PubRank

Rafael de Cabo

Author PubWeight™ 190.84‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006 20.91
2 Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004 11.39
3 Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 2007 6.47
4 Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 2008 6.22
5 Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2010 5.54
6 Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 2012 5.00
7 The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 2008 4.32
8 Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med 2011 3.84
9 SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 2012 3.69
10 Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 2012 3.52
11 Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A 2003 2.82
12 Metformin improves healthspan and lifespan in mice. Nat Commun 2013 2.68
13 Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 2009 2.65
14 Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med 2012 2.58
15 Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell 2006 2.54
16 Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci 2010 2.24
17 Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov 2012 2.22
18 JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One 2009 2.07
19 Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A 2008 1.97
20 Development of calorie restriction mimetics as a prolongevity strategy. Ann N Y Acad Sci 2004 1.92
21 Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol 2008 1.87
22 Mitochondrial biogenesis and healthy aging. Exp Gerontol 2008 1.85
23 SRT1720 improves survival and healthspan of obese mice. Sci Rep 2011 1.81
24 Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res 2008 1.75
25 Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol 2010 1.73
26 SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci 2010 1.71
27 Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Ageing Dev 2009 1.69
28 Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension 2009 1.63
29 Age-associated learning and memory deficits in two mouse versions of the Stone T-maze. Neurobiol Aging 2012 1.55
30 Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J 2009 1.52
31 Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell 2013 1.48
32 Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev 2011 1.47
33 Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol 2011 1.42
34 Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med 2012 1.42
35 Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett 2008 1.36
36 Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc Natl Acad Sci U S A 2006 1.35
37 Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem 2011 1.35
38 Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab 2012 1.35
39 RAP1 protects from obesity through its extratelomeric role regulating gene expression. Cell Rep 2013 1.31
40 Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2012 1.29
41 Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med 2006 1.28
42 Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). J Alzheimers Dis 2006 1.27
43 RNA-binding protein HuD controls insulin translation. Mol Cell 2012 1.25
44 The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion 2007 1.25
45 Dietary interventions to extend life span and health span based on calorie restriction. J Gerontol A Biol Sci Med Sci 2010 1.23
46 Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. Am J Physiol Heart Circ Physiol 2011 1.22
47 FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest 2013 1.21
48 A regulatory role for microRNA 33* in controlling lipid metabolism gene expression. Mol Cell Biol 2013 1.21
49 MicroRNA 33 regulates glucose metabolism. Mol Cell Biol 2013 1.19
50 Dietary restriction: standing up for sirtuins. Science 2010 1.17
51 Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab 2013 1.14
52 Perinatal exercise improves glucose homeostasis in adult offspring. Am J Physiol Endocrinol Metab 2012 1.13
53 Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging. J Gerontol A Biol Sci Med Sci 2012 1.09
54 Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males. PLoS One 2008 1.07
55 Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev 2006 1.06
56 SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell 2013 1.06
57 Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis. PLoS One 2011 1.05
58 AsSIRTing the DNA damage response. Trends Cell Biol 2008 1.05
59 Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet. Diabetes 2013 1.04
60 The plasma membrane redox system in aging. Ageing Res Rev 2006 1.03
61 Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats. Toxicol Appl Pharmacol 2009 1.03
62 Aging biology and novel targets for drug discovery. J Gerontol A Biol Sci Med Sci 2011 1.01
63 Bioenergetics of aging and calorie restriction. Ageing Res Rev 2006 1.01
64 The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontology 2006 1.00
65 Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction. Aging (Albany NY) 2013 1.00
