Published in Trends Biochem Sci on April 16, 2013
Signalling dynamics in the spindle checkpoint response. Nat Rev Mol Cell Biol (2014) 1.71
Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint. Genes Dev (2014) 1.65
Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests. PLoS Genet (2016) 1.43
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Nat Struct Mol Biol (2014) 1.30
Determinants of robustness in spindle assembly checkpoint signalling. Nat Cell Biol (2013) 1.28
Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein. J Biol Chem (2014) 1.14
Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet). Proc Natl Acad Sci U S A (2014) 1.10
Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores. EMBO Rep (2014) 1.01
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Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling. Proc Natl Acad Sci U S A (2014) 0.96
The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. J Biol Chem (2014) 0.96
Mechanism of APC/CCDC20 activation by mitotic phosphorylation. Proc Natl Acad Sci U S A (2016) 0.96
Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores. J Cell Biol (2015) 0.95
Control of the meiotic cell division program in plants. Plant Reprod (2013) 0.92
KNL1: bringing order to the kinetochore. Chromosoma (2013) 0.91
The spindle checkpoint and chromosome segregation in meiosis. FEBS J (2015) 0.91
Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex. J Biol Chem (2013) 0.90
Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes. Proc Natl Acad Sci U S A (2015) 0.90
Cyclin B3 controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. Cell Cycle (2015) 0.89
Shugoshins: tension-sensitive pericentromeric adaptors safeguarding chromosome segregation. Mol Cell Biol (2014) 0.89
Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol Cell (2016) 0.88
OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One (2016) 0.87
Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proc Natl Acad Sci U S A (2015) 0.86
Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells. Nat Commun (2015) 0.86
Phosphorylation of Xenopus p31(comet) potentiates mitotic checkpoint exit. Cell Cycle (2015) 0.85
A noncatalytic function of the topoisomerase II CTD in Aurora B recruitment to inner centromeres during mitosis. J Cell Biol (2016) 0.84
Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1. J Biol Chem (2015) 0.84
Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex. Proc Natl Acad Sci U S A (2016) 0.83
The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation. Nat Commun (2016) 0.82
DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity. PLoS Genet (2015) 0.82
A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling. Elife (2017) 0.82
Structure of an intermediate conformer of the spindle checkpoint protein Mad2. Proc Natl Acad Sci U S A (2015) 0.82
Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation. Proc Natl Acad Sci U S A (2016) 0.81
Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis. Cell (2016) 0.80
A novel fizzy/Cdc20-dependent mechanism suppresses necrosis in neural stem cells. Development (2014) 0.80
Generation of a Spindle Checkpoint Arrest from Synthetic Signaling Assemblies. Curr Biol (2016) 0.80
Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe. G3 (Bethesda) (2014) 0.79
Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Genes Dev (2016) 0.79
Structure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control. Int J Mol Sci (2014) 0.78
Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. Genetics (2015) 0.77
The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation. Front Physiol (2014) 0.77
Zfp207 is a Bub3 binding protein regulating meiotic chromosome alignment in mouse oocytes. Oncotarget (2016) 0.77
Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation. Nat Commun (2015) 0.77
Mps1 is SUMO-modified during the cell cycle. Oncotarget (2016) 0.76
A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment. J Cell Sci (2015) 0.76
Synthetic Physical Interactions Map Kinetochore-Checkpoint Activation Regions. G3 (Bethesda) (2016) 0.75
RZZ and Mad1 dynamics in Drosophila mitosis. Chromosome Res (2015) 0.75
The complexity of life and death decisions in mitosis. Mol Cell Oncol (2014) 0.75
Role of CCT chaperonin in the disassembly of mitotic checkpoint complexes. Proc Natl Acad Sci U S A (2017) 0.75
How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling. Bioarchitecture (2015) 0.75
Understanding the structural basis for controlling chromosome division. Philos Trans A Math Phys Eng Sci (2015) 0.75
Phosphorylation propels p31(comet) for mitotic exit. Cell Cycle (2015) 0.75
Ligand Independent and Subtype-Selective Actions of Thyroid Hormone Receptors in Human Adipose Derived Stem Cells. PLoS One (2016) 0.75
The spindle assembly checkpoint: More than just keeping track of the spindle. Trends Cell Mol Biol (2016) 0.75
Mitotic degradation of yeast Fkh1 by the Anaphase Promoting Complex is required for normal longevity, genomic stability and stress resistance. Aging (Albany NY) (2016) 0.75
The mitotic checkpoint complex (MCC): looking back and forth after 15 years. AIMS Mol Sci (2016) 0.75
Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science (2011) 5.04
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell (2006) 3.88
The spindle checkpoint, aneuploidy, and cancer. Oncogene (2004) 3.61
Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. Mol Cell (2006) 3.38
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell (2002) 3.24
The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nat Struct Mol Biol (2007) 3.15
The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol (2004) 2.87
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell (2011) 2.73
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol Cell (2004) 2.66
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases. Proc Natl Acad Sci U S A (2005) 2.60
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J (2004) 2.57
Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. Proc Natl Acad Sci U S A (2004) 2.52
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell (2006) 2.32
Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Mol Cell Biol (2005) 2.31
ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Mol Cell (2006) 2.26
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. EMBO J (2006) 2.13
Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. Dev Cell (2008) 2.00
FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation. EMBO J (2003) 1.89
Identification of two novel components of the human NDC80 kinetochore complex. J Biol Chem (2003) 1.89
Protein metamorphosis: the two-state behavior of Mad2. Structure (2008) 1.83
Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres. Curr Biol (2013) 1.69
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol Biol Cell (2006) 1.68
Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J Biol Chem (2004) 1.63
A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. Proc Natl Acad Sci U S A (2004) 1.63
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol (2007) 1.59
Adsorption of ionizable organic contaminants on multi-walled carbon nanotubes with different oxygen contents. J Hazard Mater (2010) 1.45
Structural insights into histone lysine demethylation. Curr Opin Struct Biol (2010) 1.44
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry (2007) 1.44
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol (2008) 1.41
Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.39
Gold nanoparticle based label-free SERS probe for ultrasensitive and selective detection of trinitrotoluene. J Am Chem Soc (2009) 1.38
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol (2012) 1.38
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting. Proc Natl Acad Sci U S A (2012) 1.37
Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem (2003) 1.35
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell (2008) 1.32
The Smc complexes in DNA damage response. Cell Biosci (2012) 1.31
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc Natl Acad Sci U S A (2012) 1.31
Functional analysis of the spindle-checkpoint proteins using an in vitro ubiquitination assay. Methods Mol Biol (2004) 1.30
Gold nano-popcorn-based targeted diagnosis, nanotherapy treatment, and in situ monitoring of photothermal therapy response of prostate cancer cells using surface-enhanced Raman spectroscopy. J Am Chem Soc (2010) 1.30
Mutual regulation between the spindle checkpoint and APC/C. Semin Cell Dev Biol (2011) 1.29
Selective detection of mercury (II) ion using nonlinear optical properties of gold nanoparticles. J Am Chem Soc (2008) 1.29
Photomutagenicity of 16 polycyclic aromatic hydrocarbons from the US EPA priority pollutant list. Mutat Res (2004) 1.28
HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule. Proc Natl Acad Sci U S A (2004) 1.23
A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling. J Am Chem Soc (2013) 1.23
Toxicity and environmental risks of nanomaterials: challenges and future needs. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2009) 1.22
KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome. J Biol Chem (2006) 1.21
Challenge in Understanding Size and Shape Dependent Toxicity of Gold Nanomaterials in Human Skin Keratinocytes. Chem Phys Lett (2008) 1.21
Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry (2007) 1.20
Multifunctional oval-shaped gold-nanoparticle-based selective detection of breast cancer cells using simple colorimetric and highly sensitive two-photon scattering assay. ACS Nano (2010) 1.17
Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet). Mol Biol Cell (2011) 1.15
Crm1-mediated nuclear export of Cdc14 is required for the completion of cytokinesis in budding yeast. Cell Cycle (2005) 1.13
PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution. EMBO J (2011) 1.11
Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity. BMC Biochem (2006) 1.10
Kinase signaling in the spindle checkpoint. J Biol Chem (2009) 1.09
Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. Mol Biol Cell (2011) 1.09
Effect of Surface Coating on the Toxicity of Silver Nanomaterials on Human Skin Keratinocytes. Chem Phys Lett (2010) 1.07
A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivo. Genes Dev (2005) 1.07
