Published in Proc Natl Acad Sci U S A on July 01, 2013
Targeting bromodomains: epigenetic readers of lysine acetylation. Nat Rev Drug Discov (2014) 3.54
Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration. J Virol (2013) 1.34
The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites. Cell Rep (2013) 1.26
MLV integration site selection is driven by strong enhancers and active promoters. Nucleic Acids Res (2014) 1.11
Enhancers are major targets for murine leukemia virus vector integration. J Virol (2014) 1.10
The bromodomain: from epigenome reader to druggable target. Biochim Biophys Acta (2014) 1.02
Molecular mechanisms of retroviral integration site selection. Nucleic Acids Res (2014) 1.01
Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction. Nucleic Acids Res (2014) 1.00
Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer. Biomed Res Int (2014) 0.97
Concise review: lessons learned from clinical trials of gene therapy in monogenic immunodeficiency diseases. Stem Cells Transl Med (2014) 0.97
Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding. Nucleic Acids Res (2014) 0.96
Key determinants of target DNA recognition by retroviral intasomes. Retrovirology (2015) 0.93
BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements. Mol Ther Nucleic Acids (2014) 0.91
Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection. Bioessays (2015) 0.91
Retroviral DNA Integration. Chem Rev (2016) 0.90
LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes. Genes Dev (2015) 0.89
Nuclear trafficking of retroviral RNAs and Gag proteins during late steps of replication. Viruses (2013) 0.85
3D hotspots of recurrent retroviral insertions reveal long-range interactions with cancer genes. Nat Commun (2015) 0.84
Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes. Nucleic Acids Res (2014) 0.84
Intasome architecture and chromatin density modulate retroviral integration into nucleosome. Retrovirology (2015) 0.83
Host Factors in Retroviral Integration and the Selection of Integration Target Sites. Microbiol Spectr (2014) 0.83
TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication. PLoS One (2013) 0.82
Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction. Proc Natl Acad Sci U S A (2016) 0.82
Structural and sequencing analysis of local target DNA recognition by MLV integrase. Nucleic Acids Res (2015) 0.82
Serial number tagging reveals a prominent sequence preference of retrotransposon integration. Nucleic Acids Res (2014) 0.81
Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis. PLoS Genet (2014) 0.81
Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors. Retrovirology (2014) 0.81
Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells. Mol Ther (2016) 0.80
Sites of retroviral DNA integration: From basic research to clinical applications. Crit Rev Biochem Mol Biol (2015) 0.80
Common Viral Integration Sites Identified in Avian Leukosis Virus-Induced B-Cell Lymphomas. MBio (2015) 0.79
Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte Differentiation. Stem Cell Reports (2016) 0.79
Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites. J Vis Exp (2016) 0.79
Epigenetic control of mobile DNA as an interface between experience and genome change. Front Genet (2014) 0.79
Genome-wide analysis of alpharetroviral integration in human hematopoietic stem/progenitor cells. Genes (Basel) (2014) 0.78
Genome-Wide Analysis of Transposon and Retroviral Insertions Reveals Preferential Integrations in Regions of DNA Flexibility. G3 (Bethesda) (2016) 0.78
The N-terminus of murine leukaemia virus p12 protein is required for mature core stability. PLoS Pathog (2014) 0.78
Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses. Mol Ther Methods Clin Dev (2014) 0.78
Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras. PLoS One (2016) 0.78
What Integration Sites Tell Us about HIV Persistence. Cell Host Microbe (2016) 0.78
DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity. PLoS One (2015) 0.78
Integration site and clonal expansion in human chronic retroviral infection and gene therapy. Viruses (2014) 0.78
Multifunctional facets of retrovirus integrase. World J Biol Chem (2015) 0.78
Alpharetroviral vectors: from a cancer-causing agent to a useful tool for human gene therapy. Viruses (2014) 0.77
Retroviral Integrase: Then and Now. Annu Rev Virol (2015) 0.77
Foamy virus vectors for HIV gene therapy. Viruses (2013) 0.77
Single-Nucleotide-Specific Targeting of the Tf1 Retrotransposon Promoted by the DNA-Binding Protein Sap1 of Schizosaccharomyces pombe. Genetics (2015) 0.77