66 Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. J Neurochem 2007 1.00
67 Dietary activators of Sirt1. Mol Cell Endocrinol 2008 0.98
68 Mitochondrial protection by resveratrol. Exerc Sport Sci Rev 2011 0.98
69 Mitochondrial metabolic reprogramming induced by calorie restriction. Antioxid Redox Signal 2012 0.98
70 In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets. PLoS One 2008 0.97
71 SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell 2014 0.94
72 Effects of calorie restriction on cardioprotection and cardiovascular health. J Mol Cell Cardiol 2011 0.93
73 The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster. Age (Dordr) 2011 0.93
74 Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling. Behav Brain Res 2008 0.92
75 Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells. J Immunol 2013 0.90
76 Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts. J Gerontol A Biol Sci Med Sci 2010 0.90
77 NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 2009 0.90
78 Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction. Mol Cell Endocrinol 2008 0.89
79 Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis. PLoS One 2009 0.89
80 A patent review of sirtuin activators: an update. Expert Opin Ther Pat 2012 0.89
81 Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Exp Gerontol 2007 0.85
82 Caloric restriction modulates insulin receptor signaling in liver and skeletal muscle of rat. Nutrition 2005 0.85
83 Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Exp Gerontol 2008 0.85
84 The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction. Aging Cell 2011 0.84
85 Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats. J Gerontol A Biol Sci Med Sci 2011 0.84
86 Alterations of ultrastructural and fission/fusion markers in hepatocyte mitochondria from mice following calorie restriction with different dietary fats. J Gerontol A Biol Sci Med Sci 2013 0.84
87 An unSIRTain role in longevity. Nat Med 2011 0.82
88 Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging. Aging (Albany NY) 2012 0.82
89 Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators. J Gerontol A Biol Sci Med Sci 2013 0.81
90 The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice. Exp Neurol 2010 0.81
91 Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice. Age (Dordr) 2012 0.81
92 Effect of caloric restriction on base-excision repair (BER) in the aging rat brain. Exp Gerontol 2009 0.81
93 17α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice. J Alzheimers Dis 2011 0.80
94 The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats. J Gerontol A Biol Sci Med Sci 2013 0.80
95 Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2. Antioxid Redox Signal 2014 0.80
96 Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids. Neurobiol Aging 2012 0.80
97 Animal models of aging research: implications for human aging and age-related diseases. Annu Rev Anim Biosci 2015 0.79
98 Utilizing calorie restriction to evaluate the role of sirtuins in healthspan and lifespan of mice. Methods Mol Biol 2013 0.79
99 Effect of calorie restriction and refeeding on skin wound healing in the rat. Age (Dordr) 2011 0.79
100 Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat. Ann N Y Acad Sci 2004 0.79
101 Effects of aging and calorie restriction on rat skeletal muscle glycogen synthase and glycogen phosphorylase. Exp Gerontol 2009 0.79
102 The influence of old age and poloxamer-407 on the hepatic disposition of diazepam in the isolated perfused rat liver. Pharmacology 2012 0.78
103 Aging, drugs, and drug metabolism. J Gerontol A Biol Sci Med Sci 2011 0.78
104 Determinants of serum-induced SIRT1 expression in older men: the CHAMP study. J Gerontol A Biol Sci Med Sci 2010 0.77
105 Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats. Pharmacol Biochem Behav 2011 0.77
106 Age-related loss of responsiveness to 2,5-dimethoxy-4-iodoamphetamine in liver sinusoidal endothelial cells. J Gerontol A Biol Sci Med Sci 2013 0.77
107 The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress. Age (Dordr) 2011 0.77
108 The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice. Biogerontology 2015 0.76
109 The evolution of research on ageing and nutrition. J Gerontol A Biol Sci Med Sci 2013 0.76
110 The Roy Walford legacy: diet restriction from molecules to mice to monkeys to man and onto mimetics. Exp Gerontol 2004 0.76
111 In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes. Aging Cell 2015 0.76
112 Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise. Cell Metab 2017 0.75
113 Nutrition and aging. Mech Ageing Dev 2010 0.75
114 A toast to your health, one drink at a time. Am J Clin Nutr 2010 0.75
115 Sirtuin activation: a role for plasma membrane in the cell growth puzzle. J Gerontol A Biol Sci Med Sci 2012 0.75
116 Understanding How Dogs Age: Longitudinal Analysis of Markers of Inflammation, Immune Function, and Oxidative Stress. J Gerontol A Biol Sci Med Sci 2017 0.75