Published in Dev Biol on November 01, 2004
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57
Endogenous retroviruses function as species-specific enhancer elements in the placenta. Nat Genet (2013) 1.52
Human hypoblast formation is not dependent on FGF signalling. Dev Biol (2011) 1.46
Trophoblast stem cells. Biol Reprod (2010) 1.42
Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res (2010) 1.41
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The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation. Mol Cell Biol (2010) 1.23
Ets2 is required for trophoblast stem cell self-renewal. Dev Biol (2007) 1.20
Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol Cell Biol (2009) 1.19
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Derivation and maintenance of murine trophoblast stem cells under defined conditions. Stem Cell Reports (2014) 1.02
FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast. Stem Cells Dev (2012) 1.01
FGF4-dependent stem cells derived from rat blastocysts differentiate along the trophoblast lineage. Dev Biol (2011) 1.00
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Paracrine and epigenetic control of trophectoderm differentiation from human embryonic stem cells: the role of bone morphogenic protein 4 and histone deacetylases. Stem Cells Dev (2011) 0.96
SATB homeobox proteins regulate trophoblast stem cell renewal and differentiation. J Biol Chem (2011) 0.92
Troika of the mouse blastocyst: lineage segregation and stem cells. Curr Stem Cell Res Ther (2012) 0.90
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Nat Commun (2015) 0.88
Transcriptional repressor erf determines extraembryonic ectoderm differentiation. Mol Cell Biol (2007) 0.88
Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy. Int J Dev Biol (2014) 0.87
BMP4 regulation of human trophoblast development. Int J Dev Biol (2014) 0.86
FGF4 independent derivation of trophoblast stem cells from the common vole. PLoS One (2009) 0.84
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Global hormone profiling of murine placenta reveals Secretin expression. Placenta (2011) 0.83
Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4. PLoS One (2011) 0.81
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Gender-dependent survival of allogeneic trophoblast stem cells in liver. Cell Transplant (2009) 0.78
Transforming growth factor-β1 (TGF-β1) induces mouse precartilaginous stem cell proliferation through TGF-β receptor II (TGFRII)-Akt-β-catenin signaling. Int J Mol Sci (2014) 0.78
Intrauterine trophoblast migration: A comparative view of humans and rodents. Cell Adh Migr (2016) 0.78
Notch1 signaling antagonizes transforming growth factor-β pathway and induces apoptosis in rabbit trophoblast stem cells. Stem Cells Dev (2014) 0.77
Selection of accurate reference genes in mouse trophoblast stem cells for reverse transcription-quantitative polymerase chain reaction. J Reprod Dev (2016) 0.76
Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation. J Biol Chem (2015) 0.76
Clinical and Therapeutic Implications of Follistatin in Solid Tumours. Cancer Genomics Proteomics (2016) 0.75
Generation of trophoblast stem cells. Methods Mol Biol (2012) 0.75
Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife (2016) 0.75
A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence. Stem Cells Int (2015) 0.75
Single-stranded DNA binding protein Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells. Stem Cell Res Ther (2016) 0.75
SOLD1 is expressed in bovine trophoblast cell lines and regulates cell invasiveness. Reprod Biol Endocrinol (2014) 0.75
Activin Regulates Self-renewal and Differentiation of Trophoblast Stem Cells by Down-regulating the X Chromosome Gene Bcor. J Biol Chem (2015) 0.75
Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation. Sci Rep (2017) 0.75
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol (2003) 11.17
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell (2007) 8.42
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity (2004) 6.43
Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol (2001) 6.30
Regulation of hepatic lipogenesis by the transcription factor XBP1. Science (2008) 6.02
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med (2004) 5.13
Homeostasis and inflammation in the intestine. Cell (2010) 4.60
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 4.56
Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe (2010) 4.54
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A (2003) 4.47
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science (2006) 4.46
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol (2002) 4.38
The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol (2008) 4.09
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J (2005) 3.92
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 3.91
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 3.70
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res (2004) 3.24
Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A (2003) 3.23
The role of Th1/Th2 polarization in mucosal immunity. Nat Med (2002) 3.19
Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med (2002) 3.16
Critical roles for transcription factor GATA-3 in thymocyte development. Immunity (2003) 3.15
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev (2009) 3.03
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood (2005) 2.95
Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science (2006) 2.70
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol (2010) 2.68
T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A (2002) 2.63
The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol Rev (2011) 2.50
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell (2009) 2.47
T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A (2003) 2.34
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest (2008) 2.29
A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med (2008) 2.26
Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell (2004) 2.20
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev (2003) 2.20
The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med (2007) 2.12
Signaling pathways in Th2 development. Immunol Rev (2004) 2.10
Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A (2010) 2.10
T-bet in disease. Nat Immunol (2011) 2.09
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest (2010) 1.98
Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron (2012) 1.97
Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell (2009) 1.95
The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. Cell Metab (2012) 1.90
T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. J Exp Med (2004) 1.88
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell (2011) 1.87
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A (2009) 1.86
T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A (2005) 1.83
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A (2005) 1.82
Transcription: tantalizing times for T cells. Cell (2002) 1.82
Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest (2008) 1.81
Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia. Circ Cardiovasc Genet (2011) 1.78
Protein folding stress in neurodegenerative diseases: a glimpse into the ER. Curr Opin Cell Biol (2011) 1.77
A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature (2004) 1.77
Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med (2010) 1.76
Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest (2007) 1.75
Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice. Gastroenterology (2011) 1.72
XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. J Exp Med (2009) 1.71
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med (2011) 1.70
T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol (2013) 1.70
T-bet, a T-cell-associated transcription factor, is expressed in a subset of B-cell lymphoproliferative disorders. Am J Clin Pathol (2004) 1.70
The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells. Nat Immunol (2009) 1.66
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med (2005) 1.64
NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proc Natl Acad Sci U S A (2013) 1.61
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci U S A (2008) 1.60
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci U S A (2011) 1.59
Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum. Curr Opin Immunol (2010) 1.57
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. J Biol Chem (2011) 1.55
T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma. Hum Pathol (2005) 1.52
NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells. Nat Immunol (2001) 1.51
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest (2011) 1.50
Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J Clin Invest (2006) 1.49
TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J (2009) 1.46
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IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J Immunol (2010) 1.43
Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production. J Immunol (2005) 1.41
Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci U S A (2007) 1.39
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J Biol Chem (2005) 1.39
XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum. Gastroenterology (2010) 1.37
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. Hum Mol Genet (2012) 1.36
T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells. J Immunol (2002) 1.34
Asthmatic changes in mice lacking T-bet are mediated by IL-13. Int Immunol (2005) 1.32
Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol (2012) 1.32
T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol (2008) 1.32
Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection. J Immunol (2005) 1.32
T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity. J Immunol (2006) 1.31
IRE1α activation protects mice against acetaminophen-induced hepatotoxicity. J Exp Med (2012) 1.30
The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells. Proc Natl Acad Sci U S A (2005) 1.30
TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A (2004) 1.30
The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nat Cell Biol (2010) 1.29
Intersection of the unfolded protein response and hepatic lipid metabolism. Cell Mol Life Sci (2009) 1.24
Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development. Dev Biol (2003) 1.23
T-bet, a Th1 transcription factor regulates the expression of Tim-3. Eur J Immunol (2010) 1.21