Published in J Clin Immunol on June 30, 2010
Non-canonical inflammasome activation targets caspase-11. Nature (2011) 8.85
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity (2012) 5.08
Regulation of inflammasome signaling. Nat Immunol (2012) 4.10
Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol (2013) 3.55
Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol (2011) 3.20
Targeting interleukin-1 in heart disease. Circulation (2013) 2.52
Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A (2012) 2.19
NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proc Natl Acad Sci U S A (2011) 1.83
IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathog (2013) 1.67
Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury. Crit Care Med (2014) 1.52
TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One (2012) 1.48
Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity. ACS Nano (2013) 1.47
TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun (2013) 1.32
Mitochondrial ROS fuel the inflammasome. Cell Res (2011) 1.26
Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome. Trends Immunol (2014) 1.17
Sterile inflammatory response in acute pancreatitis. Pancreas (2012) 1.15
Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death. Cell Cycle (2013) 1.14
Influenza A exacerbates Staphylococcus aureus pneumonia by attenuating IL-1β production in mice. J Immunol (2013) 1.14
The NLRP3 Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders. Mediators Inflamm (2013) 1.11
Mechanisms of disease: inflammasome activation and the development of type 2 diabetes. Front Immunol (2013) 1.11
Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies. PLoS One (2013) 1.11
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest (2015) 1.09
Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells. Front Cell Neurosci (2014) 1.05
Tissue factor, blood coagulation, and beyond: an overview. Int J Inflam (2011) 1.05
Immunological loss-of-function due to genetic gain-of-function in humans: autosomal dominance of the third kind. Curr Opin Immunol (2015) 1.03
Activation of the NLRP3 inflammasome by intracellular poly I:C. FEBS Lett (2010) 1.02
Uric acid induces trophoblast IL-1β production via the inflammasome: implications for the pathogenesis of preeclampsia. Am J Reprod Immunol (2011) 1.00
Generation of a Listeria vaccine strain by enhanced caspase-1 activation. Eur J Immunol (2011) 0.99
Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injury. Crit Care (2011) 0.99
Molecular changes and vision loss in a mouse model of closed-globe blast trauma. Invest Ophthalmol Vis Sci (2014) 0.98
Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing. Biochim Biophys Acta (2014) 0.98
A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury. EMBO Mol Med (2015) 0.97
Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection. PLoS One (2012) 0.95
NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production. PLoS Negl Trop Dis (2013) 0.94
Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis. J Biol Chem (2012) 0.92
MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2. Biochem Biophys Res Commun (2013) 0.92
Role of inflammasome activation in the pathophysiology of vascular diseases of the neurovascular unit. Antioxid Redox Signal (2014) 0.92
A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast. PLoS One (2013) 0.91
Potential role of the inflammasome-derived inflammatory cytokines in pulmonary fibrosis. Pulm Med (2011) 0.91
Aberrant expression of interleukin-1β and inflammasome activation in human malignant gliomas. PLoS One (2014) 0.90
Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis. Biochim Biophys Acta (2014) 0.87
NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases. Inflamm Res (2014) 0.87
ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio (2014) 0.87
P2X7 receptor activation induces inflammatory responses in salivary gland epithelium. Am J Physiol Cell Physiol (2012) 0.86
NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation. Int J Neuropsychopharmacol (2015) 0.85
Burkholderia cenocepacia type VI secretion system mediates escape of type II secreted proteins into the cytoplasm of infected macrophages. PLoS One (2012) 0.85
Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation. J Biol Chem (2015) 0.84
Retracted Hyaluronan activation of the Nlrp3 inflammasome contributes to the development of airway hyperresponsiveness. Environ Health Perspect (2012) 0.84
Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol Cell Biol (2014) 0.84
Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders. Neuropsychopharmacology (2016) 0.83
Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome. PLoS One (2013) 0.83
Reduction of streptolysin O (SLO) pore-forming activity enhances inflammasome activation. Toxins (Basel) (2013) 0.83
Interaction of Staphylococcus aureus with osteoblasts (Review). Exp Ther Med (2011) 0.83
Transcriptional analysis of the three Nlrp1 paralogs in mice. BMC Genomics (2013) 0.82
NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis. Brain (2015) 0.81
An update on the role of the inflammasomes in the pathogenesis of kidney diseases. Pediatr Nephrol (2015) 0.81
AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites. Proc Natl Acad Sci U S A (2015) 0.81
Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection. Am J Respir Crit Care Med (2014) 0.81
Inflammasomes in the Pathophysiology of Kidney Diseases. Kidney Dis (Basel) (2015) 0.80
Serum amyloid A induces NLRP-3-mediated IL-1β secretion in neutrophils. PLoS One (2014) 0.80
Defective pro-IL-1β responses in macrophages from aged mice. Immun Ageing (2012) 0.80
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease. Mol Neurodegener (2016) 0.79
Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor. Nanoscale (2014) 0.79
Early Life Exposure to Fructose Alters Maternal, Fetal and Neonatal Hepatic Gene Expression and Leads to Sex-Dependent Changes in Lipid Metabolism in Rat Offspring. PLoS One (2015) 0.79
