1.76

The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation. Cell Host Microbe (2009) 1.74

The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol (2007) 1.73

The multifaceted influence of the mucosal microflora on mucosal dendritic cell responses. Immunity (2009) 1.68

Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol (2006) 1.66

Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family. Cancer Res (2007) 1.54

The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis. Exp Cell Res (2006) 1.46

Enteroendocrine cells express functional Toll-like receptors. Am J Physiol Gastrointest Liver Physiol (2007) 1.42

In vivo imaging and genetic analysis link bacterial motility and symbiosis in the zebrafish gut. Proc Natl Acad Sci U S A (2007) 1.40

Colonic endocrine cells in inflammatory bowel disease. J Intern Med (1997) 1.35

Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment. J Biol Chem (2008) 1.35

Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease. Semin Immunol (2009) 1.33

Innate immune recognition of the indigenous microbial flora. Mucosal Immunol (2008) 1.33

Patterns and scales in gastrointestinal microbial ecology. Gastroenterology (2009) 1.33

Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis. Differentiation (2008) 1.30

M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis. FEMS Immunol Med Microbiol (2007) 1.27

Spontaneous and continuous cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestine lamina propria: directing the tone of the intestinal immune response. J Immunol (2001) 1.27

QIIME allows analysis of high-throughput community sequencing data. Nat Methods (2010) 85.34

A core gut microbiome in obese and lean twins. Nature (2008) 52.30

An obesity-associated gut microbiome with increased capacity for energy harvest. Nature (2006) 44.35

Microbial ecology: human gut microbes associated with obesity. Nature (2006) 36.98

Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A (2005) 33.66

Metagenomic analysis of the human distal gut microbiome. Science (2006) 29.76

The human microbiome project. Nature (2007) 28.53

The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A (2004) 26.56

Host-bacterial mutualism in the human intestine. Science (2005) 26.39

Bacterial community variation in human body habitats across space and time. Science (2009) 24.84

Evolution of mammals and their gut microbes. Science (2008) 21.40

Human gut microbiome viewed across age and geography. Nature (2012) 19.31

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08

Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell (2006) 18.83

The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med (2009) 16.02

A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science (2003) 12.57

Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature (2008) 12.45

Worlds within worlds: evolution of the vertebrate gut microbiota. Nat Rev Microbiol (2008) 12.16

Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe (2008) 11.97

XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol (2003) 11.17

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature (2012) 10.74

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci U S A (2002) 9.78

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell (2011) 9.75

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A (2007) 9.71

Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Cell (2006) 9.64

Diversity, stability and resilience of the human gut microbiota. Nature (2012) 9.09

Glycan foraging in vivo by an intestine-adapted bacterial symbiont. Science (2005) 9.08

Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science (2011) 8.88

Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (2013) 8.81

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell (2007) 8.42

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34

How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr (2002) 8.31

Human nutrition, the gut microbiome and the immune system. Nature (2011) 7.77

Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications. Nat Biotechnol (2011) 7.53

Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins. Proc Natl Acad Sci U S A (2010) 7.09

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06

Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science (2013) 6.98

Moving pictures of the human microbiome. Genome Biol (2011) 6.72

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72

Identifying genetic determinants needed to establish a human gut symbiont in its habitat. Cell Host Microbe (2009) 6.67

T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity (2004) 6.43

Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol (2001) 6.30

Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol (2003) 6.17

Regulation of hepatic lipogenesis by the transcription factor XBP1. Science (2008) 6.02

Viruses in the faecal microbiota of monozygotic twins and their mothers. Nature (2010) 5.92

Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A (2004) 5.89

Evolution of symbiotic bacteria in the distal human intestine. PLoS Biol (2007) 5.79

Honor thy symbionts. Proc Natl Acad Sci U S A (2003) 5.72

Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing. Nat Methods (2012) 5.41

Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont. Cell Host Microbe (2008) 5.39

IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe (2007) 5.18

Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Proc Natl Acad Sci U S A (2004) 5.16

The long-term stability of the human gut microbiota. Science (2013) 5.15

Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach. Proc Natl Acad Sci U S A (2006) 5.13

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med (2004) 5.13

A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism. Proc Natl Acad Sci U S A (2006) 5.04

Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice. Proc Natl Acad Sci U S A (2011) 4.85

Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr (2011) 4.60

Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? Nat Immunol (2004) 4.58

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 4.56

Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe (2010) 4.54

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A (2003) 4.47

Immunoproliferative small intestinal disease associated with Campylobacter jejuni. N Engl J Med (2004) 4.47

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science (2006) 4.46

The core gut microbiome, energy balance and obesity. J Physiol (2009) 4.45

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A (2008) 4.45

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol (2002) 4.38

Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host. PLoS Biol (2006) 4.27

The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. Sci Transl Med (2011) 4.24

Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe (2008) 4.14

The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol (2008) 4.09

Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proc Natl Acad Sci U S A (2009) 4.09

Complex glycan catabolism by the human gut microbiota: the Bacteroidetes Sus-like paradigm. J Biol Chem (2009) 4.05

Recognition and degradation of plant cell wall polysaccharides by two human gut symbionts. PLoS Biol (2011) 3.97

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J (2005) 3.92

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 3.91

NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81

Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 3.70

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65

Predicting a human gut microbiota's response to diet in gnotobiotic mice. Science (2011) 3.49

Direct sequencing of the human microbiome readily reveals community differences. Genome Biol (2010) 3.34

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res (2004) 3.24

Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A (2003) 3.23

The role of Th1/Th2 polarization in mucosal immunity. Nat Med (2002) 3.19

Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med (2002) 3.16

Critical roles for transcription factor GATA-3 in thymocyte development. Immunity (2003) 3.15

The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression. Proc Natl Acad Sci U S A (2006) 3.07

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev (2009) 3.03

Starch catabolism by a prominent human gut symbiont is directed by the recognition of amylose helices. Structure (2008) 3.02

T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood (2005) 2.95

Cohabiting family members share microbiota with one another and with their dogs. Elife (2013) 2.92

Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem (2002) 2.91

Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation. Proc Natl Acad Sci U S A (2009) 2.91

Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut. Proc Natl Acad Sci U S A (2007) 2.79

Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science (2006) 2.70

T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol (2010) 2.68

T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A (2002) 2.63