Published in Nat Neurosci on August 04, 2013
Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders. Nat Neurosci (2013) 1.56
Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2). DNA Repair (Amst) (2014) 1.17
Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell (2014) 1.15
Topoisomerase-mediated chromosomal break repair: an emerging player in many games. Nat Rev Cancer (2015) 1.15
Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci (2014) 1.11
Readers of histone methylarginine marks. Biochim Biophys Acta (2014) 1.08
The FMRP regulon: from targets to disease convergence. Front Neurosci (2013) 1.07
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability. Nat Rev Mol Cell Biol (2016) 1.05
Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I. Nucleic Acids Res (2015) 0.93
Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2). J Biol Chem (2014) 0.91
An evolving view of epigenetic complexity in the brain. Philos Trans R Soc Lond B Biol Sci (2014) 0.89
Topoisomerase 1 inhibition reversibly impairs synaptic function. Proc Natl Acad Sci U S A (2014) 0.86
Neurobiology of autism gene products: towards pathogenesis and drug targets. Psychopharmacology (Berl) (2014) 0.86
Chromatin regulators, phenotypic robustness, and autism risk. Front Genet (2014) 0.83
RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals. Nucleic Acids Res (2016) 0.81
Subcellular mRNA localisation at a glance. J Cell Sci (2014) 0.80
Maternal Modifiers and Parent-of-Origin Bias of the Autism-Associated 16p11.2 CNV. Am J Hum Genet (2015) 0.80
Targeting bacterial topoisomerase I to meet the challenge of finding new antibiotics. Future Med Chem (2015) 0.79
DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3. Proc Natl Acad Sci U S A (2016) 0.79
FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks. Nucleic Acids Res (2016) 0.78
The elusive quest for RNA knots. RNA Biol (2016) 0.77
The Top3β way to untangle RNA. Nat Neurosci (2013) 0.76
Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon. J Anat (2015) 0.75
Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction. Nucleic Acids Res (2017) 0.75
Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factor. Sci Rep (2017) 0.75
Topoisomerases and the regulation of neural function. Nat Rev Neurosci (2016) 0.75
Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells. Cell Discov (2017) 0.75
Inhibition of Zn(II) binding type IA topoisomerases by organomercury compounds and Hg(II). PLoS One (2015) 0.75
Synthesizing topological structures containing RNA. Nat Commun (2017) 0.75
Genetics: RNA topoisomerase involved in neurodevelopmental disorders. Nat Rev Neurol (2013) 0.75
Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells. Sci Rep (2017) 0.75
Type IA topoisomerases can be "magicians" for both DNA and RNA in all domains of life. RNA Biol (2017) 0.75
Whole-genome re-sequencing. Curr Opin Genet Dev (2006) 35.24
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science (2008) 20.68
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell (1991) 17.00
HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature (2008) 14.17
Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol (2002) 11.79
De novo gene disruptions in children on the autistic spectrum. Neuron (2012) 9.69
Genome-wide association study identifies five new schizophrenia loci. Nat Genet (2011) 9.07
Natural RNA circles function as efficient microRNA sponges. Nature (2013) 8.93
Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell (2011) 8.46
Circularization of mRNA by eukaryotic translation initiation factors. Mol Cell (1998) 6.47
Eukaryotic stress granules: the ins and outs of translation. Mol Cell (2009) 6.09
Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell (2001) 4.21
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association. Mol Cell (1997) 3.71
De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia. Nat Genet (2012) 3.49
Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome. Cell (1994) 3.01
FMRP targets distinct mRNA sequence elements to regulate protein expression. Nature (2012) 2.95
The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95. Proc Natl Acad Sci U S A (2003) 2.82
BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. EMBO J (2005) 2.60
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat Neurosci (2004) 2.41
Tudor domains bind symmetrical dimethylated arginines. J Biol Chem (2005) 2.23
Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. Mol Cell Biol (2000) 2.18
The pathophysiology of fragile X (and what it teaches us about synapses). Annu Rev Neurosci (2012) 2.16
FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway. EMBO J (2007) 2.00
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev (2008) 1.97
Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation. J Neurosci (2007) 1.78
Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis. Proc Natl Acad Sci U S A (1998) 1.76
Family history of schizophrenia and bipolar disorder as risk factors for autism. Arch Gen Psychiatry (2012) 1.76
Control of axonal branching and synapse formation by focal adhesion kinase. Nat Neurosci (2004) 1.74
The fragile X mental retardation protein is associated with ribosomes. Nat Genet (1996) 1.72
5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage. Genes Dev (2010) 1.64
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol (2010) 1.61
Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders. Nat Neurosci (2013) 1.56
A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases-schizophrenia as a case. Bioinformatics (2009) 1.50
FMRP is associated to the ribosomes via RNA. Hum Mol Genet (1996) 1.49
Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids. Mol Cell Biol (2006) 1.41
Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. Proc Natl Acad Sci U S A (2001) 1.40
An RNA topoisomerase. Proc Natl Acad Sci U S A (1996) 1.37
Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. Nat Neurosci (2011) 1.36
Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication. EMBO J (2010) 1.36
TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. Hum Mol Genet (2008) 1.36
Diverse types of genetic variation converge on functional gene networks involved in schizophrenia. Nat Neurosci (2012) 1.34
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell (2012) 1.28
Hairpin RNA: a secondary structure of primary importance. Cell Mol Life Sci (2006) 1.27
Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. Hum Mol Genet (2008) 1.20
Drosophila melanogaster topoisomerase IIIalpha preferentially relaxes a positively or negatively supercoiled bubble substrate and is essential during development. J Biol Chem (2004) 1.18
RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase. Mol Cell Biol (2010) 1.17
Fragile X protein functions with lgl and the par complex in flies and mice. Dev Cell (2005) 1.14
Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1. J Biol Chem (2010) 1.10
Cloning and characterization of Drosophila topoisomerase IIIbeta. Relaxation of hypernegatively supercoiled DNA. J Biol Chem (2000) 1.09
Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp. Hum Mol Genet (2005) 1.07
RNA pseudoknots and the regulation of protein synthesis. Biochem Soc Trans (2008) 1.06
Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. Structure (2010) 1.03
Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth. Neural Dev (2008) 0.95
Genetic modifiers of dFMR1 encode RNA granule components in Drosophila. Genetics (2009) 0.94
Development of autoimmunity in mice lacking DNA topoisomerase 3beta. Proc Natl Acad Sci U S A (2007) 0.85
A new Drosophila gene wh (wuho) with WD40 repeats is essential for spermatogenesis and has maximal expression in hub cells. Dev Biol (2006) 0.81
Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta. Proc Natl Acad Sci U S A (2008) 0.81
Differential Expressions of Synaptogenic Markers between Primary Cultured Cortical and Hippocampal Neurons. Exp Neurobiol (2012) 0.79
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res (2004) 9.18
Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol (2007) 6.69
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell (2007) 5.29
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci U S A (2004) 5.15
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nat Genet (2006) 4.98
Dynamics of global gene expression changes during mouse preimplantation development. Dev Cell (2004) 4.97
A novel ubiquitin ligase is deficient in Fanconi anemia. Nat Genet (2003) 4.79
Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet (2004) 4.77
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet (2005) 4.57
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J (2004) 4.45
HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev (2009) 4.41
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci U S A (2003) 4.34
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell (2007) 4.28
Superoxide flashes in single mitochondria. Cell (2008) 4.08
LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol Cell Biol (2003) 3.85
Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc Natl Acad Sci U S A (2002) 3.71
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. Proc Natl Acad Sci U S A (2003) 3.52
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A (2002) 3.46
A web-based tool for principal component and significance analysis of microarray data. Bioinformatics (2005) 3.42
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex. Proc Natl Acad Sci U S A (2003) 3.37
Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells. DNA Res (2008) 3.29
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis. AJNR Am J Neuroradiol (2005) 3.11
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase. Science (2008) 3.09
p16(INK4a) translation suppressed by miR-24. PLoS One (2008) 3.08
The synthetic genetic interaction spectrum of essential genes. Nat Genet (2005) 3.06
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Proc Natl Acad Sci U S A (2006) 3.00
Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J Biol Chem (2003) 2.91
X-linked inheritance of Fanconi anemia complementation group B. Nat Genet (2004) 2.86
Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. Mol Cell Biol (2005) 2.83
Calorie restriction mimetics: an emerging research field. Aging Cell (2006) 2.82
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. Nat Struct Mol Biol (2012) 2.81
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proc Natl Acad Sci U S A (2008) 2.76
Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science (2005) 2.72
PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes. Genes Dev (2005) 2.70
Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science (2011) 2.69
Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene (2003) 2.69
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat Methods (2010) 2.67
Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem (2006) 2.67
miR-519 suppresses tumor growth by reducing HuR levels. Cell Cycle (2010) 2.63
Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol (2010) 2.63
Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence. Biol Chem (2008) 2.60
BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. EMBO J (2005) 2.60
Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA (2010) 2.59
Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet (2013) 2.59
Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol Cell Biol (2006) 2.59
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling. PLoS One (2006) 2.46
Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature (2010) 2.46
Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Cell (2002) 2.43
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol (2012) 2.40
P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling. J Biol Chem (2003) 2.38
Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol (2010) 2.38
HuR: post-transcriptional paths to malignancy. RNA Biol (2005) 2.38
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell (2010) 2.36
MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation (2010) 2.35
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J (2005) 2.34
Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell (2004) 2.34
Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J (2005) 2.33
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A (2009) 2.30
miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci U S A (2008) 2.29
Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis. Cancer Res (2003) 2.28
Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data. BMC Genomics (2008) 2.27
MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90. Mol Cell Biol (2008) 2.26
Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels. Nat Genet (2012) 2.25