Capsular Polysaccharide Is Involved in NLRP3 Inflammasome Activation by Klebsiella pneumoniae Serotype K1. Infect Immun (2015) 0.79
Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells. Oncotarget (2016) 0.78
New insights into acne pathogenesis: propionibacterium acnes activates the inflammasome. J Invest Dermatol (2014) 0.78
Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation. Oncotarget (2016) 0.78
Differential gene expression profile of first-generation and second-generation rapamycin-resistant allogeneic T cells. Cytotherapy (2013) 0.78
Immunostimulatory effects of silica nanoparticles in human monocytes. Immune Netw (2013) 0.78
The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity. Periodontol 2000 (2015) 0.78
In vivo and in vitro characterization of the immune stimulating activity of the Neisserial porin PorB. PLoS One (2013) 0.78
Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production. Mediators Inflamm (2016) 0.77
Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors. J Neuroinflammation (2017) 0.77
Bamboo vinegar decreases inflammatory mediator expression and NLRP3 inflammasome activation by inhibiting reactive oxygen species generation and protein kinase C-α/δ activation. PLoS One (2013) 0.76
Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Am J Obstet Gynecol (2016) 0.76
Ultrasonically enhanced rifampin activity against internalized Staphylococcus aureus. Exp Ther Med (2012) 0.76
NLRP3 inflammasome is essential for the development of chronic obstructive pulmonary disease. Int J Clin Exp Pathol (2015) 0.76
The inflammasome as a target of modulation by DNA viruses. Future Virol (2013) 0.75
Semiconductor Electronic Label-Free Assay for Predictive Toxicology. Sci Rep (2016) 0.75
Lung inflammation caused by inhaled toxicants: a review. Int J Chron Obstruct Pulmon Dis (2016) 0.75
Increased Expression of the NOD-like Receptor Family, Pyrin Domain Containing 3 Inflammasome in Dermatomyositis and Polymyositis is a Potential Contributor to Their Pathogenesis. Chin Med J (Engl) (2016) 0.75
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. J Neuroinflammation (2017) 0.75
Cathepsins in heart disease-chewing on the heartache? Am J Physiol Heart Circ Physiol (2015) 0.75
Hypoxia primes human normal prostate epithelial cells and cancer cell lines for the NLRP3 and AIM2 inflammasome activation. Oncotarget (2016) 0.75
Inhibition of endotoxin-induced airway epithelial cell injury by a novel family of pyrrol derivates. Lab Invest (2016) 0.75
Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy. Intensive Care Med Exp (2017) 0.75
Effect of TiO₂ Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness. Allergy Asthma Immunol Res (2017) 0.75
NLR family pyrin domain containing 3 (NLRP3) inflammasome gene polymorphism rs7512998 (C>T) predicts aging-related increase of blood pressure, the TAMRISK study. Immun Ageing (2015) 0.75
Potential Roles of Mitochondria-Associated ER Membranes (MAMs) in Traumatic Brain Injury. Cell Mol Neurobiol (2017) 0.75
A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP. PLoS One (2017) 0.75
Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome. Oncotarget (2017) 0.75
Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses. Sci Rep (2017) 0.75
Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature (2006) 24.43
The inflammasomes. Cell (2010) 19.37
Cryopyrin activates the inflammasome in response to toxins and ATP. Nature (2006) 18.74
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol (2008) 16.65
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science (2008) 16.54
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol (2008) 10.39
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77
Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature (2008) 9.16
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature (2008) 9.01
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ (2007) 8.85
Pyroptosis: host cell death and inflammation. Nat Rev Microbiol (2009) 7.63
Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem (2006) 5.92
Active caspase-1 is a regulator of unconventional protein secretion. Cell (2008) 5.89
The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A (2008) 5.59
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature (2009) 5.00
Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell (2006) 4.63
ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem (2006) 4.33
Inflammasomes: guardians of cytosolic sanctity. Immunol Rev (2009) 3.58
Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47
Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One (2009) 2.93
Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol (2007) 2.73
Superoxide dismutase 1 regulates caspase-1 and endotoxic shock. Nat Immunol (2008) 2.72
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol (2007) 2.68
The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol (2007) 2.57
Molecular mechanisms involved in inflammasome activation. Trends Cell Biol (2009) 2.29
Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. Cell Death Differ (2003) 2.02
Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells. Blood (2007) 2.00
NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury. J Biol Chem (2009) 1.91
CA-074Me protection against anthrax lethal toxin. Infect Immun (2009) 1.55
Identifying infection-associated genes of Candida albicans in the postgenomic era. FEMS Yeast Res (2009) 1.19
Human monocyte stimulus-coupled IL-1beta posttranslational processing: modulation via monovalent cations. Am J Physiol (1998) 1.12
Differing caspase-1 activation states in monocyte versus macrophage models of IL-1beta processing and release. J Leukoc Biol (2004) 1.04
Human monocyte interleukin-1beta posttranslational processing. Evidence of a volume-regulated response. J Biol Chem (1996) 0.95
Inflammasome activation. The missing link: how the inflammasome senses oxidative stress. Immunol Cell Biol (2010) 0.88