Chloridodiphen-yl{[1-(1,3-thia-zol-2-yl-κN)ethyl-idene]-4-phenyl-thio-semicarbazidato-κN,S}tin(IV) methanol monosolvate. Acta Crystallogr Sect E Struct Rep Online (2011) 1.07
ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. PLoS One (2008) 1.06
Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition. Proc Natl Acad Sci U S A (2010) 1.04
UVA light-induced DNA cleavage by isomeric methylbenz[a]anthracenes. Chem Res Toxicol (2002) 1.02
Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl. Genes Dev (2012) 1.02
A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ (2011) 1.00
Rapid colorimetric identification and targeted photothermal lysis of Salmonella bacteria by using bioconjugated oval-shaped gold nanoparticles. Chemistry (2010) 1.00
Photomutagenicity of cosmetic ingredient chemicals azulene and guaiazulene. Mutat Res (2003) 0.98
Photoirradiation of representative polycyclic aromatic hydrocarbons and twelve isomeric methylbenz[a]anthracene with UVA light: formation of lipid peroxidation. Toxicol Ind Health (2006) 0.98
Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1. J Biol Chem (2008) 0.98
Seven-coordinate anion complex with a tren-based urea: binding discrepancy of hydrogen sulfate in solid and solution states. Org Biomol Chem (2011) 0.97
Structure of the human cohesin inhibitor Wapl. Proc Natl Acad Sci U S A (2013) 0.95
Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila. EMBO J (2003) 0.95
Limitation of the MTT and XTT assays for measuring cell viability due to superoxide formation induced by nano-scale TiO2. Toxicol In Vitro (2011) 0.95
Phototoxicity and environmental transformation of polycyclic aromatic hydrocarbons (PAHs)-light-induced reactive oxygen species, lipid peroxidation, and DNA damage. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2012) 0.93
Integrating plasmonic nanoparticles with TiO₂ photonic crystal for enhancement of visible-light-driven photocatalysis. Environ Sci Technol (2012) 0.92
Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs. PLoS One (2010) 0.90
Iodido{4-phenyl-1-[1-(1,3-thia-zol-2-yl-κN)ethyl-idene]thio-semicarbazidato-κN',S}{4-phenyl-1-[1-(1,3-thia-zol-2-yl)ethyl-idene]thio-semicarbazide-κS}mercury(II). Acta Crystallogr Sect E Struct Rep Online (2011) 0.90
Arsenic-induced genotoxic and cytotoxic effects in human keratinocytes, melanocytes and dendritic cells. Int J Environ Res Public Health (2004) 0.90
Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14. J Biol Chem (2004) 0.90
Light-induced cytotoxicity of 16 polycyclic aromatic hydrocarbons on the US EPA priority pollutant list in human skin HaCaT keratinocytes: relationship between phototoxicity and excited state properties. Environ Toxicol (2007) 0.89
Phototoxicity and DNA damage induced by the cosmetic ingredient chemical azulene in human Jurkat T-cells. Mutat Res (2004) 0.89
Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells. Cancer Res (2009) 0.89
Photodecomposition and phototoxicity of natural retinoids. Int J Environ Res Public Health (2005) 0.88
Distinguishing "looped-out" and "stacked-in" DNA bulge conformation using fluorescent 2-aminopurine replacing a purine base. J Biomol Struct Dyn (2002) 0.88
Synthesis and photoirradiation of isomeric ethylchrysenes by UVA light leading to lipid peroxidation. Int J Environ Res Public Health (2007) 0.87
Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint. Cell Div (2007) 0.87
Highly sensitive and selective dynamic light-scattering assay for TNT detection using p-ATP attached gold nanoparticle. ACS Appl Mater Interfaces (2010) 0.86
Quality assurance and safety of herbal dietary supplements. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2009) 0.86
Light-induced mutagenicity in Salmonella TA102 and genotoxicity/cytotoxicity in human T-cells by 3,3'-dichlorobenzidine: a chemical used in the manufacture of dyes and pigments and in tattoo inks. Toxicology (2005) 0.86
Photocatalytic oxidation of aqueous ammonia using atomic single layer graphitic-C3N4. Environ Sci Technol (2014) 0.85
Regulation of CDC14: pathways and checkpoints of mitotic exit. Front Biosci (2003) 0.85
Toxic effects of gold nanoparticles on Salmonella typhimurium bacteria. Toxicol Ind Health (2011) 0.85
DNA damage and repair of human skin keratinocytes concurrently exposed to pyrene derivatives and UVA light. Toxicol Res (Camb) (2013) 0.85
A CpG oligodeoxynucleotide acts as a potent adjuvant for inactivated rabies virus vaccine. Vaccine (2008) 0.84
Toxicity of kava kava. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2008) 0.84
Basic apoptotic and necrotic cell death in human liver carcinoma (HepG2 ) cells induced by synthetic azamacrocycle. Environ Toxicol (2012) 0.83
Interface engineering catalytic graphene for smart colorimetric biosensing. ACS Nano (2012) 0.83
Gold Nanoparticle Based Surface Enhanced Fluorescence For Detection of Organophosphorus Agents. Chem Phys Lett (2008) 0.83
Label-free fluorescent detection of Cu(II) ions based on DNA cleavage-dependent graphene-quenched DNAzymes. Chem Commun (Camb) (2011) 0.83
Photodegradation of selected PCBs in the presence of Nano-TiO2 as catalyst and H2O2 as an oxidant. Int J Environ Res Public Health (2010) 0.82