B'-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase. Nucleic Acids Res (2015) 0.76
Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions. J Virol (2016) 0.76
Retroviral DNA Transposition: Themes and Variations. Microbiol Spectr (2014) 0.76
Applications of DNA integrating elements: Facing the bias bully. Mob Genet Elements (2015) 0.76
Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12. J Virol (2016) 0.76
Gamma-Retrovirus Integration Marks Cell Type-Specific Cancer Genes: A Novel Profiling Tool in Cancer Genomics. PLoS One (2016) 0.76
Bromodomain 4: a cellular Swiss army knife. J Leukoc Biol (2016) 0.76
Retargeted Foamy Virus Vectors Integrate Less Frequently Near Proto-oncogenes. Sci Rep (2016) 0.76
Transcriptional, epigenetic and retroviral signatures identify regulatory regions involved in hematopoietic lineage commitment. Sci Rep (2016) 0.76
Toward a safer integration profile of MLV-based retroviral vectors. Mol Ther (2014) 0.75
Chromatin states shape insertion profiles of the piggyBac, Tol2 and Sleeping Beauty transposons and murine leukemia virus. Sci Rep (2017) 0.75
Hotspots of MLV integration in the hematopoietic tumor genome. Oncogene (2016) 0.75
Integration site selection by retroviruses and transposable elements in eukaryotes. Nat Rev Genet (2017) 0.75
The FACT Complex Promotes Avian Leukosis Virus DNA Integration. J Virol (2017) 0.75
Characterization of Equine Infectious Anemia Virus Integration in the Horse Genome. Viruses (2015) 0.75
X-ray Crystal Structure of the N-Terminal Region of Moloney Murine Leukemia Virus Integrase and its Implications for Viral DNA Recognition. Proteins (2017) 0.75
Impact of Chromatin on HIV Replication. Genes (Basel) (2015) 0.75
INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes. Mol Ther Methods Clin Dev (2016) 0.75
Interactions between Retroviruses and the Host Cell Genome. Mol Ther Methods Clin Dev (2017) 0.75
Genetic Modification of T Cells. Biomedicines (2016) 0.75
Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy. Mol Ther Nucleic Acids (2017) 0.75
Selective inhibition of BET bromodomains. Nature (2010) 18.79
HIV-1 integration in the human genome favors active genes and local hotspots. Cell (2002) 12.60
Transcription start regions in the human genome are favored targets for MLV integration. Science (2003) 12.21
The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation. J Biol Chem (2007) 5.06
Retroviral intasome assembly and inhibition of DNA strand transfer. Nature (2010) 4.99
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J Biol Chem (2002) 4.91
A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med (2005) 4.88
Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell (2004) 4.38
An essential role for LEDGF/p75 in HIV integration. Science (2006) 4.18
LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes Dev (2007) 3.96
Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog (2006) 3.67
Selection of target sites for mobile DNA integration in the human genome. PLoS Comput Biol (2006) 3.21
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. Proc Natl Acad Sci U S A (2005) 3.18
The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell (2008) 3.05
Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. Mol Cell (2004) 2.99
BET domain co-regulators in obesity, inflammation and cancer. Nat Rev Cancer (2012) 2.80
The bromodomain: a chromatin-targeting module? Nat Struct Biol (1999) 2.72
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding. J Biol Chem (2005) 2.28
HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2. PLoS Pathog (2011) 2.00
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (2012) 1.88
Interaction of bovine papillomavirus E2 protein with Brd4 stabilizes its association with chromatin. J Virol (2005) 1.87
Reactivation of latent HIV-1 by inhibition of BRD4. Cell Rep (2012) 1.84
Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing. PLoS Genet (2012) 1.82
Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p. Mol Cell Biol (2001) 1.81
Controlling integration specificity of a yeast retrotransposon. Proc Natl Acad Sci U S A (2003) 1.74
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proc Natl Acad Sci U S A (2010) 1.68
Retroviral DNA integration: HIV and the role of LEDGF/p75. Trends Genet (2006) 1.62
Integration target site selection by a resurrected human endogenous retrovirus. Genes Dev (2009) 1.62
Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein. J Biol Chem (2008) 1.61
Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes. Nucleic Acids Res (2013) 1.37
Retroviral integrations in gene therapy trials. Mol Ther (2012) 1.34
TFIIIB subunit Bdp1p is required for periodic integration of the Ty1 retrotransposon and targeting of Isw2p to S. cerevisiae tDNAs. Genes Dev (2005) 1.33
Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure. J Biol Chem (2012) 1.30
LEDGF (p75) promotes DNA-end resection and homologous recombination. Nat Struct Mol Biol (2012) 1.27
Gammaretroviral integration into nucleosomal target DNA in vivo. J Virol (2011) 1.23
Retrotransposon Tf1 is targeted to Pol II promoters by transcription activators. Mol Cell (2008) 1.23
Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors. Retrovirology (2008) 1.20
Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins. Genome Biol (2012) 1.18
Gene therapy for primary adaptive immune deficiencies. J Allergy Clin Immunol (2011) 1.09
Brd4: tethering, segregation and beyond. Trends Microbiol (2004) 1.05
Gene therapy for primary immunodeficiencies. Hum Gene Ther (2012) 1.03
WHAT do viruses BET on? Front Biosci (Landmark Ed) (2010) 0.99
Development of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome. Curr Opin Mol Ther (2006) 0.96
MuLV IN mutants responsive to HDAC inhibitors enhance transcription from unintegrated retroviral DNA. Virology (2012) 0.93
Assembly and catalysis of concerted two-end integration events by Moloney murine leukemia virus integrase. J Virol (2001) 0.88
Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses. Retrovirology (2012) 0.83
QIIME allows analysis of high-throughput community sequencing data. Nat Methods (2010) 85.34
Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30
Linking long-term dietary patterns with gut microbial enterotypes. Science (2011) 17.30
PyNAST: a flexible tool for aligning sequences to a template alignment. Bioinformatics (2009) 15.93
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest (2008) 9.42
Short pyrosequencing reads suffice for accurate microbial community analysis. Nucleic Acids Res (2007) 9.15
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell (2008) 8.41
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS Biol (2004) 8.27
Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications. Nat Biotechnol (2011) 7.53
DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutations. Nucleic Acids Res (2007) 6.89
Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science (2003) 6.22
The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis. PLoS Pathog (2008) 5.28
Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol (2007) 5.20
Sampling and pyrosequencing methods for characterizing bacterial communities in the human gut using 16S sequence tags. BMC Microbiol (2010) 4.97
In vivo genome editing restores haemostasis in a mouse model of haemophilia. Nature (2011) 4.81
Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med (2011) 4.78
HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications. Genome Res (2007) 4.72
Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol (2006) 4.53
Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog (2009) 4.24
Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci U S A (2006) 4.23
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science (2012) 4.20
Bayesian community-wide culture-independent microbial source tracking. Nat Methods (2011) 3.88
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog (2006) 3.67
Efficacy of gene therapy for X-linked severe combined immunodeficiency. N Engl J Med (2010) 3.54
Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol (2005) 3.47
Human immunodeficiency virus cDNA metabolism: notable stability of two-long terminal repeat circles. J Virol (2002) 3.46
The human gut virome: inter-individual variation and dynamic response to diet. Genome Res (2011) 3.32
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Sci Transl Med (2012) 3.29
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature (2013) 3.21
Selection of target sites for mobile DNA integration in the human genome. PLoS Comput Biol (2006) 3.21
Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J Exp Med (2002) 2.94
The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood (2008) 2.83
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83
Direct charging of tRNA(CUA) with pyrrolysine in vitro and in vivo. Nature (2004) 2.69
HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathog (2011) 2.68
The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J Exp Med (2003) 2.65
DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer. Nucleic Acids Res (2008) 2.64
Disordered microbial communities in the upper respiratory tract of cigarette smokers. PLoS One (2010) 2.60
p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study. J Natl Cancer Inst (2003) 2.54
Rapid evolution of the human gut virome. Proc Natl Acad Sci U S A (2013) 2.53
The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity (2010) 2.53
Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity (2010) 2.52
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat Med (2012) 2.49
Assessing the potential for AAV vector genotoxicity in a murine model. Blood (2010) 2.48
Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting. PLoS One (2007) 2.48
Hepatitis C virus transmission bottlenecks analyzed by deep sequencing. J Virol (2010) 2.45
Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells. Nat Biotechnol (2010) 2.43
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J Exp Med (2005) 2.39
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med (2005) 2.34
Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci U S A (2008) 2.26
Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC. J Exp Med (2010) 2.26
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood (2011) 2.25
Associating microbiome composition with environmental covariates using generalized UniFrac distances. Bioinformatics (2012) 2.19
Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice. J Clin Invest (2012) 2.18
The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones. Blood (2011) 2.11
The interferon response inhibits HIV particle production by induction of TRIM22. PLoS Pathog (2008) 2.06
Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial. Blood (2010) 2.05
HIV interactions with monocytes and dendritic cells: viral latency and reservoirs. Retrovirology (2009) 2.02
HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2. PLoS Pathog (2011) 2.00
Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1. Blood (2006) 1.98
Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells. Mol Ther (2009) 1.97
SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons. Retrovirology (2012) 1.96
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med (2009) 1.85
Integration site selection by HIV-based vectors in dividing and growth-arrested IMR-90 lung fibroblasts. Mol Ther (2005) 1.85
Interactions of HIV-1 Gag with assembly cofactors. Biochemistry (2006) 1.83
The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells. J Immunol (2003) 1.79
HIV integration site selection: targeting in macrophages and the effects of different routes of viral entry. Mol Ther (2006) 1.75
Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2. Oncogene (2005) 1.73
HIV DNA integration. Cold Spring Harb Perspect Med (2012) 1.73
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin. Mol Ther (2010) 1.72
miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells. Blood (2010) 1.71
Inhibition of retroviral pathogenesis by RNA interference. Curr Biol (2002) 1.70
Development of the dendritic cell system during mouse ontogeny. J Immunol (2004) 1.68
Safe harbours for the integration of new DNA in the human genome. Nat Rev Cancer (2011) 1.67
Widespread colonization of the lung by Tropheryma whipplei in HIV infection. Am J Respir Crit Care Med (2013) 1.66
Retroviral DNA integration--mechanism and consequences. Adv Genet (2005) 1.66
Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch. J Mol Biol (2006) 1.65
Functionally distinct transmission of human immunodeficiency virus type 1 mediated by immature and mature dendritic cells. J Virol (2007) 1.65
Archaea and fungi of the human gut microbiome: correlations with diet and bacterial residents. PLoS One (2013) 1.64
Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV. Blood (2012) 1.64
Lung-enriched organisms and aberrant bacterial and fungal respiratory microbiota after lung transplant. Am J Respir Crit Care Med (2012) 1.64
Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation. Blood (2008) 1.63
Massively parallel pyrosequencing in HIV research. AIDS (2008) 1.63
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). J Med Chem (2010) 1.63
Retroviral DNA integration: HIV and the role of LEDGF/p75. Trends Genet (2006) 1.62
Integration target site selection by a resurrected human endogenous retrovirus. Genes Dev (2009) 1.62
Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Proc Natl Acad Sci U S A (2011) 1.61
Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein. J Biol Chem (2008) 1.61