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature (2012) 10.74
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell (2011) 9.75
Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol (2006) 9.53
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature (2008) 9.16
Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27
MAP kinases in the immune response. Annu Rev Immunol (2001) 7.62
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49
Interchromosomal associations between alternatively expressed loci. Nature (2005) 7.45
IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity (2007) 6.61
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature (2007) 6.58
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science (2006) 6.55
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol (2007) 6.20
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity (2006) 6.00
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci U S A (2005) 5.96
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity (2006) 5.91
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity (2007) 5.73
The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A (2008) 5.59
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell (2004) 5.50
Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature (2005) 5.32
A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol (2009) 5.26
A toll-like receptor that prevents infection by uropathogenic bacteria. Science (2004) 5.26
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (2009) 5.24
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest (2009) 5.09
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med (2007) 4.95
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A (2004) 4.88
TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science (2005) 4.86
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med (2005) 4.85
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat Immunol (2006) 4.70
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol (2004) 4.67
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity (2008) 4.67
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
Transforming growth factor-beta in T-cell biology. Nat Rev Immunol (2002) 4.50
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med (2007) 4.47
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol (2006) 4.44
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med (2005) 4.28
Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med (2006) 4.28
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A (2004) 4.12
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity (2007) 4.07
Control of TH17 cells occurs in the small intestine. Nature (2011) 4.03
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity (2006) 4.02
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer (2013) 4.02
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A (2009) 3.99
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med (2006) 3.76
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A (2006) 3.74
The inflammasome: first line of the immune response to cell stress. Cell (2006) 3.73
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host Microbe (2007) 3.52
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med (2005) 3.43
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J Exp Med (2008) 3.39
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity (2011) 3.38
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest (2004) 3.38
Mechanism of p38 MAP kinase activation in vivo. Genes Dev (2003) 3.36
T helper cell differentiation: regulation by cis elements and epigenetics. Immunity (2006) 3.33
Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell (2006) 3.32
Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity (2008) 3.26
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A (2004) 3.26
Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol (2010) 3.25
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med (2008) 3.15
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol (2002) 3.04
Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat Immunol (2005) 2.96
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A (2003) 2.94
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest (2008) 2.91
Regulation of the Th2 cytokine locus by a locus control region. Immunity (2003) 2.84
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med (2004) 2.84
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity (2009) 2.82
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci U S A (2006) 2.75
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol (2005) 2.75
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol (2009) 2.73
Does Toll-like receptor 3 play a biological role in virus infections? Virology (2004) 2.73
Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity (2009) 2.66
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol (2006) 2.65
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med (2009) 2.61
Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med (2002) 2.60
Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe (2009) 2.58
Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity (2003) 2.56
STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity (2003) 2.54
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 2.54
TH2, allergy and group 2 innate lymphoid cells. Nat Immunol (2013) 2.52
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev (2004) 2.51
An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med (2008) 2.50
A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A (2003) 2.47
Transforming growth factor-beta and the immune response: implications for anticancer therapy. Clin Cancer Res (2007) 2.44
Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity (2009) 2.44
Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol (2004) 2.44
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med (2013) 2.39
JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell (2003) 2.39