Published in Pflugers Arch on July 01, 2014
Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels. Proc Natl Acad Sci U S A (2016) 0.81
The role of canonical transient receptor potential channels in seizure and excitotoxicity. Cells (2014) 0.80
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol (2015) 0.79
Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o. Biochem J (2016) 0.75
Differential Contribution of Ca(2+)-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex. Front Cell Neurosci (2017) 0.75
The TRP ion channel family. Nat Rev Neurosci (2001) 5.15
Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol (2001) 2.94
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem (2003) 2.29
Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem (2000) 2.22
Connections of the rat lateral septal complex. Brain Res Brain Res Rev (1997) 2.00
Selective association of TRPC channel subunits in rat brain synaptosomes. J Biol Chem (2002) 1.97
Regulation of affect by the lateral septum: implications for neuropsychiatry. Brain Res Brain Res Rev (2004) 1.77
The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrations. Annu Rev Pharmacol Toxicol (2009) 1.65
Leptin excites proopiomelanocortin neurons via activation of TRPC channels. J Neurosci (2010) 1.63
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol (2009) 1.51
TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels. Cell Calcium (2003) 1.47
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 1.44
Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PLoS One (2007) 1.41
Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity. Nat Neurosci (2009) 1.31
TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels. J Biol Chem (2009) 1.27
Chemoarchitecture of the rat lateral septal nucleus. Brain Res Brain Res Rev (1997) 1.26
Contribution of transient receptor potential channels to the control of GABA release from dendrites. Proc Natl Acad Sci U S A (2003) 1.25
TRPC Channels Mediate a Muscarinic Receptor-Induced Afterdepolarization in Cerebral Cortex. J Neurosci (2009) 1.17
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem (2011) 1.16
Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation. J Biol Chem (2005) 1.15
Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors. Neuron (2009) 1.14
Differential distribution of TRP Ca2+ channel isoforms in mouse brain. Neuroreport (1998) 1.11
Metabotropic glutamate receptors: intracellular signaling pathways. Curr Opin Pharmacol (2006) 1.10
Receptor-operated cation channels formed by TRPC4 and TRPC5. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.10
TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex. Hippocampus (2011) 1.06
Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol (2012) 1.03
Metabotropic glutamate receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca²⁺ wave-dependent activation of SK and TRPC channels. J Physiol (2011) 1.01
Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol Pharmacol (2011) 1.00
NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells. J Neurosci (2012) 0.98
Synaptic activation of transient receptor potential channels by metabotropic glutamate receptors in the lateral amygdala. Neuroscience (2005) 0.98
A self-limiting regulation of vasoconstrictor-activated TRPC3/C6/C7 channels coupled to PI(4,5)P₂-diacylglycerol signalling. J Physiol (2011) 0.94
Plasma membrane insertion of TRPC5 channels contributes to the cholinergic plateau potential in hippocampal CA1 pyramidal neurons. Hippocampus (2010) 0.92
Immunohistochemical study on the distribution of TRPC channels in the rat hippocampus. Brain Res (2006) 0.89
A calcium-dependent slow afterdepolarization recorded in rat dorsolateral septal nucleus neurons in vitro. J Neurophysiol (1990) 0.85
Activities of neurons within the rat dorsolateral septal nucleus (DLSN). Prog Neurobiol (1995) 0.83
An essential role of PI(4,5)P₂ for maintaining the activity of the transient receptor potential canonical (TRPC)4β. Pflugers Arch (2013) 0.83
Action of a metabotropic glutamate receptor agonist in rat lateral septum: induction of a sodium-dependent inward aftercurrent. Brain Res (1997) 0.82
Ionic channels formed by TRPC4. Handb Exp Pharmacol (2007) 0.81
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature (2009) 4.41
The TRP channels, a remarkably functional family. Cell (2002) 4.06
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem (2002) 3.14
Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ Res (2002) 3.05
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol (2008) 2.71
2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem (2004) 2.71
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
TRPC3 channels are required for synaptic transmission and motor coordination. Neuron (2008) 2.30
Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem (2003) 2.21
Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel. Blood (2002) 2.16
Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. Proc Natl Acad Sci U S A (2008) 2.11
Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Proc Natl Acad Sci U S A (2010) 1.85
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther (2011) 1.85
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking. Curr Biol (2010) 1.84
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem (2004) 1.82
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. J Cell Biol (2004) 1.80
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+. J Biol Chem (2010) 1.74
Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle. Proc Natl Acad Sci U S A (2007) 1.71
Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol (2007) 1.68
TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes. J Biol Chem (2003) 1.53
Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J Biol Chem (2005) 1.52
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 1.44
Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels. J Biol Chem (2007) 1.42
De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med (2009) 1.42
TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells. J Biol Chem (2006) 1.39
Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. J Biol Chem (2008) 1.35
Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger. J Biol Chem (2004) 1.32
Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1. Mol Cell (2002) 1.32
Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene (2003) 1.31
Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity. Nat Neurosci (2009) 1.31
Potentiation of TRPV3 channel function by unsaturated fatty acids. J Cell Physiol (2006) 1.31
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology (2009) 1.31
Functional role of TRPC proteins in native systems: implications from knockout and knock-down studies. J Physiol (2005) 1.28
Characterization of a human peptide deformylase: implications for antibacterial drug design. Biochemistry (2003) 1.27
Trafficking and assembly of the cold-sensitive TRPM8 channel. J Biol Chem (2006) 1.26
Contribution of transient receptor potential channels to the control of GABA release from dendrites. Proc Natl Acad Sci U S A (2003) 1.25
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res (2006) 1.24
The selectivity filter of the cation channel TRPM4. J Biol Chem (2005) 1.24
L-type CaV1.2 calcium channels: from in vitro findings to in vivo function. Physiol Rev (2014) 1.23
Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis. Cell (2004) 1.22
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. Pflugers Arch (2009) 1.19
Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes. Pflugers Arch (2005) 1.17
Ca2+-selective transient receptor potential V channel architecture and function require a specific ankyrin repeat. J Biol Chem (2004) 1.17
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem (2011) 1.16
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch (2009) 1.16
TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol (2012) 1.16
Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation. J Biol Chem (2005) 1.15
Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity. J Biomol Screen (2010) 1.14
Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake. Proc Natl Acad Sci U S A (2013) 1.14
An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of TRPV1 channels. J Biol Chem (2004) 1.14
Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium (2007) 1.13
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci (2011) 1.12
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med (2012) 1.11
Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Proc Natl Acad Sci U S A (2006) 1.11
2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels. Am J Physiol Lung Cell Mol Physiol (2005) 1.08
Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels. J Biol Chem (2002) 1.07
Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. J Clin Invest (2010) 1.07
Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta. J Biol Chem (2008) 1.07
Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. Circ Res (2005) 1.07
Diversity of telomere palindromic sequences and replication genes among Streptomyces linear plasmids. Appl Environ Microbiol (2006) 1.06
Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels. J Biol Chem (2011) 1.06
Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells. Infect Immun (2002) 1.06
TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression. Biochem Biophys Res Commun (2004) 1.05
Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol (2010) 1.05
Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol (2012) 1.03
Modified cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel beta3 subunit. J Biol Chem (2003) 1.03
Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors. Am J Physiol Regul Integr Comp Physiol (2006) 1.03